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Leukemia & Lymphoma Volume 59, 2018 - Issue 6
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Original Article: Research

The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells

Noriyoshi IriyamaDepartment of Medicine, Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan; Correspondence[email protected]
,
Hirotsugu HinoDepartment of Biochemistry, Tokyo Medical University, Tokyo, Japan
,
Shota MoriyaDepartment of Biochemistry, Tokyo Medical University, Tokyo, Japan
,
Masaki HiramotoDepartment of Biochemistry, Tokyo Medical University, Tokyo, Japan
,
Yoshihiro HattaDepartment of Medicine, Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan;
,
Masami TakeiDepartment of Medicine, Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan;
&
Keisuke MiyazawaDepartment of Biochemistry, Tokyo Medical University, Tokyo, JapanCorrespondence[email protected]
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Pages 1439-1450 | Received 05 Apr 2017, Accepted 30 Aug 2017, Published online: 18 Sep 2017

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Jie Yao, Shuming Tang, Chenyan Shi, Yunzhi Lin, Lanlan Ge, Qinghua Chen, Baoru Ou, Dongyu Liu, Yuyang Miao, Qiujie Xie, Xudong Tang, Jia Fei, Guangyi Yang, Jun Tian & Xiaobin Zeng. (2023) Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma. Autophagy 19:4, pages 1221-1238.
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Foteini Theodorakakou, Meletios A. Dimopoulos & Efstathios Kastritis. (2021) Mutation-dependent treatment approaches for patients with complex multiple myeloma. Expert Review of Precision Medicine and Drug Development 6:3, pages 189-201.
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Laurence Booth, Jane L. Roberts, Rumeesa Rais, Richard E. Cutler$suffix/text()$suffix/text(), Irmina Diala, Alshad S. Lalani, Andrew Poklepovic & Paul Dent. (2019) Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition. Cancer Biology & Therapy 20:2, pages 157-168.
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Articles from other publishers (2)

S Parylo, A Vennepureddy, V Dhar, P Patibandla & A Sokoloff. (2018) Role of cyclin-dependent kinase 4/6 inhibitors in the current and future eras of cancer treatment. Journal of Oncology Pharmacy Practice 25:1, pages 110-129.
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Liandong Jing, Yanbo Tang & Zhiyan Xiao. (2018) Discovery of novel CDK inhibitors via scaffold hopping from CAN508. Bioorganic & Medicinal Chemistry Letters 28:8, pages 1386-1391.
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