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Yunkyoung Lee, Dohee Kim & Chang-Joong Lee. (2020) Suppressive effects of valproic acid on caudal fin regeneration in adult zebrafish. Animal Cells and Systems 24:6, pages 349-358.
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Curt Balch, Kaleb Naegeli, Seungyoon Nam, Brett Ballard, Alan Hyslop, Christina Melki, Elizabeth Reilly, Man-Wook Hur & Kenneth P. Nephew. (2012) A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells. Cancer Biology & Therapy 13:8, pages 681-693.
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Denise S Hill, Bogdan J Wlodarczyk, Ana M Palacios & Richard H Finnell. (2010) Teratogenic effects of antiepileptic drugs. Expert Review of Neurotherapeutics 10:6, pages 943-959.
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KathrynZ. Guyton, Stanley Barone$suffix/text()$suffix/text(), RebeccaC. Brown, SusanY. Euling, Jennifer Jinot & Susan Makris. (2008) Mode of Action Frameworks: A Critical Analysis. Journal of Toxicology and Environmental Health, Part B 11:1, pages 16-31.
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Alan R. Boobis, John E. Doe, Barbara Heinrich-Hirsch, M. E. (Bette) Meek, Sharon Munn, Mathuros Ruchirawat, Josef Schlatter, Jennifer Seed & Carolyn Vickers. (2008) IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans. Critical Reviews in Toxicology 38:2, pages 87-96.
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Joseph G Sinkovics. (2007) Adult human sarcomas. II. Medical oncology. Expert Review of Anticancer Therapy 7:2, pages 183-210.
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Articles from other publishers (70)
Haley McConkey & Bekim Sadikovic. 2024. Epigenetics in Human Disease. Epigenetics in Human Disease
1031
1076
.
Shengde Wu, Corie Ellison, Jorge Naciff, Michael Karb, Cindy Obringer, Gang Yan, Yuqing Shan, Alex Smith, Xiaohong Wang & George P Daston. (2023) Structure-activity relationship read-across and transcriptomics for branched carboxylic acids. Toxicological Sciences 191:2, pages 343-356.
Crossref
Crossref
Abd-Elrahman Said Hassan, Yimeng Lina Du, Su Yeon Lee, Aijun Wang & Diana Lee Farmer. (2022) Spina Bifida: A Review of the Genetics, Pathophysiology and Emerging Cellular Therapies. Journal of Developmental Biology 10:2, pages 22.
Crossref
Crossref
Asher Ornoy, Liza Weinstein-Fudim & Maria Becker. (2022) SAMe, Choline, and Valproic Acid as Possible Epigenetic Drugs: Their Effects in Pregnancy with a Special Emphasis on Animal Studies. Pharmaceuticals 15:2, pages 192.
Crossref
Crossref
Janee Gelineau-van Waes. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology
955
981
.
Chiara Parodi, Elisabetta Di Fede, Angela Peron, Ilaria Viganò, Paolo Grazioli, Silvia Castiglioni, Richard H. Finnell, Cristina Gervasini, Aglaia Vignoli & Valentina Massa. (2021) Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies. Frontiers in Cell and Developmental Biology 9.
Crossref
Crossref
Maria Jimena Salcedo-Arellano, Ana Maria Cabal-Herrera, Ruchi Harendra Punatar, Courtney Jessica Clark, Christopher Allen Romney & Randi J Hagerman. (2020) Overlapping Molecular Pathways Leading to Autism Spectrum Disorders, Fragile X Syndrome, and Targeted Treatments. Neurotherapeutics 18:1, pages 265-283.
Crossref
Crossref
Johannes Meisig, Nadine Dreser, Marion Kapitza, Margit Henry, Tamara Rotshteyn, Jörg Rahnenführer, Jan G Hengstler, Agapios Sachinidis, Tanja Waldmann, Marcel Leist & Nils Blüthgen. (2020) Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation. Nucleic Acids Research 48:22, pages 12577-12592.
Crossref
Crossref
I.G.E. Gebuijs, J.R. Metz, J. Zethof, C.E.L. Carels, F.A.D.T.G. Wagener & J.W. Von den Hoff. (2020) The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae. Mechanisms of Development 163, pages 103632.
Crossref
Crossref
Ágota Ádám, Róbert Kemecsei, Verónica Company, Raquel Murcia-Ramón, Iris Juarez, László I. Gerecsei, Gergely Zachar, Diego Echevarría, Eduardo Puelles, Salvador Martínez & András Csillag. (2020) Gestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegmental Area. Frontiers in Neuroanatomy 14.
Crossref
Crossref
Anna Maria Tartaglione, Sara Schiavi, Gemma Calamandrei & Viviana Trezza. (2019) Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder. Neuropharmacology 159, pages 107477.
Crossref
Crossref
Gergely Zachar, András S. Tóth, László I. Gerecsei, Sándor Zsebők, Ágota Ádám & András Csillag. (2019) Valproate Exposure in ovo Attenuates the Acquisition of Social Preferences of Young Post-hatch Domestic Chicks. Frontiers in Physiology 10.
Crossref
Crossref
Aseel Eid & Jason R. Richardson. 2019. Pharmacoepigenetics. Pharmacoepigenetics
801
816
.
Veronica Arora, Anju Joshi, Meena Lall, Shruti Agarwal, Sunita Bijarnia Mahay, Ratna Dua puri & Ishwar Chander Verma. (2018) Fetal valproate syndrome as a phenocopy of Kleefstra syndrome. Birth Defects Research 110:15, pages 1205-1209.
Crossref
Crossref
Shayan Fakhraei Lahiji, Seol Hwa Seo, Suyong Kim, Manita Dangol, Jiyong Shim, Cheng Guo Li, Yonghao Ma, Chisong Lee, Geonwoo Kang, Huisuk Yang, Kang-Yell Choi & Hyungil Jung. (2018) Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth. Biomaterials 167, pages 69-79.
Crossref
Crossref
J. Magby & J. Richardson. 2018. Comprehensive Toxicology. Comprehensive Toxicology
41
49
.
Jason J. Yi, Smita R. Paranjape, Matthew P. Walker, Rajarshi Choudhury, Justin M. Wolter, Giulia Fragola, Michael J. Emanuele, Michael B. Major & Mark J. Zylka. (2017) The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. Journal of Biological Chemistry 292:30, pages 12503-12515.
Crossref
Crossref
Jeanette R. Pleasure, David Pleasure & Samuel J. Pleasure. 2017. Fetal and Neonatal Physiology. Fetal and Neonatal Physiology
1326
1333.e3
.
Kenneth A. Voss, Ronald T. Riley, Nicole M. Gardner & Janee Gelineau-van Waes. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology
925
943
.
J. Magby & J. Richardson. 2017. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Vickie Kwan, Brianna K. Unda & Karun K. Singh. (2016) Wnt signaling networks in autism spectrum disorder and intellectual disability. Journal of Neurodevelopmental Disorders 8:1.
Crossref
Crossref
Josephine Kugler, Rolf Kemler, Andreas Luch & Michael Oelgeschläger. (2016) Editor's Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line. Toxicological Sciences 152:2, pages 382-394.
Crossref
Crossref
Nicole M. Gardner, Ronald T. Riley, Jency L. Showker, Kenneth A. Voss, Andrew J. Sachs, Joyce R. Maddox & Janee B. Gelineau-van Waes. (2016) Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. Toxicology and Applied Pharmacology 298, pages 56-65.
Crossref
Crossref
Nicole M. Gardner, Ronald T. Riley, Jency L. Showker, Kenneth A. Voss, Andrew J. Sachs, Joyce R. Maddox & Janee B. Gelineau-van Waes. (2016) Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects. Toxicological Sciences 150:1, pages 161-168.
Crossref
Crossref
A P Deveau, A M Forrester, A J Coombs, G S Wagner, C Grabher, I C Chute, D Léger, M Mingay, G Alexe, V Rajan, R Liwski, M Hirst, K Stegmaier, S M Lewis, A T Look & J N Berman. (2015) Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease. Leukemia 29:10, pages 2086-2097.
Crossref
Crossref
Josephine Kugler, Julian Tharmann, Susana M. Chuva de Sousa Lopes, Rolf Kemler, Andreas Luch & Michael Oelgeschläger. (2015) A Bmp Reporter Transgene Mouse Embryonic Stem Cell Model as a Tool to Identify and Characterize Chemical Teratogens. Toxicological Sciences 146:2, pages 374-385.
Crossref
Crossref
Cheng Huang, Xiang-Hui Fu, Dong Zhou & Jin-Mei Li. (2015) The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?. Neurochemical Research 40:7, pages 1319-1332.
Crossref
Crossref
Tianci Chu, Hengxing Zhou, Lu Lu, Xiaohong Kong, Tianyi Wang, Bin Pan & Shiqing Feng. (2015) Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential. Regenerative Medicine 10:2, pages 193-209.
Crossref
Crossref
Todd M. Mowery, Sarah M. Wilson, Polina V. Kostylev, Blair Dina, Jennifer B. Buchholz, Anne L. Prieto & Preston E. Garraghty. (2014) Embryological exposure to valproic acid disrupts morphology of the deep cerebellar nuclei in a sexually dimorphic way. International Journal of Developmental Neuroscience 40:1, pages 15-23.
Crossref
Crossref
Emily L. Williams & Manuel F. Casanova. 2015. Studies on Psychiatric Disorders. Studies on Psychiatric Disorders
373
392
.
Qing-Qiang Shi, Guo-Wei Zuo, Zi-Qiang Feng, Lv-Cui Zhao, Lian Luo, Zhi-Mei You, Dang-Yang Li, Jing Xia, Jing Li & Di-Long Chen. (2014) Effect of Trichostatin A on Anti HepG2 Liver Carcinoma Cells: Inhibition of HDAC Activity and Activation of Wnt/β-Catenin Signaling. Asian Pacific Journal of Cancer Prevention 15:18, pages 7849-7855.
Crossref
Crossref
Sunhyo Ryu, Yonghee Lee, Moo Hyun, Sun Choi, Kwan Jeong, Young Park, Hoon Kang, Kui Park, Cheryl Armstrong, Andrew Johnson, Peter Song & Beom Kim. (2014) Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles. International Journal of Molecular Sciences 15:9, pages 16800-16815.
Crossref
Crossref
Esther de Jong, Lianne van Beek & Aldert H. Piersma. (2014) Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo. Reproductive Toxicology 48, pages 62-71.
Crossref
Crossref
Julie Bauman, Monte Shaheen, Claire F. Verschraegen, Steven A. Belinsky, M. Houman Fekrazad, Fa-Chyi Lee, Ian Rabinowitz, Meera Ravindranathan & Dennie V. JonesJr.Jr.. (2014) A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers. Translational Oncology 7:3, pages 349-354.
Crossref
Crossref
Seong Jin Jo, Hyoseung Shin, Young Woon Park, Seung Hwan Paik, Won Seok Park, Yeon Su Jeong, Hong Ju Shin & Ohsang Kwon. (2014) Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis. The Journal of Dermatology 41:4, pages 285-291.
Crossref
Crossref
Tanja Waldmann, Eugen Rempel, Nina V. Balmer, André König, Raivo Kolde, John Antonydas Gaspar, Margit Henry, Jürgen Hescheler, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler & Marcel Leist. (2014) Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells. Chemical Research in Toxicology 27:3, pages 408-420.
Crossref
Crossref
Nina V. Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits, Tanja Waldmann, Liang Zhao, Helena T. Hogberg & Erwin van Vliet. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems
399
432
.
Sandra Stempin, Susanne Andres, Maja Bumke Scheer, Ariane Rode, Heinz Nau, Albrecht Seidel & Alfonso Lampen. (2013) Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reproductive Toxicology 42, pages 49-57.
Crossref
Crossref
Elisa C.M. Tonk, Joshua F. Robinson, Aart Verhoef, Peter T. Theunissen, Jeroen L.A. Pennings & Aldert H. Piersma. (2013) Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models. Reproductive Toxicology 41, pages 57-66.
Crossref
Crossref
Neelakanteswar Aluru, Kristina L. Deak, Matthew J. Jenny & Mark E. Hahn. (2013) Developmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish. Neurotoxicology and Teratology 40, pages 46-58.
Crossref
Crossref
Seong Jin Jo, Soon-Jin Choi, Sun-Young Yoon, Ji Yeon Lee, Won-Seok Park, Phil-June Park, Kyu Han Kim, Hee Chul Eun & Ohsang Kwon. (2013) Valproic acid promotes human hair growth in in vitro culture model. Journal of Dermatological Science 72:1, pages 16-24.
Crossref
Crossref
Mark Cronin, Judith Madden, Steven Enoch & David RobertsK R Przybylak & T. W. Schultz. 2013. Chemical Toxicity Prediction. Chemical Toxicity Prediction
44
71
.
A.H. Piersma, S. Bosgra, M.B.M. van Duursen, S.A.B. Hermsen, L.R.A. Jonker, E.D. Kroese, S.C. van der Linden, H. Man, M.J.E. Roelofs, S.H.W. Schulpen, M. Schwarz, F. Uibel, B.M.A. van Vugt-Lussenburg, J. Westerhout, A.P.M. Wolterbeek & B. van der Burg. (2013) Evaluation of an alternative in vitro test battery for detecting reproductive toxicants. Reproductive Toxicology 38, pages 53-64.
Crossref
Crossref
Chi-Tso Chiu, Zhifei Wang, Joshua G. Hunsberger & De-Maw Chuang. (2013) Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder. Pharmacological Reviews 65:1, pages 105-142.
Crossref
Crossref
A.M. Persico. 2013. Neural Circuit Development and Function in the Brain. Neural Circuit Development and Function in the Brain
651
694
.
Nina V. Balmer, Matthias K. Weng, Bastian Zimmer, Violeta N. Ivanova, Stuart M. Chambers, Elena Nikolaeva, Smita Jagtap, Agapios Sachinidis, Jürgen Hescheler, Tanja Waldmann & Marcel Leist. (2012) Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Human Molecular Genetics 21:18, pages 4104-4114.
Crossref
Crossref
Bogdan J. Wlodarczyk, Ana M. Palacios, Timothy M. George & Richard H. Finnell. (2012) Antiepileptic drugs and pregnancy outcomes. American Journal of Medical Genetics Part A 158A:8, pages 2071-2090.
Crossref
Crossref
Michal Zapotocky, Ester Mejstrikova, Karel Smetana, Jan Stary, Jan Trka & Julia Starkova. (2012) Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically. Cancer Letters 319:2, pages 144-153.
Crossref
Crossref
Ingrid W.T. Selderslaghs, Ronny Blust & Hilda E. Witters. (2012) Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds. Reproductive Toxicology 33:2, pages 142-154.
Crossref
Crossref
K R Przybylak & T. W. Schultz. 2011. Kinase Drug Discovery. Kinase Drug Discovery
44
71
.
Bogdan J. Wlodarczyk, Ana M. Palacios, Claudia J. Chapa, Huiping Zhu, Timothy M. George & Richard H. Finnell. (2011) Genetic basis of susceptibility to teratogen induced birth defects. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 157:3, pages 215-226.
Crossref
Crossref
Ercan Tureci, Ziya Asan, Mediha Eser, Taner Tanriverdi, Faruk Alkan & Pamir Erdincler. (2011) The effects of valproic acid and levetiracetam on chicken embryos. Journal of Clinical Neuroscience 18:6, pages 816-820.
Crossref
Crossref
Emily Williams & Manuel Casanova. (2011) Above genetics: Lessons from cerebral development in autism. Translational Neuroscience 2:2.
Crossref
Crossref
NAGHME ADAB & MICHAEL F O'DONOGHUE. (2010) ANTI-EPILEPTIC DRUGS AND BRAIN AND BEHAVIOURAL DEVELOPMENT IN ANIMAL MODELS AND HUMANS. Fetal and Maternal Medicine Review 21:4, pages 283-306.
Crossref
Crossref
Ovanes MekenyanT. W. Schultz. 2010. In Silico Toxicology. In Silico Toxicology
346
371
.
Keiko IwataHideo MatsuzakiNori TakeiTakayuki ManabeNorio Mori. (2010) Animal Models of Autism: An Epigenetic and Environmental Viewpoint. Journal of Central Nervous System Disease 2, pages JCNSD.S6188.
Crossref
Crossref
Emily Ho & Roderick H. Dashwood. (2010) Dietary Manipulation of Histone Structure and Function. Journal of Nutrigenetics and Nutrigenomics 3:4-6, pages 231-238.
Crossref
Crossref
J.P. Magby & J.R. Richardson. 2010. Comprehensive Toxicology. Comprehensive Toxicology
29
38
.
H Zhu, S Kartiko & RH Finnell. (2009) Importance of gene-environment interactions in the etiology of selected birth defects. Clinical Genetics 75:5, pages 409-423.
Crossref
Crossref
Alexander G. Bassuk, Robyn H. Wallace, Aimee Buhr, Andrew R. Buller, Zaid Afawi, Masahito Shimojo, Shingo Miyata, Shan Chen, Pedro Gonzalez-Alegre, Hilary L. Griesbach, Shu Wu, Marcus Nashelsky, Eszter K. Vladar, Dragana Antic, Polly J. Ferguson, Sebahattin Cirak, Thomas Voit, Matthew P. Scott, Jeffrey D. Axelrod, Christina Gurnett, Azhar S. Daoud, Sara Kivity, Miriam Y. Neufeld, Aziz Mazarib, Rachel Straussberg, Simri Walid, Amos D. Korczyn, Diane C. Slusarski, Samuel F. Berkovic & Hatem I. El-Shanti. (2008) A Homozygous Mutation in Human PRICKLE1 Causes an Autosomal-Recessive Progressive Myoclonus Epilepsy-Ataxia Syndrome. The American Journal of Human Genetics 83:5, pages 572-581.
Crossref
Crossref
Ingo Helbig, Nicholas A. Matigian, Lata Vadlamudi, Kate M. Lawrence, Marta A. Bayly, Sharon M. Bain, Dileepa Diyagama, Ingrid E. Scheffer, John C. Mulley, Andrew J. Holloway, Leanne M. Dibbens, Samuel F. Berkovic & Nicholas K. Hayward. (2008) Gene expression analysis in absence epilepsy using a monozygotic twin design. Epilepsia 49:9, pages 1546-1554.
Crossref
Crossref
Bora Kim, Lyda M. Rincón Castro, Sana Jawed & Lennard P. Niles. (2008) Clinically relevant concentrations of valproic acid modulate melatonin MT1 receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. European Journal of Pharmacology 589:1-3, pages 45-48.
Crossref
Crossref
Sarah Adler, Jenny Lindqvist, Katarina Uddenberg, Johan Hyllner & Raimund Strehl. (2008) Testing Potential Developmental Toxicants with a Cytotoxicity Assay Based on Human Embryonic Stem Cells. Alternatives to Laboratory Animals 36:2, pages 129-140.
Crossref
Crossref
Muhammad Farooq, K.N. Sulochana, Xiufang Pan, Jiawei To, Donglai Sheng, Zhiyuan Gong & Ruowen Ge. (2008) Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish. Developmental Biology 317:1, pages 336-353.
Crossref
Crossref
Glen W. Humphrey, Yong-Hong Wang, Tazuko Hirai, Raji Padmanabhan, David M. Panchision, Laura F. Newell, Ronald D.G. McKay & Bruce H. Howard. (2008) Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells. Differentiation 76:4, pages 348-356.
Crossref
Crossref
S S Moy & J J Nadler. (2007) Advances in behavioral genetics: mouse models of autism. Molecular Psychiatry 13:1, pages 4-26.
Crossref
Crossref
Irene E. Zohn & Anjali A. Sarkar. 2008. Mouse Models of Developmental Genetic Disease. Mouse Models of Developmental Genetic Disease
1
35
.
Eli Hatchwell & John M. Greally. (2007) The potential role of epigenomic dysregulation in complex human disease. Trends in Genetics 23:11, pages 588-595.
Crossref
Crossref
Min-Ho Lee, Il Hong, Mingoo Kim, Byung Hoon Lee, Ju-Han Kim, Kyung-Sun Kang, Hyung-Lae Kim, Byung-Il Yoon, Heekyoung Chung, Gu Kong & Mi-Ock Lee. (2007) Gene expression profiles of murine fatty liver induced by the administration of valproic acid. Toxicology and Applied Pharmacology 220:1, pages 45-59.
Crossref
Crossref
M. Naldi, V. Andrisano, J. Fiori, N. Calonghi, E. Pagnotta, C. Parolin, G. Pieraccini & L. Masotti. (2006) Histone proteins determined in a human colon cancer by high-performance liquid chromatography and mass spectrometry. Journal of Chromatography A 1129:1, pages 73-81.
Crossref
Crossref