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Journal of Environmental Science and Health, Part C
Environmental Carcinogenesis and Ecotoxicology Reviews
Volume 31, 2013 - Issue 4
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Original Articles

Friend or Foe? The Current Epidemiologic Evidence on Selenium and Human Cancer Risk

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Pages 305-341 | Published online: 30 Oct 2013

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Read on this site (2)

Marzieh Heydari, Mehdi Shayanfar, Giuve Sharifi, Parvane Saneei, Omid Sadeghi & Ahmad Esmaillzadeh. (2021) The Association between Dietary Total Antioxidant Capacity and Glioma in Adults. Nutrition and Cancer 73:10, pages 1947-1956.
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Ewa Jablonska & Marco Vinceti. (2015) Selenium and Human Health: Witnessing a Copernican Revolution?. Journal of Environmental Science and Health, Part C 33:3, pages 328-368.
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Articles from other publishers (68)

Marco Vinceti, Tommaso Filippini, Ashis Biswas, Bernhard Michalke, Karaj S. Dhillon & Ravi Naidu. 2024. Inorganic Contaminants and Radionuclides. Inorganic Contaminants and Radionuclides 427 480 .
Zixing Wang, Wentao Gu, Xiaobo Guo, Fang Xue, Jing Zhao, Wei Han, Hairong Li, Wangyue Chen, Yaoda Hu, Cuihong Yang, Luwen Zhang, Peng Wu, Yali Chen, Yujie Zhao, Jin Du & Jingmei Jiang. (2023) Spatial association of surface water quality and human cancer in China. npj Clean Water 6:1.
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Liting Zhang, Zhijun Wang, Yuanchen Liu, Xi Wang, Xiaoyang Xie & Li Zhang. (2023) Distribution Pattern and Influencing Factors of Soil Selenium in Northern Hebei Province, China. Geochemistry International 61:7, pages 750-767.
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Ying Sun, Zhineng Wang, Pin Gong, Wenbo Yao, Qian Ba & Hui Wang. (2023) Review on the health-promoting effect of adequate selenium status. Frontiers in Nutrition 10.
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Maurizio Tommasini. 2023. Chalcogen Chemistry: Fundamentals and Applications. Chalcogen Chemistry: Fundamentals and Applications 683 704 .
Tewodros Rango Godebo, Hannah Stoner, Pornpimol Kodsup, Mikaela Stoltzfus, Syprose Nyachoti, Sydney Atkins & Marc Jeuland. (2023) Selenium in drinking water and cereal grains, and biomarkers of Se status in urine and fingernails of the Main Ethiopian Rift Valley population. Journal of Trace Elements in Medicine and Biology, pages 127137.
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Marco Vinceti, Tommaso Filippini, Ewa Jablonska, Yoshiro Saito & Lauren A. Wise. (2022) Safety of selenium exposure and limitations of selenoprotein maximization: Molecular and epidemiologic perspectives. Environmental Research 211, pages 113092.
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Francesca Gorini & Cristina Vassalle. (2022) Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology. Antioxidants 11:6, pages 1188.
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Deepali Sharma, Aayushi Arora, Preeti Oswal, Anurag Bahuguna, Anupama Datta & Arun Kumar. (2022) Organosulphur and organoselenium compounds as emerging building blocks for catalytic systems for O -arylation of phenols, a C–O coupling reaction . Dalton Transactions 51:21, pages 8103-8132.
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Kaitlin H. Wade, James Yarmolinsky, Edward Giovannucci, Sarah J. Lewis, Iona Y. Millwood, Marcus R. Munafò, Fleur Meddens, Kimberley Burrows, Joshua A. Bell, Neil M. Davies, Daniela Mariosa, Noora Kanerva, Emma E. Vincent, Karl Smith-Byrne, Florence Guida, Marc J. Gunter, Eleanor Sanderson, Frank Dudbridge, Stephen Burgess, Marilyn C. Cornelis, Tom G. Richardson, Maria Carolina Borges, Jack Bowden, Gibran Hemani, Yoonsu Cho, Wes Spiller, Rebecca C. Richmond, Alice R. Carter, Ryan Langdon, Deborah A. Lawlor, Robin G. Walters, Karani Santhanakrishnan Vimaleswaran, Annie Anderson, Meda R. Sandu, Kate Tilling, George Davey Smith, Richard M. Martin & Caroline L. Relton. (2022) Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer. Cancer Causes & Control 33:5, pages 631-652.
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Francesca Gorini, Laura Sabatino, Alessandro Pingitore & Cristina Vassalle. (2021) Selenium: An Element of Life Essential for Thyroid Function. Molecules 26:23, pages 7084.
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Teresa Urbano, Tommaso Filippini, Daniela Lasagni, Tiziana De Luca, Peter Grill, Sabrina Sucato, Elisa Polledri, Guy Djeukeu Noumbi, Marcella Malavolti, Annalisa Santachiara, Thelma A. Pertinhez, Roberto Baricchi, Silvia Fustinoni, Bernhard Michalke & Marco Vinceti. (2021) Association of Urinary and Dietary Selenium and of Serum Selenium Species with Serum Alanine Aminotransferase in a Healthy Italian Population. Antioxidants 10:10, pages 1516.
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Barbara R. Cardoso, Sabine Braat & Ross M. Graham. (2021) Selenium Status Is Associated With Insulin Resistance Markers in Adults: Findings From the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES). Frontiers in Nutrition 8.
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Marco Vinceti, Marialaura Bonaccio, Tommaso Filippini, Simona Costanzo, Lauren A. Wise, Augusto Di Castelnuovo, Emilia Ruggiero, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano & Licia Iacoviello. (2021) Dietary selenium intake and risk of hospitalization for type 2 diabetes in the Moli-sani study cohort. Nutrition, Metabolism and Cardiovascular Diseases 31:6, pages 1738-1746.
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Marco Vinceti, Tommaso Filippini, Lauren A. Wise & Kenneth J. Rothman. (2021) A systematic review and dose-response meta-analysis of exposure to environmental selenium and the risk of type 2 diabetes in nonexperimental studies. Environmental Research 197, pages 111210.
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Minhao Xie, Xinyang Sun, Peng Li, Xinchun Shen & Yong Fang. (2021) Selenium in cereals: Insight into species of the element from total amount. Comprehensive Reviews in Food Science and Food Safety 20:3, pages 2914-2940.
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Nikolay Solovyev, Evgenii Drobyshev, Bastian Blume & Bernhard Michalke. (2021) Selenium at the Neural Barriers: AReview. Frontiers in Neuroscience 15.
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Natanael Endrew Souto Maior Torres Bonfim, Adrivanio Baranoski & Mário Sérgio Mantovani. (2020) Cytotoxicity of sodium selenite in HaCaT cells induces cell death and alters the mRNA expression of PUMA, ATR, and mTOR genes. Journal of Trace Elements in Medicine and Biology 62, pages 126605.
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Merl F. Raisbeck. (2020) Selenosis in Ruminants. Veterinary Clinics of North America: Food Animal Practice 36:3, pages 775-789.
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Dan Guo, Michael Hendryx, Xiaoyun Liang, JoAnn E. Manson, Ka He, Mara Z. Vitolins, Yueyao Li & Juhua Luo. (2020) Association between selenium intake and breast cancer risk: results from the Women’s Health Initiative. Breast Cancer Research and Treatment 183:1, pages 217-226.
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Rajinder Chawla, Tommaso Filippini, Rinchu Loomba, Silvia Cilloni, Karaj S. Dhillon & Marco Vinceti. (2020) Exposure to a high selenium environment in Punjab, India: Biomarkers and health conditions. Science of The Total Environment 719, pages 134541.
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Isaac A. Adedara, Adekola T. Fabunmi, Folashade C. Ayenitaju, Oluwadarasimi E. Atanda, Adetutu A. Adebowale, Babajide O. Ajayi, Olatunde Owoeye, Joao B.T. Rocha & Ebenezer O. Farombi. (2020) Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats. NeuroToxicology 76, pages 99-110.
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Marco Vinceti, Bernhard Michalke, Carlotta Malagoli, Marcel Eichmüller, Tommaso Filippini, Manuela Tondelli, Annalisa Bargellini, Giulia Vinceti, Giovanna Zamboni & Annalisa Chiari. (2019) Selenium and selenium species in the etiology of Alzheimer’s dementia: The potential for bias of the case-control study design. Journal of Trace Elements in Medicine and Biology 53, pages 154-162.
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M. Vinceti, R. Chawla, T. Filippini, C. Dutt, S. Cilloni, R. Loomba, A. Bargellini, N. Orsini, K.S. Dhillon & P. Whelton. (2019) Blood pressure levels and hypertension prevalence in a high selenium environment: results from a cross-sectional study. Nutrition, Metabolism and Cardiovascular Diseases 29:4, pages 398-408.
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Natalie H. Matthews, Katherine Fitch, Wen-Qing Li, J. Steven Morris, David C. Christiani, Abrar A. Qureshi & Eunyoung Cho. (2019) Exposure to Trace Elements and Risk of Skin Cancer: A Systematic Review of Epidemiologic Studies. Cancer Epidemiology, Biomarkers & Prevention 28:1, pages 3-21.
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Marco Vinceti, Tommaso Filippini & Lauren A. Wise. (2018) Environmental Selenium and Human Health: an Update. Current Environmental Health Reports 5:4, pages 464-485.
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Mostafa Elhodaky & Alan Diamond. (2018) Selenium-Binding Protein 1 in Human Health and Disease. International Journal of Molecular Sciences 19:11, pages 3437.
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Natalia V. Dolgova, Susan Nehzati, Sanjukta Choudhury, Tracy C. MacDonald, Nathan R. Regnier, Andrew M. Crawford, Olena Ponomarenko, Graham N. George & Ingrid J. Pickering. (2018) X-ray spectroscopy and imaging of selenium in living systems. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:11, pages 2383-2392.
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James Yarmolinsky, Kaitlin H. Wade, Rebecca C. Richmond, Ryan J. Langdon, Caroline J. Bull, Kate M. Tilling, Caroline L. Relton, Sarah J. Lewis, George Davey Smith & Richard M. Martin. (2018) Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?. Cancer Epidemiology, Biomarkers & Prevention 27:9, pages 995-1010.
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Marco Vinceti, Tommaso Filippini & Kenneth J. Rothman. (2018) Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. European Journal of Epidemiology 33:9, pages 789-810.
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Tommaso Filippini, Bernhard Michalke, Lauren A. Wise, Carlotta Malagoli, Marcella Malavolti, Luciano Vescovi, Chiara Salvia, Annalisa Bargellini, Sabina Sieri, Vittorio Krogh, Margherita Ferrante & Marco Vinceti. (2018) Diet composition and serum levels of selenium species: A cross-sectional study. Food and Chemical Toxicology 115, pages 482-490.
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Baijiao An, Bo Wang, Jinhui Hu, Shaoyu Xu, Ling Huang, Xingshu Li & Albert S. C. Chan. (2018) Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents. Journal of Medicinal Chemistry 61:6, pages 2571-2588.
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Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice PA Zeegers, Markus Horneber, Roberto D'Amico & Catherine M Crespi. (2018) Selenium for preventing cancer. Cochrane Database of Systematic Reviews 2020:2.
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Baijiao An, Shun Zhang, Jinhui Hu, Tingting Pan, Ling Huang, Johnny Cheuk-on Tang, Xingshu Li & Albert S. C. Chan. (2018) The design, synthesis and evaluation of selenium-containing 4-anilinoquinazoline hybrids as anticancer agents and a study of their mechanism. Organic & Biomolecular Chemistry 16:25, pages 4701-4714.
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Wei Li, Milton Talukder, Xue-Tong Sun, Cong Zhang, Xue-Nan Li, Jing Ge & Jin-Long Li. (2018) Selenoprotein W as a molecular target of d -amino acid oxidase is regulated by d -amino acid in chicken neurons . Metallomics 10:5, pages 751-758.
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Tommaso Filippini, Bernhard Michalke, Jessica Mandrioli, Aristidis M. Tsatsakis, Jennifer Weuve & Marco Vinceti. 2018. Selenium. Selenium 231 248 .
Eder João Lenardão, Claudio Santi & Luca SancinetoEder João Lenardão, Claudio Santi & Luca Sancineto. 2018. New Frontiers in Organoselenium Compounds. New Frontiers in Organoselenium Compounds 99 143 .
Marco Vinceti, Annalisa Chiari, Marcel Eichmüller, Kenneth J. Rothman, Tommaso Filippini, Carlotta Malagoli, Jennifer Weuve, Manuela Tondelli, Giovanna Zamboni, Paolo F. Nichelli & Bernhard Michalke. (2017) A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment. Alzheimer's Research & Therapy 9:1.
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Tommaso Filippini, Angela Ferrari, Bernhard Michalke, Peter Grill, Luciano Vescovi, Chiara Salvia, Carlotta Malagoli, Marcella Malavolti, Sabina Sieri, Vittorio Krogh, Annalisa Bargellini, Antonio Martino, Margherita Ferrante & Marco Vinceti. (2017) Toenail selenium as an indicator of environmental exposure: A cross-sectional study. Molecular Medicine Reports 15:5, pages 3405-3412.
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Marco Vinceti, Tommaso Filippini, Silvia Cilloni, Annalisa Bargellini, Anna Valeria Vergoni, Aristides Tsatsakis & Margherita Ferrante. (2017) Health risk assessment of environmental selenium: Emerging evidence and challenges. Molecular Medicine Reports 15:5, pages 3323-3335.
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Tanja Wiesenhofer, Kevin A. Francesconi & Doris Kuehnelt. (2017) A time-efficient flow injection/ICPMS method for the direct determination of total selenium in human urine. Microchemical Journal 130, pages 310-315.
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Claudia Lennicke, Jette Rahn, Anna P. Kipp, Biljana P. Dojčinović, Andreas S. Müller, Ludger A. Wessjohann, Rudolf Lichtenfels & Barbara Seliger. (2017) Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice. Biochimica et Biophysica Acta (BBA) - General Subjects 1861:1, pages 3323-3334.
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Marco Vinceti, Tommaso Filippini, Silvia Cilloni & Catherine M. Crespi. 2017. Selenium and Selenoproteins in Cancer. Selenium and Selenoproteins in Cancer 1 48 .
Dolph Lee Hatfield, Bradley Allen Carlson, Petra Akiko Tsuji, Ryuta Tobe & Vadim N. Gladyshev. 2017. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals 463 473 .
Marco Vinceti, Paola Ballotari, Craig Steinmaus, Carlotta Malagoli, Ferdinando Luberto, Marcella Malavolti & Paolo Giorgi Rossi. (2016) Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water. Environmental Research 150, pages 348-356.
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Marco Vinceti & Kenneth J Rothman. (2016) More results but no clear conclusion on selenium and cancer. The American Journal of Clinical Nutrition 104:2, pages 245-246.
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Jagoda K. Wrobel, Gretchen Wolff, Rijin Xiao, Ronan F. Power & Michal Toborek. (2015) Dietary Selenium Supplementation Modulates Growth of Brain Metastatic Tumors and Changes the Expression of Adhesion Molecules in Brain Microvessels. Biological Trace Element Research 172:2, pages 395-407.
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Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin & Arun K. Sharma. (2016) Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents. Journal of Medicinal Chemistry 59:5, pages 1946-1959.
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Beatriz Romano, Juan Antonio Palop, Carmen Sanmart?n & Elena Lizarraga. (2015) Thermal analysis of novel selenocarbamates. Journal of Thermal Analysis and Calorimetry 123:3, pages 1951-1962.
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Xianlei Cai, Chen Wang, Wanqi Yu, Wenjie Fan, Shan Wang, Ning Shen, Pengcheng Wu, Xiuyang Li & Fudi Wang. (2016) Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Scientific Reports 6:1.
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N. V. Dolgova, M. J. Hackett, T. C. MacDonald, S. Nehzati, A. K. James, P. H. Krone, G. N. George & I. J. Pickering. (2016) Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms. Metallomics 8:3, pages 305-312.
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Petra A. Tsuji, Bradley A. Carlson, Byeong Jae Lee, Vadim N. Gladyshev & Dolph L. Hatfield. 2016. Selenium. Selenium 441 449 .
Marco Vinceti, Barbara Burlingame, Tommaso Filippini, Androniki Naska, Annalisa Bargellini & Paola Borella. 2016. Selenium. Selenium 365 376 .
Doris Kuehnelt, Karin Engström, Helena Skröder, Sabine Kokarnig, Carina Schlebusch, Maria Kippler, Ayman Alhamdow, Barbro Nermell, Kevin Francesconi, Karin Broberg & Marie Vahter. (2015) Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene. The American Journal of Clinical Nutrition 102:6, pages 1406-1415.
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Nikolay D. Solovyev. (2015) Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling. Journal of Inorganic Biochemistry 153, pages 1-12.
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Ryuta Tobe, Bradley Carlson, Petra Tsuji, Byeong Lee, Vadim Gladyshev & Dolph Hatfield. (2015) Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers 7:4, pages 2262-2276.
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Karam El-Bayoumy, Raghu Sinha & John RichieJrJr. 2015. Diversity of Selenium Functions in Health and Disease. Diversity of Selenium Functions in Health and Disease 137 170 .
Ethiene Estevam, Karolina Witek, Lisa Faulstich, Muhammad Nasim, Gniewomir Latacz, Enrique Domínguez-Álvarez, Katarzyna Kieć-Kononowicz, Marilene Demasi, Jadwiga Handzlik & Claus Jacob. (2015) Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design. Molecules 20:8, pages 13894-13912.
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Marco Vinceti, Peter Grill, Carlotta Malagoli, Tommaso Filippini, Simone Storani, Marcella Malavolti & Bernhard Michalke. (2015) Selenium speciation in human serum and its implications for epidemiologic research: a cross-sectional study. Journal of Trace Elements in Medicine and Biology 31, pages 1-10.
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Yinjiu Huang, Xiaomei Hu, Gang Liu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang, Yuyuan Zhang & Yanan Pu. (2014) A potential anticancer agent 1,2-di(quinazolin-4-yl)diselane induces apoptosis in non-small-cell lung cancer A549 cells. Medicinal Chemistry Research 24:5, pages 2085-2096.
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Ram B. Jain & Y. Sammy Choi. (2015) Normal reference ranges for and variability in the levels of blood manganese and selenium by gender, age, and race/ethnicity for general U.S. population. Journal of Trace Elements in Medicine and Biology 30, pages 142-152.
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David J. Hughes, Veronika Fedirko, Mazda Jenab, Lutz Schomburg, Catherine M?plan, Heinz Freisling, H.Bas Bueno-de-Mesquita, Sandra Hybsier, Niels-Peter Becker, Magdalena Czuban, Anne Tj?nneland, Malene Outzen, Marie-Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman K?hn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Petra H Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria-Dolores Chirlaque, Maria-Jose S?nchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ram?n Quir?s, Magdalena Stepien, So Yeon Kong, Talita Duarte-Salles, Elio Riboli & John E. Hesketh. (2015) Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International Journal of Cancer 136:5, pages 1149-1161.
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Marco Vinceti, Sara Grioni, Dorothea Alber, Dario Consonni, Carlotta Malagoli, Claudia Agnoli, Marcella Malavolti, Valeria Pala, Vittorio Krogh & Sabina Sieri. (2015) Toenail selenium and risk of type 2 diabetes: the ORDET cohort study. Journal of Trace Elements in Medicine and Biology 29, pages 145-150.
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Xiaokang Zhu, Mingdong Jiang, Erqun Song, Xiaoji Jiang & Yang Song. (2015) Selenium deficiency sensitizes the skin for UVB-induced oxidative damage and inflammation which involved the activation of p38 MAPK signaling. Food and Chemical Toxicology 75, pages 139-145.
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Marco Vinceti, Jessica Mandrioli, Paola Borella, Bernhard Michalke, Aristidis Tsatsakis & Yoram Finkelstein. (2014) Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies. Toxicology Letters 230:2, pages 295-303.
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Merrill J. Christensen. (2014) Selenium and Prostate Cancer Prevention: What Next—If Anything?. Cancer Prevention Research 7:8, pages 781-785.
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Julia E. Heck, Andrew S. Park, Jiaheng Qiu, Myles Cockburn & Beate Ritz. (2014) Risk of leukemia in relation to exposure to ambient air toxics in pregnancy and early childhood. International Journal of Hygiene and Environmental Health 217:6, pages 662-668.
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Marco Vinceti, Gabriele Dennert, Catherine M Crespi, Marcel Zwahlen, Maree Brinkman, Maurice PA Zeegers, Markus Horneber, Roberto D'Amico & Cinzia Del Giovane. (2014) Selenium for preventing cancer. Cochrane Database of Systematic Reviews.
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