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The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies

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Song Deng, Kaiwei Cai, Chaoying Pei, Xingyuan Zhang, Xiaoyi Xiao, Ye Chen, Ying Chen, Rongyao Liang, Yanlong Chen, Pei Li, Zhiyong Xie & Qiongfeng Liao. (2023) 16S rRNA and Metagenomics Combined with UPLC-Q/TOF-MS Metabolomics Analysis Reveals the Potential Mechanism of Radix Astragali Against Hyperuricemia in Mice. Drug Design, Development and Therapy 17, pages 1371-1386.
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Yu Chen, Liyong Luo, Shanshan Hu, Renyou Gan & Liang Zeng. (2023) The chemistry, processing, and preclinical anti-hyperuricemia potential of tea: a comprehensive review. Critical Reviews in Food Science and Nutrition 63:24, pages 7065-7090.
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Lei Sun, Caixin Ni, Jianxin Zhao, Gang Wang & Wei Chen. (2022) Probiotics, bioactive compounds and dietary patterns for the effective management of hyperuricemia: a review. Critical Reviews in Food Science and Nutrition 0:0, pages 1-16.
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Jue Xu, Maolin Tu, Xiankang Fan, Yuxing Guo, Tao Zhang, Xiaoqun Zeng, Zhendong Cai, Zhen Wu & Daodong Pan. (2023) A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage . Food Science and Human Wellness, pages 1-18.
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Biqian Wei, Pengfei Ren, Ruzhen Yang, Yuan Gao, Qingjuan Tang, Changhu Xue & Yuming Wang. (2023) Ameliorative Effect of Mannuronate Oligosaccharides on Hyperuricemic Mice via Promoting Uric Acid Excretion and Modulating Gut Microbiota. Nutrients 15:2, pages 417.
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Xuewei Zhou, Kaina Qiao, Huimin Wu & Yuyu Zhang. (2023) The Impact of Food Additives on the Abundance and Composition of Gut Microbiota. Molecules 28:2, pages 631.
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Peng Wang, Xiaoqi Zhang, Xian Zheng, Jingru Gao, Mengfei Shang, Jinghan Xu & Hui Liang. (2022) Folic Acid Protects against Hyperuricemia in C57BL/6J Mice via Ameliorating Gut–Kidney Axis Dysfunction. Journal of Agricultural and Food Chemistry 70:50, pages 15787-15803.
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Shuting Tong, Peiyu Zhang, Qi Cheng, Mo Chen, Xin Chen, Zitao Wang, Xiaoyong Lu & Huaxiang Wu. (2022) The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment. Frontiers in Cellular and Infection Microbiology 12.
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Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian & Guiming Fu. (2022) Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz . Food & Function 13:22, pages 11780-11793.
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Yongmei Li, Lu Li, Jinhong Tian, Fengxin Zheng, Hui Liao, Zean Zhao, Yanyu Chen, Jianxin Pang & Ting Wu. (2022) Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids. Foods 11:21, pages 3482.
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M. S. Eliseev, E. N. Kharlamova, O. V. Zhelyabina & A. M. Lila. (2022) Microbiota as a new pathogenetic factor in the development of chronic hyperuricemia and gout. Part I: the current state of the problem. Modern Rheumatology Journal 16:5, pages 7-12.
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Yanjun Li, Jun Zhu, Guodong Lin, Kan Gao, Yunxia Yu, Su Chen, Lie Chen, Zuoguo Chen & Li Li. (2022) Probiotic effects of Lacticaseibacillus rhamnosus 1155 and Limosilactobacillus fermentum 2644 on hyperuricemic rats. Frontiers in Nutrition 9.
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Kun Wang, Shanshan Wu, Pan Li, Nan Xiao, Jiamin Wen, Jinming Lin, Siming Lu, Xin Cai, Yanan Xu & Bing Du. (2022) Sacha Inchi Oil Press-Cake Protein Hydrolysates Exhibit Anti-Hyperuricemic Activity via Attenuating Renal Damage and Regulating Gut Microbiota. Foods 11:16, pages 2534.
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KaiYu XU, Ling LIU, Jia YIN, Yan HE & HongWei ZHOU. (2022) The mechanism and application prospects of the brain-gut axis in ischemic stroke and its complications. SCIENTIA SINICA Vitae.
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Xin-yu Fang, Liang-wei Qi, Hai-feng Chen, Peng Gao, Qin Zhang, Rui-xue Leng, Yin-guang Fan, Bao-zhu Li, Hai-feng Pan & Dong-qing Ye. (2022) The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout. Frontiers in Nutrition 9.
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Xin Yuan, Ruimin Chen, Ying Zhang, Xiangquan Lin & Xiaohong Yang. (2022) Altered Gut Microbiota in Children With Hyperuricemia. Frontiers in Endocrinology 13.
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Shuiqing He, Qianqian Xiong, Chong Tian, Li Li, Jing Zhao, Xuechun Lin, Xiaolei Guo, Yuqin He, Wangqun Liang, Xuezhi Zuo & Chenjiang Ying. (2021) Inulin-type prebiotics reduce serum uric acid levels via gut microbiota modulation: a randomized, controlled crossover trial in peritoneal dialysis patients. European Journal of Nutrition 61:2, pages 665-677.
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Chien-Ning Hsu, Hong-Ren Yu, Julie Y. H. Chan, Kay L. H. Wu, Wei-Chia Lee & You-Lin Tain. (2022) The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease. Nutrients 14:5, pages 1031.
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Hui Yin, Na Liu & Jie Chen. (2022) The Role of the Intestine in the Development of Hyperuricemia. Frontiers in Immunology 13.
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Siyue Song, Yu Lou, Yingying Mao, Xianghui Wen, Moqi Fan, Zhixing He, Yang Shen, Chengping Wen & Tiejuan Shao. (2022) Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice. Frontiers in Immunology 13.
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Chunsheng Zhu, Bao Sun, Bing Zhang & Zheng Zhou. (2021) An update of genetics, co‐morbidities and management of hyperuricaemia. Clinical and Experimental Pharmacology and Physiology 48:10, pages 1305-1316.
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Xiaoqing Li, Yihan Chen, Xiaoxiang Gao, Yijing Wu, Hesham Rushdy El-Seedi, Yong Cao & Chao Zhao. (2021) Antihyperuricemic Effect of Green Alga Ulva lactuca Ulvan through Regulating Urate Transporters . Journal of Agricultural and Food Chemistry 69:38, pages 11225-11235.
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Qian Ren, Lu Cheng, Fan Guo, Sibei Tao, Chunle Zhang, Liang Ma & Ping Fu. (2021) Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation. Journal of Agricultural and Food Chemistry 69:37, pages 10932-10942.
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Yuanyuan Xu, Xirong Cao, Haoan Zhao, Erlin Yang, Yue Wang, Ni Cheng & Wei Cao. (2021) Impact of Camellia japonica Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice. Nutrients 13:8, pages 2665.
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Mark L. Dreher. (2021) A Comprehensive Review of Almond Clinical Trials on Weight Measures, Metabolic Health Biomarkers and Outcomes, and the Gut Microbiota. Nutrients 13:6, pages 1968.
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Nan Fan, Lvyu Li, Heng Xia, Yinfang Gao, Yongkun Li, Huan Chen, Yu Yun & Weigang Duan. (2021) Aboriginal Bacterial Flora in the Uricase-Deficient Rat Gut is Not the Main Factor Affecting Serum Uric Acid. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-14.
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