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Research Article

Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: A new therapeutic option

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Pages 11-19 | Published online: 01 Jul 2009

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Clive S. Zent, Deborah A. Bowen, Michael J. Conte, Betsy R. LaPlant & Timothy G. Call. (2016) Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with everolimus (RAD001) and alemtuzumab: a Phase I/II study. Leukemia & Lymphoma 57:7, pages 1585-1591.
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Izaskun Ceberio, Sean M. Devlin, Craig Sauter, Juliet N. Barker, Hugo Castro-Malaspina, Sergio Giralt, Doris M. Ponce, Lauren Lechner, Molly A. Maloy, Jenna D. Goldberg & Miguel-Angel Perales. (2015) Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant. Leukemia & Lymphoma 56:3, pages 663-670.
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Matthew S. Davids & Jennifer R. Brown. (2012) Targeting the B cell receptor pathway in chronic lymphocytic leukemia. Leukemia & Lymphoma 53:12, pages 2362-2370.
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S Galimberti & M Petrini. (2010) Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma. Cancer Management and Research 2, pages 181-189.
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Rami Hayun, Eitan Okun, Alain Berrebi, Lev Shvidel, Lucette Bassous, Benjamin Sredni & Uri Nir. (2009) Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells. Leukemia & Lymphoma 50:4, pages 625-632.
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Thomas Decker. (2008) Is mTOR inhibition a therapeutic option in chronic lymphocytic leukemia?. Leukemia & Lymphoma 49:12, pages 2235-2236.
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Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn, Jamie Lees, Jennifer Cassels, Jiatian Li, Rinako Nakagawa, Owen J. Sansom & Alison M. Michie. (2023) mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia. Leukemia 37:12, pages 2414-2425.
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Rachel ThijssenJohanna ter BurgBrett GarrickGregor G. W. van BochoveJennifer R. BrownStacey M. FernandesMaría Solé RodríguezJean-Marie MichotMichael HallekBarbara EichhorstHans Christian ReinhardtJohanna BendellIngrid A. M. Derks, Roel J. W. van Kampen, Kristen HegeMarie José Kersten, Torsten TroweEllen H. FilvaroffEric Eldering & Arnon P. Kater. (2016) Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. Blood 128:4, pages 574-583.
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Austin Y. Shull, Satish K. Noonepalle, Farrukh T. Awan, Jimei Liu, Lirong Pei, Roni J. Bollag, Huda Salman, Zhiyong Ding & Huidong Shi. (2015) RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia. Oncotarget 6:16, pages 14632-14645.
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Leigh A. Humphries, J. Claire Godbersen, Olga V. Danilova, Prabhjot Kaur, Brock C. Christensen & Alexey V. Danilov. (2013) Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia. British Journal of Haematology 163:5, pages 590-602.
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Karolina Nemes, Anna Sebestyén, Ágnes Márk, Melinda Hajdu, István Kenessey, Tamás Sticz, Eszter Nagy, Gábor Barna, Zsófia Váradi, Gábor Kovács, László Kopper & Monika Csóka. (2013) Mammalian Target of Rapamycin (mTOR) Activity Dependent Phospho-Protein Expression in Childhood Acute Lymphoblastic Leukemia (ALL). PLoS ONE 8:4, pages e59335.
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Carsten U. Niemann, Jade Jones & Adrian Wiestner. 2013. Advances in Chronic Lymphocytic Leukemia. Advances in Chronic Lymphocytic Leukemia 259 291 .
Jianguo Tao & Chih-Chi Andrew Hu. 2012. Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics. Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics 1 20 .
Kevin R. Kelly, Julie H. Rowe, Swaminathan Padmanabhan, Steffan T. Nawrocki & Jennifer S. Carew. (2011) Mammalian target of rapamycin as a target in hematological malignancies. Targeted Oncology 6:1, pages 53-61.
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N Chapuis, J Tamburini, A S Green, L Willems, V Bardet, S Park, C Lacombe, P Mayeux & D Bouscary. (2010) Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies. Leukemia 24:10, pages 1686-1699.
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Clive S. Zent, Betsy R. LaPlant, Patrick B. Johnston, Timothy G. Call, Thomas M. Habermann, Ivana N. Micallef & Thomas E. Witzig. (2010) The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation. Cancer, pages NA-NA.
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M Plander, S Seegers, P Ugocsai, S Diermeier-Daucher, J Iványi, G Schmitz, F Hofstädter, S Schwarz, E Orsó, R Knüchel & G Brockhoff. (2009) Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles. Leukemia 23:11, pages 2118-2128.
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David T. Teachey, Stephan A. Grupp & Valerie I. Brown. (2009) Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies. British Journal of Haematology 145:5, pages 569-580.
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Thomas Decker, Michael Sandherr, Katharina Goetze, Madlen Oelsner, Ingo Ringshausen & Christian Peschel. (2008) A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Annals of Hematology 88:3, pages 221-227.
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G. D'Ythurbide, P. Coppo, A. Adem, P. Callard, J. Dantal, F. Chantrel, M. Godin, L. Braun-Parvez, B. Moulin, P. Moskovtchenko, N. Ouali, E. Rondeau & A. Hertig. (2008) Chronic Lymphocytic Leukemia: A Hazardous Condition Before Kidney Transplantation. American Journal of Transplantation 8:11, pages 2471-2475.
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Valerie I. Brown, Alix E. Seif, Gregor S. D. Reid, David T. Teachey & Stephan A. Grupp. (2008) Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease. Immunologic Research 42:1-3, pages 84-105.
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Aaron E. Foster, Malcolm K. Brenner & Gianpietro Dotti. (2008) Adoptive T-cell immunotherapy of chronic lymphocytic leukaemia. Best Practice & Research Clinical Haematology 21:3, pages 375-389.
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Edwin P. Alyea, Shuli Li, Haesook T. Kim, Corey Cutler, Vincent Ho, Robert J. Soiffer & Joseph H. Antin. (2008) Sirolimus, Tacrolimus, and Low-Dose Methotrexate as Graft-versus-Host Disease Prophylaxis in Related and Unrelated Donor Reduced-Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 14:8, pages 920-926.
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Isam A. Abdel-Karim & Francis J. Giles. (2008) Mammalian Target of Rapamycin as a Target in Hematological Malignancies. Current Problems in Cancer 32:4, pages 161-177.
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Julio Pascual, Ioannis N. Boletis & Josep M. Campistol. (2006) Everolimus (Certican) in renal transplantation: a review of clinical trial data, current usage, and future directions. Transplantation Reviews 20:1, pages 1-18.
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