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Articles

Arsenic trioxide: An anti cancer missile with multiple warheads

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Pages 205-213 | Published online: 04 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen & Xiongzhi Wu. (2017) Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & Lymphoma 58:10, pages 2439-2451.
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Katarina Reberšek, Darja Marija Žontar, Peter Černelč & Helena Podgornik. (2014) Selective apoptosis of multiple myeloma cells in primary samples induced by arsenic trioxide. Hematology 19:6, pages 346-351.
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Mark R Litzow. (2008) Arsenic trioxide. Expert Opinion on Pharmacotherapy 9:10, pages 1773-1785.
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Articles from other publishers (41)

Yu-Sheng Wang, Ji-Zhong Yin, Xiao-Qian Shi, Xue-Wei Zhao, Bing Li & Meng-Hang Yang. (2023) MDM2-mediated Inhibitory Effect of Arsenic Trioxide on Small Cell Lung Cancer Cell Line by Degrading Mutant p53. Anti-Cancer Agents in Medicinal Chemistry 23:16, pages 1829-1837.
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Judith A. Carrall, Wilford Lie, Jacob M. Lambert, Hugh H. Harris, Barry Lai & Carolyn T. Dillon. (2023) Optimizing Arsenic Therapy by Selectively Targeting Leukemia Cells. Journal of Medicinal Chemistry 66:17, pages 12101-12114.
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An‐Liang Huang, Fan Yang, Ping Cheng, Dian‐ying Liao, Li Zhou, Xing‐Li Ji, Dou‐Dou Peng, Li Zhang, Ting‐Ting Cheng, Li Ma & Xian‐Gen Xia. (2022) Honokiol attenuate the arsenic trioxide‐induced cardiotoxicity by reducing the myocardial apoptosis. Pharmacology Research & Perspectives 10:2.
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Mahdieh Raeeszadeh, Pouria Karimi, Nadia Khademi & Pejman Mortazavi. (2022) The Effect of Broccoli Extract in Arsenic-Induced Experimental Poisoning on the Hematological, Biochemical, and Electrophoretic Parameters of the Liver and Kidney of Rats. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-9.
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Chunmou Li, Xiaomin Peng, Chuchu Feng, Xilin Xiong, Jianxin Li, Ning Liao, Zhen Yang, Aiguo Liu, Pingping Wu, Xuehong Liang, Yunyan He, Xin Tian, Yunbi Lin, Songmi Wang & Yang Li. (2021) Excellent Early Outcomes of Combined Chemotherapy With Arsenic Trioxide for Stage 4/M Neuroblastoma in Children: A Multicenter Nonrandomized Controlled Trial. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 28:7, pages 791-800.
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Harishkumar Madhyastha, Radha Madhyastha, Yuichi Nakajima & Masugi Maruyama. (2017) Deciphering the molecular events during arsenic induced transcription signal cascade activation in cellular milieu. BioMetals 31:1, pages 7-15.
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Anliang Huang, Dan Yue, Danying Liao, Liuliu Cheng, Jinhu Ma, Yuquan Wei, Aiping Tong & Ping Cheng. (2016) SurvivinT34A increases the therapeutic efficacy of arsenic trioxide in mouse hepatocellular carcinoma models. Oncology Reports 36:6, pages 3283-3290.
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Yong Zhang, Xianxian Wu, Yang Li, Haiying Zhang, Zhange Li, Ying Zhang, Longyin Zhang, Jiaming Ju, Xin Liu, Xiaohui Chen, Peter V. Glybochko, Vladimir Nikolenko, Philipp Kopylov, Chaoqian Xu & Baofeng Yang. (2016) Endothelial to mesenchymal transition contributes to arsenic-trioxide-induced cardiac fibrosis. Scientific Reports 6:1.
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Ye Cheng, Yunqian Li, Chengyuan Ma, Yang Song, Haiyang Xu, Hongquan Yu, Songbai Xu, Qingchun Mu, Haisong Li, Yong Chen & Gang Zhao. (2016) Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction. Oncotarget 7:11, pages 12682-12692.
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Yih-An King, Yu-Jen Chiu, Hao-Ping Chen, Daih-Huang Kuo, Chi-Cheng Lu & Jai-Sing Yang. (2016) Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environmental Toxicology 31:3, pages 314-328.
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Hebing Zhou, Jinqing Li, Yuan Jian, Tingting Chen, Haiteng Deng, Juan Zhang, Hui Zeng, Zhijuan Shan & Wenming Chen. (2016) Effects and mechanism of arsenic trioxide in combination with rmhTRAIL in multiple myeloma. Experimental Hematology 44:2, pages 125-131.e11.
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Valentina Gandin & Aristi Fernandes. (2015) Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents. Molecules 20:7, pages 12732-12756.
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Meysam Yousefi, Seyed H. Ghaffari, Ali Zekri, Samad Ghanizadeh-Vesali, Elham Hosseini, Masoumeh Rostami, Saeed Hassani, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2013) Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide. Neurochemistry International 63:8, pages 809-817.
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Ali Zekri, Seyed H. Ghaffari, Meysam Yousefi, Samad Ghanizadeh-Vesali, Majid Mojarrad, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2013) Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide-induced apoptosis. Molecular and Cellular Endocrinology 377:1-2, pages 84-92.
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Yuan Xia, Hai Fang, Ji Zhang & Yanzhi Du. (2013) Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107 combined with arsenic trioxide. Experimental Biology and Medicine 238:8, pages 932-942.
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Ling-Huei Yih, Nai-Chi Hsu, Yi-Chen Wu, Wen-Yen Yen & Hsiao-Hui Kuo. (2013) Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicology and Applied Pharmacology 267:3, pages 228-237.
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P.A. Lay & A. Levina. 2013. Comprehensive Inorganic Chemistry II. Comprehensive Inorganic Chemistry II 835 856 .
Ling-Huei Yih, Yi-Chen Wu, Nai-Chi Hsu & Hsiao-Hui Kuo. (2012) Arsenic Trioxide Induces Abnormal Mitotic Spindles Through a PIP4KIIγ/Rho Pathway. Toxicological Sciences 128:1, pages 115-125.
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Majid Zaki Dizaji, Mohsen Malehmir, Ardeshir Ghavamzadeh, Kamran Alimoghaddam & Seyed H. Ghaffari. (2011) Synergistic Effects of Arsenic Trioxide and Silibinin on Apoptosis and Invasion in Human Glioblastoma U87MG Cell Line. Neurochemical Research 37:2, pages 370-380.
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Liu Liu, Chen Chen, Wei Gong, Yuanjing Li, Matthew L. Edin, Darryl C. Zeldin & Dao Wen Wang. (2011) Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide. Journal of Pharmacology and Experimental Therapeutics 339:2, pages 451-463.
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Chia-Wen Chien, Ju-Hsien Yao, Shih-Yu Chang, Pei-Chih Lee & Te-Chang Lee. (2011) Enhanced suppression of tumor growth by concomitant treatment of human lung cancer cells with suberoylanilide hydroxamic acid and arsenic trioxide. Toxicology and Applied Pharmacology 257:1, pages 59-66.
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Yihu Zheng, Mengtao Zhou, Aifang Ye, Qiu Li, Yongheng Bai & Qiyu Zhang. (2010) The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. World Journal of Surgical Oncology 8:1.
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Fei Zhong, Shineng Zhang, Chunkui Shao, Jing Yang & Xiangyuan Wu. (2009) Arsenic Trioxide Inhibits Cholangiocarcinoma Cell Growth and induces Apoptosis. Pathology & Oncology Research 16:3, pages 413-420.
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Yunbo Zhen, Shiguang Zhao, Qiang Li, Yi Li & Keiji Kawamoto. (2010) Arsenic trioxide-mediated Notch pathway inhibition depletes the cancer stem-like cell population in gliomas. Cancer Letters 292:1, pages 64-72.
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Martina Canestraro, Sara Galimberti, Hakan Savli, Giuseppe Alberto Palumbo, Daniele Tibullo, Balint Nagy, Francesca Guerrini, Simona Piaggi, Naci Cine, Maria Rita Metelli & Mario Petrini. (2010) Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genetics and Cytogenetics 199:2, pages 110-120.
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O. BAIREY, A. VANICHKIN & O. SHPILBERG. (2010) Arsenic‐trioxide‐induced apoptosis of chronic lymphocytic leukemia cells. International Journal of Laboratory Hematology 32:1p1.
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S. Ying, K. Myers, S. Bottomley, T. Helleday & H. E. Bryant. (2009) BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells. Nucleic Acids Research 37:15, pages 5105-5113.
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Bruce A. Boswell, Anh-Chi N. Le & Linda S. Musil. (2009) Upregulation and maintenance of gap junctional communication in lens cells. Experimental Eye Research 88:5, pages 919-927.
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Yi-Chen Wu, Wen-Yen Yen, Te-Chang Lee & Ling-Huei Yih. (2009) Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. Toxicology and Applied Pharmacology 236:2, pages 231-238.
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Katsuya Iuchi, Kiwamu Akagi & Tatsuo Yagura. (2009) Heterocyclic Organobismuth(III) Compound Targets Tubulin to Induce G2/M Arrest in HeLa Cells. Journal of Pharmacological Sciences 109:4, pages 573-582.
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Victoria L. Bae-Jump, Chunxiao Zhou, John F. Boggess & Paola A. Gehrig. (2008) Arsenic Trioxide (As2O3) Inhibits Expression of Estrogen Receptor—alpha Through Regulation of the Mitogen-activated Protein Kinase (MAPK) Pathway in Endometrial Cancer Cells. Reproductive Sciences 15:10, pages 1011-1017.
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Benjamin Gesundheit, Lea Malach, Reuven Or & Talia Hahn. (2008) Neuroblastoma Cell Death is Induced by Inorganic Arsenic Trioxide (As2O3) and Inhibited by a Normal Human Bone Marrow Cell-Derived Factor. Cancer Microenvironment 1:1, pages 153-157.
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Eun Hee Kim, Mi Jin Yoon, Seung U. Kim, Taeg Kyu Kwon, Seonghyang Sohn & Kyeong Sook Choi. (2008) Arsenic Trioxide Sensitizes Human Glioma Cells, but not Normal Astrocytes, to TRAIL-Induced Apoptosis via CCAAT/Enhancer-Binding Protein Homologous Protein–Dependent DR5 Up-regulation. Cancer Research 68:1, pages 266-275.
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Pierre J. Dilda, Gabriel G. Perrone, Amanda Philp, Richard B. Lock, Ian W. Dawes & Philip J. Hogg. (2008) Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid. The International Journal of Biochemistry & Cell Biology 40:5, pages 1016-1029.
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Beat C. BornhauserLaura BonapaceDan LindholmRodrigo MartinezGunnar Cario, Martin Schrappe, Felix K. NiggliBeat W. SchäferJean-Pierre Bourquin. (2007) Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway. Blood 110:6, pages 2084-2091.
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Yusan Chou, Cheng-Ho Tsai, Kwo-Chang Ueng, Tin-Yi Tian, Shu-Chen Chen & Hung-I Yeh. (2007) Endothelial gap junctions are down-regulated by arsenic trioxide. European Journal of Pharmacology 569:1-2, pages 29-36.
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Jun Lu, Eng-Hui Chew & Arne Holmgren. (2007) Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proceedings of the National Academy of Sciences 104:30, pages 12288-12293.
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Eun Hee Kim, Seonghyang Sohn, Hyuk Jae Kwon, Seung U. Kim, Min-Jung Kim, Su-Jae Lee & Kyeong Sook Choi. (2007) Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells. Cancer Research 67:13, pages 6314-6324.
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