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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 3
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Original Articles

Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β1-Smads signal pathway

Xiang-Chun Shen Research Division of Pharmacology, Guiyang Medical University, Guiyang, 550004, ChinaCorrespondence[email protected]
,
Yu-Ping Yang Research Division of Pharmacology, Guiyang Medical University, Guiyang, 550004, China
,
Ting-Ting Xiao Research Division of Pharmacology, Guiyang Medical University, Guiyang, 550004, China
,
Jiao Peng Research Division of Pharmacology, Guiyang Medical University, Guiyang, 550004, China
&
Xing-De Liu First Affiliated Hospital of Guiyang Medical University, Guiyang Medical University, Guiyang, 550004, ChinaCorrespondence[email protected]
Pages 215-224 | Received 09 Oct 2010, Accepted 22 Dec 2010, Published online: 15 Mar 2011

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Hong-Wei Wang, Lei Shi, Yan-Ping Xu, Xing-Ya Qin & Qi-Zhi Wang. (2016) Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-β1-Smad3 pathway. Renal Failure 38:6, pages 945-951.
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Jorge Fragoso-Medina & Angel Zarain-Herzberg. (2014) SERCA2a: its role in the development of heart failure and as a potential therapeutic target. Research Reports in Clinical Cardiology 5, pages 43-55.
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Articles from other publishers (26)

Duong Quang Huan, Nguyen Quang Hop & Ninh The Son. (2023) Oxymatrine: A current overview of its health benefits. Fitoterapia, pages 105565.
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Sanket Seksaria, Sidharth Mehan, Bhaskar J. Dutta, Ghanshyam D. Gupta, Subrahmanya S. Ganti & Amrita Singh. (2023) Oxymatrine and insulin resistance: Focusing on mechanistic intricacies involve in diabetes associated cardiomyopathy via SIRT1/AMPK and TGF‐β signaling pathway. Journal of Biochemical and Molecular Toxicology 37:5.
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Renhui Luo, Lili Xie, Yingmei Lin, Jun Shao & Zhejing Lin. (2022) Oxymatrine suppresses oral squamous cell carcinoma progression by suppressing CXC chemokine receptor 4 in an m 6 A modification decrease dependent manner . Oncology Reports 48:4.
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Meifang Wu, Yanguang Guo, Ying Wu, Kaizu Xu & Liming Lin. (2021) Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-β1/Smads Pathway. Frontiers in Pharmacology 12.
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Wuxia Zhang, Lei Wang, Ziwen Lu, Baofu Wang, Yang Li, Jingjing Yang, Jinxin Meng, Jinzhong Zhao, Mingjing Zhao & Peng Li. (2020) Discovery of Natural Compounds for Cardiac Fibrosis by a Transcriptome-Based Functional Gene Module Reference Approach. Journal of Natural Products 83:10, pages 2923-2930.
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Huimeng Qi, Qin Cao & Qiang Liu. (2020) MicroRNA-183 exerts a protective role in lupus nephritis through blunting the activation of TGF-β/Smad/TLR3 pathway via reducing Tgfbr1. Experimental Cell Research 394:2, pages 112138.
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Ying Xiao, Can Peng, Yawen Xiao, Dan Liang, Zhiping Yuan, Zhiyang Li, Mingjun Shi, Yuanyuan Wang, Fan Zhang & Bing Guo. (2020) Oxymatrine Inhibits Twist-Mediated Renal Tubulointerstitial Fibrosis by Upregulating Id2 Expression. Frontiers in Physiology 11.
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Mengmeng Du, Yudong Zhang, Xiaohua Shi & Ming Liu. (2020) Comparative efficacy and safety of traditional Chinese medicine for lipodermatosclerosis. Medicine 99:47, pages e23386.
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Xu Lan, Junnan Zhao, Ying Zhang, Yao Chen, Yue Liu & Fengqin Xu. (2020) Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside. Pharmacological Research 151, pages 104541.
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Shaza H. Aly, Ahmed M. Elissawy, Omayma A. Eldahshan, Mohamed A. Elshanawany, Thomas Efferth & Abdel Nasser B. Singab. (2019) The pharmacology of the genus Sophora (Fabaceae): An updated review. Phytomedicine 64, pages 153070.
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Clarissa Esmeralda Halim, Shannon Lee Xinjing, Lu Fan, Jacqueline Bailey Vitarbo, Frank Arfuso, Chay Hoon Tan, Acharan S. Narula, Alan Prem Kumar, Gautam Sethi & Kwang Seok Ahn. (2019) Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models. Pharmacological Research 147, pages 104327.
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Lorena Avila-Carrasco, Pedro Majano, José Antonio Sánchez-Toméro, Rafael Selgas, Manuel López-Cabrera, Abelardo Aguilera & Guadalupe González Mateo. (2019) Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition. Frontiers in Pharmacology 10.
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Dawei Wang, Xiaoqian Lou, Xiao‑Ming Jiang, Chenxi Yang, Xiao‑Liang Liu & Nan Zhang. (2018) Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Molecular Medicine Reports.
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Dawei Wang, Xiao Lou, Xiao‑Ming Jiang, Chenxi Yang, Xiao‑Liang Liu & Nan Zhang. (2018) Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway. Molecular Medicine Reports.
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Yini Xu, Hai Xiao, Hong Luo, Yan Chen, Yanyan Zhang, Ling Tao, Yan Jiang, Yuqi Chen & Xiangchun Shen. (2017) Inhibitory effects of oxymatrine on TGF-β1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways. Molecular Medicine Reports 16:4, pages 5354-5362.
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Ruifeng Bai, Xu Yin, Xiao Feng, Yuan Cao, Yan Wu, Zhixiang Zhu, Chun Li, Pengfei Tu & Xingyun Chai. (2017) Corydalis hendersonii Hemsl. protects against myocardial injury by attenuating inflammation and fibrosis via NF-κB and JAK2-STAT3 signaling pathways. Journal of Ethnopharmacology 207, pages 174-183.
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Yan Jiang, Yanxin Zhu, Qiuju Mu, Hong Luo, Yan Zhi & Xiangchun Shen. (2017) Oxymatrine provides protection against Coxsackievirus B3-induced myocarditis in BALB/c mice. Antiviral Research 141, pages 133-139.
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Lingyun Fu, Yini Xu, Ling Tu, Haifeng Huang, Yanyan Zhang, Yan Chen, Ling Tao & Xiangchun Shen. (2016) Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study. BMC Complementary and Alternative Medicine 16:1.
Crossref
Chiu‐Mei Lin, Hang Chang, Bao‐Wei Wang & Kou‐Gi Shyu. (2016) Suppressive effect of epigallocatechin‐3‐O‐gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo . Journal of Cellular and Molecular Medicine 20:11, pages 2045-2055.
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Mei-Li Lu, Xiao-Hui Xiang & Shi-Hai Xia. (2016) Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine. Phytotherapy Research 30:7, pages 1104-1112.
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Lirong Liu, Yuanyuan Wang, Rui Yan, Shuang Li, Mingjun Shi, Ying Xiao & Bing Guo. (2016) Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway. PLOS ONE 11:3, pages e0151986.
Crossref
WW Lu, R Zhang, JS Zhu, LQ Xia & J Zhang. (2015) Oxymatrine and cancer therapy. European Journal of Inflammation 13:3, pages 148-153.
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Wei Zhang, Jian Zhang, Yansheng Kang, Jingjing Liu, Xiaoqing Wang, Qingbin Xu, Yilei Wang, Xiaoya Xu & Guidong Dai. (2014) Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. European Journal of Pharmacology 745, pages 29-35.
Crossref
Ting-Ting Xiao, Yuan-Yuan Wang, Yan Zhang, Cong-Hui Bai & Xiang-Chun Shen. (2014) Similar to Spironolactone, Oxymatrine Is Protective in Aldosterone-Induced Cardiomyocyte Injury via Inhibition of Calpain and Apoptosis-Inducing Factor Signaling. PLoS ONE 9:2, pages e88856.
Crossref
T. K. LimT. K. Lim. 2014. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 906 924 .
W. Cai & J. Chen. 2013. Bioactive Food as Dietary Interventions for Cardiovascular Disease. Bioactive Food as Dietary Interventions for Cardiovascular Disease 551 590 .

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