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Lipid-modifying activity of curcuminoids: A systematic review and meta-analysis of randomized controlled trials

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Zhuo Sun, Xiaohui Wei, Jianan Bai, Wenyun Li, Jiaqi Yang, Zequn Deng, Min Wu, Tao Ying & Gengsheng He. (2023) The effects of curcumin on anthropometric and cardiometabolic parameters of patients with metabolic related diseases: a systematic review and dose-effect meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 63:28, pages 9282-9298.
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Ying Peng, Mingyue Ao, Baohua Dong, Yunxiu Jiang, Lingying Yu, Zhimin Chen, Changjiang Hu & Runchun Xu. (2021) Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures. Drug Design, Development and Therapy 15, pages 4503-4525.
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Joana Furtado de Figueiredo Neta, Vivian Saraiva Veras, Danilo Ferreira de Sousa, Maria da Conceição dos Santos Oliveira Cunha, Maria Veraci Oliveira Queiroz, José Claudio Garcia Lira Neto, Marta Maria Coelho Damasceno, Márcio Flávio Moura de Araújo & Roberto Wagner Júnior Freire de Freitas. (2021) Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial. International Journal of Food Sciences and Nutrition 72:7, pages 968-977.
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Ajaikumar B. Kunnumakkara, Choudhary Harsha, Kishore Banik, Rajesh Vikkurthi, Bethsebie L. Sailo, Devivasha Bordoloi, Subash C. Gupta & Bharat B. Aggarwal. (2019) Is curcumin bioavailability a problem in humans: lessons from clinical trials. Expert Opinion on Drug Metabolism & Toxicology 15:9, pages 705-733.
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Articles from other publishers (45)

Roghayeh Molani‐Gol, Azadeh Dehghani & Maryam Rafraf. (2023) Effects of curcumin/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non‐alcoholic fatty liver patients: An umbrella meta‐analysis. Phytotherapy Research.
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Qiong Wang, Hui Zhang, Qingzhe Jin & Xingguo Wang. (2023) Effects of Dietary Plant-derived Low-Ratio Linoleic Acid/Alpha-Linolenic Acid on Blood Lipid Profiles: A Systematic Review and Meta-Analysis. Foods 12:16, pages 3005.
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Saeid Mirzai & Luke J. Laffin. (2023) Supplements for Lipid Lowering: What Does the Evidence Show?. Current Cardiology Reports 25:8, pages 795-805.
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Ashim Kumar Sen, Ramachandran Balaraman, Dhanya B. Sen, Dillip Kumar Dash & Rajesh A. Maheshwari. (2023) Medicinal Herbs as an Alternative Treatment in the Management of Hyperlipidemia. Journal of Natural Remedies, pages 325-337.
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Claudio Procaccini, Paola de Candia, Claudia Russo, Giusy De Rosa, Maria Teresa Lepore, Alessandra Colamatteo & Giuseppe Matarese. (2023) Caloric restriction for the immunometabolic control of human health. Cardiovascular Research.
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Vali Musazadeh, Fatemeh Golandam, Amir Hossein Faghfouri, Mahdi Abdoli Shadbad, Majid Keramati, Amir Hossein Moridpour, Zeynab Kavyani & Elnaz Faghfuri. (2022) Curcumin supplementation contributes to relieving anthropometric and glycemic indices, as an adjunct therapy: A meta-research review of meta-analyses. Journal of Functional Foods 99, pages 105357.
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Vali Musazadeh, Neda Roshanravan, Mehdi Mohammadizadeh, Zeynab Kavyani, Parvin Dehghan & Erfan Mosharkesh. (2022) Curcumin as a novel approach in improving lipid profile: An umbrella meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases 32:11, pages 2493-2504.
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Luis E. Simental-Mendía, Najeeb Shah, Thozhukat Sathyapalan, Muhammed Majeed, Alexander N. Orekhov, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2021) Effect of Curcumin on Glycaemic and Lipid Parameters in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Reproductive Sciences 29:11, pages 3124-3133.
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Wensong Lu, Fedora Khatibi Shahidi, Khatereh Khorsandi, Reza Hosseinzadeh, Asma Gul & Veronica Balick. (2022) An update on molecular mechanisms of curcumin effect on diabetes. Journal of Food Biochemistry 46:10.
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Xiaofeng Zhang, Jinlan Deng, Yujun Tang, Xiaoxian Guan, Xiaoli Chen & Jianming Fan. (2022) Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans. Phytotherapy Research 36:8, pages 3080-3101.
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Agustina Dwi Retno Nurcahyanti, Fonny Cokro, Martha P. Wulanjati, Mona F. Mahmoud, Michael Wink & Mansour Sobeh. (2022) Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management. Frontiers in Nutrition 9.
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Stanisław Surma, Amirhossein Sahebkar, Jakub Urbański, Peter E. Penson & Maciej Banach. (2022) Curcumin - The Nutraceutical With Pleiotropic Effects? Which Cardiometabolic Subjects Might Benefit the Most?. Frontiers in Nutrition 9.
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Cydne A. Perry & Kishore M. Gadde. (2022) The Role of Calorie Restriction in the Prevention of Cardiovascular Disease. Current Atherosclerosis Reports 24:4, pages 235-242.
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Kunal Gupta, Hannah Testa, Tara Greenwood, Megan Kostek, Keally Haushalter, Penny M Kris-Etherton & Kristina S Petersen. (2022) The effect of herbs and spices on risk factors for cardiometabolic diseases: a review of human clinical trials. Nutrition Reviews 80:3, pages 400-427.
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Jean M. Bokelmann. 2022. Medicinal Herbs in Primary Care. Medicinal Herbs in Primary Care 615 636 .
Tuğba Günbatan. 2022. Novel Drug Targets With Traditional Herbal Medicines. Novel Drug Targets With Traditional Herbal Medicines 191 208 .
Mohammad Jalili-Nik, Khadijeh Mahboobnia, Paul C. Guest, Muhammed Majeed, Khalid Al-Rasadi, Tannaz Jamialahmadi & Amirhossein Sahebkar. 2022. Physical Exercise and Natural and Synthetic Products in Health and Disease. Physical Exercise and Natural and Synthetic Products in Health and Disease 395 400 .
Basel Abdelazeem, Kirellos Said Abbas, Joseph Shehata, Nischit Baral, Sandi Banour & Mustafa Hassan. (2021) The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta‐analysis of randomized clinical trials. Phytotherapy Research 36:1, pages 22-32.
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Mohammad Sadegh Adel Mehraban, Ozra Tabatabaei-Malazy, Roja Rahimi, Marzieh Daniali, Patricia Khashayar & Bagher Larijani. (2021) Targeting dyslipidemia by herbal medicines: A systematic review of meta-analyses. Journal of Ethnopharmacology 280, pages 114407.
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Qihong Zhang, Hui Wang, Zongmiao Feng, Zhaohui Lu, Chen Su, Yunchun Zhao, Jingbo Yu, Alexandr V. Dushkin & Weike Su. (2021) Preparation of pectin-tannic acid coated core-shell nanoparticle for enhanced bioavailability and antihyperlipidemic activity of curcumin. Food Hydrocolloids 119, pages 106858.
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Antonio Palazón-Bru, David Hernández-Lozano & Vicente Francisco Gil-Guillén. (2020) Which Physical Exercise Interventions Increase HDL-Cholesterol Levels? A Systematic Review of Meta-analyses of Randomized Controlled Trials. Sports Medicine 51:2, pages 243-253.
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Seyed Mojtaba Sohrevardi, Behrooz Heydari, Mahmoud Reza Azarpazhooh, Mohammad Teymourzadeh, Luis E. Simental-Mendía, Stephen L. Atkin, Amirhossein Sahebkar & Mojgan Karimi-Zarchi. 2021. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health 109 117 .
Fatemeh Forouzanfar, Muhammed Majeed, Tannaz Jamialahmadi & Amirhosein Sahebkar. 2021. Studies on Biomarkers and New Targets in Aging Research in Iran. Studies on Biomarkers and New Targets in Aging Research in Iran 363 373 .
Mohammad Amin Khodadadegan, Shakiba Azami, Paul C. Guest, Tannaz Jamialahmadi & Amirhossein Sahebkar. 2021. Studies on Biomarkers and New Targets in Aging Research in Iran. Studies on Biomarkers and New Targets in Aging Research in Iran 283 294 .
Sahar Rafiee, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan, Tannaz Jamialahmadi & Amirhossein Sahebkar. 2021. Studies on Biomarkers and New Targets in Aging Research in Iran. Studies on Biomarkers and New Targets in Aging Research in Iran 165 177 .
Albino Carrizzo, Carmine Izzo, Maurizio Forte, Eduardo Sommella, Paola Di Pietro, Eleonora Venturini, Michele Ciccarelli, Gennaro Galasso, Speranza Rubattu, Petro Campiglia, Sebastiano Sciarretta, Giacomo Frati & Carmine Vecchione. (2020) A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases. International Journal of Molecular Sciences 21:22, pages 8706.
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Shima Hasanzadeh, Morgayn I. Read, Abigail R. Bland, Muhammed Majeed, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2020) Curcumin: an inflammasome silencer. Pharmacological Research 159, pages 104921.
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Yiling Mai, Xin Zhang, Zetian Li, Xiaohua Wu, Baoer Zeng, Yuan Fang, Laiquan Zou, Jiubo Zhao & Thomas Hummel. (2020) Olfaction is a Marker of Severity but Not Diagnosis in Anorexia Nervosa: a Systematic Review and Meta-Analysis. Neuropsychology Review 30:2, pages 251-266.
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Maria Pia Adorni, Francesca Zimetti, Maria Giovanna Lupo, Massimiliano Ruscica & Nicola Ferri. (2020) Naturally Occurring PCSK9 Inhibitors. Nutrients 12:5, pages 1440.
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Julia C. Kuszewski, Rachel H.X. Wong, Lisa G. Wood & Peter R.C. Howe. (2020) Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial. Nutrition, Metabolism and Cardiovascular Diseases 30:4, pages 625-633.
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Arrigo F. G. Cicero, Amirhossein Sahebkar, Federica Fogacci, Marilisa Bove, Marina Giovannini & Claudio Borghi. (2019) Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. European Journal of Nutrition 59:2, pages 477-483.
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Mohammad Jalali, Marzieh Mahmoodi, Zahra Mosallanezhad, Ronak Jalali, Mohammad Hadi Imanieh & Seyedeh Parisa Moosavian. (2020) The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine 48, pages 102283.
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Amir Hadi, Makan Pourmasoumi, Ehsan Ghaedi & Amirhossein Sahebkar. (2019) The effect of Curcumin/Turmeric on blood pressure modulation: A systematic review and meta-analysis. Pharmacological Research 150, pages 104505.
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Fatemeh Forouzanfar, George Barreto, Muhammed Majeed & Amirhossein Sahebkar. (2019) Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach. BioFactors 45:5, pages 631-640.
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Amanda Bergamin, Evangeline Mantzioris, Giordana Cross, Permal Deo, Sanjay Garg & Alison M. Hill. (2019) Nutraceuticals: Reviewing their Role in Chronic Disease Prevention and Management. Pharmaceutical Medicine 33:4, pages 291-309.
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Ryan du Preez, Jessica Pahl, Meenakshi Arora, M. N. V. Ravi Kumar, Lindsay Brown & Sunil K. Panchal. (2019) Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome. Nutrients 11:7, pages 1542.
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Zhongcao Wei, Na Liu, Xinxing Tantai, Xin Xing, Cailan Xiao, Lirong Chen & Jinhai Wang. (2018) The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Hepatology International 13:3, pages 302-313.
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Narges Fereydouni, Majid Darroudi, Jebrail Movaffagh, Azadeh Shahroodi, Alexandra E. Butler, Shiva Ganjali & Amirhossein Sahebkar. (2018) Curcumin nanofibers for the purpose of wound healing. Journal of Cellular Physiology 234:5, pages 5537-5554.
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Nalinee Poolsup, Naeti Suksomboon, Putu Dian Marani Kurnianta & Kulchalee Deawjaroen. (2019) Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis. PLOS ONE 14:4, pages e0215840.
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Reza Goodarzi, Kamran Sabzian, Farideh Shishehbor & Anahita Mansoori. (2019) Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research 33:3, pages 561-570.
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Kowsar Bavarsad, George E. Barreto, Mousa-Al-Reza Hadjzadeh & Amirhossein Sahebkar. (2018) Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System. Molecular Neurobiology 56:2, pages 1391-1404.
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Yunes Panahi, Omid Fazlolahzadeh, Stephen L. Atkin, Muhammed Majeed, Alexandra E. Butler, Thomas P. Johnston & Amirhossein Sahebkar. (2018) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review. Journal of Cellular Physiology 234:2, pages 1165-1178.
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Mahdi Hatamipour, Mahin Ramezani, Sayyed Abolghasem Sajadi Tabassi, Thomas P. Johnston, Mahnaz Ramezani & Amirhosein Sahebkar. (2018) Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties. Journal of Cellular Physiology 233:12, pages 9247-9260.
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Elham Zendedel, Alexandra E Butler, Stephen L Atkin & Amirhossein Sahebkar. (2018) Impact of curcumin on sirtuins: A review. Journal of Cellular Biochemistry 119:12, pages 10291-10300.
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Negin Parsamanesh, Maryam Moossavi, Afsane Bahrami, Alexandra E. Butler & Amirhossein Sahebkar. (2018) Therapeutic potential of curcumin in diabetic complications. Pharmacological Research 136, pages 181-193.
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