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Applied Occupational and Environmental Hygiene Volume 11, 1996 - Issue 7: Proceedings of the 4th Symposium on Repirable Dust in the Mineral Industries
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X. Pulmonary Response-Dust Interaction: Enhanced Pulmonary Response to the Inhalation of Freshly Fractured Silica as Compared with Aged Dust Exposure: Vincent Castranova, William H. Pailes, Nar S. Dalal, Philip R. Miles, Linda Bowman, Val Vallyathan, Donna Pack, Kenneth C. Weber, Ann Hubbs, Dian Schwegler-Berry, Jean Xiang, Richard Dey, Jack Blackford, Jane Y.C. Ma, MarkBurger, Dale A. Shoemaker, Jack R. Pretty, Dawn M. Ramsey, Jeff L. McLaurin, Amir Khan, Paul A . Baron, Charles P. Children, Lloyd E. Stettler, and Alex W. Teass

Enhanced Pulmonary Response to the Inhalation of Freshly Fractured Silica as Compared with Aged Dust Exposure

Vincent Castranova Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
William H. Pailes Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
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Nar S. Dalai Department of Chemistry, West Virginia University, Morgantown, West Virginia, 26506, USA
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Philip R. Miles Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
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Linda Bowman Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
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Val Vallyathan Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
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Donna Pack Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Kenneth C. Weber Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Ann Hubbs Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Diane Schwegler-Berry Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Jean Xiang Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Richard Dey Department of Anatomy, West Virginia University, Morgantown, West Virginia, 26506, USA
,
Jack Blackford Department of Anatomy, West Virginia University, Morgantown, West Virginia, 26506, USA
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Jane Y.C. Ma Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Mark Barger Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA
,
Dale A. Shoemaker Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Jack R. Pretty Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Dawn M. Ramsey Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Jeff L. McLaurin Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Amir Khan Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Paul A. Baron Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Charles P. Childress Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
,
Lloyd E. Stettler Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
&
Alex W. Teass Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226, USA
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Pages 937-941 | Published online: 24 Feb 2011

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Paul J. A. Borm, Lang Tran & Ken Donaldson. (2011) The carcinogenic action of crystalline silica: A review of the evidence supporting secondary inflammation-driven genotoxicity as a principal mechanism. Critical Reviews in Toxicology 41:9, pages 756-770.
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W. Miles, W. F. Moll, R. D. Hamilton & R. K. Brown. (2008) Physicochemical and Mineralogical Characterization of Test Materials used in 28-Day and 90-Day Intratracheal Instillation Toxicology Studies in Rats. Inhalation Toxicology 20:11, pages 981-993.
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Jennifer S. Le Blond, Claire J. Horwell, Peter J. Baxter, Sabina A. K. Michnowicz, Maura Tomatis, Bice Fubini, Pierre Delmelle, Christina Dunster & Herman Patia. (2010) Mineralogical analyses and in vitro screening tests for the rapid evaluation of the health hazard of volcanic ash at Rabaul volcano, Papua New Guinea. Bulletin of Volcanology 72:9, pages 1077-1092.
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Marco Giovine, Marina Pozzolini, Ivana Fenoglio, Sonia Scarfi, Mara Ghiazza, Umberto Benatti & Bice Fubini. (2016) Crystalline silica incubated in ascorbic acid acquires a higher cytotoxic potential. Toxicology and Industrial Health 18:5, pages 249-255.
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Dale W. Porter, Mark Barger, Victor A. Robinson, Stephen S. Leonard, Douglas Landsittel & Vincent Castranova. (2002) Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the rat. Toxicology 175:1-3, pages 63-71.
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