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Toxicology Methods Volume 10, 2000 - Issue 4
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Research Article

CHARACTERIZATION OF AN APPROACH TO DEVELOPMENTAL IMMUNOTOXICOLOGY ASSESSMENT IN THE RAT USING SRBC AS THE ANTIGEN

Gregory S. Ladics The DuPont Company, Haskell Laboratory, Newark, Delaware, USA
,
Charlene Smith The DuPont Company, Haskell Laboratory, Newark, Delaware, USA
,
Terry L Bunn College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
,
Rodney R. Dietert College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
,
Phyllis K. Anderson Toxicology, Environmental Research and Consulting Laboratory, Dow Chemical Co., Midland, Michigan, USA
,
Connie M. Wiescinski Toxicology, Environmental Research and Consulting Laboratory, Dow Chemical Co., Midland, Michigan, USA
&
Michael P. Holsapple Toxicology, Environmental Research and Consulting Laboratory, Dow Chemical Co., Midland, Michigan, USA
 show all
Pages 283-311 | Published online: 30 Sep 2008

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Mark Collinge, Mitchell Thorn, Vanessa Peachee & Kimber White$suffix/text()$suffix/text(). (2013) Validation of a Candida albicans delayed-type hypersensitivity (DTH) model in female juvenile rats for use in immunotoxicity assessments. Journal of Immunotoxicology 10:4, pages 341-348.
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Mark Collinge, Leigh Ann Burns-Naas, Gary J. Chellman, Thomas T. Kawabata, Wendy J. Komocsar, Joseph R. Piccotti, Jacintha Shenton & Daniel Wierda. (2012) Developmental immunotoxicity (DIT) testing of pharmaceuticals: Current practices, state of the science, knowledge gaps, and recommendations. Journal of Immunotoxicology 9:2, pages 210-230.
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Rodney R. Dietert. (2008) Developmental immunotoxicology (DIT): windows of vulnerability, immune dysfunction and safety assessment. Journal of Immunotoxicology 5:4, pages 401-412.
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Gregory S. Ladics. (2007) Primary Immune Response to Sheep Red Blood Cells (SRBC) as the Conventional T-Cell Dependent Antibody Response (TDAR) Test. Journal of Immunotoxicology 4:2, pages 149-152.
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Articles from other publishers (29)

Suhas Sureshchandra, Nicole E Marshall & Ilhem Messaoudi. (2019) Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming. Journal of Leukocyte Biology 106:5, pages 1035-1050.
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M. Holsapple, R. Prell & S. Comstock. 2018. Comprehensive Toxicology. Comprehensive Toxicology 467 497 .
Gregory S. Ladics. 2018. Immunotoxicity Testing. Immunotoxicity Testing 83 94 .
George A. Parker, Catherine A. Picut, Cynthia Swanson & Jonathan D. Toot. (2015) Histologic Features of Postnatal Development of Immune System Organs in the Sprague-Dawley Rat. Toxicologic Pathology 43:6, pages 794-815.
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Darrell R. Boverhof, Greg Ladics, Bob Luebke, Jane Botham, Emanuela Corsini, Ellen Evans, Dori Germolec, Michael Holsapple, Scott E Loveless, Haitian Lu, Jan Willem van der Laan, Kimber L. WhiteJr.Jr. & Yung Yang. (2014) Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: A workshop summary. Regulatory Toxicology and Pharmacology 68:1, pages 96-107.
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Mary Sue Marty, Barbara H. Neal, Carol L. Zablotny, Barry L. Yano, Amanda K. Andrus, Michael R. Woolhiser, Darrell R. Boverhof, Shakil A. Saghir, Adam W. Perala, Julie K. Passage, Marie A. Lawson, James S. Bus, James C. LambIVIV & Larry Hammond. (2013) An F1-Extended One-Generation Reproductive Toxicity Study in Crl:CD(SD) Rats With 2,4-Dichlorophenoxyacetic Acid. Toxicological Sciences 136:2, pages 527-547.
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Bridgette D. Semple, Klas Blomgren, Kayleen Gimlin, Donna M. Ferriero & Linda J. Noble-Haeusslein. (2013) Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Progress in Neurobiology 106-107, pages 1-16.
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Leigh Ann Burns-Naas & Marc J. Pallardy. 2013. Nonclinical Safety Assessment. Nonclinical Safety Assessment 313 346 .
Michael P. Holsapple & Raegan O’Lone. (2012) Juvenile Immunotoxicology. Toxicologic Pathology 40:2, pages 248-254.
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Ronald D. HoodLeigh Ann Burns-Naas. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 491 508 .
Ghada Elmesallamy, Marwa Abass, Nahla Refat & Amal Atta. (2011) Differential effects of alprazolam and clonazepam on the immune system and blood vessels of non-stressed and stressed adult male albino rats. Interdisciplinary Toxicology 4:3, pages 132-143.
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LaRonda L. Morford, Christopher J. Bowman, Diann L. Blanset, Ingrid B. Bøgh, Gary J. Chellman, Wendy G. Halpern, Gerhard F. Weinbauer & Timothy P. Coogan. (2011) Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices. Birth Defects Research Part B: Developmental and Reproductive Toxicology, pages n/a-n/a.
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T.L. Guo & K.L. White. 2010. Comprehensive Toxicology. Comprehensive Toxicology 567 590 .
E.C.M. Tonk, A.H. Piersma & H. Van Loveren. 2010. Comprehensive Toxicology. Comprehensive Toxicology 249 269 .
Rodney R. Dietert. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Kiyoshi Kushima, Shozo Sakuma, Shuichi Furusawa & Michio Fujiwara. (2009) Prenatal administration of indomethacin modulates Th2 cytokines in juvenile rats. Toxicology Letters 185:1, pages 32-37.
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Rodney R. Dietert & Leigh Ann Burns-Naas. 2008. Immunotoxicology Strategies for Pharmaceutical Safety Assessment. Immunotoxicology Strategies for Pharmaceutical Safety Assessment 271 297 .
Leigh Ann Burns-Naas, Kenneth L. Hastings, Gregory S. Ladics, Susan L. Makris, George A. Parker & Michael P. Holsapple. (2008) What’s So Special about the Developing Immune System?. International Journal of Toxicology 27:2, pages 223-254.
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Gregory S. Ladics. (2007) Use of SRBC antibody responses for immunotoxicity testing. Methods 41:1, pages 9-19.
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Rodney R. Dietert & Michael P. Holsapple. (2007) Methodologies for developmental immunotoxicity (DIT) testing. Methods 41:1, pages 123-131.
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Paul C. Barrow, Françoise Horand & Guillaume Ravel. (2006) Developmental immunotoxicity investigations in the SD rat following pre- and post-natal exposure to cyclosporin. Birth Defects Research Part B: Developmental and Reproductive Toxicology 77:5, pages 430-437.
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J Seppen, N P van Til, R van der Rijt, J K Hiralall, C Kunne & R P J Oude Elferink. (2005) Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats. Gene Therapy 13:8, pages 672-677.
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Paul C. Barrow & Guillaume Ravel. (2005) Immune assessments in developmental and juvenile toxicology: Practical considerations for the regulatory safety testing of pharmaceuticals. Regulatory Toxicology and Pharmacology 43:1, pages 35-44.
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Tracey Zoetis, Melissa Tassinari, Cedo Bagi, Karen Walthall & Mark Hurtt. 2005. Developmental and Reproductive Toxicology. Developmental and Reproductive Toxicology 969 1130 .
Michael P Holsapple, Dennis J Paustenbach, Gail Charnley, Lori J West, Michael I Luster, Rodney R Dietert & Leigh Ann Burns-Naas. (2004) Symposium summary: Children's Health Risk—What's So Special about the Developing Immune System?. Toxicology and Applied Pharmacology 199:1, pages 61-70.
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. 2004. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology 327 354 .
Michael P. Holsapple, Lori J. West & Kenneth S. Landreth. (2003) Species comparison of anatomical and functional immune system development. Birth Defects Research Part B: Developmental and Reproductive Toxicology 68:4, pages 321-334.
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Michael I LusterJack H DeanDori R Germolec. (2003) Consensus workshop on methods to evaluate developmental immunotoxicity.. Environmental Health Perspectives 111:4, pages 579-583.
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M P Holsapple. (2016) Developmental immunotoxicology and risk assessment: a workshop summary. Human & Experimental Toxicology 21:9-10, pages 473-478.
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