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Critical Reviews in Toxicology Volume 47, 2017 - Issue 9
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Review Articles

A comprehensive framework for evaluating the environmental health and safety implications of engineered nanomaterials

William K. Boyesa National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3598-0032
ORCID Icon,
Luka L. Thorntona National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA; ORCID Iconhttps://orcid.org/0000-0003-2185-6281
ORCID Icon,
Souhail R. Al-Abedb National Risk Management Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH, USA; ORCID Iconhttps://orcid.org/0000-0002-5595-1300
ORCID Icon,
Christian P. Andersenc National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Corvallis, OR, USA; ORCID Iconhttps://orcid.org/0000-0003-2169-2520
ORCID Icon,
Dermont C. Bouchardd National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Athens, GA, USA; ORCID Iconhttps://orcid.org/0000-0002-7467-0248
ORCID Icon,
Robert M. Burgesse National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Narragansett, RI, USA; ORCID Iconhttps://orcid.org/0000-0003-4504-5125
ORCID Icon,
Elaine A. Cohen Hubala National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA; ORCID Iconhttps://orcid.org/0000-0002-9650-3483
ORCID Icon,
Kay T. Hoe National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Narragansett, RI, USA; ORCID Iconhttps://orcid.org/0000-0002-6750-4487
ORCID Icon,
Michael F. Hughesa National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA; ORCID Iconhttps://orcid.org/0000-0002-5571-5447
ORCID Icon,
Kirk Kitchina National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA; ORCID Iconhttps://orcid.org/0000-0003-0693-8967
ORCID Icon,
Jay R. Reichmanc National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Corvallis, OR, USA;
,
Kim R. Rogersf National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
,
Jeffrey A. Rossa National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA; ORCID Iconhttps://orcid.org/0000-0002-7002-4548
ORCID Icon,
Paul T. Rygiewiczc National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Corvallis, OR, USA;
,
Kirk G. Scheckelb National Risk Management Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH, USA; ORCID Iconhttps://orcid.org/0000-0001-9326-9241
ORCID Icon,
Sheau-Fung Thaia National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA;
,
Richard G. Zeppd National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Athens, GA, USA;
&
Robert M. Zuckera National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA;
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Pages 771-814 | Received 22 Oct 2016, Accepted 05 May 2017, Published online: 29 Jun 2017

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Articles from other publishers (46)

Eid Alshammari, Yingxue Zhang, Alexander Yang & Zhe Yang. 2023. Impact of Engineered Nanomaterials in Genomics and Epigenomics. Impact of Engineered Nanomaterials in Genomics and Epigenomics 309 318 .
Salem S. Salem & Azamal Husen. 2023. Engineered Nanomaterials for Sustainable Agricultural Production, Soil Improvement and Stress Management. Engineered Nanomaterials for Sustainable Agricultural Production, Soil Improvement and Stress Management 311 336 .
Asif Iqbal, Muhammad Hassan Raza, Haleema Jadoon, Aleesha Jamshed, Bakht B Khan, Muhammad IK Rehman, Muhammad Noman & Muhammad Faizan Zafar. (2022) Applications of nanomaterials for health and environment protection. MOJ Ecology & Environmental Sciences 7:3, pages 84-87.
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Marissa S. Giroux, Zahra Zahra, Omobayo A. Salawu, Robert M. Burgess, Kay T. Ho & Adeyemi S. Adeleye. (2022) Assessing the environmental effects related to quantum dot structure, function, synthesis and exposure. Environmental Science: Nano 9:3, pages 867-910.
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William K. Boyes, Bradley Beach, Gayle Chan, B. Lila M. Thornton, Paul Harten & Holly M. Mortensen. (2022) An EPA database on the effects of engineered nanomaterials-NaKnowBase. Scientific Data 9:1.
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Saber Amiri, Zahra Motalebi Moghanjougi, Narmin Nezamdoost-Sani & Mahmoud Rezazadeh-Bari. 2022. Protective Textiles from Natural Resources. Protective Textiles from Natural Resources 839 879 .
Christian P. Andersen & Cyren M. Rico. 2022. Plant Exposure to Engineered Nanoparticles. Plant Exposure to Engineered Nanoparticles 151 170 .
Luca Marchiol, Laura Pilotto, Daniel Lizzi & Guido Fellet. 2022. Plant Exposure to Engineered Nanoparticles. Plant Exposure to Engineered Nanoparticles 83 118 .
Natalia Fernández-Bertólez, Carla Costa, Fátima Brandão, João Paulo Teixeira, Eduardo Pásaro, Vanessa Valdiglesias & Blanca Laffon. 2022. Nanotoxicology in Safety Assessment of Nanomaterials. Nanotoxicology in Safety Assessment of Nanomaterials 303 350 .
Raquel Von Hohendorff, Wilson Engelmann & Daniele Weber S. Leal. 2021. Nanotechnology in Medicine. Nanotechnology in Medicine 315 348 .
Jay R. Reichman, Mark G. Johnson, Paul T. Rygiewicz, Bonnie M. Smith, Michael A. Bollman, Marjorie J. Storm, George A. King & Christian P. Andersen. (2021) Focused Microbiome Shifts in Reconstructed Wetlands Correlated with Elevated Copper Concentrations Originating from Micronized Copper Azole–Treated Wood. Environmental Toxicology and Chemistry 40:12, pages 3351-3368.
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Lionel Marcon, Jana Oliveras & Víctor F. Puntes. (2021) In situ nanoremediation of soils and groundwaters from the nanoparticle's standpoint: A review. Science of The Total Environment 791, pages 148324.
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M.G. Johnson, T.P. Luxton, P.T. Rygiewicz, J.R. Reichman, M.A. Bollman, G.A. King, M.J. Storm, M.S. Nash & C.P. Andersen. (2021) Transformation and release of micronized Cu used as a wood preservative in treated wood in wetland soil. Environmental Pollution 287, pages 117189.
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Tae Hwan Shin, Saraswathy Nithiyanandam, Da Yeon Lee, Do Hyeon Kwon, Ji Su Hwang, Seok Gi Kim, Yong Eun Jang, Shaherin Basith, Sungsu Park, Jung-Soon Mo & Gwang Lee. (2021) Analysis of Nanotoxicity with Integrated Omics and Mechanobiology. Nanomaterials 11:9, pages 2385.
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Tyler P. Nicholas, William K. Boyes, David K. Scoville, Tomomi W. Workman, Terrance J. Kavanagh, William A. Altemeier & Elaine M. Faustman. (2021) The effects of gene × environment interactions on silver nanoparticle toxicity in the respiratory system: An adverse outcome pathway. WIREs Nanomedicine and Nanobiotechnology 13:5.
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Natalia Fernández-Bertólez, Fátima Brandão, Carla Costa, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon & Vanessa Valdiglesias. (2021) Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO2 Nanoparticles on SH-SY5Y Cells. International Journal of Molecular Sciences 22:16, pages 8558.
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Hengjie Yu, Dan Luo, Limin Dai & Fang Cheng. (2021) In silico nanosafety assessment tools and their ecosystem-level integration prospect . Nanoscale 13:19, pages 8722-8739.
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Manisha Bhateria, C. Yahavi, Anushka Pandey, Shiv Singh & Sheelendra Pratap Singh. 2021. Handbook of Functionalized Nanomaterials. Handbook of Functionalized Nanomaterials 165 196 .
Robert M. Zucker, Jayna Ortenzio, Laura L. Degn & William K. Boyes. (2020) Detection of large extracellular silver nanoparticle rings observed during mitosis using darkfield microscopy. PLOS ONE 15:12, pages e0240268.
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Nicholas J. Niemuth, Yonqian Zhang, Aurash A. Mohaimani, Angela Schmoldt, Elizabeth D. Laudadio, Robert J. Hamers & Rebecca D. Klaper. (2020) Protein Fe–S Centers as a Molecular Target of Toxicity of a Complex Transition Metal Oxide Nanomaterial with Downstream Impacts on Metabolism and Growth. Environmental Science & Technology 54:23, pages 15257-15266.
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Oliwia Metryka, Daniel Wasilkowski, Anna Nowak, Małgorzata Adamczyk-Habrajska & Agnieszka Mrozik. (2020) Impact of an Engineered Copper-Titanium Dioxide Nanocomposite and Parent Substrates on the Bacteria Viability, Antioxidant Enzymes and Fatty Acid Profiling. International Journal of Molecular Sciences 21:23, pages 9089.
Crossref
Shaopeng Chen, Wei Chen & Sijin Liu. (2020) Continuous efforts to understand the environmental health and safety (EHS) of nanomaterials for safer applications. Ecotoxicology and Environmental Safety 202, pages 110894.
Crossref
Susana P.B. Sousa, Tânia Peixoto, Raquel M. Santos, Ascensão Lopes, Maria da Conceição Paiva & António T. Marques. (2020) Health and Safety Concerns Related to CNT and Graphene Products, and Related Composites. Journal of Composites Science 4:3, pages 106.
Crossref
William K. Boyes & Christoph van Thriel. (2020) Neurotoxicology of Nanomaterials. Chemical Research in Toxicology 33:5, pages 1121-1144.
Crossref
Dino Metarapi & Johannes T. van Elteren. (2020) Fundamentals of single particle analysis in biomatrices by laser ablation-inductively coupled plasma mass spectrometry. Journal of Analytical Atomic Spectrometry 35:4, pages 784-793.
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Mandeep Singh Bakshi. (2020) Impact of nanomaterials on ecosystems: Mechanistic aspects in vivo. Environmental Research 182, pages 109099.
Crossref
Irisdoris R. Souza, Lucas R. Silva, Letícia S.P. Fernandes, Lilian D. Salgado, Helena C. Silva de Assis, Daniele S. Firak, Larissa Bach, Ronaldo Santos-Filho, Carmen L. Voigt, Ariana C. Barros, Patricio Peralta-Zamora, Ney Mattoso, Celia Regina C. Franco, Lia C. Soares Medeiros, Bruna H. Marcon, Marta M. Cestari, Bruno F. Sant’Anna-Santos & Daniela M. Leme. (2020) Visible-light reduced silver nanoparticles’ toxicity in Allium cepa test system. Environmental Pollution 257, pages 113551.
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Penny Nymark, Martine Bakker, Susan Dekkers, Remy Franken, Wouter Fransman, Amaia García‐Bilbao, Dario Greco, Mary Gulumian, Niels Hadrup, Sabina Halappanavar, Vesa Hongisto, Karin Sørig Hougaard, Keld Alstrup Jensen, Pekka Kohonen, Antti Joonas Koivisto, Miikka Dal Maso, Thies Oosterwijk, Mikko Poikkimäki, Isabel Rodriguez‐Llopis, Rob Stierum, Jorid Birkelund Sørli & Roland Grafström. (2020) Toward Rigorous Materials Production: New Approach Methodologies Have Extensive Potential to Improve Current Safety Assessment Practices. Small 16:6, pages 1904749.
Crossref
Sara T. Humes & Tara Sabo-Attwood. 2020. Information Resources in Toxicology. Information Resources in Toxicology 425 436 .
Robert Martin Zucker & William K. Boyes. 2020. Nanoparticles in Biology and Medicine. Nanoparticles in Biology and Medicine 415 436 .
Na Liu & Meng Tang. (2019) Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles. Journal of Applied Toxicology 40:1, pages 16-36.
Crossref
Sandra Jesus, Mélanie Schmutz, Claudia Som, Gerrit Borchard, Peter Wick & Olga Borges. (2019) Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far. Frontiers in Bioengineering and Biotechnology 7.
Crossref
Robert M. Zucker, Jayna Ortenzio, Laura L. Degn, Jeremy M. Lerner & William K. Boyes. (2019) Biophysical comparison of four silver nanoparticles coatings using microscopy, hyperspectral imaging and flow cytometry. PLOS ONE 14:7, pages e0219078.
Crossref
Qinjie Weng, Xi Hu, Jiahuan Zheng, Fan Xia, Nan Wang, Hongwei Liao, Ying Liu, Dokyoon Kim, Jianan Liu, Fangyuan Li, Qiaojun He, Bo Yang, Chunying Chen, Taeghwan Hyeon & Daishun Ling. (2019) Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1MRI Contrast Agents in Renal Failure Rats. ACS Nano 13:6, pages 6801-6812.
Crossref
Monika Mortimer & Patricia A. Holden. 2019. Exposure to Engineered Nanomaterials in the Environment. Exposure to Engineered Nanomaterials in the Environment 61 103 .
Hossain Md Anawar & Vladimir Strezov. 2019. Emerging and Nanomaterial Contaminants in Wastewater. Emerging and Nanomaterial Contaminants in Wastewater 43 62 .
Stefano Cucurachi & Carlos Felipe Blanco Rocha. 2019. Nanotechnology in Eco-efficient Construction. Nanotechnology in Eco-efficient Construction 815 846 .
Tirto Soenaryo, Shizuaki Murata & Anatoly Zinchenko. (2018) Efficient prevention of nanomaterials transport in the porous media by treatment with polyelectrolytes. Chemosphere 210, pages 567-576.
Crossref
Jay R. Reichman, Paul T. Rygiewicz, Mark G. Johnson, Michael A. Bollman, Bonnie M. Smith, Q. Todd Krantz, Charly J. King, Kasey D. Kovalcik & Christian P. Andersen. (2018) Douglas-Fir ( Pseudotsuga menziesii (Mirb.) Franco) Transcriptome Profile Changes Induced by Diesel Emissions Generated with CeO 2 Nanoparticle Fuel Borne Catalyst . Environmental Science & Technology 52:17, pages 10067-10077.
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Matthew Faria, Mattias Björnmalm, Kristofer J. Thurecht, Stephen J. Kent, Robert G. Parton, Maria Kavallaris, Angus P. R. Johnston, J. Justin Gooding, Simon R. Corrie, Ben J. Boyd, Pall Thordarson, Andrew K. Whittaker, Molly M. Stevens, Clive A. Prestidge, Christopher J. H. Porter, Wolfgang J. Parak, Thomas P. Davis, Edmund J. Crampin & Frank Caruso. (2018) Minimum information reporting in bio–nano experimental literature. Nature Nanotechnology 13:9, pages 777-785.
Crossref
Phoebe A. Stapleton, Christopher J. Wingard, Timothy R. Nurkiewicz, Alison C. Holloway, Judith T. Zelikoff, Thomas B. Knudsen & Lynette K. Rogers. (2018) Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reproductive Toxicology 79, pages 16-20.
Crossref
Yi Cao, Yu Gong, Wenzhen Liao, Yunfeng Luo, Chaohua Wu, Maolin Wang & Qianyu Yang. (2018) A review of cardiovascular toxicity of TiO2, ZnO and Ag nanoparticles (NPs). BioMetals 31:4, pages 457-476.
Crossref
Gerald T. Ankley & Stephen W. Edwards. (2018) The adverse outcome pathway: A multifaceted framework supporting 21st century toxicology. Current Opinion in Toxicology 9, pages 1-7.
Crossref
Tae Hwan Shin, Da Yeon Lee, Hyeon-Seong Lee, Hyung Jin Park, Moon Suk Jin, Man-Jeong Paik, Balachandran Manavalan, Jung-Soon Mo & Gwang Lee. (2018) Integration of metabolomics and transcriptomics in nanotoxicity studies. BMB Reports 51:1, pages 14-20.
Crossref
W.K. Boyes. 2018. Comprehensive Toxicology. Comprehensive Toxicology 34 43 .
Mahendra Rai, Indarchand Gupta, Avinash P. Ingle, Jayanta Kumar Biswas & Olga V. Sinitsyna. 2018. Nanomaterials: Ecotoxicity, Safety, and Public Perception. Nanomaterials: Ecotoxicity, Safety, and Public Perception 3 18 .

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