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Original Article: Clinical

Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML

, M.D., , &
Pages 2145-2151 | Received 05 Jun 2007, Accepted 13 Aug 2007, Published online: 01 Jul 2009

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Jose Maria Raya, Taida Martín-Santos, Elisa Luño, Carmen Sanzo, Maria Luz Perez-Sirvent, Esperanza Such, José Tomás Navarro, Fuensanta Millá, Esther Alonso, Alicia Domingo, María Rozman, Marina Díaz-Beva, Ana Batlle, Sonia González-de-Villambrosia, Esperanza Tuset, Teresa Vallespí, Margarita Ortega, Alfredo Bermejo, Marisa Martín-Ramos, Valeria Peri, Francesc Solé & Lourdes Florensa. (2015) Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): Clinical and biological features and comparison with other acute myeloid leukemias with cytogenetic aberrations involving long arm of chromosome 3. Hematology 20:8, pages 435-441.
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Peter Valent & Rotraud Wieser. (2009) Update on genetic and molecular markers associated with myelodysplastic syndromes. Leukemia & Lymphoma 50:3, pages 341-348.
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Wolfgang Sperr & Peter Valent. (2007) Biology and clinical features of myeloid neoplasms with inv(3) (q21q26) or t(3;3) (q21q26). Leukemia & Lymphoma 48:11, pages 2096-2097.
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Claudio Ortolani. 2021. Flow Cytometry of Hematological Malignancies. Flow Cytometry of Hematological Malignancies 301 427 .
Tracy I. George & Ashish Bajel. (2021) Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms. Pathology 53:3, pages 312-327.
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Maria Teresa Voso, Eleonora De Bellis & Tiziana Ottone. 2021. Acute Myeloid Leukemia. Acute Myeloid Leukemia 23 54 .
Marta Sitges, Blanca Boluda, Ana Garrido, Mireia Morgades, Isabel Granada, Eva Barragan, Montserrat Arnan, Josefina Serrano, Mar Tormo, Juan Miguel Bergua, Mercedes Colorado, Olga Salamero, Jordi Esteve, Celina Benavente, Manuel Pérez‐Encinas, Rosa Coll, Josep‐Maria Martí‐Tutusaus, Salut Brunet, Jorge Sierra, Miguel Ángel Sanz, Pau Montesinos, Josep‐Maria Ribera, Susana Vives, Antonieta Molero, Laura Gallur, Bárbara Gallur, Alex Bataller, Marina Díaz‐Beya, David Gallardo, Ferran Vall‐llovera, Josep Maria Martí‐Tutusaus, María Belén Vidriales, Rosalía Riaza‐Grau, Mario Legarda, María Jose Sayas, Juan Antonio Vera, Alfons Serrano, Carlos Rodríguez, Joan Bargay, Daniel García, Cristina Gil & María Pilar Martínez. (2020) Acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2): Study of 61 patients treated with intensive protocols. European Journal of Haematology 105:2, pages 138-147.
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Barbara J. Bain. 2017. Leukaemia Diagnosis. Leukaemia Diagnosis 135 248 .
Bertil Johansson & Christine J. Harrison. 2015. Cancer Cytogenetics. Cancer Cytogenetics 62 125 .
Vincent-Philippe LavalléePatrick GendronSébastien LemieuxGiovanni D’Angelo, Josée Hébert & Guy Sauvageau. (2015) EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations. Blood 125:1, pages 140-143.
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Heesun J. Rogers & Eric D. Hsi. (2013) Myeloid Neoplasms with inv(3)(q21q26.2) or t(3;3)(q21;q26.2). Surgical Pathology Clinics 6:4, pages 677-692.
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A. Rashidi, S. McNeill, J. Winters, B. Alexander & M. Roullet. (2013) T-cell acute lymphoblastic leukemia/lymphoma with inversion(3)(q21q26). International Journal of Laboratory Hematology 35:5, pages e34-e36.
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Shaoying Li, C. Cameron Yin, L. Jeffrey Medeiros, Carlos Bueso-Ramos, Gary Lu & Pei Lin. (2012) Myelodysplastic Syndrome/Acute Myeloid Leukemia With t(3;21)(q26.2;q22) Is Commonly a Therapy-Related Disease Associated With Poor Outcome. American Journal of Clinical Pathology 138:1, pages 146-152.
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Wei Cui, Jianlan Sun, Claudiu V. Cotta, L. Jeffrey Medeiros & Pei Lin. (2011) Myelodysplastic Syndrome With inv(3)(q21q26.2) or t(3;3)(q21;q26.2) Has a High Risk for Progression to Acute Myeloid Leukemia. American Journal of Clinical Pathology 136:2, pages 282-288.
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Claudio Ortolani. 2011. Flow Cytometry of Hematological Malignancies. Flow Cytometry of Hematological Malignancies 160 300 .
C Haferlach, U Bacher, T Haferlach, F Dicker, T Alpermann, W Kern & S Schnittger. (2011) The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML. Leukemia 25:5, pages 874-877.
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Jianlan Sun, Sergej N Konoplev, Xuemei Wang, Wei Cui, Su S Chen, L Jeffrey Medeiros & Pei Lin. (2011) De novo acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): a clinicopathologic and cytogenetic study of an entity recently added to the WHO classification. Modern Pathology 24:3, pages 384-389.
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Hyejin LeeChihyun ChoMin-Jung KwonMyung-Hyun NamChang Kyu LeeYoung Kee Kim. (2011) A Case of Concomitant Inv(3)(q21q26) and Cryptic BCR/ABL1 Rearrangement in the Blast Crisis of Chronic Myeloid Leukemia. Laboratory Medicine Online 1:3, pages 163.
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Sun Ah Lee, Jihyang Lim, Myungshin Kim, Yonggoo Kim & Kyungja Han. (2010) A Case of t(3;3)(q21;q26.2) Associated with Severe Multilineage Dysplasia and Multi-drug Resistance in Blastic Crisis of Chronic Myelogenous Leukemia. Annals of Laboratory Medicine 30:6, pages 595-599.
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Sanne LugthartStefan GröschelH. Berna BeverlooSabine KayserPeter J.M. ValkShama Lydia van Zelderen-BholaGert Jan OssenkoppeleEdo VellengaEva van den Berg-de RuiterUrs SchanzGregor VerhoefPeter VandenbergheAugustin FerrantClaus-Henning KöhneMichael PfreundschuhHeinz A. HorstElisabeth KollerMarie von Lilienfeld-ToalMartin BentzArnold GanserBrigitte SchlegelbergerMartine JotterandJürgen KrauterThomas PabstMatthias TheobaldRichard F. SchlenkRuud DelwelKonstanze DöhnerBob LöwenbergHartmut Döhner. (2010) Clinical, Molecular, and Prognostic Significance of WHO Type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and Various Other 3q Abnormalities in Acute Myeloid Leukemia. Journal of Clinical Oncology 28:24, pages 3890-3898.
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Barbara J. Bain. 2010. Leukaemia Diagnosis. Leukaemia Diagnosis 114 218 .
Bertil Johansson & Christine J. Harrison. 2010. Cancer Cytogenetics. Cancer Cytogenetics 45 139 .
Amy Heerema-McKenney & Daniel A. Arber. (2009) Acute Myeloid Leukemia. Hematology/Oncology Clinics of North America 23:4, pages 633-654.
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U Bacher, C Haferlach, S Schnittger, W Kern, N Kroeger, A R Zander & T Haferlach. (2009) Interactive diagnostics in the indication to allogeneic SCT in AML. Bone Marrow Transplantation 43:10, pages 745-756.
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Peter Valent. (2009) Clinical impact of genetic and molecular markers in myelodysplastic syndromes (MDS). memo - Magazine of European Medical Oncology 2:S1, pages 13-17.
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