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Original Articles

The Occurrence, Fate and Biological Activities of C-glycosyl Flavonoids in the Human Diet

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Hanne Vissenaekens, Hanne Criel, Charlotte Grootaert, Katleen Raes, Guy Smagghe & John Van Camp. (2022) Flavonoids and cellular stress: a complex interplay affecting human health. Critical Reviews in Food Science and Nutrition 62:31, pages 8535-8566.
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Pedro Mena & Letizia Bresciani. (2020) Dietary fibre modifies gut microbiota: what’s the role of (poly)phenols?. International Journal of Food Sciences and Nutrition 71:7, pages 783-784.
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Federico Scossa, Federico Roda, Takayuki Tohge, Milen I. Georgiev & Alisdair R. Fernie. (2019) The Hot and the Colorful: Understanding the Metabolism, Genetics and Evolution of Consumer Preferred Metabolic Traits in Pepper and Related Species. Critical Reviews in Plant Sciences 38:5-6, pages 339-381.
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Guilin Chen, Mingzhi Zhu & Mingquan Guo. (2019) Research advances in traditional and modern use of Nelumbo nucifera: phytochemicals, health promoting activities and beyond. Critical Reviews in Food Science and Nutrition 59:sup1, pages S189-S209.
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Christo J. F. Muller, Christiaan J. Malherbe, Nireshni Chellan, Kazumi Yagasaki, Yutaka Miura & Elizabeth Joubert. (2018) Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome. Critical Reviews in Food Science and Nutrition 58:2, pages 227-246.
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Articles from other publishers (65)

Sara M. Tomé, Raquel G. Soengas & Artur M. S. Silva. (2023) Application of the Heck Reaction for the Synthesis of C-Glycosyl Phenolic Compounds. Synthesis 55:23, pages 4000-4010.
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Johannes Bitter, Martin Pfeiffer, Annika J. E. Borg, Kirill Kuhlmann, Tea Pavkov-Keller, Pedro A. Sánchez-Murcia & Bernd Nidetzky. (2023) Enzymatic β-elimination in natural product O- and C-glycoside deglycosylation. Nature Communications 14:1.
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So-Hyun Park, Hang Yeon Jeong, Pyeong Geun Choi, Min Jung Kim, Hyo-Deok Seo, Jeong-Hoon Hahm, Jiyun Ahn & Chang Hwa Jung. (2023) C-Glycosidic flavone-rich Passiflora incarnata L. leaf extracts decrease body weight and fatty liver in obese mice. Food Bioscience 55, pages 103028.
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Simin Liu, Jiamei Liu, Linguo Zhao & Jianjun Pei. (2023) Engineering Escherichia coli for efficient and economic production of C-glycosylflavonoids by deleting YhhW and regulating pH. Bioprocess and Biosystems Engineering 46:9, pages 1251-1264.
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Ireneusz Sowa, Jarosław Mołdoch, Sławomir Dresler, Tomasz Kubrak, Agata Soluch, Dariusz Szczepanek, Maciej Strzemski, Roman Paduch & Magdalena Wójciak. (2023) Phytochemical Profiling, Antioxidant Activity, and Protective Effect against H2O2-Induced Oxidative Stress of Carlina vulgaris Extract. Molecules 28:14, pages 5422.
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Ruth E. Barrientos, Javier Romero-Parra, Fredi Cifuentes, Javier Palacios, Néstor Jaime Romero-Jola, Adrián Paredes, Gabriel Vargas-Arana & Mario J. Simirgiotis. (2023) Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (Drimys winteri J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits. Foods 12:13, pages 2580.
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Aecio Luís de Sousa Dias, Julie-Anne Fenger, Emmanuelle Meudec, Arnaud Verbaere, Pierre Costet, Clotilde Hue, Florent Coste, Sophie Lair, Véronique Cheynier, Jean-Claude Boulet & Nicolas Sommerer. (2023) Shades of Fine Dark Chocolate Colors: Polyphenol Metabolomics and Molecular Networking to Enlighten the Brown from the Black. Metabolites 13:5, pages 667.
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Francesco Gai, Michał A. Janiak, Katarzyna Sulewska, Pier Giorgio Peiretti & Magdalena Karamać. (2023) Phenolic Compound Profile and Antioxidant Capacity of Flax (Linum usitatissimum L.) Harvested at Different Growth Stages. Molecules 28:4, pages 1807.
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Paula Garcia-Oliveira, Anxo Carreira-Casais, Eliana Pereira, Maria Inês Dias, Carla Pereira, Ricardo C. Calhelha, Dejan Stojković, Marina Sokovic, Jesus Simal-Gandara, Miguel A. Prieto, Cristina Caleja & Lillian Barros. (2022) From Tradition to Health: Chemical and Bioactive Characterization of Five Traditional Plants. Molecules 27:19, pages 6495.
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Indrapal Singh Aidhen, Sriranjani Srikanth & Heera Lal. (2022) The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds. European Journal of Organic Chemistry 2022:35.
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Florencia M. Correa Uriburu, Florencia Cattaneo, Luis M. Maldonado, Iris C. Zampini, María R. Alberto & María I. Isla. (2022) Prosopis alba Seed as a Functional Food Waste for Food Formulation Enrichment. Foods 11:18, pages 2857.
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María Eugenia Orqueda, Sebastian Torres, Iris Catiana Zampini & María Inés Isla. (2022) In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of Ziziphus mistol from Argentina. Foods 11:14, pages 2125.
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Sha Wang, Siqi Liu, Jing Wang, Jiayue Tao, Mengjiao Wu, Wenfu Ma & Rufeng Wang. (2022) A newly isolated human intestinal strain deglycosylating flavonoid C-glycosides. Archives of Microbiology 204:6.
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Zihan Zhu, Biming Zhong, Zihong Yang, Wanrong Zhao, Linghong Shi, Ahsan Aziz, Abdur Rauf, Abdullah S.M. Aljohani, Fahad A. Alhumaydhi & Hafiz Ansar Rasul Suleria. (2022) LC-ESI-QTOF-MS/MS Characterization and Estimation of the Antioxidant Potential of Phenolic Compounds from Different Parts of the Lotus ( Nelumbo nucifera ) Seed and Rhizome . ACS Omega 7:17, pages 14630-14642.
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Liangqin Xie, Zeyuan Deng, Jie Zhang, Huanhuan Dong, Wei Wang, Banghuai Xing & Xiaoru Liu. (2022) Comparison of Flavonoid O-Glycoside, C-Glycoside and Their Aglycones on Antioxidant Capacity and Metabolism during In Vitro Digestion and In Vivo. Foods 11:6, pages 882.
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Zhi Tao, Shiqi Zheng, Shuangyue Liu, Jing Wang, Di Geng & Rufeng Wang. (2022) Isolation and identification of <i>Enterococcus gallinarum</i> P581a, a strain of intestinal bacteria deglycosylating flavone <i>C</i>-glycosides. The Journal of General and Applied Microbiology 68:3, pages 125-133.
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María Inés Isla, Jorgelina Pérez, Florencia Cattaneo, Ivana Fabiola Rodríguez, Florencia María Correa Uriburu & Iris Catiana Zampini. 2022. Prosopis as a Heat Tolerant Nitrogen Fixing Desert Food Legume. Prosopis as a Heat Tolerant Nitrogen Fixing Desert Food Legume 275 286 .
Christo J. F. Muller, Elizabeth Joubert, Nireshni Chellan, Yutaka Miura & Kazumi Yagasaki. (2021) New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes—A Review. International Journal of Molecular Sciences 23:1, pages 356.
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Shreeya Ravisankar, Halef Dizlek & Joseph M. Awika. (2021) Changes in extractable phenolic profile during natural fermentation of wheat, sorghum and teff. Food Research International 145, pages 110426.
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Patrícia I. C. Godinho, Raquel G. Soengas & Vera L. M. Silva. (2021) Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents. Pharmaceuticals 14:6, pages 546.
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Linlong Ma, Yong Yang, Dan Cao, Yanli Liu, Ziming Gong, Sezai Ercisli, Zhengfei Luo & Xiaofang Jin. (2021) Analysis of the Biochemical and Volatile Components of Qianlincha and Qiandingcha Prepared from Eurya alata Kobuski and Camellia cuspidate. Agronomy 11:4, pages 657.
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Md Yousof Ali, Susoma Jannat & M. Mizanur Rahman. (2021) Investigation of C-glycosylated apigenin and luteolin derivatives’ effects on protein tyrosine phosphatase 1B inhibition with molecular and cellular approaches. Computational Toxicology 17, pages 100141.
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Michał P. Maliński, Małgorzata Anna Kikowska, Agata Soluch, Mariusz Kowalczyk, Anna Stochmal & Barbara Thiem. (2021) Phytochemical Screening, Phenolic Compounds and Antioxidant Activity of Biomass from Lychnis flos-cuculi L. In Vitro Cultures and Intact Plants. Plants 10:2, pages 206.
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F. Bucar, Jianbo Xiao & S. Ochensberger. 2021. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 117 153 .
Débora Pagliuso, Carmen Eusebia Palacios Jara, Adriana Grandis, Eric Lam, Marcelo José Pena Ferreira & Marcos Silveira Buckeridge. (2020) Flavonoids from duckweeds: potential applications in the human diet. RSC Advances 10:73, pages 44981-44988.
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Honghui Liu, Yan Wang, Mingxia Lv, Yi Luo, Bu-Ming Liu, Yan Huang, Mian Wang & Jianyi Wang. (2020) Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation. Bioorganic Chemistry 105, pages 104370.
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Yunsheng Xue, Yunping Liu, Yuxin Xie, Chunxue Cong, Guirong Wang, Lin An, Yangxin Teng, Mohan Chen & Ling Zhang. (2020) Antioxidant activity and mechanism of dihydrochalcone C-glycosides: Effects of C-glycosylation and hydroxyl groups. Phytochemistry 179, pages 112393.
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Jiebiao Chen, Yue Wang, Tailin Zhu, Sijia Yang, Jinping Cao, Xian Li, Li-Shu Wang & Chongde Sun. (2020) Beneficial Regulatory Effects of Polymethoxyflavone—Rich Fraction from Ougan (Citrus reticulata cv. Suavissima) Fruit on Gut Microbiota and Identification of Its Intestinal Metabolites in Mice. Antioxidants 9:9, pages 831.
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Shreeya Ravisankar, Valeria A.V. Queiroz & Joseph M. Awika. (2020) Rye flavonoids – Structural profile of the flavones in diverse varieties and effect of fermentation and heat on their structure and antioxidant properties. Food Chemistry 324, pages 126871.
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Francesca Danesi, Luca Calani, Veronica Valli, Letizia Bresciani, Daniele Del Rio & Alessandra Bordoni. (2020) (Poly)phenolic Content and Profile and Antioxidant Capacity of Whole-Grain Cookies are Better Estimated by Simulated Digestion than Chemical Extraction. Molecules 25:12, pages 2792.
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Ivana Fabiola Rodríguez, Florencia Cattaneo, Ximena Valdecantos Zech, Erika Svavh, María Jorgelina Pérez, Iris Catiana Zampini & María Inés Isla. (2020) Aloja and añapa, two traditional beverages obtained from Prosopis alba pods: Nutritional and functional characterization. Food Bioscience 35, pages 100546.
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Daniel J. Giurleo, H. Rodolfo Juliani, Larry S. Amekuse, Julie Asante Dartey, James E. Simon & Qingli Wu. 2020. African Natural Plant Products, Volume III: Discoveries and Innovations in Chemistry, Bioactivity, and Applications. African Natural Plant Products, Volume III: Discoveries and Innovations in Chemistry, Bioactivity, and Applications 249 264 .
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Shiqi Zheng, Di Geng, Shuangyue Liu, Qingqing Wang, Siqi Liu & Rufeng Wang. (2019) A newly isolated human intestinal bacterium strain capable of deglycosylating flavone C-glycosides and its functional properties. Microbial Cell Factories 18:1.
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Keling Cheng, Xuan Zeng, Hao Wu, Weiwei Su, Weiyang Fan, Yang Bai, Hongliang Yao & Peibo Li. (2019) Effects of Naringin on the Activity and mRNA Expression of CYP Isozymes in Rats. Natural Product Communications 14:12, pages 1934578X1989418.
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Hanne Vissenaekens, Charlotte Grootaert, Andreja Rajkovic, Kristof De Schutter, Katleen Raes, Guy Smagghe, Tom Van de Wiele & John Van Camp. (2019) Cell line-dependent increase in cellular quercetin accumulation upon stress induced by valinomycin and lipopolysaccharide, but not by TNF-α. Food Research International 125, pages 108596.
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Micheline Grignon-Dubois & Bernadette Rezzonico. (2019) First insight into the phenolic content of Spartina maritima : isolation, characterization and quantification of four C -glycosidic flavonoids . Botanica Marina 62:4, pages 379-389.
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Hui Li, Siyi Pan & Xiaoyun Xu. (2019) Structure characteristics of flavonoids for cyclooxygenase-2 mRNA inhibition in lipopolysaccharide-induced inflammatory macrophages. European Journal of Pharmacology 856, pages 172416.
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Hirbod Bahrani, Ken Thoms, Monica Båga, Jamie Larsen, Robert Graf, Andre Laroche, Ramaswami Sammynaiken & Ravindra N Chibbar. (2019) Preferential accumulation of glycosylated cyanidins in winter-hardy rye (Secale cereale L.) genotypes during cold acclimation. Environmental and Experimental Botany.
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Guohong Zhou, Renliang Yan, Xiaogen Wang, Shaolin Li, Jin Lin, Jia Liu & Zhendong Zhao. (2019) The overlooked rotational isomerism of C-glycosyl flavonoids. Phytochemistry Reviews 18:2, pages 443-461.
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Bowei Zhang, Yuesheng Dong, Na Yu, Yuming Sun, Yan Xing, Fan Yang, Xiaoxia Yu, Wenlong Sun, Jin Sun, Xia Li & Zhilong Xiu. (2019) Intestinal metabolism of baicalein after oral administration in mice: Pharmacokinetics and mechanisms. Journal of Functional Foods 54, pages 53-63.
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Duangjai Tungmunnithum, Darawan Pinthong & Christophe Hano. (2018) Flavonoids from Nelumbo nucifera Gaertn., a Medicinal Plant: Uses in Traditional Medicine, Phytochemistry and Pharmacological Activities. Medicines 5:4, pages 127.
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Bowei Zhang, Wenlong Sun, Na Yu, Jin Sun, Xiaoxia Yu, Xia Li, Yan Xing, Dong Yan, Qianzhi Ding, Zhilong Xiu, Baiping Ma, Liyan Yu & Yuesheng Dong. (2018) Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats. Journal of Functional Foods 46, pages 256-267.
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Zhibin Liang & Qing X. Li. (2018) Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3β Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C -Glycosylflavones . ACS Chemical Neuroscience 9:5, pages 1166-1183.
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