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Original Articles

Diosgenin-3-O-α-l-Rhamnopyranosyl-(1→4)-β-d-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway

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Pages 115-125 | Received 01 Jul 2003, Accepted 01 Mar 2003, Published online: 15 Aug 2006

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Articles from other publishers (21)

Bizhen Luo, Dong Li, Ke Hu, Min Chen, Xiaoqin Sun, Ruisen Lu & Shujing Wei. (2023) Genome Survey Sequencing of the Medical Plant Dioscorea futschauensis : Genomic Characteristics Estimation and Genomic Resources Development . Journal of Biobased Materials and Bioenergy 17:6, pages 803-811.
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Prajya Arya & Pradyuman Kumar. (2021) Diosgenin a steroidal compound: An emerging way to cancer management. Journal of Food Biochemistry 45:12.
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Muhammad Murtala Mainasara, Mohd Fadzelly Abu Bakar, Abdah Md Akim, Alona C Linatoc, Fazleen Izzany Abu Bakar & Yazan K. H. Ranneh. (2021) Secondary Metabolites, Antioxidant, and Antiproliferative Activities of Dioscorea bulbifera Leaf Collected from Endau Rompin, Johor, Malaysia. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-10.
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Jack Ho Wong, Stephen Cho Wing Sze, Tzi Bun Ng, Randy Chi Fai Cheung, Chit Tam, Kalin Yanbo Zhang, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye, Hexiang Wang, Fang Liu, David Wai Chan, Hextan Yuen Sheung Ngan, Ou Sha, Guohui Li, Ryan Tse, Tak Fu Tse & Helen Chan. (2019) Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants. Current Medicinal Chemistry 25:40, pages 5613-5630.
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Gautam Sethi, Muthu Shanmugam, Sudha Warrier, Myriam Merarchi, Frank Arfuso, Alan Kumar & Anupam Bishayee. (2018) Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review. Nutrients 10:5, pages 645.
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Khalid El Bairi, Mounir Ouzir, Najda Agnieszka & Loubna Khalki. (2017) Anticancer potential of Trigonella foenum graecum: Cellular and molecular targets. Biomedicine & Pharmacotherapy 90, pages 479-491.
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Akinori Haratake, Daisuke Watase, Shuichi Setoguchi, Nami Nagata-Akaho, Kazuhisa Matsunaga & Jiro Takata. (2017) Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action. Life Sciences 174, pages 77-82.
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G. Bhuvanalakshmi, Basappa, Kanchugarakoppal S. Rangappa, Arun Dharmarajan, Gautam Sethi, Alan P. Kumar & Sudha Warrier. (2017) Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4. Frontiers in Pharmacology 8.
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Chih-Tai Chen, Zhi-Hong Wang, Cheng-Chin Hsu, Hui-Hsuan Lin & Jing-Hsien Chen. (2015) In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity. Nutrients 7:6, pages 4938-4954.
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Jayaraman Jagadeesan, Kulanthaivel Langeswaran, Subbaraj Gowthamkumar & Maruthaiveeran Periyaswamy Balasubramanian. (2013) Diosgenin exhibits beneficial efficiency on human mammary carcinoma cell line MCF-7 and against N-nitroso-N-methylurea (NMU) induced experimental mammary carcinoma. Biomedicine & Preventive Nutrition 3:4, pages 381-388.
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Bharat Aggarwal, Sahdeo Prasad, Bokyung Sung, Sunil Krishnan & Sushovan Guha. (2013) Prevention and Treatment of Colorectal Cancer by Natural Agents from Mother Nature. Current Colorectal Cancer Reports 9:1, pages 37-56.
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Dae Sung Kim, Byoung Kook Jeon, Young Eun Lee, Won Hong Woo & Yeun Ja Mun. (2012) Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-8.
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Aymen Jabrane, Hichem Ben Jannet, Tomofumi Miyamoto, Jean-François Mirjolet, Olivier Duchamp, Féthia Harzallah-Skhiri & Marie-Aleth Lacaille-Dubois. (2011) Spirostane and cholestane glycosides from the bulbs of Allium nigrum L. Food Chemistry 125:2, pages 447-455.
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Hildebert Wagner, Rudolf Bauer, Dieter Melchart, Pei-Gen Xiao & Anton Staudinger. 2011. Chromatographic Fingerprint Analysis of Herbal Medicines. Chromatographic Fingerprint Analysis of Herbal Medicines 615 631 .
Feng Li, Prasana Priscilla Fernandez, Peramaiyan Rajendran, Kam M. Hui & Gautam Sethi. (2010) Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Letters 292:2, pages 197-207.
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Yayoi Tada, Naoko Kanda, Akinori Haratake, Megumi Tobiishi, Hideyo Uchiwa & Shinichi Watanabe. (2009) Novel effects of diosgenin on skin aging. Steroids 74:6, pages 504-511.
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Hongwei Liu, Jiankuan Li, Wenhua Zhao, Li Bao, Xiaohong Song, Ying Xia, Xue Wang, Chao Zhang, Xiaozhu Wang, Xinsheng Yao & Ming Li. (2009) Fatty Acid Synthase Inhibitors from Geum japonicum Thunb. var. chinense . Chemistry & Biodiversity 6:3, pages 402-410.
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Marc Sautour, Anne-Claire Mitaine-Offer & Marie-Aleth Lacaille-Dubois. (2007) The Dioscorea genus: a review of bioactive steroid saponins. Journal of Natural Medicines 61:2, pages 91-101.
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Guanghui Wang, Haifeng Chen, Minghui Huang, Naili Wang, Jinchao Zhang, Yaou Zhang, Ganrong Bai, Wang-Fun Fong, Mengsu Yang & Xinsheng Yao. (2006) Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Letters 241:1, pages 102-109.
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S Shishodia & B B Aggarwal. (2005) Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression. Oncogene 25:10, pages 1463-1473.
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Hongwei Liu, Xue Zhang, Hao Gao, Nali Wang, Sanlin Jin, Bin Cai, Xinsheng Yao & Guoping Cai. (2005) Two New Triterpenoid Glycosides Isolated from Aesculus assamica GRIFF. CHEMICAL & PHARMACEUTICAL BULLETIN 53:10, pages 1310-1313.
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