In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests

References

• Abubakar A, Saito T, Kitazawa H, Kawai Y, Itoh T. Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J Dairy Sci 1998; 81: 3131–3138
   PubMed Web of Science ®Google Scholar
• Augustijns P, Annaert P, Heylen P, Van den Mooter G, Kinget R. Drug absorption studies of prodrug esters using the Caco-2 model: evaluation of ester hydrolysis and transepithelial transport. Int J Pharm 1998; 166: 45–53
   Google Scholar
• Boisset M, Botham RP, Haegele KD, Lenfant B, Pachot JI. Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo: Importance of drug ionisation in the in vitro prediction of in vivo absorption. Eur J Pharm Sci 2000; 10: 215–224
   PubMed Web of Science ®Google Scholar
• Burton PS, Conradi RA, Ho NFH, Hilgers AR, Borchardt RT. How structural features influence the biomembrane permeability of peptides. J Pharm Sci 1996; 85: 1336–1340
   PubMed Web of Science ®Google Scholar
• Chao AC, Nguyen JV, Broughall M, Griffin A, Fix JA, Daddona PE. In vitro and in vivo evaluation of effects of sodium caprate on enteral peptide absorption and on mucosal morphology. Int J Pharm 1999; 191: 15–24
   PubMed Web of Science ®Google Scholar
• Daniel H, Herget M. Intestinal and renal transport of peptides at the cellular and molecular level. Peptides in mammalian protein metabolism. Tissue utilization and clinical targeting, GK Grimble, FRC Backwell. Portland Press Ltd, LondonUK 1998
   Google Scholar
• Dziuba J, Minkiewicz P, Nalecz D. Biologically active peptides from plant and animal proteins. Pol J Food Nutr Sci 1999; 8: 3–16
   Google Scholar
• Eriksson U, Danilczyk U, Penninger JM. Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol 2002; 12: R745–R752
   PubMed Web of Science ®Google Scholar
• Fitzgerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Brit J Nutr 2000; 84: S33–S37
   PubMed Web of Science ®Google Scholar
• French JF, Anderson BA, Downs TR, Dage RC. Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase in rats with hypertension. J Cardiovasc Pharmacol 1995; 26: 107–113
   PubMed Web of Science ®Google Scholar
• Fuglsang A, Nilsson D, Nyborg NCB. Cardiovascular effects of fermented milk containing angiotensin-converting enzyme inhibitors evaluated in permanently catheterized, spontaneously hypertensive rats. Appl Environ Microbiol 2002; 68: 3566–3569
   PubMed Web of Science ®Google Scholar
• Fujita H, Usui H, Kurahashi K, Yoshikawa M. Isolation and characterization of Ovokinin, a Bradykinin B-1 Agonist peptide derived from Ovalbumin. Peptides 1995; 16: 785–790
   PubMed Web of Science ®Google Scholar
• Gardner MLG. Transmucosal passage of intact peptides. Peptides in mammalian metabolism. Tissue utilization and clinical targeting, GK Grimble, FRC Backwell. Portland Press Ltd, LondonUK 1998
   Google Scholar
• Hashimoto K, Matsunaga N, Shimizu M. Effect of vegetable extracts on the transepithelial permeability of the human intestinal Caco-2 cell monolayer. Biosci Biotechnol Biochem 1994; 58: 1345–1346
   PubMed Web of Science ®Google Scholar
• Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T. A placebo controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 1996; 64: 767–771
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Masuda O, Nakamura Y, Takano T. Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats. J Nutr 1996; 126: 3063–3068
   PubMed Web of Science ®Google Scholar
• Matoba N, Usui H, Fujita H, Yoshikawa M. A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett 1999; 452: 181–184
   PubMed Web of Science ®Google Scholar
• Matsufuji H, Matsui T, Ohshige S, Kawasaki T, Osajima K, Osajima Y. Antihypertensive effects of angiotensin fragments in SHR. Biosci Biotechnol Biochem 1995; 59: 1398–1401
   PubMed Web of Science ®Google Scholar
• Matsui T, Li CH, Tanaka T, Maki T, Osajima Y, Matsumoto K. Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma. Biol Pharm Bull 2000; 23: 427–431
   PubMed Web of Science ®Google Scholar
• Matsui T, Tamaya K, Seki E, Osajima K, Matsumoto K, Kawasaki T. Absorption of Val-Tyr with in vitro angiotensin I-converting enzyme inhibitory activity into the circulating blood system of mild hypertensive subjects. Biol Pharm Bull 2002a; 25: 1228–1230
   PubMed Web of Science ®Google Scholar
• Matsui T, Tamaya K, Seki E, Osajima K, Matsumoto K, Kawasaki T. Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system. Clin Exp Pharmacol Physiol 2002b; 29: 204–208
   PubMed Web of Science ®Google Scholar
• Moskowitz DW. Is ‘somatic’ angiotensin-I-converting enzyme a mechanosensor?. Diabetes Technol Therap 2003; 4: 841–858
   Google Scholar
• Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol 2000; 279: G851–G857
   PubMed Web of Science ®Google Scholar
• Pappenheimer JR, Karnovsky ML, Maggio JE. Absorption and excretion of undegradable peptides: Role of lipid solubility and net charge. J Pharmacol Exp Therap 1997; 280: 292–300
   Google Scholar
• Pihlanto-Leppälä A. Bioactive peptides derived from bovine whey proteins: opioid and ACE-inhibitory peptides. Trends Food Sci Technol 2001; 11: 347–356
   Web of Science ®Google Scholar
• Rubio LA, Seiquer I. Transport of amino acids from in vitro digested legume proteins or casein in Caco-2 cell cultures. J Agric Food Chem 2002; 50: 5202–5206
   PubMed Web of Science ®Google Scholar
• Satake M, Enjoh M, Nakamura Y, Takano T, Kawamura Y, Arai S, Shimizu M. Transepithelial transport of the bioactive tripeptide, Val-Pro- Pro, in human intestinal Caco-2 cell monolayers. Biosci Biotechnol Biochem 2002; 66: 378–384
   PubMed Web of Science ®Google Scholar
• Seppo L, Jauhiainen T, Poussa T, Korpela R. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. American J Clin Nutr 2003; 77: 326–330
   PubMed Web of Science ®Google Scholar
• Shimizu M. Modulation of intestinal functions by food substances. Nahrung-Food 1999; 43: 154–158
   PubMedGoogle Scholar
• Shimizu M, Tsunogai M, Arai S. Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 1997; 18: 681–687
   PubMed Web of Science ®Google Scholar
• Shin ZI, Yu R, Park SA, Chung DK, Ahn CW, Nam HS, Kim KS, Lee HJ. His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo. J Agric Food Chem 2001; 49: 3004–3009
   PubMed Web of Science ®Google Scholar
• Sipola M, Finckenberg P, Korpela R, Vapaatalo H, Nurminen ML. Effect of long-term intake of milk products on blood pressure in hypertensive rats. J Dairy Res 2002; 69: 103–111
   PubMed Web of Science ®Google Scholar
• Takano T. Milk derived peptides and hypertension reduction. Int Dairy J 1998; 8: 375–381
   Web of Science ®Google Scholar
• Vermeirssen V, Van Camp J, Decroos K, Van Wijmelbeke L, Verstraete W. The impact of fermentation and in vitro digestion on the formation of ACE inhibitory activity from pea and whey protein. J Dairy Sci 2003a; 86: 429–438
   PubMed Web of Science ®Google Scholar
• Vermeirssen V, Van Camp J, Devos L, Verstraete W. Release of angiotensin I converting enzyme (ACE) inhibitory activity during in vitro gastrointestinal digestion: from batch experiment to semi-continuous model. J Agric Food Chem 2003b; 51: 5680–5687
   PubMed Web of Science ®Google Scholar
• Vermeirssen V, Van Camp J, Verstraete W. Optimisation and validation of an Angiotensin Converting Enzyme (ACE) inhibition assay for the screening of bioactive peptides. J Biochem Biophys Methods 2002; 51: 75–87
   PubMedGoogle Scholar
• Vermeirssen V, Van Camp J, Verstraete W. Fractionation of angiotensin I converting enzyme inhibitory activity from pea and whey protein in vitro gastrointestinal digests. J Sci Food Agric 2005; 85: 399–405
   Web of Science ®Google Scholar
• Walker D, Thwaites DT, Simmons NL, Gilbert HJ, Hirst BH. Substrate upregulation of the human small intestinal peptide transporter, hPepT1. J Physiol-London 1998; 507: 697–706
   PubMed Web of Science ®Google Scholar
• Wilson G, Hassan IF, Dix CJ, Williamson I, Shah R, Mackay M, Artursson P. Transport and permeability properties of human Caco-2 cells-An in vitro model of the intestinal epithelial-cell barrier. J Controlled Release 1990; 11: 25–40
   Web of Science ®Google Scholar
• Winckler C, Breves G, Boll M, Daniel H. Characteristics of dipeptide transport in pig jejunum in vitro. J Comp Physiol B-Biochem Systemic Environ Physiol 1999; 169: 495–500
   Google Scholar
• Wu JP, Ding XL. Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats. J Agric Food Chem 2001; 49: 501–506
   PubMed Web of Science ®Google Scholar
• Yamamoto N. Antihypertensive peptides derived from food proteins. Biopolymers 1997; 43: 129–134
   PubMed Web of Science ®Google Scholar
• Yang CY, Dantzig AH, Pidgeon C. Intestinal peptide transport systems and oral drug availability. Pharm Res 1999; 16: 1331–1343
   PubMed Web of Science ®Google Scholar
• Yoshii H, Tachi N, Ohba R, Sakamura O, Takeyama H, Itani T. Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks. Comp Biochem Physiol C-Toxicol Pharmacol 2001; 128: 27–33
   PubMed Web of Science ®Google Scholar
• Yoshioka M, Erickson R, Woodley J, Gulli R, Guan D, Kim YS. Role of rat intestinal brush-border membrane angiotensin-converting enzyme in dietary protein digestion. Am J Physiol 1987; 253: G781–G786
   PubMed Web of Science ®Google Scholar