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Critical Reviews in Food Science and Nutrition Volume 62, 2022 - Issue 8
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Recent advances on 2′-fucosyllactose: physiological properties, applications, and production approaches

Yingying Zhua State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Li Wana State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Wen Lia State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Dawei Nia State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Wenli Zhanga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Xin Yanb Department of Microbiology, College of Life Sciences, Key Laboratory for Microbiological Engineering of Agricultural Environment of Ministry of Agriculture, Nanjing Agricultural University, Nanjing, ChinaView further author information
&
Wanmeng Mua State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China;c International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, ChinaCorrespondence[email protected]
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Pages 2083-2092 | Published online: 01 Dec 2020

Citations (29)

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Read on this site (3)

Meltem Dinleyici, Jana Barbieur, Ener Cagri Dinleyici & Yvan Vandenplas. (2023) Functional effects of human milk oligosaccharides (HMOs). Gut Microbes 15:1.
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Zeyu Li, Yingying Zhu, Dawei Ni, Wenli Zhang & Wanmeng Mu. (2023) Occurrence, functional properties, and preparation of 3-fucosyllactose, one of the smallest human milk oligosaccharides. Critical Reviews in Food Science and Nutrition 63:28, pages 9364-9378.
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Longhao Yang, Yingying Zhu, Wenli Zhang & Wanmeng Mu. (2023) Recent progress in health effects and biosynthesis of lacto-N-tetraose, the most dominant core structure of human milk oligosaccharide. Critical Reviews in Food Science and Nutrition 0:0, pages 1-10.
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Articles from other publishers (26)

Mengshi Xiao, Xinmiao Ren, Jiaying Cheng, Xiaodan Fu, Rong Li, Changliang Zhu, Qing Kong & Haijin Mou. (2023) Structural characterization of a novel fucosylated trisaccharide prepared from bacterial exopolysaccharides and evaluation of its prebiotic activity. Food Chemistry 420, pages 136144.
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Sungahm Ahn & Donghwa Chung. (2023) Thermal characteristics of crystalline and amorphous 2′-fucosyllactose, a human milk oligosaccharide. Food Chemistry 410, pages 135438.
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Jun-Min Lee, Bu-Soo Park & Min-Kyu Oh. (2023) Production of 2′-fucosyllactose using ⍺1,2-fucosyltransferase from a GRAS bacterial strain. Enzyme and Microbial Technology 167, pages 110232.
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Yihan Chen, Yingying Zhu, Hao Wang, Roulin Chen, Yuanlin Liu, Wenli Zhang & Wanmeng Mu. (2023) De novo biosynthesis of 2′-fucosyllactose in a metabolically engineered Escherichia coli using a novel ɑ1,2-fucosyltransferase from Azospirillum lipoferum. Bioresource Technology 374, pages 128818.
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Yingying Zhu, Roulin Chen, Hao Wang, Yihan Chen, Yuanlin Liu, Jingwen Zhou & Wanmeng Mu. (2023) Elimination of Byproduct Generation and Enhancement of 2′-Fucosyllactose Synthesis by Expressing a Novel α1,2-Fucosyltransferase in Engineered Escherichia coli . Journal of Agricultural and Food Chemistry 71:12, pages 4915-4923.
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Xue Sun, Zetao Peng, Chang Li, Yanling Zheng, Ya'nan Cheng, Jianfei Zong, Fuping Lu, Yu Li & Qinggang Li. (2023) Combinatorial metabolic engineering and tolerance evolving of Escherichia coli for high production of 2′-fucosyllactose. Bioresource Technology 372, pages 128667.
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Jiawei Meng, Yingying Zhu, Roulin Chen, Yuanlin Liu, Wenli Zhang & Wanmeng Mu. (2023) Microbial Synthesis of l -Fucose with High Productivity by a Metabolically Engineered Escherichia coli . Journal of Agricultural and Food Chemistry 71:5, pages 2464-2471.
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Roulin Chen, Li Wan, Yingying Zhu, Yuanlin Liu, Wenli Zhang & Wanmeng Mu. (2022) Spatial organization of pathway enzymes via self‐assembly to improve 2′‐fucosyllactose biosynthesis in engineered Escherichia coli . Biotechnology and Bioengineering 120:2, pages 524-535.
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Yingying Zhu, Jiameng Zhang, Wenli Zhang & Wanmeng Mu. (2023) Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose. Biotechnology Advances 62, pages 108058.
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Mengli Li, Chenchen Li, Yejiao Luo, Miaomiao Hu, Zhu Liu & Tao Zhang. (2022) Multi‐level metabolic engineering of Escherichia coli for high‐titer biosynthesis of 2′‐fucosyllactose and 3‐fucosyllactose . Microbial Biotechnology 15:12, pages 2970-2981.
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Xiaoxia Liu, Yunhui Zhang, Wanhua Li, Jia Yin, Bowei Zhang, Jin Wang & Shuo Wang. (2022) Differential responses on gut microbiota and microbial metabolome of 2′-fucosyllactose and galactooligosaccharide against DSS-induced colitis. Food Research International 162, pages 112072.
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José Antonio Curiel, Ángela Peirotén, Susana Langa, Estela de Vega, Laura Blasco & José María Landete. (2022) Characterization and stabilization of the α-L-fucosidase set from Lacticaseibacillus rhamnosus INIA P603. Applied Microbiology and Biotechnology 106:24, pages 8067-8077.
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Mengli Li, Yejiao Luo, Miaomiao Hu, Chenchen Li, Zhu Liu & Tao Zhang. (2022) Module-Guided Metabolic Rewiring for Fucosyllactose Biosynthesis in Engineered Escherichia coli with Lactose De Novo Pathway . Journal of Agricultural and Food Chemistry 70:46, pages 14761-14770.
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Qinggang Xie, Youbo Zhang, Jinlan Zhang, Dongying Cui, Qile Zhou & Mingruo Guo. (2022) Promotion effect of the blend containing 2'-FL, OPN and DHA on oligodendrocyte progenitor cells myelination in vitro. Frontiers in Nutrition 9.
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Yuanlin Liu, Yingying Zhu, Hao Wang, Li Wan, Wenli Zhang & Wanmeng Mu. (2022) Strategies for Enhancing Microbial Production of 2′-Fucosyllactose, the Most Abundant Human Milk Oligosaccharide. Journal of Agricultural and Food Chemistry 70:37, pages 11481-11499.
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Minghua Ji, Yufei Liu, Shiqiu Xie, Cong Fu, Min Liu, Jiping Shi & Junsong Sun. (2022) De novo synthesis of 2'-fucosyllactose in engineered Bacillus subtilis ATCC 6051a. Process Biochemistry 120, pages 178-185.
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Yuanlin Liu, Yingying Zhu, Li Wan, Roulin Chen, Wenli Zhang & Wanmeng Mu. (2022) High-Level De Novo Biosynthesis of 2′-Fucosyllactose by Metabolically Engineered Escherichia coli . Journal of Agricultural and Food Chemistry 70:29, pages 9017-9025.
Crossref
Pan Zhang, Yingying Zhu, Zeyu Li, Wenli Zhang & Wanmeng Mu. (2022) Recent Advances on Lacto- N -neotetraose, a Commercially Added Human Milk Oligosaccharide in Infant Formula . Journal of Agricultural and Food Chemistry 70:15, pages 4534-4547.
Crossref
Yuliya Kulikova, Stanislav Sukhikh, Olga Kalashnikova, Evgeny Chupakhin, Svetlana Ivanova, Boris Chubarenko, Julia Gorbunova & Olga Babich. (2022) Assessment of the Resource Potential of Baltic Sea Macroalgae. Applied Sciences 12:7, pages 3599.
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Rui Hu, Min Zhang, Wenchao Liu, Arun S. Mujumdar & Baosong Bai. (2022) Novel synergistic freezing methods and technologies for enhanced food product quality: A critical review. Comprehensive Reviews in Food Science and Food Safety 21:2, pages 1979-2001.
Crossref
Geng Chen, Hao Wu, Yingying Zhu, Li Wan, Wenli Zhang & Wanmeng Mu. (2022) Glycosyltransferase from Bacteroides gallinaceum Is a Novel α-1,3-Fucosyltransferase that Can Be Used for 3-Fucosyllactose Production In Vivo by Metabolically Engineered Escherichia coli . Journal of Agricultural and Food Chemistry 70:6, pages 1934-1942.
Crossref
Duoduo Hu, Hao Wu, Yingying Zhu, Wenli Zhang & Wanmeng Mu. (2021) Engineering Escherichia coli for highly efficient production of lacto-N-triose II from N-acetylglucosamine, the monomer of chitin. Biotechnology for Biofuels 14:1.
Crossref
Renate Akkerman, Madelon J. Logtenberg, Martin Beukema, Bart J. de Haan, Marijke M. Faas, Erwin G. Zoetendal, Henk A. Schols & Paul de Vos. (2021) Chicory inulin enhances fermentation of 2′-fucosyllactose by infant fecal microbiota and differentially influences immature dendritic cell and T-cell cytokine responses under normal and Th2-polarizing conditions. Food & Function 12:19, pages 9018-9029.
Crossref
Yingying Zhu, Zeyu Li, Guocong Luo, Hao Wu, Wenli Zhang & Wanmeng Mu. (2021) Metabolic Engineering of Escherichia coli for Efficient Biosynthesis of Lacto- N -tetraose Using a Novel β-1,3-Galactosyltransferase from Pseudogulbenkiania ferrooxidans . Journal of Agricultural and Food Chemistry 69:38, pages 11342-11349.
Crossref
Guocong Luo, Yingying Zhu, Jiawei Meng, Li Wan, Wenli Zhang & Wanmeng Mu. (2021) A Novel β-1,4-Galactosyltransferase from Histophilus somni Enables Efficient Biosynthesis of Lacto- N -Neotetraose via Both Enzymatic and Cell Factory Approaches . Journal of Agricultural and Food Chemistry 69:20, pages 5683-5690.
Crossref
Mengyao Lu, Imann Mosleh & Alireza Abbaspourrad. (2021) Engineered Microbial Routes for Human Milk Oligosaccharides Synthesis. ACS Synthetic Biology 10:5, pages 923-938.
Crossref

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