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Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy

, , M.D., &
Pages 71-76 | Published online: 21 Sep 2009

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Michael Wakeman & David T Archer. (2020) Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?. Diabetes, Metabolic Syndrome and Obesity 13, pages 2093-2108.
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Lawrence R. Solomon. (2016) Vitamin B12-responsive neuropathies: A case series. Nutritional Neuroscience 19:4, pages 162-168.
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Articles from other publishers (29)

Kezheng Li, Yinuo Chen, Jiali Xie, Weiwei Cai, Chunyang Pang, Can Cui, Yu Huan & Binbin Deng. (2023) How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview. Ageing Research Reviews 91, pages 102064.
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Faeze Gharibpoor, Banafsheh Ghavidel-Parsa, Nazila Sattari, Ali Bidari, Fatemeh Nejatifar & Ali Montazeri. (2022) Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatology 6:1.
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Preston R. McMullin, Alexander Thomas Hynes, Mohammed Ahnaf Arefin, Moawiz Saeed, Sarvani Gandhavadi, Nuha Arefin & Maxim S. Eckmann. (2022) Infusion Therapy in the Treatment of Neuropathic Pain. Current Pain and Headache Reports 26:9, pages 693-699.
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Kamila S Batista, Vanessa M Cintra, Paulo A F Lucena, Raul Manhães-de-Castro, Ana E Toscano, Larissa P Costa, Maria E B S Queiroz, Suellen M de Andrade, Omar Guzman-Quevedo & Jailane de S Aquino. (2022) The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle–gut–brain axis and implications for SARS-CoV-2 infection. Nutrition Reviews 80:3, pages 561-578.
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Stephen Karaganis & Xue‐Jun Song. (2021) B vitamins as a treatment for diabetic pain and neuropathy. Journal of Clinical Pharmacy and Therapeutics 46:5, pages 1199-1212.
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Hanan Khalil, Cynthia D. Ang & Viviane Khalil. (2021) Vitamin B for treating diabetic peripheral neuropathy – A systematic review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 15:5, pages 102213.
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Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Eleni Margariti, Parthena Giannoulaki, Georgios Batanis, Solomon Tesfaye & Kοnstantinos Kantartzis. (2021) Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 13:2, pages 395.
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V.N. Khramilin & O.S. Davydov. (2021) Painful diabetic polyneuropathy: evidence-based diagnosis and treatment. Russian Journal of Pain 19:4, pages 44.
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P. R. Kamchatnov, B. A. Abusueva, S. B. Khanmurzaeva & N. B. Khanmurzaeva. (2020) Choosing of therapy for a patient with dorsalgia. Terapevticheskii arkhiv 92:9, pages 102-107.
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Thomas Julian, Rubiya Syeed, Nicholas Glascow, Efthalia Angelopoulou & Panagiotis Zis. (2020) B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review. Nutrients 12:8, pages 2221.
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Bruce H.R. Wolffenbuttel, Hanneke J.C.M. Wouters, M. Rebecca Heiner-Fokkema & Melanie M. van der Klauw. (2019) The Many Faces of Cobalamin (Vitamin B12) Deficiency. Mayo Clinic Proceedings: Innovations, Quality & Outcomes 3:2, pages 200-214.
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Rizaldy Taslim Pinzon & Rosa De Lima Renita Sanyasi. (2019) Efektivitas Penggunaan Kombinasi Vitamin B pada Pasien Neuropati Diabetikum. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 5:1, pages 6.
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A. A Pilipovich. (2018) The use of B vitamins in the treatment of polyneuropathy of different genesis. CardioSomatics 9:2, pages 36-42.
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Tess E Cooper, Lauren C Heathcote, Jacqui Clinch, Jeffrey I. Gold, Richard Howard, Susan M Lord, Neil Schechter, Chantal Wood & Philip J Wiffen. (2017) Antidepressants for chronic non-cancer pain in children and adolescents. Cochrane Database of Systematic Reviews.
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Serkan Ozen, Murat Atabey Ozer & Mehmet Orçun Akdemir. (2017) Vitamin B12 deficiency evaluation and treatment in severe dry eye disease with neuropathic ocular pain. Graefe's Archive for Clinical and Experimental Ophthalmology 255:6, pages 1173-1177.
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Christian S. Hansen, Jan S. Jensen, Martin Ridderstråle, Dorte Vistisen, Marit E. Jørgensen & Jesper Fleischer. (2017) Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. Journal of Diabetes and its Complications 31:1, pages 202-208.
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Gang Xǔ, Site Xu, Chao Cheng, Gang Xú, Wei‐Zhen Tang & Jie Xu. (2015) Local Administration of Methylcobalamin and Lidocaine for Acute Ophthalmic Herpetic Neuralgia: A Single‐Center Randomized Controlled Trial. Pain Practice 16:7, pages 869-881.
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Lawrence R. Solomon. (2016) Functional vitamin B12 deficiency in advanced malignancy: implications for the management of neuropathy and neuropathic pain. Supportive Care in Cancer 24:8, pages 3489-3494.
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Arlene Keller Surós. (2016) Food for Thought. Physician Assistant Clinics 1:1, pages 77-100.
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Gang Xǔ, Site Xu, Wei-Zhen Tang, Gang Xú, Chao Cheng & Jie Xu. (2015) Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia. Pain Medicine, pages pnv005.
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Rohit Shetty, Kalyani Deshpande, Arkasubhra Ghosh & Swaminathan Sethu. (2015) Management of Ocular Neuropathic Pain With Vitamin B12 Supplements. Cornea 34:10, pages 1324-1325.
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Caroline M. Kopruszinski, Renata C. Reis, Elisangela Bressan, Peter W. Reeh & Juliana G. Chichorro. (2015) Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects. European Journal of Pharmacology 762, pages 326-332.
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Matthew J. Zdilla. (2015) Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion. Clinical Diabetes 33:2, pages 90-95.
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Gang Xu, Zhong-Wei Lv, Yan Feng, Wei-Zhen Tang & Gang Xiao Xu. (2013) A Single-Center Randomized Controlled Trial of Local Methylcobalamin Injection for Subacute Herpetic Neuralgia. Pain Medicine 14:6, pages 884-894.
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Davis Kibirige & Raymond Mwebaze. (2013) Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?. Journal of Diabetes & Metabolic Disorders 12:1.
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Lawrence R. Solomon. (2013) Vitamin B 12 and Peripheral Nerve Function in Elderly Adults: “Functional” B 12 Deficiency As a Confounding Variable . Journal of the American Geriatrics Society 61:2, pages 310-311.
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Soner Tatlidede, M. Baris Baslo, Özay Özkaya, Tufan Soydan, Elif Kocasoy Orhan & Ayşin Karasoy Yeşilada. (2012) Does Vitamin B Alter the Efficacy of Botulinum Toxin?. Aesthetic Plastic Surgery 36:3, pages 692-697.
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Mohammed Shakil Patel, Zurqa Rasul & Philip Sell. (2011) Dual pathology as a result of spinal stenosis and vitamin B12 deficiency. European Spine Journal 20:12, pages 2247-2251.
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Lawrence R. Solomon. (2011) Diabetes as a Cause of Clinically Significant Functional Cobalamin Deficiency. Diabetes Care 34:5, pages 1077-1080.
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