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Critical Reviews in Toxicology Volume 38, 2008 - Issue 4
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Research Article

Dose-Response Features of Neuroprotective Agents: An Integrative Summary

Edward J. Calabrese Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA
Pages 253-348 | Published online: 10 Oct 2008

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Edward J. Calabrese. (2008) Pharmacological Enhancement of Neuronal Survival. Critical Reviews in Toxicology 38:4, pages 349-389.
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Edward J. Calabrese. (2008) Neuroscience and Hormesis: Overview and General Findings. Critical Reviews in Toxicology 38:4, pages 249-252.
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Articles from other publishers (37)

Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea & Rosanna Di Paola. (2023) Bioactive Compounds of the Mediterranean Diet as Nutritional Support to Fight Neurodegenerative Disease. International Journal of Molecular Sciences 24:8, pages 7318.
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Elizabeth S. Fisher, Yanan Chen, Mikaela M. Sifuentes, Jeremy J. Stubblefield, Damian Lozano, Deborah M. Holstein, JingMei Ren, Matthew Davenport, Nicholas DeRosa, Tsung-pei Chen, Gerard Nickel, Theodore E. Liston & James D. Lechleiter. (2022) Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke. Frontiers in Stroke 1.
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Fahadul Islam, Md Mohaimenul Islam, Atkia Farzana Khan Meem, Mohamed H. Nafady, Md Rezaul Islam, Aklima Akter, Saikat Mitra, Fahad A. Alhumaydhi, Talha Bin Emran, Ameer Khusro, Jesus Simal-Gandara, Aziz Eftekhari, Fatemeh Karimi & Mehdi Baghayeri. (2022) Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases. Chemosphere 307, pages 136020.
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Maria Laura Ontario, Rosalba Siracusa, Sergio Modafferi, Maria Scuto, Sebastiano Sciuto, Valentina Greco, Maria Paola Bertuccio, Angela Trovato Salinaro, Roberto Crea, Edward J. Calabrese, Rosanna Di Paola & Vittorio Calabrese. (2022) Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox. Mechanisms of Ageing and Development 203, pages 111637.
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Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Thozhukat Sathyapalan, Muhammed Majeed & Amirhossein Sahebkar. (2022) PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease. Current Neuropharmacology 20:2, pages 309-323.
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Edward J. Calabrese & Evgenios Agathokleous. (2021) Hormesis: Transforming disciplines that rely on the dose response. IUBMB Life 74:1, pages 8-23.
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Lilian do Amaral, Neife Aparecida Guinaim dos Santos, Flávia Malvestio Sisti, Elaine Del Bel & Antônio Cardozo dos Santos. (2021) The antibiotic doxycycline mimics the NGF signaling in PC12 cells: A relevant mechanism for neuroprotection. Chemico-Biological Interactions 341, pages 109454.
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Edward J. Calabrese, Vittorio Calabrese & James Giordano. (2021) Putative hormetic mechanisms and effects of atypical antipsychotic agents: Implications for study design and clinical psychopharmacotherapeutics. Chemico-Biological Interactions 333, pages 109327.
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Edward J. Calabrese, Mark P. Mattson, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese & James Giordano. 2020. Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases. Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases 271 301 .
N. A. Vasilieva, E. F. Shevtsova, G. I. Van’kin, N. N. Lermontova, T. P. Serkova, N. S. Nikolaeva & S. O. Bachurin. (2019) Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range. Bulletin of Experimental Biology and Medicine 167:6, pages 740-743.
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Vittorio Calabrese, Aurelia Santoro, Angela Trovato Salinaro, Sergio Modafferi, Maria Scuto, Ferdaous Albouchi, Daniela Monti, James Giordano, Mario Zappia, Claudio Franceschi & Edward J Calabrese. (2018) Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities. Journal of Neuroscience Research 96:10, pages 1641-1662.
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Ayumi MoriChiho YabutaYayoi KishimotoSeiko KozaiAkira OhtoriThomas R. ShearerMitsuyoshi Azuma. (2017) In Silico Ocular Pharmacokinetic Modeling: Delivery of Topical FK962 to Retina . Journal of Ocular Pharmacology and Therapeutics 33:7, pages 556-566.
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Manuela Pennisi, Rosalia Crupi, Rosanna Di Paola, Maria Laura Ontario, Rita Bella, Edward J. Calabrese, Roberto Crea, Salvatore Cuzzocrea & Vittorio Calabrese. (2017) Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease. Journal of Neuroscience Research 95:7, pages 1360-1372.
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Donald G Stein. (2017) Lost and found: what we have learned from the progesterone for traumatic brain injury trials. Future Neurology 12:2, pages 57-59.
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Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Xiaotong Wang, Meiwan Chen, Peng Li, Huanxing Su, Jian-Bo Wan, Simon Ming Yuen Lee, Kechun Liu & Chengwei He. (2017) Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biology 11, pages 1-11.
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Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Lijuan Ma, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Meiwan Chen, Peng Li, Huanxing Su, Simon Ming Yuen Lee, Kechun Liu, Jian-Bo Wan & Chengwei He. (2017) Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Scientific Reports 7:1.
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EdwardJ Calabrese, Vittorio Calabrese & James Giordano. (2017) The role of hormesis in the functional performance and protection of neural systems. Brain Circulation 3:1, pages 1.
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Emi Nakajima, Ryan D. Walkup, Thomas R. Shearer & Mitsuyoshi Azuma. (2016) FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells. Graefe's Archive for Clinical and Experimental Ophthalmology 255:1, pages 107-112.
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Vittorio Calabrese, James Giordano, Anna Signorile, Maria Laura Ontario, Sergio Castorina, Concetta De Pasquale, Gunter Eckert & Edward J. Calabrese. (2016) Major pathogenic mechanisms in vascular dementia: Roles of cellular stress response and hormesis in neuroprotection. Journal of Neuroscience Research 94:12, pages 1588-1603.
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V. Calabrese, J. Giordano, M. Ruggieri, D. Berritta, A. Trovato, M.L. Ontario, R. Bianchini & E.J. Calabrese. (2016) Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders. Journal of Neuroscience Research 94:12, pages 1488-1498.
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Edward J. Calabrese, Gaurav Dhawan, Rachna Kapoor, Ivo Iavicoli & Vittorio Calabrese. (2016) HORMESIS: A Fundamental Concept with Widespread Biological and Biomedical Applications. Gerontology 62:5, pages 530-535.
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Lingbin Sun, Zhenghong Zuo, Meng Chen, Yixin Chen & Chonggang Wang. (2015) Reproductive and transgenerational toxicities of phenanthrene on female marine medaka ( Oryzias melastigma ). Aquatic Toxicology 162, pages 109-116.
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Edward J. Calabrese, Ivo Iavicoli & Vittorio Calabrese. (2012) Hormesis: why it is important to biogerontologists. Biogerontology 13:3, pages 215-235.
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Chiho Yabuta, Takayuki Oka, Yayoi Kishimoto, Akira Ohtori, Ayumi Yoshimatsu & Mitsuyoshi Azuma. (2012) Topical FK962 Facilitates Axonal Regeneration and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits. American Journal of Ophthalmology 153:4, pages 651-660.e1.
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Lucija Sarc, Branka Wraber & Metoda Lipnik-Stangelj. (2010) Ethanol and acetaldehyde disturb TNF-alpha and IL-6 production in cultured astrocytes. Human & Experimental Toxicology 30:9, pages 1256-1265.
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Kenneth I. Maynard. (2011) Hormesis Pervasiveness and its Potential Implications for Pharmaceutical Research and Development. Dose-Response 9:3, pages dose-response.1.
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Jakob O. Strom, Annette Theodorsson & Elvar Theodorsson. (2011) Hormesis and Female Sex Hormones. Pharmaceuticals 4:5, pages 726-740.
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Edward J CalabreseMark P Mattson & Vittorio Calabrese. (2010) Resveratrol commonly displays hormesis: Occurrence and biomedical significance. Human & Experimental Toxicology 29:12, pages 980-1015.
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Vittorio CalabreseCarolin CorneliusAlbena T. Dinkova-KostovaEdward J. CalabreseMark P. Mattson. (2010) Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders. Antioxidants & Redox Signaling 13:11, pages 1763-1811.
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Paolo F. Ricci & Edward J. Calabrese. 2010. Cancer Risk Assessment. Cancer Risk Assessment 191 206 .
Linjuan Sun, Shengli Xu, Ming Zhou, Chaodong Wang, Yanchuan Wu & Piu Chan. (2010) Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice. Brain Research 1335, pages 74-82.
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Edward J Calabrese. (2010) Hormesis is central to toxicology, pharmacology and risk assessment. Human & Experimental Toxicology 29:4, pages 249-261.
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Edward J. Calabrese. (2009) Getting the dose–response wrong: why hormesis became marginalized and the threshold model accepted. Archives of Toxicology 83:3, pages 227-247.
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Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova‐Kostova & Edward J. Calabrese. (2009) Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis. BioFactors 35:2, pages 146-160.
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George R. Hoffmann. (2009) A Perspective on the Scientific, Philosophical, and Policy Dimensions of Hormesis. Dose-Response 7:1, pages dose-response.0.
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EJ Calabrese. (2009) Hormesis, non-linearity, and risk communication. Human & Experimental Toxicology 28:1, pages 5-6.
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Wensheng Lin, Phillip E. Kunkler, Heather P. Harding, David Ron, Richard P. Kraig & Brian Popko. (2008) Enhanced Integrated Stress Response Promotes Myelinating Oligodendrocyte Survival in Response to Interferon-γ. The American Journal of Pathology 173:5, pages 1508-1517.
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