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Journal of Asian Natural Products Research Volume 16, 2014 - Issue 8
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Articles

l-3-n-Butylphthalide attenuates β-amyloid-induced toxicity in neuroblastoma SH-SY5Y cells through regulating mitochondrion-mediated apoptosis and MAPK signaling

Hui LeiState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
,
Chun-Yang ZhaoState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
,
Dong-Mei LiuState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
,
Yu ZhangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
,
Lin LiState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
,
Xiao-Liang WangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected] [email protected]
&
Ying PengState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected] [email protected]
 show all
Pages 854-864 | Received 25 May 2014, Accepted 24 Jun 2014, Published online: 30 Aug 2014

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Bo Zhen, Jia-Wen Hu, Jia-Jia Wang, Meng-Jiao Shi, Li Li, Ren Ci, Jian-Dong Jiang & Teng-Fei Ji. (2019) Hyperascyrins L − N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron. Journal of Asian Natural Products Research 21:5, pages 409-418.
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Chun-Yang Zhao, Hui Lei, Yu Zhang, Lin Li, Shao-Feng Xu, Jie Cai, Ping-Ping Li, Ling Wang, Xiao-Liang Wang & Ying Peng. (2016) L-3-n-Butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and upregulating Heme oxygenase-1 in lipopolysaccharide-treated mice. Journal of Asian Natural Products Research 18:3, pages 289-302.
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Articles from other publishers (37)

Lin HAN, Qingyang WANG & Xiaoming LIU. (2023) The effect of butylphthalide on aminoacid content in the brain of epileptic mice. Minerva Pediatrics 74:6.
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Ruo-Lan Li, Ling-Yu Wang, Hu-Xinyue Duan, Qing Zhang, Xiaohui Guo, Chunjie Wu & Wei Peng. (2022) Regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases. Frontiers in Pharmacology 13.
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Bing-qiu Li, Ling-zhi Xu, Fang-yu Li, Ying Li, Yu Zhao, Heng Zhang, Mei-na Quan & Jian-ping Jia. (2022) CaMKIIα Signaling Is Required for the Neuroprotective Effects of Dl-3-n-Butylphthalide in Alzheimer’s Disease. Molecular Neurobiology 59:6, pages 3370-3381.
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Luping Yang, Ni Ni, Yanlong Hong & Lan Shen. (2022) A novel sight of the primary active compounds from Umbelliferae: focusing on mitochondria. Medicinal Chemistry Research 31:2, pages 217-231.
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Xin Jin, Jia-Ling Guo, Lin Wang, Xin Zhong, Wei-Fan Yao, Hua Gao & Ming-Yan Liu. (2021) Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatments of Alzheimer’s disease: A comprehensive review. European Journal of Medicinal Chemistry 218, pages 113401.
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Jin Wang, Xiaojuan Guo, Wenhui Lu, Jie Liu, Hong Zhang, Qingyun Quan, Hang Su, Li Ma, Fan Gao & Qiumin Qu. (2021) Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer’s Disease: A Multicenter, Prospective Cohort Study. Journal of Alzheimer's Disease 80:2, pages 673-681.
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Min Xiong, Xiaohua Feng, Lingyuan Tang, Caihong Li & Lan Yu. (2021) Butylphthalide enhances recovery from sudden deafness. American Journal of Otolaryngology 42:2, pages 102891.
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Longjian Huang, Jiaqi Lan, Jingshu Tang, Yuying Kang, Xinhong Feng, Lei Wu & Ying Peng. (2020) L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer’s disease mouse model and cultured hippocampal neurons. Molecular Neurobiology 58:3, pages 1260-1274.
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José Marco-Contelles & Yihua Zhang. (2020) From Seeds of Apium graveolens Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3- n -Butylphthalide . Journal of Medicinal Chemistry 63:21, pages 12485-12510.
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Wei Wang, Ting Wang, Shunjie Bai, Zhi Chen, Xunzhong Qi & Peng Xie. (2020) Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway. Translational Psychiatry 10:1.
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Feng Niu, Aruna Sharma, Zhenguo Wang, Lianyuan Feng, Dafin F. Muresanu, Seaab Sahib, Z. Ryan Tian, José Vicente Lafuente, Anca D. Buzoianu, Ala Nozari, Ranjana Patnaik, Lars Wiklund & Hari Shanker Sharma. 2020. Neuropharmacology of Neuroprotection. Neuropharmacology of Neuroprotection 101 155 .
Ayong Tian, Xiaochuan Ma, Hui Li & Rongwei Zhang. (2019) Dl‑3n‑butylphthalide improves spatial learning and memory in rats with vascular dementia by reducing autophagy via regulation of the mTOR signaling pathway. Experimental and Therapeutic Medicine.
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Rixin Luo, Runqi Wangqin, Lihong Zhu & Wei Bi. (2019) Neuroprotective mechanisms of 3‑n‑butylphthalide in neurodegenerative diseases (Review). Biomedical Reports.
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Xi-Qian Chen, Ke Qiu, Hui Liu, Qiang He, Jia-Hui Bai & Wei Lu. (2019) Application and prospects of butylphthalide for the treatment of neurologic diseases. Chinese Medical Journal 132:12, pages 1467-1477.
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Yuming Zhao, Dongmei Liu, Jiang Li, XiaoJie Zhang & Xiaoliang Wang. (2019) L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis. Neurochemistry International 124, pages 94-105.
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Yajing Chen, Tingting Wu, Heng Li, Xuan Li, Qing Li, Xiaoying Zhu, Mei Yu, Sheng-Han Kuo, Fang Huang & Yun-Cheng Wu. (2019) Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation. Frontiers in Aging Neuroscience 11.
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Dan-Dan Xu, Wen-Ting Li, Dan Jiang, Huai-Guo Wu, Ming-Shan Ren, Mei-Qiao Chen & Yuan-Bo Wu. (2019) 3-N-Butylphthalide mitigates high glucose-induced injury to Schwann cells: association with nitrosation and apoptosis. Neural Regeneration Research 14:3, pages 513.
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Feng Niu, Aruna Sharma, Lianyuan Feng, Asya Ozkizilcik, Dafin F. Muresanu, José Vicente Lafuente, Z. Ryan Tian, Ala Nozari & Hari Shanker Sharma. 2019. Nanoneuroprotection and Nanoneurotoxicology. Nanoneuroprotection and Nanoneurotoxicology 89 118 .
Jiao Wang, Mengjiao Shi, Jiajia Wang, Jin Li & Tengfei Ji. (2018) Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum acmosepalum. Molecules 24:1, pages 50.
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Ghazaleh Kheiri, Mahsa Dolatshahi, Farzaneh Rahmani & Nima Rezaei. (2018) Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy. Reviews in the Neurosciences 30:1, pages 9-30.
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Jia-Wen Hu, Meng-Jiao Shi, Jia-Jia Wang, Li Li, Jian-Dong Jiang & Teng-Fei Ji. (2018) Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron . Journal of Natural Products 81:11, pages 2348-2356.
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Shan Wang, Longjian Huang, Yong Zhang, Yuchen Peng, Xiaoliang Wang & Ying Peng. (2018) Protective Effects of L-3-n-Butylphthalide Against H2O2-Induced Injury in Neural Stem Cells by Activation of PI3K/Akt and Mash1 Pathway. Neuroscience 393, pages 164-174.
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Hui Lei, Yu Zhang, Longjian Huang, Shaofeng Xu, Jiang Li, Lichao Yang, Ling Wang, Changhong Xing, Xiaoliang Wang & Ying Peng. (2018) L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotoxicity Research 34:3, pages 477-488.
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Longjian Huang, Shan Wang, Fei Ma, Yong Zhang, Yuchen Peng, Changhong Xing, Yipu Feng, Xiaoliang Wang & Ying Peng. (2018) From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacological Research 135, pages 201-211.
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Mengqi Yang, Ruili Dang, Pengfei Xu, Yujin Guo, Wenxiu Han, Dehua Liao & Pei Jiang. (2018) Dl-3-n-Butylphthalide improves lipopolysaccharide-induced depressive-like behavior in rats: involvement of Nrf2 and NF-κB pathways. Psychopharmacology 235:9, pages 2573-2585.
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Zhen-zhen Yuan, You-rui Suo, Xue-yan Hao, Shu-lin Wang, Gang Li & Hong-lun Wang. (2018) Triterpenic Acids from <i>Potentilla parvifolia</i> and Their Protective Effects against Okadaic Acid Induced Neurotoxicity in Differentiated SH-SY5Y Cells. Biological and Pharmaceutical Bulletin 41:6, pages 885-890.
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Kumju Youn, Seonah Lee & Mira Jun. (2018) Gamma-linolenic acid ameliorates Aβ-induced neuroinflammation through NF-κB and MAPK signalling pathways. Journal of Functional Foods 42, pages 30-37.
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Jing Xu, Yaping Huai, Nan Meng, Yanhong Dong, Zhijuan Liu, Qianqian Qi, Ming Hu, Mingyue Fan, Wei Jin & Peiyuan Lv. (2017) l-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia–Reperfusion Injury. Neurochemical Research 42:10, pages 2968-2981.
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Jong Kil Lee & Nam-Jung Kim. (2017) Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease. Molecules 22:8, pages 1287.
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Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Rashmi K. Ambasta & Pravir Kumar. (2017) Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:5, pages 1132-1146.
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Prakash C. Bhatt, Preeti Pandey, Bibhu P. Panda, Firoz Anwar & Vikas Kumar. (2017) Commentary: L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease. Frontiers in Aging Neuroscience 9.
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Yu Zhang, Long-Jian Huang, Si Shi, Shao-Feng Xu, Xiao-Liang Wang & Ying Peng. (2016) L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease. CNS Neuroscience & Therapeutics 22:12, pages 979-987.
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Wei Xu, Li Yang & Ji Li. (2016) Protection against β-amyloid-induced neurotoxicity by naturally occurring Z-ligustilide through the concurrent regulation of p38 and PI3-K/Akt pathways. Neurochemistry International 100, pages 44-51.
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Wan Gao, Wei-Zhen Hou, Jun Zhao, Fang Xu, Li Li, Fang Xu, Hua Sun, Jian-Guo Xing, Ying Peng, Xiao-Liang Wang, Teng-Fei Ji & Zheng-Yi Gu. (2016) Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum . Journal of Natural Products 79:6, pages 1538-1547.
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Idriss Ali Abdoulaye & Yi Jing Guo. (2016) A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. BioMed Research International 2016, pages 1-9.
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Greg Goldblatt, Jason O. Matos, Jeremy Gornto & Suren A. Tatulian. (2015) Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides. Physical Chemistry Chemical Physics 17:48, pages 32149-32160.
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Michael C. Powanda, Michael W. Whitehouse & K D. Rainsford. 2015. Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases. Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases 133 153 .

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