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Research Article

Oxidative DNA Damage: Biological Significance and Methods of Analysis

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Pages 331-457 | Published online: 29 Sep 2008

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Read on this site (7)

Jean-Luc Ravanat. (2012) Chromatographic methods for the analysis of oxidatively damaged DNA. Free Radical Research 46:4, pages 479-491.
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Marcus S. Cooke, Lars Barregard, Vilas Mistry, Neelam Potdar, Rafal Rozalski, Daniel Gackowski, Agnieszka Siomek, Marek Foksinski, Peter Svoboda, Hiroshi Kasai, Justin C. Konje, Gerd Sallsten, Mark D. Evans & Ryszard Olinski. (2009) Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine. Biomarkers 14:2, pages 103-110.
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Mark D. Evans, Rajinder Singh, Vilas Mistry, Karendeep Sandhu, Peter B. Farmer & Marcus S. Cooke. (2008) Analysis of urinary 8-oxo-7,8-dihydro-purine-2’-deoxyribonucleosides by LC-MS/MS and improved ELISA. Free Radical Research 42:10, pages 831-840.
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Eun-Sun Hwang & PhyllisE. Bowen. (2007) DNA Damage, a Biomarker of Carcinogenesis: Its Measurement and Modulation by Diet and Environment. Critical Reviews in Food Science and Nutrition 47:1, pages 27-50.
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Michelle L. O'Brien, Brett T. Spear & Howard P. Glauert. (2005) Role of Oxidative Stress in Peroxisome Proliferator-Mediated Carcinogenesis. Critical Reviews in Toxicology 35:1, pages 61-88.
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Giuseppe M. Campo, Angela Avenoso, Salvatore Campo, Angela D'Ascola, Alida M. Ferlazzo & Alberto Calatroni. (2004) Reduction of DNA Fragmentation and Hydroxyl Radical Production by Hyaluronic Acid and Chondroitin-4-sulphate in Iron Plus Ascorbate-induced Oxidative Stress in Fibroblast Cultures. Free Radical Research 38:6, pages 601-611.
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M. Purschke, U. Kasten‐Pisula, I. Brammer & E. Dikomey. (2004) Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation‐induced DNA base damage. International Journal of Radiation Biology 80:1, pages 29-38.
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Danni Wu, Baodong Liu, Junfa Yin, Tian Xu, Shuli Zhao, Qun Xu, Xi Chen & Hailin Wang. (2017) Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC–MS/MS. Journal of Chromatography B 1064, pages 1-6.
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Sean G. Rudd, Nicholas C.K. Valerie & Thomas Helleday. (2016) Pathways controlling dNTP pools to maintain genome stability. DNA Repair 44, pages 193-204.
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Miroslav Fojta. 2016. Biosensors for Security and Bioterrorism Applications. Biosensors for Security and Bioterrorism Applications 309 331 .
Małgorzata Zielińska-Przyjemska, Ewa Ignatowicz, Violetta Krajka-Kuźniak & Wanda Baer-Dubowska. (2015) Effect of tannic acid, resveratrol and its derivatives, on oxidative damage and apoptosis in human neutrophils. Food and Chemical Toxicology 84, pages 37-46.
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Cuiping Li & Hailin Wang. (2015) Selective enzymatic cleavage and labeling for sensitive capillary electrophoresis laser-induced fluorescence analysis of oxidized DNA bases. Journal of Chromatography A 1406, pages 324-330.
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Enes Atmaca & Abdurrahman Aksoy. (2015) d -phenothrin-induced oxidative DNA damage in rat liver and kidney determined by HPLC-ECD/DAD . Environmental Toxicology 30:5, pages 607-613.
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DANIEL B. ALENCAR, ARTHUR A. MELO, GISELLE C. SILVA, REBECA L. LIMA, KELMA M.S. PIRES-CAVALCANTE, RÔMULO F. CARNEIRO, ADRIANA S. RABELO, OSCARINA V. SOUSA, REGINE H.S.F. VIEIRA, FRANCISCO A. VIANA, ALEXANDRE H. SAMPAIO & SILVANA SAKER-SAMPAIO. (2015) Antioxidant, hemolytic, antimicrobial, and cytotoxic activities of the tropical Atlantic marine zoanthid Palythoa caribaeorum. Anais da Academia Brasileira de Ciências 87:2, pages 1113-1123.
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James A. Shapiro. (2014) Physiology of the read–write genome. The Journal of Physiology 592:11, pages 2319-2341.
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Henrik E. Poulsen, Laia Llovera Nadal, Kasper Broedbaek, Peter E. Nielsen & Allan Weimann. (2014) Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:2, pages 801-808.
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Miriam Rossi, Francesco Caruso, Roberto Antonioletti, Angela Viglianti, Gianandrea Traversi, Stefano Leone, Emiliano Basso & Renata Cozzi. (2013) Scavenging of hydroxyl radical by resveratrol and related natural stilbenes after hydrogen peroxide attack on DNA. Chemico-Biological Interactions 206:2, pages 175-185.
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Felipe S. Barreto & Ronald S. Burton. (2013) Elevated oxidative damage is correlated with reduced fitness in interpopulation hybrids of a marine copepod. Proceedings of the Royal Society B: Biological Sciences 280:1767, pages 20131521.
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Joanna Joyner-Matos & Lauren J. Chapman. (2013) Persisting in papyrus: Size, oxidative stress, and fitness in freshwater organisms adapted to sustained hypoxia. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 165:4, pages 405-416.
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Mark C. Fogarty, Ciara M. Hughes, George Burke, John C. Brown & Gareth W. Davison. (2012) Acute and chronic watercress supplementation attenuates exercise-induced peripheral mononuclear cell DNA damage and lipid peroxidation. British Journal of Nutrition 109:2, pages 293-301.
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Andrzej Wiczkowski. (2013) 8-hydroxy-2’-deoxyguanosine in colorectal adenocarcinoma – is it a result of oxidative stress?. Medical Science Monitor 19, pages 690-695.
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Jean Cadet, Thierry Douki, Jean-Luc Ravanat & J. Richard Wagner. 2013. Frontiers of Bioanalytical Chemistry. Frontiers of Bioanalytical Chemistry 269 288 .
Jean Cadet, Thierry Douki, Jean-Luc Ravanat & J. Richard Wagner. (2012) Measurement of oxidatively generated base damage to nucleic acids in cells: facts and artifacts. Bioanalytical Reviews 4:2-4, pages 55-74.
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Umesh Kumar, Meenakshi Mishra & Veeru Prakash. (2012) Assessment of antioxidant enzymes and free radical scavenging activity of selected medicinal plants. Free Radicals and Antioxidants 2:3, pages 58-63.
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Chiemi Hosozumi, Akira Toriba, Thanyarat Chuesaard, Takayuki Kameda, Ning Tang & Kazuichi Hayakawa. (2012) Analysis of 8-hydroxy-2′-deoxyguanosine in human urine using hydrophilic interaction chromatography with tandem mass spectrometry. Journal of Chromatography B 893-894, pages 173-176.
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Joanna Joyner-Matos, Laura C Bean, Heidi L Richardson, Tammy Sammeli & Charles F Baer. (2011) No Evidence of Elevated Germline Mutation Accumulation Under Oxidative Stress in Caenorhabditis elegans . Genetics 189:4, pages 1439-1447.
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Sebahat OzdemCahit Nacitarhan, Mehmet S Gulay, Fatma S Hatipoglu & Sadi S Ozdem. (2011) The effect of ascorbic acid supplementation on endosulfan toxicity in rabbits. Toxicology and Industrial Health 27:5, pages 437-446.
Crossref
Jan Labuda. 2011. Nucleic Acid Biosensors for Environmental Pollution Monitoring. Nucleic Acid Biosensors for Environmental Pollution Monitoring 121 140 .
Corey A Cohn, Shawn C Fisher, Bruce J Brownawell & Martin AA Schoonen. (2010) Adenine oxidation by pyrite-generated hydroxyl radicals. Geochemical Transactions 11:1.
Crossref
Paul T. Henderson, Mark D. Evans & Marcus S. Cooke. (2010) Salvage of oxidized guanine derivatives in the (2′-deoxy)ribonucleotide pool as source of mutations in DNA. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 703:1, pages 11-17.
Crossref
Phyllis E. Bowen. 2010. Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications. Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications 283 318 .
In Deok Kim & Bae Jin Ha. (2009) Paeoniflorin protects RAW 264.7 macrophages from LPS-induced cytotoxicity and genotoxicity. Toxicology in Vitro 23:6, pages 1014-1019.
Crossref
Stefanie Reichhold, Oliver Neubauer, Andrew C. Bulmer, Siegfried Knasmüller & Karl-Heinz Wagner. (2009) Endurance exercise and DNA stability: Is there a link to duration and intensity?. Mutation Research/Reviews in Mutation Research 682:1, pages 28-38.
Crossref
Marcus S. Cooke, Paul T. Henderson & Mark D. Evans. (2009) Sources of Extracellular, Oxidatively-Modified DNA Lesions: Implications for Their Measurement in Urine. Journal of Clinical Biochemistry and Nutrition 45:3, pages 255-270.
Crossref
Pat Monaghan, Neil B. Metcalfe & Roxana Torres. (2009) Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation. Ecology Letters 12:1, pages 75-92.
Crossref
Witold M. Winnik & Kirk T. Kitchin. (2008) Measurement of oxidative stress parameters using liquid chromatography–tandem mass spectroscopy (LC–MS/MS). Toxicology and Applied Pharmacology 233:1, pages 100-106.
Crossref
Joanne L. Watters, Jessie A. Satia & Lawrence L. Kupper. (2008) Correlates of antioxidant nutrients and oxidative DNA damage differ by race in a cross-sectional study of healthy African American and white adults. Nutrition Research 28:9, pages 565-576.
Crossref
Kyung Jin Lee, Jae Ho Choi, Yong Pil Hwang, Young Chul Chung & Hye Gwang Jeong. (2008) Protective effect of caffeic acid phenethyl ester on tert-butyl hydroperoxide-induced oxidative hepatotoxicity and DNA damage. Food and Chemical Toxicology 46:7, pages 2445-2450.
Crossref
Ivona Brasnjevic, Patrick R. Hof, Harry W.M. Steinbusch & Christoph Schmitz. (2008) Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair 7:7, pages 1087-1097.
Crossref
Ming Zhang, Aiguo Wang, Tao Xia & Ping He. (2008) Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-κB in primary cultured rat hippocampal neurons. Toxicology Letters 179:1, pages 1-5.
Crossref
S. A. Gatz & L. Wiesmuller. (2008) Take a break--resveratrol in action on DNA. Carcinogenesis 29:2, pages 321-332.
Crossref
Nathan M. Novotny, Jay L. Grosfeld, Katharyn E. Turner, Frederick J. Rescorla, Xinzhu Pu, James E. Klaunig, Robert J. Hickey, Linda H. Malkas & John A. Sandoval. (2008) Oxidative status in neuroblastoma: a source of stress?. Journal of Pediatric Surgery 43:2, pages 330-334.
Crossref
Mu-Rong Chao, Cheng-Chieh Yen & Chiung-Wen Hu. (2008) Prevention of artifactual oxidation in determination of cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine by isotope-dilution LC–MS/MS with automated solid-phase extraction. Free Radical Biology and Medicine 44:3, pages 464-473.
Crossref
Marcus S. Cooke, Ryszard Olinski & Steffen Loft. (2008) Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine. Cancer Epidemiology, Biomarkers & Prevention 17:1, pages 3-14.
Crossref
Marcus S. Cooke, Joy E. Osborne, Rajinder Singh, Vilas Mistry, Peter B. Farmer, Mark D. Evans & Peter E. Hutchinson. (2007) Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients. Free Radical Biology and Medicine 43:9, pages 1328-1334.
Crossref
Kyung Jin Lee & Hye Gwang Jeong. (2007) Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicology Letters 173:2, pages 80-87.
Crossref
Marcus S. Cooke & Mark D. Evans. (2007) 8-Oxo-deoxyguanosine: Reduce, reuse, recycle?. Proceedings of the National Academy of Sciences 104:34, pages 13535-13536.
Crossref
Elizabeth de la Fuente, Gonzalo Villagra & Soledad Bollo. (2007) Electrochemical Nucleic Acid Biosensors for the Detection of Interaction Between Peroxynitrite and DNA. Electroanalysis 19:14, pages 1518-1523.
Crossref
Ken C. Hunter & Stacey D. Wetmore. (2007) Environmental Effects on the Enhancement in Natural and Damaged DNA Nucleobase Acidity Because of Discrete Hydrogen-Bonding Interactions. The Journal of Physical Chemistry A 111:10, pages 1933-1942.
Crossref
Thierry Lemineur, Ginette Deby-Dupont & Jean-Charles Preiser. (2006) Biomarkers of oxidative stress in critically ill patients: what should be measured, when and how?. Current Opinion in Clinical Nutrition & Metabolic Care 9:6, pages 704-710.
Crossref
Anna Martirosyan, Stephen Leonard, Xianglin Shi, Brian Griffith, Peter Gannett & Jeannine Strobl. (2006) Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells. Journal of Pharmacology and Experimental Therapeutics 317:2, pages 546-552.
Crossref
E.O. Gregg, A.-L. Fisher, F. Lowe, M. McEwan & E.D. Massey. (2006) An approach to the validation of biomarkers of harm for use in a tobacco context. Regulatory Toxicology and Pharmacology 44:3, pages 262-267.
Crossref
N.K. Chemeris, A.B. Gapeyev, N.P. Sirota, O.Yu. Gudkova, A.V. Tankanag, I.V. Konovalov, M.E. Buzoverya, V.G. Suvorov & V.A. Logunov. (2006) Lack of direct DNA damage in human blood leukocytes and lymphocytes after in vitro exposure to high power microwave pulses. Bioelectromagnetics 27:3, pages 197-203.
Crossref
Rebecca Conners, Elizabeth Hooley, Anthony R. Clarke, Siân Thomas & R. Leo Brady. (2006) Recognition of Oxidatively Modified Bases within the Biotin-binding Site of Avidin. Journal of Molecular Biology 357:1, pages 263-274.
Crossref
David Ratel, Jean-Luc Ravanat, François Berger & Didier Wion. (2006) N6-methyladenine: the other methylated base of DNA. BioEssays 28:3, pages 309-315.
Crossref
Henrik E. Poulsen, Allan Weimann & Barry B. Halliwell. 2006. Cigarette Smoke and Oxidative Stress. Cigarette Smoke and Oxidative Stress 387 402 .
Ian A. Blair, John A Lawson, Harry Ischiropoulos & Garret A. FitzGerald. 2006. Antioxidants and Cardiovascular Disease. Antioxidants and Cardiovascular Disease 131 165 .
Giuseppe M. Campo, Angela Avenoso, Angela D’Ascola, Salvatore Campo, Alida M. Ferlazzo, Dario Samà & Alberto Calatroni. (2005) Purified human plasma glycosaminoglycans limit oxidative injury induced by iron plus ascorbate in skin fibroblast cultures. Toxicology in Vitro 19:5, pages 561-572.
Crossref
Henrik E. Poulsen. (2005) Oxidative DNA modifications. Experimental and Toxicologic Pathology 57, pages 161-169.
Crossref
Kateřina Cahová-Kuchaříková, Miroslav Fojta, Tomáš Mozga & Emil Paleček. (2005) Use of DNA Repair Enzymes in Electrochemical Detection of Damage to DNA Bases in Vitro and in Cells. Analytical Chemistry 77:9, pages 2920-2927.
Crossref
Miroslav Fojta. 2005. Electrochemistry of Nucleic Acids and Proteins – Towards Electrochemical Sensors for Genomics and Proteomics. Electrochemistry of Nucleic Acids and Proteins – Towards Electrochemical Sensors for Genomics and Proteomics 385 431 .
A. V. Usatov, E. V. Mashkina & E. P. Gus?kov. (2005) The effect of oxidative stress on nitrosomethylurea-induced mutagenesis in sunflower Helianthus annuus L.. Russian Journal of Genetics 41:1, pages 53-59.
Crossref
A. V. Usatov, E. V. Mashkina & E. P. Gus’kov. (2005) The effect of oxidative stress on nitrosomethylurea-induced mutagenesis in sunflower Helianthus annuus L.. Russian Journal of Genetics 41:1, pages 53-59.
Crossref
Yun Ok Park, Eun-Sun Hwang & Tae Wha Moon. (2005) The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells. BioFactors 23:3, pages 129-139.
Crossref
Keith A. Friedman & Adam Heller. (2004) Guanosine Distribution and Oxidation Resistance in Eight Eukaryotic Genomes. Journal of the American Chemical Society 126:8, pages 2368-2371.
Crossref
Li-Mei Qiu. (2003) Observation of DNA damage of human hepatoma cells irradiated by heavy ions using comet assay. World Journal of Gastroenterology 9:7, pages 1450.
Crossref

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