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REVIEWS ON PROTEIN ACYLATION AND MICRODOMAINS IN MEMBRANE FUNCTION

Palmitoylation cycles and regulation of protein function (Review)

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Pages 42-54 | Received 14 Nov 2008, Published online: 09 Jul 2009

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Wei Yang, Dolores Di Vizio, Marc Kirchner, Hanno Steen & Michael R. Freeman. (2010) Proteome Scale Characterization of Human S-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes. Molecular & Cellular Proteomics 9:1, pages 54-70.
Crossref
J. K. Alexander, A. P. Govind, R. C. Drisdel, M. P. Blanton, Y. Vallejo, T. T. Lam & W. N. Green. (2009) Palmitoylation of Nicotinic Acetylcholine Receptors. Journal of Molecular Neuroscience 40:1-2, pages 12-20.
Crossref
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Crossref
Duk-Won Doug Chung, Nadia Ponts, Serena Cervantes & Karine G. Le Roch. (2009) Post-translational modifications in Plasmodium: More than you think!. Molecular and Biochemical Parasitology 168:2, pages 123-134.
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Crossref
Michael L. Reese & John C. Boothroyd. (2009) A Helical Membrane-Binding Domain Targets the Toxoplasma ROP2 Family to the Parasitophorous Vacuole . Traffic 10:10, pages 1458-1470.
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