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Original Articles

Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis

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Pages 155-166 | Received 01 Jul 2003, Accepted 07 Oct 2003, Published online: 22 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Qing Tang, Lihua Liu, Hongyan Zhang, Jing Xiao & Swei Sunny Hann. (2020) Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells. Drug Design, Development and Therapy 14, pages 577-589.
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Long Su, LiHua Liu, YingLi Wang, GuangZhi Yan & Yang Zhang. (2014) Long-term systemic toxicity of shikonin derivatives in Wistar rats. Pharmaceutical Biology 52:4, pages 486-490.
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Yi-ying Wu, Ling Zhu, Xiu-ying Ma, Zheng-jun Shao, Jian Chen, Xia-jing Chen, Li-hong Wan & Li-ming Zhou. (2011) The anti-proliferation effect of Aikete injection on hepatocellular carcinoma in vitro and in vivo. Pharmaceutical Biology 49:5, pages 531-538.
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Hong-Ming Cheng, Ying-Kun Qiu, Zhen Wu & Yu-Fen Zhao. (2011) DNA damage induced by shikonin in the presence of Cu(II) ions: potential mechanism of its activity to apoptotic cell death. Journal of Asian Natural Products Research 13:1, pages 12-19.
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Articles from other publishers (37)

Danlu Chi, Yuejiao Zhang, Xinwei Lin, Qimei Gong & Zhongchun Tong. (2022) Caspase-1 Inhibition Reduces Occurrence of PANoptosis in Macrophages Infected by E. faecalis OG1RF. Journal of Clinical Medicine 11:20, pages 6204.
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Ziyan Xu, Liru Huang, Tiantian Zhang, Yuwei Liu, Fang Fang, Xinyue Wu, Wen Chen, Lingning Lan, Yangbo Zhang, Na Li & Ping Hu. (2022) Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3β signalling. Oncology Letters 24:3.
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Snehlata Yadav, Ajay Sharma, Gulzar Ahmad Nayik, Raymond Cooper, Garima Bhardwaj, Harvinder Singh Sohal, Vishal Mutreja, Ramandeep Kaur, Franklin Ore Areche, Mohannad AlOudat, Ayaz Mukarram Shaikh, Béla Kovács & Abdelhakam Esmaeil Mohamed Ahmed. (2022) Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology. Frontiers in Pharmacology 13.
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Zhenlong Yu, Jian Gao, Xiaolei Zhang, Yulin Peng, Wenlong Wei, Jianrong Xu, Zhenwei Li, Chao Wang, Meirong Zhou, Xiangge Tian, Lei Feng, Xiaokui Huo, Min Liu, Mingliang Ye, De-an Guo & Xiaochi Ma. (2022) Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth. Signal Transduction and Targeted Therapy 7:1.
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Giulia Greco, Elena Catanzaro & Carmela Fimognari. (2021) Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer. Cancers 13:2, pages 304.
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Miao-Miao Liu, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Carlos L. Cespedes-Acuña, Li Jiang & Zhao-Jun Wei. (2020) Apigenin 7-O-glucoside promotes cell apoptosis through the PTEN/PI3K/AKT pathway and inhibits cell migration in cervical cancer HeLa cells. Food and Chemical Toxicology 146, pages 111843.
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Mei Liao, Pan Yan, Xuechen Liu, Zhifeng Du, Shuailong Jia, Rahmetulla Aybek, Aiqian Li, Sulaiman Kaisa & Hongliang Jiang. (2020) Spectrum-effect relationship for anti-tumor activity of shikonins and shikonofurans in medicinal Zicao by UHPLC-MS/MS and chemometric approaches. Journal of Chromatography B 1136, pages 121924.
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Takeshi Terabayashi, Asako Tokumaru, Toshimasa Ishizaki & Katsuhiro Hanada. 2020. DNA Electrophoresis. DNA Electrophoresis 89 99 .
Shoude Zhang, Qiang Gao, Wei Li, Luwei Zhu, Qianhan Shang, Shuo Feng, Junmei Jia, Qiangqiang Jia, Shuo Shen & Zhanhai Su. (2019) Shikonin inhibits cancer cell cycling by targeting Cdc25s. BMC Cancer 19:1.
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Xia Han, Kyoung Ah Kang, Mei Jing Piao, Ao Xuan Zhen, Yu Jae Hyun, Hyun Min Kim, Yea Seong Ryu & Jin Won Hyun. (2019) Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways. Biomolecules & Therapeutics 27:1, pages 41-47.
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Hui Wang, Zheng Liu, Xiangchen Li, Ruijie Zhao, Yabin Pu, Handong Wu & Weijun Guan. (2017) Shikonin causes apoptosis by disrupting intracellular calcium homeostasis and mitochondrial function in human hepatoma cells. Experimental and Therapeutic Medicine.
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Zijian Zhou, Bin Lu, Chen Wang, Zongqi Wang, Tianfei Luo, Meihua Piao, Fankai Meng, Guangfan Chi, Yinan Luo & Pengfei Ge. (2017) RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species. Cancer Letters 390, pages 77-90.
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Da Jeong Kim, Ji Hye Lee, Hae Ryoun Park & Young Whan Choi. (2016) Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis. Archives of Oral Biology 70, pages 149-157.
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Karuppaiya Palaniyandi, Shenghua Wang & Fang Chen. 2016. Medicinal Plants - Recent Advances in Research and Development. Medicinal Plants - Recent Advances in Research and Development 327 362 .
Jing Liu, Ping Wang, Yi-xue Xue, Zhen Li, Cheng-bin Qu & Yun-hui Liu. (2015) Enhanced antitumor effect of shikonin by inhibiting Endoplasmic Reticulum Stress via JNK/c-Jun pathway in human glioblastoma stem cells. Biochemical and Biophysical Research Communications 466:1, pages 103-110.
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DAN QU, XIAO-MAN XU, MENG ZHANG, TING-SHU JIANG, YI ZHANG & SHENG-QI LI. (2015) Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling. Molecular Medicine Reports 12:1, pages 1305-1313.
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ZHENFENG HAO, JING QIAN & JISHI YANG. (2015) Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK. Oncology Letters 9:2, pages 629-633.
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Ke Gong, Zhenxing Zhang, Yicheng Chen, Hong-Bing Shu & Wenhua Li. (2014) Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma. European Journal of Pharmacology 738, pages 142-152.
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Morteza Eskandani & Hossein Nazemiyeh. (2014) Self-reporter shikonin-Act-loaded solid lipid nanoparticle: Formulation, physicochemical characterization and geno/cytotoxicity evaluation. European Journal of Pharmaceutical Sciences 59, pages 49-57.
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Mu-Jang Lee, Shao-Hsuan Kao, Jing-En Hunag, Gwo-Tarng Sheu, Chi-Wei Yeh, You-Cheng Hseu, Chau-Jong Wang & Li-Sung Hsu. (2014) Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species. Chemico-Biological Interactions 211, pages 44-53.
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Shahla Karim Baloch†Li-Jun Ling†Han-Yue Qiu, Lin Ma, Hong-Yan Lin, Shou-Cheng Huang, Jin-Liang Qi, Xiao-Ming Wang, Gui-Hua Lu & Yong-Hua Yang. (2014) Synthesis and biological evaluation of novel shikonin ester derivatives as potential anti-cancer agents. RSC Advances 4:67, pages 35588.
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Jin-Lan Piao, Zheng-Guo Cui, Yukihiro Furusawa, Kanwal Ahmed, Mati Ur Rehman, Yoshiaki Tabuchi, Makoto Kadowaki & Takashi Kondo. (2013) The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells. Chemico-Biological Interactions 205:2, pages 119-127.
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Changmin Chen, Kumaran Shanmugasundaram, Alan C. Rigby & Andrew L. Kung. (2013) Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent. European Journal of Pharmaceutical Sciences 49:1, pages 18-26.
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Seetharaman Rajasekar, Da Jung Park, Cheol Park, Sejin Park, Young Hoon Park, Sun Tae Kim, Yung Hyun Choi & Young Whan Choi. (2012) In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma. Journal of Ethnopharmacology 144:2, pages 335-345.
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Ching-Hsein Chen, Miao-Ling Lin, Ping-Lin Ong & Jen-Tsung Yang. (2012) Novel Multiple Apoptotic Mechanism of Shikonin in Human Glioma Cells. Annals of Surgical Oncology 19:9, pages 3097-3106.
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Wei Wu, Peng Liu & Jianyong Li. (2012) Necroptosis: An emerging form of programmed cell death. Critical Reviews in Oncology/Hematology 82:3, pages 249-258.
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Yi‐ying Wu, Li‐hong Wan, Xiao‐wei Zheng, Zhen‐jun Shao, Jian Chen, Xia‐jing Chen, Li‐tao Liu, Wen‐juan Kuang, Xian‐shu Tan & Li‐ming Zhou. (2011) Inhibitory Effects of β,β‐Dimethylacrylshikonin on Hepatocellular Carcinoma In Vitro and In Vivo . Phytotherapy Research 26:5, pages 764-771.
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Katarzyna Sykłowska-Baranek, Agnieszka Pietrosiuk, Anna Gawron, Anna Kawiak, Ewa Łojkowska, Małgorzata Jeziorek & Ioanna Chinou. (2011) Enhanced production of antitumour naphthoquinones in transgenic hairy root lines of Lithospermum canescens. Plant Cell, Tissue and Organ Culture (PCTOC) 108:2, pages 213-219.
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Tatjana Stanojković, Aleksandra Konić-Ristić, Teodora Janković, Gordana Zdunić & Katarina Šavikin. 2012. Materia Medica for Various Cancers. Materia Medica for Various Cancers 129 150 .
Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen & Yitao Wang. (2011) Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine 6:1.
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Sui Huang, Lanfang Yu & Peng Shen. (2010) Simultaneous Quantitative Analysis of Shikonin and Deoxyshikonin in Rat Plasma by Rapid LC–ESI–MS–MS. Chromatographia 72:1-2, pages 63-69.
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MeiXiang Zhu, Yanbing Gao, Zhen Wu & YuFen Zhao. (2009) A rapid HPLC/ESI‐MS/MS method for quantitative analysis of isovalerylshikonin in rat plasma. Biomedical Chromatography 24:4, pages 413-419.
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I-Chang Chang, Yu-Jen Huang, Tsay-I Chiang, Chi-Wei Yeh & Li-Sung Hsu. (2010) Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 33:5, pages 816-824.
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Huanjie Yang, Ping Zhou, Hongbiao Huang, Di Chen, Ningfang Ma, Qiuzhi Cindy Cui, Shouxing Shen, Weihua Dong, Xiaoyan Zhang, Wen Lian, Xuejun Wang, Q. Ping Dou & Jinbao Liu. (2009) Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo . International Journal of Cancer 124:10, pages 2450-2459.
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Yanyan Xuan & Xun Hu. (2009) Naturally-occurring shikonin analogues – A class of necroptotic inducers that circumvent cancer drug resistance. Cancer Letters 274:2, pages 233-242.
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Weidong Han, Ling Li, Shuang Qiu, Qinghua Lu, Qiangrong Pan, Ying Gu, Jianhong Luo & Xun Hu. (2007) Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Molecular Cancer Therapeutics 6:5, pages 1641-1649.
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Yue HOU, Tao GUO, Chunfu WU, Xiang HE & Minghong ZHAO. (2006) Effect of Shikonin on Human Breast Cancer Cells Proliferation and Apoptosis In Vitro. YAKUGAKU ZASSHI 126:12, pages 1383-1386.
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