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Leukemia & Lymphoma Volume 48, 2007 - Issue 10
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Original Article: Research

Induction of multiple myeloma-specific cytotoxic T lymphocyte stimulation by dendritic cell pulsing with purified and optimized myeloma cell lysates

Je-Jung Lee Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, KoreaCorrespondence[email protected]
, M.D. Ph.D.,
Bo-Hwa Choi Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Hyun-Kyu Kang Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Myong-Suk Park Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Jung-Sun Park Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Sang-Ki Kim Clinical Vaccine R&D Center, Chonnam National University
,
Thanh-Nhan Nguyen Pham Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Duck Cho Clinical Vaccine R&D Center, Chonnam National University
,
Jong-Hee Nam Clinical Vaccine R&D Center, Chonnam National University
,
Young-Jin Kim Clinical Vaccine R&D Center, Chonnam National University
,
Joon-Haeng Rhee Clinical Vaccine R&D Center, Chonnam National University
,
Deok-Hwan Yang Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Yeo-Kyeoung Kim Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
,
Hyeoung-Joon Kim Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
&
Ik-Joo Chung Clinical Vaccine R&D Center, Chonnam National University; Department of Hematology – Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, KoreaCorrespondence[email protected]
, M.D. Ph.D. show all
Pages 2022-2031 | Received 31 Oct 2006, Accepted 17 Jul 2007, Published online: 01 Jul 2009

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Young-Hee Kim, Thi-Anh-Thuy Tran, Thi-Hoang-Oanh Duong, Shin Jung, In-Young Kim, Kyung-Sub Moon, Woo-Youl Jang, Hyun-Ju Lee, Je-Jung Lee & Tae-Young Jung. (2020) Feasibility of dendritic cell-based vaccine against glioblastoma by using cytoplasmic transduction peptide (CTP)-fused protein antigens combined with anti-PD1. Human Vaccines & Immunotherapeutics 16:11, pages 2840-2848.
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Jacalyn Rosenblatt, Michal Bar-Natan, Nikhil C Munshi & David E Avigan. (2014) Immunotherapy for multiple myeloma. Expert Review of Hematology 7:1, pages 91-96.
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David Avigan & Dimitrios Tzachanis. (2010) Cancer vaccines in hematologic malignancies: advances, challenges and therapeutic potential. Expert Review of Vaccines 9:5, pages 451-454.
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David S. Ritchie. (2007) Plasma cell lysate as an antigen source in multiple myeloma immunotherapy. Leukemia & Lymphoma 48:10, pages 1894-1895.
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Articles from other publishers (33)

Hiroko Nishida. (2021) Rapid Progress in Immunotherapies for Multiple Myeloma: An Updated Comprehensive Review. Cancers 13:11, pages 2712.
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Thi-Anh-Thuy Tran, Young-Hee Kim, Shin Jung, In-Young Kim, Kyung-Sub Moon, Woo-Youl Jang, Hyun-Ju Lee, Je-Jung Lee & Tae-Young Jung. (2021) Branched Multipeptide-combined Adjuvants Potentially Improve the Antitumor Effects on Glioblastoma. Journal of Immunotherapy 44:4, pages 151-161.
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Jessica J. Liegel & David E. Avigan. 2020. Cancer Immunology. Cancer Immunology 75 102 .
J Bae, T Hideshima, G L Zhang, J Zhou, D B Keskin, N C Munshi & K C Anderson. (2017) Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma. Leukemia 32:3, pages 752-764.
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Sung-Hoon Jung, Hyun-Ju Lee, Manh-Cuong Vo, Hyeoung-Joon Kim & Je-Jung Lee. (2017) Immunotherapy for the treatment of multiple myeloma. Critical Reviews in Oncology/Hematology 111, pages 87-93.
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Manh-Cuong Vo, Truc Anh-NguyenThi, Hyun-Ju Lee, Thanh-Nhan Nguyen-Pham, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Hyeoung-Joon Kim & Je-Jung Lee. (2017) Lenalidomide enhances the function of dendritic cells generated from patients with multiple myeloma. Experimental Hematology 46, pages 48-55.
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Shah Md. Shahjahan Miah, Timothy K. Erick & Dwaine F. Emerich. 2017. Cell Therapy. Cell Therapy 99 120 .
Paola Neri, Nizar J. Bahlis & Sagar Lonial. (2016) New Strategies in Multiple Myeloma: Immunotherapy as a Novel Approach to Treat Patients with Multiple Myeloma. Clinical Cancer Research 22:24, pages 5959-5965.
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Junshik Hong & Jae Hoon Lee. (2016) Recent advances in multiple myeloma: a Korean perspective. The Korean Journal of Internal Medicine 31:5, pages 820-834.
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Rebecca Karp Leaf, Hearn Jay Cho & David Avigan. (2015) Immunotherapy for Multiple Myeloma, Past, Present, and Future: Monoclonal Antibodies, Vaccines, and Cellular Therapies. Current Hematologic Malignancy Reports 10:4, pages 395-404.
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Alessandro Allegra, Giuseppa Penna, Vanessa Innao, Bruna Greve, Valerio Maisano, Sabina Russo & Caterina Musolino. (2015) Vaccination of multiple myeloma: Current strategies and future prospects. Critical Reviews in Oncology/Hematology 96:2, pages 339-354.
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My-Dung HoangSung-Hoon JungHyun-Ju LeeYoun-Kyung LeeThanh-Nhan Nguyen-PhamNu-Ri ChoiManh-Cuong VoSeung-Shin LeeJae-Sook AhnDeok-Hwan YangYeo-Kyeoung KimHyeoung-Joon KimJe-Jung Lee. (2015) Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic. Chonnam Medical Journal 51:1, pages 1.
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Michal Bar-Natan, Kenneth C. Anderson & David E. Avigan. 2015. Cancer Immunology. Cancer Immunology 69 91 .
Jooeun Bae, Nikhil C. Munshi & Kenneth C. Anderson. (2014) Immunotherapy Strategies in Multiple Myeloma. Hematology/Oncology Clinics of North America 28:5, pages 927-943.
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E. C. Hwang, M.‐S. Lim, C.‐M. Im, D.‐D. Kwon, H.‐J. Lee, T.‐N. Nguyen‐Pham, Y.‐K. Lee & J.‐J. Lee. (2013) Generation of Potent Cytotoxic T Lymphocytes Against Castration‐Resistant Prostate Cancer Cells by Dendritic Cells Loaded With Dying Allogeneic Prostate Cancer Cells . Scandinavian Journal of Immunology 77:2, pages 117-124.
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Jooeun Bae, R. H. Prabhala & Nikhil C. Munshi. 2013. Advances in Biology and Therapy of Multiple Myeloma. Advances in Biology and Therapy of Multiple Myeloma 131 154 .
Ross Brown, P. Joy Ho, John Gibson & Douglas Joshua. 2013. Advances in Biology and Therapy of Multiple Myeloma. Advances in Biology and Therapy of Multiple Myeloma 3 24 .
Jon Arnason & David Avigan. (2012) Evolution of cellular immunotherapy: from allogeneic transplant to dendritic cell vaccination as treatment for multiple myeloma. Immunotherapy 4:10, pages 1043-1051.
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Thanh-Nhan Nguyen-PhamYoun-Kyung LeeHyun-Ju LeeMi-Hyun KimDeok-Hwan YangHyeoung-Joon KimJe-Jung Lee. (2012) Cellular immunotherapy using dendritic cells against multiple myeloma. The Korean Journal of Hematology 47:1, pages 17.
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Ivetta Danylesko, Katia Beider, Avichai Shimoni & Arnon Nagler. (2012) Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions. Clinical and Developmental Immunology 2012, pages 1-28.
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Thanh-Nhan Nguyen-Pham, Yoon-Kyung Lee, Hyeoung-Joon Kim & Je-Jung Lee. (2012) Immunotherapy Using Dendritic Cells against Multiple Myeloma: How to Improve?. Clinical and Developmental Immunology 2012, pages 1-13.
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Thanh-Nhan Nguyen-Pham, Deok-Hwan Yang, Truc-Anh Thi Nguyen, Mi-Seon Lim, Cheol Yi Hong, Mi-Hyun Kim, Hyun Ju Lee, Youn-Kyung Lee, Duck Cho, Soo-Young Bae, Jae-Sook Ahn, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim & Je-Jung Lee. (2011) Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy. Cellular & Molecular Immunology 9:1, pages 45-53.
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Deok-Hwan Yang, Mi-Hyun Kim, Youn-Kyung Lee, Cheol Yi Hong, Hyun Ju Lee, Thanh-Nhan Nguyen-Pham, Soo Young Bae, Jae-Sook Ahn, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim, Pawel Kalinski & Je-Jung Lee. (2011) Successful cross-presentation of allogeneic myeloma cells by autologous alpha-type 1-polarized dendritic cells as an effective tumor antigen in myeloma patients with matched monoclonal immunoglobulins. Annals of Hematology 90:12, pages 1419-1426.
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Jooeun Bae, Yu‐Tzu Tai, Kenneth C. Anderson & Nikhil C. Munshi. (2011) Novel epitope evoking CD138 antigen‐specific cytotoxic T lymphocytes targeting multiple myeloma and other plasma cell disorders. British Journal of Haematology 155:3, pages 349-361.
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J Bae, R Carrasco, A-H Lee, R Prabhala, Y-T Tai, K C Anderson & N C Munshi. (2011) Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma. Leukemia 25:10, pages 1610-1619.
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Thanh-Nhan Nguyen-Pham, Chang-Min Im, Truc-Anh Thi Nguyen, Mi-Seon Lim, Cheol Yi Hong, Mi-Hyun Kim, Hyun Ju Lee, Youn-Kyung Lee, Duck Cho, Jae-Sook Ahn, Deok-Hwan Yang, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim & Je-Jung Lee. (2011) Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma. Leukemia Research 35:9, pages 1241-1247.
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Min-Ho Park, Deok-Hwan Yang, Mi-Hyun Kim, Jae-Hong Jang, Yoon-Young Jang, Youn-Kyung Lee, Chun-Ji Jin, Than Nhan Nguyen Pham, Truc Anh Nguyen Thi, Mi-Seon Lim, Hyun-Ju Lee, Cheol Yi Hong, Jung-Han Yoon & Je-Jung Lee. (2011) Alpha-Type 1 Polarized Dendritic Cells Loaded with Apoptotic Allogeneic Breast Cancer Cells Can Induce Potent Cytotoxic T Lymphocytes against Breast Cancer. Cancer Research and Treatment 43:1, pages 56-66.
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Deok-Hwan Yang, Mi-Hyun Kim, Cheol Yi Hong, Youn-Kyung Lee, Chun-Ji Jin, Thanh-Nhan Nguyen Pham, Jae-Sook Ahn, Woo-Kyun Bae, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim, Pawel Kalinski & Je-Jung Lee. (2010) Alpha-type 1-polarized dendritic cells loaded with apoptotic allogeneic myeloma cell line induce strong CTL responses against autologous myeloma cells. Annals of Hematology 89:8, pages 795-801.
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Jae Hoon Lee, Dong Soon Lee, Je Jung Lee, Yoon Hwan Chang, Jong Youl Jin, Deog-Yeon Jo, Soo Mee Bang, Hyo Jung Kim, Jin Seok Kim, Kihyun Kim, Hyeon Seok Eom, Chang Ki Min, Sung Soo Yoon, Sun Hee Kim, Cheolwon Suh & Kyung Sam Cho. (2010) Multiple myeloma in Korea: past, present, and future perspectives. Experience of the Korean Multiple Myeloma Working Party. International Journal of Hematology 92:1, pages 52-57.
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David S Ritchie, Hang Quach, Kate Fielding & Paul Neeson. (2010) Drug-mediated and cellular immunotherapy in multiple myeloma. Immunotherapy 2:2, pages 243-255.
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Sang-Ki Kim, Thanh-Nhan Nguyen Pham, Tuyet Minh Nguyen Hoang, Hyun-Kyu Kang, Chun-Ji Jin, Jong-Hee Nam, Sang-Young Chung, So-Jin-Na Choi, Deok-Hwan Yang, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim & Je-Jung Lee. (2009) Induction of myeloma-specific cytotoxic T lymphocytes ex vivo by CD40-activated B cells loaded with myeloma tumor antigens. Annals of Hematology 88:11, pages 1113-1123.
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Amorette Barber, Tong Zhang, Christina J. Megli, Jillian Wu, Kenneth R. Meehan & Charles L. Sentman. (2008) Chimeric NKG2D receptor–expressing T cells as an immunotherapy for multiple myeloma. Experimental Hematology 36:10, pages 1318-1328.
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Jacalyn Rosenblatt & David Avigan. (2008) Cellular immunotherapy for multiple myeloma. Best Practice & Research Clinical Haematology 21:3, pages 559-577.
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