Friend or Foe? The Current Epidemiologic Evidence on Selenium and Human Cancer Risk

REFERENCES

• Brozmanova , J , Manikova , D , Vlckova , V and Chovanec , M. 2010 . Selenium: a double-edged sword for defense and offence in cancer . Arch Toxicol. , 84 : 919 – 938 .
   PubMed Web of Science ®Google Scholar
• Dennert , G , Zwahlen , M , Brinkman , M , Vinceti , M , Zeegers , M P and Horneber , M. 2011 . Selenium for preventing cancer . Cochrane Database Syst Rev. , 5 : CD005195
   PubMed Web of Science ®Google Scholar
• Bodnar , M , Konieczka , P and Namiesnik , J. 2012 . The properties, functions, and use of selenium compounds in living organisms . J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. , 30 : 225 – 252 .
   PubMed Web of Science ®Google Scholar
• Steinbrenner , H , Speckmann , B and Sies , H. 2013 . Towards understanding success and failures in the use of selenium for cancer prevention . Antioxid Redox Signal. , 19 : 181 – 191 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Maraldi , T , Bergomi , M and Malagoli , C. 2009 . Risk of chronic low-dose selenium overexposure in humans: insights from epidemiology and biochemistry . Rev Environ Health. , 24 : 231 – 248 .
   PubMedGoogle Scholar
• Frost , DV. 1972 . The two faces of selenium—can selenophobia be cured? . CRC Crit Rev Toxicol. , 1 : 467 – 514 .
   PubMedGoogle Scholar
• Casey , CE. 1988 . Selenophilia . Proc Nutr Soc. , 47 : 55 – 62 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Solovyev , N , Mandrioli , J , Crespi , C M , Bonvicini , F , Arcolin , E , Georgoulopoulou , E and Michalke , B. 2013 . Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite . Neurotoxicology. , 38 : 25 – 32 .
   PubMed Web of Science ®Google Scholar
• Rees , K , Hartley , L , Day , C , Flowers , N , Clarke , A and Stranges , S. 2013 . Selenium supplementation for the primary prevention of cardiovascular disease . Cochrane Database Syst Rev. , 1 : CD009671
   PubMedGoogle Scholar
• Rocourt , C R , Wu , M , Chen , B P and Cheng , WH. 2012 . The catalytic subunit of DNA-dependent protein kinase is downstream of ATM and feeds forward oxidative stress in the selenium-induced senescence response . J Nutr Biochem. , 24 : 781 – 787 .
   PubMed Web of Science ®Google Scholar
• Sunde , RA. 2012 . “ Selenium ” . In Modern Nutrition in Health and Disease. 11th Ed , Edited by: Ross , A C , Caballero , B , Cousins , R J , Tucker , K L and Ziegler , T R . 225 – 237 . Philadelphia : Lippincott Williams & Wilkins .
   Google Scholar
• Nelson , A A , Fitzhugh , O G and Calvery , HO. 1943 . Liver tumors following cirrhosis caused by selenium in rats . Cancer Res. , 3 : 230 – 236 .
   Google Scholar
• Birt , D F , Julius , A D , Runice , C E , White , L T , Lawson , T and Pour , PM. 1988 . Enhancement of BOP-induced pancreatic carcinogenesis in selenium-fed Syrian golden hamsters under specific dietary conditions . Nutr Cancer. , 11 : 21 – 33 .
   PubMed Web of Science ®Google Scholar
• 2011 . National Toxicology Program. Selenium sulfide . Rep Carcinog. , 12 : 376 – 377 .
   PubMedGoogle Scholar
• Clayton , C C and Baumann , CA. 1949 . Diet and azo dye tumors: effect of diet during a period when the dye is not fed . Cancer Res. , 9 : 575 – 582 .
   PubMed Web of Science ®Google Scholar
• Jackson , M I and Combs , G F Jr. 2008 . Selenium and anticarcinogenesis: underlying mechanisms . Curr Opin Clin Nutr Metab Care. , 11 : 718 – 726 .
   PubMed Web of Science ®Google Scholar
• Csallany , A S , Su , L C and Menken , BZ. 1984 . Effect of selenite, vitamin E and N,N’-diphenyl-p-phenylenediamine on liver organic solvent-soluble lipofuscin pigments in mice . J Nutr. , 114 : 1582 – 1587 .
   PubMed Web of Science ®Google Scholar
• Lu , J , Jiang , C , Kaeck , M , Ganther , H , Vadhanavikit , S , Ip , C and Thompson , H. 1995 . Dissociation of the genotoxic and growth inhibitory effects of selenium . Biochem Pharmacol. , 50 : 213 – 219 .
   PubMed Web of Science ®Google Scholar
• Hatfield , D L , Yoo , M H , Carlson , B A and Gladyshev , VN. 2009 . Selenoproteins that function in cancer prevention and promotion . Biochim Biophys Acta. , 1790 : 1541 – 1545 .
   PubMed Web of Science ®Google Scholar
• Kasaikina , M V , Lobanov , A V , Malinouski , M Y , Lee , B C , Seravalli , J Fomenko , D E . 2011 . Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression . J Biol Chem. , 286 : 17005 – 17014 .
   PubMed Web of Science ®Google Scholar
• Shamberger , R J and Frost , DV. 1969 . Possible protective effect of selenium against human cancer . Can Med Assoc J. , 100 : 682
   PubMed Web of Science ®Google Scholar
• Shamberger , R J , Tytko , S A and Willis , CE. 1976 . Antioxidants and cancer. Part VI. Selenium and age-adjusted human cancer mortality . Arch Environ Health. , 31 : 231 – 235 .
   PubMedGoogle Scholar
• Schrauzer , G N , White , D A and Schneider , CJ. 1977 . Cancer mortality correlation studies—III: statistical associations with dietary selenium intakes . Bioinorg Chem. , 7 : 23 – 31 .
   PubMedGoogle Scholar
• Jansson , B , Jacobs , M M and Griffin , AC. 1978 . Gastrointestinal cancer: epidemiology and experimental studies . Adv Exp Med Biol. , 91 : 305 – 321 .
   Google Scholar
• Cech , I , Holguin , A , Sokolow , H and Smith , V. 1984 . Selenium availability in Texas: possible clinical significance . South Med J. , 77 : 1415 – 1420 .
   PubMed Web of Science ®Google Scholar
• Clark , L C , Cantor , K P and Allaway , WH. 1991 . Selenium in forage crops and cancer mortality in U.S. counties . Arch Environ Health. , 46 : 37 – 42 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Rovesti , S , Bergomi , M and Vivoli , G. 2000 . The epidemiology of selenium and human cancer . Tumori. , 86 : 105 – 118 .
   PubMed Web of Science ®Google Scholar
• Guo , W , Chow , W , Zheng , W , Li , J and Blot , WJ. 1994 . Diet, serum markers and breast cancer mortality in China . Jpn J Cancer Res. , 85 : 572 – 577 .
   PubMedGoogle Scholar
• Semnani , S , Roshandel , G , Zendehbad , A , Keshtkar , A , Rahimzadeh , H , Abdolahi , N , Besharat , S , Moradi , A , Mirkarimi , H and Hasheminasab , S. 2010 . Soils selenium level and esophageal cancer: an ecological study in a high risk area for esophageal cancer . J Trace Elem Med Biol. , 24 : 174 – 177 .
   PubMed Web of Science ®Google Scholar
• Zhang , L , Lv , J and Liao , C. 2012 . Dietary exposure estimates of 14 trace elements in Xuanwei and Fuyuan, two high lung cancer incidence areas in China . Biol Trace Elem Res. , 146 : 287 – 292 .
   PubMed Web of Science ®Google Scholar
• Krogh , V , Pala , V , Vinceti , M , Berrino , F , Ganzi , A Micheli , A . 2003 . Toenail selenium as biomarker: reproducibility over a one-year period and factors influencing reproducibility . J Trace Elem Med Biol. , 17 ( Suppl 1 ) : 31 – 36 .
   PubMedGoogle Scholar
• Solovyev , N , Berthele , A and Michalke , B. 2013 . Selenium speciation in paired serum and cerebrospinal fluid samples . Anal Bioanal Chem. , 405 : 1875 – 1884 .
   PubMed Web of Science ®Google Scholar
• Swanson , C A , Longnecker , M P , Veillon , C , Howe , M , Levander , O A , Taylor , P R , McAdam , P A , Brown , C C , Stampfer , M J and Willett , WC. 1990 . Selenium intake, age, gender, and smoking in relation to indices of selenium status of adults residing in a seleniferous area . Am J Clin Nutr. , 52 : 858 – 862 .
   PubMed Web of Science ®Google Scholar
• van den Brandt , P A , Goldbohm , R A , van't Veer , P , Bode , P , Hermus , R J and Sturmans , F. 1993 . Predictors of toenail selenium levels in men and women . Cancer Epidemiol Biomarkers Prev. , 2 : 107 – 112 .
   PubMed Web of Science ®Google Scholar
• Ovaskainen , M L , Virtamo , J , Alfthan , G , Haukka , J , Pietinen , P , Taylor , P R and Huttunen , JK. 1993 . Toenail selenium as an indicator of selenium intake among middle-aged men in an area with low soil selenium . Am J Clin Nutr. , 57 : 662 – 665 .
   PubMed Web of Science ®Google Scholar
• Longnecker , M P , Stram , D O , Taylor , P R , Levander , O A , Howe , M Veillon , C . 1996 . Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake . Epidemiology. , 7 : 384 – 390 .
   PubMed Web of Science ®Google Scholar
• Pestitschek , M , Sonneck-Koenne , C , Zakavi , S R , Li , S , Knoll , P and Mirzaei , S. 2013 . Selenium intake and selenium blood levels: a novel food frequency questionnaire . Wien Klin Wochenschr. , 125 : 160 – 164 .
   PubMed Web of Science ®Google Scholar
• Hunter , D J , Morris , J S , Chute , C G , Kushner , E , Colditz , G A , Stampfer , M J , Speizer , F E and Willett , WC. 1990 . Predictors of selenium concentration in human toenails . Am J Epidemiol. , 132 : 114 – 122 .
   PubMed Web of Science ®Google Scholar
• Karita , K , Sasaki , S , Ishihara , J and Tsugane , S. 2003 . Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study to assess selenium intake: comparison with dietary records and blood levels . J Epidemiol. , 13 : S92 – 97 .
   PubMed Web of Science ®Google Scholar
• Satia , J A , King , I B , Morris , J S , Stratton , K and White , E. 2006 . Toenail and plasma levels as biomarkers of selenium exposure . Ann Epidemiol. , 16 : 53 – 58 .
   PubMed Web of Science ®Google Scholar
• Salbe , A D and Levander , OA. 1990 . Effect of various dietary factors on the deposition of selenium in the hair and nails of rats . J Nutr. , 120 : 200 – 206 .
   PubMed Web of Science ®Google Scholar
• Salbe , A D and Levander , OA. 1990 . Comparative toxicity and tissue retention of selenium in methionine-deficient rats fed sodium selenate or L-selenomethionine . J Nutr. , 120 : 207 – 212 .
   PubMed Web of Science ®Google Scholar
• Panter , K E , Hartley , W J , James , L F , Mayland , H F , Stegelmeier , B L and Kechele , PO. 1996 . Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs . Fund Appl Toxicol. , 32 : 217 – 223 .
   PubMedGoogle Scholar
• Ashton , K , Hooper , L , Harvey , L J , Hurst , R , Casgrain , A and Fairweather-Tait , SJ. 2009 . Methods of assessment of selenium status in humans: a systematic review . Am J Clin Nutr. , 89 : 2025S – 2039S .
   PubMed Web of Science ®Google Scholar
• Maraldi , T , Riccio , M , Zambonin , L , Vinceti , M , De Pol , A and Hakim , G. 2011 . Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation . Neurotoxicology. , 32 : 180 – 187 .
   PubMed Web of Science ®Google Scholar
• Thomas , J K and Janz , DM. 2011 . Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response . Aquat Toxicol. , 102 : 79 – 86 .
   PubMed Web of Science ®Google Scholar
• Lu , Y , Zhang , A , Li , C , Zhang , P , Su , X , Li , Y , Mu , C and Li , T. 2013 . The link between selenium binding protein from Sinonovacula constricta and environmental pollutions exposure . Fish Shellfish Immunol. , 35 : 271 – 277 .
   PubMed Web of Science ®Google Scholar
• Pacitti , D , Wang , T , Page , M M , Martin , S A , Sweetman , J , Feldmann , J and Secombes , CJ. 2013 . Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure . Aquat Toxicol. , 130–131 : 97 – 111 .
   PubMed Web of Science ®Google Scholar
• Lee , E H , Myung , S K , Jeon , Y J , Kim , Y , Chang , Y J , Ju , W , Seo , H G and Huh , BY. 2011 . Effects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials . Nutr Cancer. , 63 : 1185 – 1195 .
   PubMed Web of Science ®Google Scholar
• Hurst , R , Hooper , L , Norat , T , Lau , R , Aune , D Greenwood , D C . 2012 . Selenium and prostate cancer: systematic review and meta-analysis . Am J Clin Nutr. , 96 : 111 – 122 .
   PubMed Web of Science ®Google Scholar
• Takata , Y , Kristal , A R , King , I B , Song , X , Diamond , A M Foster , C B . 2011 . Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis . Cancer Epidemiol Biomarkers Prev. , 20 : 1822 – 1830 .
   PubMed Web of Science ®Google Scholar
• Hansen , R D , Albieri , V , Tjonneland , A , Overvad , K , Andersen , K K and Raaschou-Nielsen , O. 2013 . Effects of smoking and antioxidant micronutrients on risk of colorectal cancer . Clin Gastroenterol Hepatol. , 11 : 406 – 415 e3 .
   PubMed Web of Science ®Google Scholar
• Menkes , M S , Comstock , G W , Vuilleumier , J P , Helsing , K J , Rider , A A and Brookmeyer , R. 1986 . Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer . N Engl J Med. , 315 : 1250 – 1254 .
   PubMed Web of Science ®Google Scholar
• van Noord , P A , Maas , M J , van der Tweel , I and Collette , C. 1993 . Selenium and the risk of postmenopausal breast cancer in the DOM cohort . Breast Cancer Res Treat. , 25 : 11 – 19 .
   PubMed Web of Science ®Google Scholar
• Garland , M , Morris , J S , Stampfer , M J , Colditz , G A , Spate , V L , Baskett , C K , Rosner , B , Speizer , F E , Willett , W C and Hunter , DJ. 1995 . Prospective study of toenail selenium levels and cancer among women . J Natl Cancer Inst. , 87 : 497 – 505 .
   PubMed Web of Science ®Google Scholar
• Hartman , T J , Albanes , D , Pietinen , P , Hartman , A M , Rautalahti , M , Tangrea , J A and Taylor , PR. 1998 . The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study . Cancer Epidemiol Biomarkers Prev. , 7 : 335 – 340 .
   PubMed Web of Science ®Google Scholar
• Ratnasinghe , D , Tangrea , J A , Forman , M R , Hartman , T , Gunter , E W Qiao , Y L . 2000 . Serum tocopherols, selenium and lung cancer risk among tin miners in China . Cancer Causes Control. , 11 : 129 – 135 .
   PubMed Web of Science ®Google Scholar
• Suadicani , P , Hein , H O and Gyntelberg , F. 2012 . Serum selenium level and risk of lung cancer mortality: a 16-year follow-up of the Copenhagen Male Study . Eur Respir J. , 39 : 1443 – 1448 .
   PubMed Web of Science ®Google Scholar
• Salonen , J T , Alfthan , G , Huttunen , J K and Puska , P. 1984 . Association between serum selenium and the risk of cancer . Am J Epidemiol. , 120 : 342 – 349 .
   PubMed Web of Science ®Google Scholar
• Knekt , P , Aromaa , A , Maatela , J , Alfthan , G , Aaran , R K , Hakama , M , Hakulinen , T , Peto , R and Teppo , L. 1990 . Serum selenium and subsequent risk of cancer among Finnish men and women . J Natl Cancer Inst. , 82 : 864 – 868 .
   PubMed Web of Science ®Google Scholar
• Combs , G F Jr. 2001 . Selenium in global food systems . Br J Nutr. , 85 : 517 – 547 .
   PubMed Web of Science ®Google Scholar
• Valdiglesias , V , Pasaro , E , Mendez , J and Laffon , B. 2010 . In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review . Arch Toxicol. , 84 : 337 – 351 .
   PubMed Web of Science ®Google Scholar
• Nogueira , C W and Rocha , JB. 2011 . Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds . Arch Toxicol. , 85 : 1313 – 1359 .
   PubMed Web of Science ®Google Scholar
• Benko , I , Nagy , G , Tanczos , B , Ungvari , E , Sztrik , A , Eszenyi , P , Prokisch , J and Banfalvi , G. 2012 . Subacute toxicity of nano-selenium compared to other selenium species in mice . Environ Toxicol Chem. , 31 : 2812 – 2820 .
   PubMed Web of Science ®Google Scholar
• Weekley , C M , Aitken , J B , Finney , L , Vogt , S , Witting , P K and Harris , HH. 2013 . Selenium metabolism in cancer cells: the combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems . Nutrients. , 5 : 1734 – 1756 .
   PubMed Web of Science ®Google Scholar
• Hazane-Puch , F , Champelovier , P , Arnaud , J , Garrel , C , Ballester , B , Faure , P and Laporte , F. 2013 . Long-term selenium supplementation in HaCaT cells: importance of chemical form for antagonist (protective versus toxic) activities . Biol Trace Elem Res. , 154 : 288 – 298 .
   PubMed Web of Science ®Google Scholar
• Borella , P , Bargellini , A and Medici , CI. 1996 . Chemical form of selenium greatly affects metal uptake and responses by cultured human lymphocytes . Biol Trace Elem Res. , 51 : 43 – 54 .
   PubMed Web of Science ®Google Scholar
• Kim , C Y , Kim , G N , Wiacek , J L , Chen , C Y and Kim , KH. 2012 . Selenate inhibits adipogenesis through induction of transforming growth factor-beta1 (TGF-beta1) signaling . Biochem Biophys Res Commun. , 426 : 551 – 557 .
   PubMed Web of Science ®Google Scholar
• Kipp , A P , Frombach , J , Deubel , S and Brigelius-Flohe , R. 2013 . Selenoprotein w as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis . Methods Enzymol. , 527 : 87 – 112 .
   PubMed Web of Science ®Google Scholar
• Davis , T Z , Stegelmeier , B L , Welch , K D , Pfister , J A , Panter , K E and Hall , JO. 2013 . Comparative oral dose toxicokinetics of selenium compounds commonly found in selenium accumulator plants . J Anim Sci. , 91 : 4501 – 4509 .
   PubMed Web of Science ®Google Scholar
• Zwolak , I and Zaporowska , H. 2012 . Selenium interactions and toxicity: a review: Selenium interactions and toxicity . Cell Biol Toxicol. , 28 : 31 – 46 .
   PubMed Web of Science ®Google Scholar
• George , C M , Gamble , M , Slavkovich , V , Levy , D , Ahmed , A , Ahsan , H and Graziano , J. 2013 . A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh . Environ Health. , 12 : 52
   PubMed Web of Science ®Google Scholar
• Shiobara , Y , Yoshida , T and Suzuki , KT. 1998 . Effects of dietary selenium species on Se concentrations in hair, blood, and urine . Toxicol Appl Pharmacol. , 152 : 309 – 314 .
   PubMed Web of Science ®Google Scholar
• Behne , D , Gessner , H and Kyriakopoulos , A. 1996 . Information on the selenium status of several body compartments of rats from the selenium concentrations in blood fractions, hair and nails . J Trace Elem Med Biol. , 10 : 174 – 179 .
   PubMed Web of Science ®Google Scholar
• Scharpf , M , Schweizer , U , Arzberger , T , Roggendorf , W , Schomburg , L and Kohrle , J. 2007 . Neuronal and ependymal expression of selenoprotein P in the human brain . J Neural Transm. , 114 : 877 – 884 .
   PubMed Web of Science ®Google Scholar
• Antunes Soares , F , Farina , M , Boettcher , A C , Braga , A L and Batista , TRJ. 2005 . Organic and inorganic forms of selenium inhibited differently fish (Rhamdia quelen) and rat (Rattus norvergicus albinus) delta-aminolevulinate dehydratase . Environ Res. , 98 : 46 – 54 .
   PubMed Web of Science ®Google Scholar
• Xiao , R , Qiao , J T , Zhao , H F , Liang , J , Yu , H L , Liu , J , Guo , A M and Wang , W. 2006 . Sodium selenite induces apoptosis in cultured cortical neurons with special concomitant changes in expression of the apoptosis-related genes . Neurotoxicology. , 27 : 478 – 484 .
   PubMed Web of Science ®Google Scholar
• Ayaz , M , Dalkilic , N , Tuncer , S and Bariskaner , H. 2008 . Selenium-induced changes on rat sciatic nerve fibers: compound action potentials . Methods Find Exp Clin Pharmacol. , 30 : 271 – 275 .
   PubMed Web of Science ®Google Scholar
• Nischwitz , V , Berthele , A and Michalke , B. 2008 . Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: an approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier . Anal Chim Acta. , 627 : 258 – 269 .
   PubMed Web of Science ®Google Scholar
• Michalke , B , Halbach , S and Nischwitz , V. 2009 . JEM spotlight: metal speciation related to neurotoxicity in humans . J Environ Monit. , 11 : 939 – 954 .
   PubMed Web of Science ®Google Scholar
• Steinbrecher , A , Meplan , C , Hesketh , J , Schomburg , L , Endermann , T , Jansen , E , Akesson , B , Rohrmann , S and Linseisen , J. 2010 . Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men . Cancer Epidemiol Biomarkers Prev. , 19 : 2958 – 2968 .
   PubMed Web of Science ®Google Scholar
• Slattery , M L , Lundgreen , A , Welbourn , B , Corcoran , C and Wolff , RK. 2012 . Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer . PLoS One. , 7 : e37312
   PubMed Web of Science ®Google Scholar
• Meplan , C and Hesketh , J. 2012 . The influence of selenium and selenoprotein gene variants on colorectal cancer risk . Mutagenesis. , 27 : 177 – 186 .
   PubMed Web of Science ®Google Scholar
• Jablonska , E , Gromadzinska , J , Sobala , W , Reszka , E and Wasowicz , W. 2008 . Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism . Eur J Nutr. , 47 : 47 – 54 .
   PubMed Web of Science ®Google Scholar
• Chan , J M , Oh , W K , Xie , W , Regan , M M , Stampfer , M J , King , I B , Abe , M and Kantoff , PW. 2009 . Plasma selenium, manganese superoxide dismutase, and intermediate- or high-risk prostate cancer . J Clin Oncol. , 27 : 3577 – 3583 .
   PubMed Web of Science ®Google Scholar
• Blot , W J , Li , J Y , Taylor , P R , Guo , W , Dawsey , S M and Li , B. 1995 . The Linxian trials: mortality rates by vitamin-mineral intervention group . Am J Clin Nutr. , 62 : 1424S – 1426S .
   PubMed Web of Science ®Google Scholar
• Hercberg , S , Ezzedine , K , Guinot , C , Preziosi , P , Galan , P Bertrais , S . 2007 . Antioxidant supplementation increases the risk of skin cancers in women but not in men . J Nutr. , 137 : 2098 – 2105 .
   PubMed Web of Science ®Google Scholar
• Ezzedine , K , Latreille , J , Kesse-Guyot , E , Galan , P , Hercberg , S , Guinot , C and Malvy , D. 2010 . Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation . Eur J Cancer. , 46 : 3316 – 3322 .
   PubMed Web of Science ®Google Scholar
• Li , H , Li , H Q , Wang , Y , Xu , H X , Fan , W T , Wang , M L , Sun , P H and Xie , XY. 2004 . An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum . Chin Med J (Engl). , 117 : 1155 – 1160 .
   PubMed Web of Science ®Google Scholar
• Yu , S Y , Zhu , Y J , Li , W G , Huang , Q S , Huang , C Z , Zhang , Q N and Hou , C. 1991 . A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China . Biol Trace Elem Res. , 29 : 289 – 294 .
   PubMed Web of Science ®Google Scholar
• Yu , S Y , Zhu , Y J and Li , WG. 1997 . Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong . Biol Trace Elem Res. , 56 : 117 – 124 .
   PubMed Web of Science ®Google Scholar
• Li , W , Zhu , Y , Yan , X , Zhang , Q , Li , X , Ni , Z , Shen , Z , Yao , H and Zhu , J. 2000 . [The prevention of primary liver cancer by selenium in high risk populations] . Zhonghua Yu Fang Yi Xue Za Zhi. , 34 : 336 – 338 .
   PubMedGoogle Scholar
• Duffield-Lillico , A J , Reid , M E , Turnbull , B W , Combs , G FJ , Slate , E H , Fischbach , L A , Marshall , J R and Clark , LC. 2002 . Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial . Cancer Epidemiol Biomarkers Prev. , 11 : 630 – 639 .
   PubMed Web of Science ®Google Scholar
• Duffield-Lillico , A J , Slate , E H , Reid , M E , Turnbull , B W , Wilkins , P A Combs , G F Jr . 2003 . Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial . J Natl Cancer Inst. , 95 : 1477 – 1481 .
   PubMed Web of Science ®Google Scholar
• Duffield-Lillico , A J , Dalkin , B L , Reid , M E , Turnbull , B W , Slate , E H , Jacobs , E T , Marshall , J R and Clark , LC. 2003 . Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial . BJU Int. , 91 : 608 – 612 .
   PubMed Web of Science ®Google Scholar
• Marshall , J R , Tangen , C M , Sakr , W A , Wood , D P Jr , Berry , D L Klein , E A . 2011 . Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917 . Cancer Prev Res (Phila). , 4 : 1761 – 1769 .
   PubMed Web of Science ®Google Scholar
• Algotar , A M , Stratton , M S , Ahmann , F R , Ranger-Moore , J , Nagle , R B Thompson , P A . 2013 . Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer . Prostate. , 73 : 328 – 335 .
   PubMed Web of Science ®Google Scholar
• Dreno , B , Euvrard , S , Frances , C , Moyse , D and Nandeuil , A. 2007 . Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients . Eur J Dermatol. , 17 : 140 – 145 .
   PubMed Web of Science ®Google Scholar
• Lippman , S M , Klein , E A , Goodman , P J , Lucia , M S , Thompson , I M Ford , L G . 2009 . Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) . JAMA. , 301 : 39 – 51 .
   PubMed Web of Science ®Google Scholar
• Klein , E A , Thompson , I M Jr , Tangen , C M , Crowley , J J , Lucia , M S Goodman , P J . 2011 . Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) . JAMA. , 306 : 1549 – 1556 .
   PubMed Web of Science ®Google Scholar
• Lubinski , J , Jaworska , K , Durda , K , Jakubowska , A , Huzarski , T and Byrski , T . 2011 . et al. Selenium and the risk of cancer in BRCA1 carriers . Hered Cancer Clin Pract. , 9 ( Suppl 2 ) : A5
   PubMedGoogle Scholar
• Clark , L C , Combs , G FJ , Turnbull , B W , Slate , E H , Chalker , D K Chow , J . 1996 . Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group . JAMA. , 276 : 1957 – 1963 .
   PubMed Web of Science ®Google Scholar
• Reid , M E , Duffield-Lillico , A J , Garland , L , Turnbull , B W , Clark , L C and Marshall , JR. 2002 . Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial . Cancer Epidemiol Biomarkers Prev. , 11 : 1285 – 1291 .
   PubMed Web of Science ®Google Scholar
• Reid , M E , Stratton , M S , Lillico , A J , Fakih , M , Natarajan , R , Clark , L C and Marshall , JR. 2004 . A report of high-dose selenium supplementation: response and toxicities . J Trace Elem Med Biol. , 18 : 69 – 74 .
   PubMed Web of Science ®Google Scholar
• Dalkin , B W , Lillico , A J , Reid , M E , Jacobs , E T , Combs , G F , Slate , E , Turnbull , B W and Marshall , J R . 2001 . Selenium and chemoprevention against prostate cancer: an update of the Clark results. 92nd Meeting of the American Association for Cancer Research , New Orleans , LA : American Association for Cancer Research .
   Google Scholar
• Willett , W C , Polk , B F , Morris , J S , Stampfer , M J , Pressel , S , Rosner , B , Taylor , J O , Schneider , K and Hames , CG. 1983 . Prediagnostic serum selenium and risk of cancer . Lancet. , 2 : 130 – 134 .
   PubMed Web of Science ®Google Scholar
• Salonen , J T , Salonen , R , Lappetelainen , R , Maenpaa , P H , Alfthan , G and Puska , P. 1985 . Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data . Br Med J. , 290 : 417 – 420 .
   PubMed Web of Science ®Google Scholar
• Peleg , I , Morris , S and Hames , CG. 1985 . Is serum selenium a risk factor for cancer? . Med Oncol Tumor Pharmacother. , 2 : 157 – 163 .
   PubMedGoogle Scholar
• Kok , F J , de Bruijn , A M , Hofman , A , Vermeeren , R and Valkenburg , HA. 1987 . Is serum selenium a risk factor for cancer in men only? . Am J Epidemiol. , 125 : 12 – 16 .
   PubMed Web of Science ®Google Scholar
• Lippman , S M , Goodman , P J , Klein , E A , Parnes , H L , Thompson , I M Jr Kristal , A R . 2005 . Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT) . J Natl Cancer Inst. , 97 : 94 – 102 .
   PubMed Web of Science ®Google Scholar
• Goodman , P J , Hartline , J A , Tangen , C M , Crowley , J J , Minasian , L M Klein , E A . 2013 . Moving a randomized clinical trial into an observational cohort . Clin Trials. , 10 : 131 – 142 .
   PubMed Web of Science ®Google Scholar
• Kristal , A R and Lippman , SM. 2009 . Nutritional prevention of cancer: new directions for an increasingly complex challenge . J Natl Cancer Inst. , 101 : 363 – 365 .
   PubMed Web of Science ®Google Scholar
• Lotan , Y , Goodman , P J , Youssef , R F , Svatek , R S , Shariat , S F , Tangen , C M , Thompson , I M Jr and Klein , EA. 2012 . Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT . J Urol. , 187 : 2005 – 2010 .
   PubMed Web of Science ®Google Scholar
• Stranges , S , Marshall , J R , Natarajan , R , Donahue , R P , Trevisan , M , Combs , G F , Cappuccio , F P , Ceriello , A and Reid , ME. 2007 . Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial . Ann Intern Med. , 147 : 217 – 223 .
   PubMed Web of Science ®Google Scholar
• Moyad , MA. 2012 . Heart healthy = prostate healthy: SELECT, the symbolic end of preventing prostate cancer via heart unhealthy and over anti-oxidation mechanisms? . Asian J Androl. , 14 : 243 – 244 .
   PubMed Web of Science ®Google Scholar
• Haldimann , M , Venner , T Y and Zimmerli , B. 1996 . Determination of selenium in the serum of healthy Swiss adults and correlation to dietary intake . J Trace Elem Med Biol. , 10 : 31 – 45 .
   PubMed Web of Science ®Google Scholar
• World Health Organization. Trace elements in human nutrition and health. 1996; Geneva, Switzerland: WHO press
   Google Scholar
• Leblanc , J C , Guerin , T , Noel , L , Calamassi-Tran , G , Volatier , J L and Verger , P. 2005 . Dietary exposure estimates of 18 elements from the 1st French Total Diet Study . Food Addit Contam. , 22 : 624 – 641 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Nacci , G , Rocchi , E , Cassinadri , T , Vivoli , R , Marchesi , C and Bergomi , M. 2000 . Mortality in a population with long-term exposure to inorganic selenium via drinking water . J Clin Epidemiol. , 53 : 1062 – 1068 .
   PubMed Web of Science ®Google Scholar
• Marshall , J R , Reid , M E and Lillico , A. 2002 . Nutritional prevention of cancer: review of glaucoma data , Tucson : University of Arizona .
   Google Scholar
• Vinceti , M , Rothman , K J , Bergomi , M , Borciani , N , Serra , L and Vivoli , G. 1998 . Excess melanoma incidence in a cohort exposed to high levels of environmental selenium . Cancer Epidemiol Biomarkers Prev. , 7 : 853 – 856 .
   PubMed Web of Science ®Google Scholar
• Rothman , KJ. 1990 . No adjustments are needed for multiple comparisons . Epidemiology. , 1 : 43 – 46 .
   PubMedGoogle Scholar
• Reid , M E , Duffield-Lillico , A J , Slate , E , Natarajan , N , Turnbull , B , Jacobs , E , Combs , G F Jr , Alberts , D S , Clark , L C and Marshall , JR. 2008 . The nutritional prevention of cancer: 400 mcg per day selenium treatment . Nutr Cancer. , 60 : 155 – 163 .
   PubMed Web of Science ®Google Scholar
• Fleshner , N E , Kapusta , L , Donnelly , B , Tanguay , S , Chin , J Hersey , K . 2011 . Progression from high-grade prostatic intraepithelial neoplasia to cancer: a randomized trial of combination vitamin-E, soy, and selenium . J Clin Oncol. , 29 : 2386 – 2390 .
   PubMed Web of Science ®Google Scholar
• Stratton , M S , Reid , M E , Schwartzberg , G , Minter , F E , Monroe , B K , Alberts , D S , Marshall , J R and Ahmann , FR. 2003 . Selenium and prevention of prostate cancer in high-risk men: the Negative Biopsy Study . Anticancer Drugs. , 14 : 589 – 594 .
   PubMed Web of Science ®Google Scholar
• Penney , K L , Schumacher , F R , Li , H , Kraft , P , Morris , J S , Kurth , T , Mucci , L A , Hunter , D J , Kantoff , P W , Stampfer , M J and Ma , J. 2010 . A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival . Cancer Prev Res (Phila). , 3 : 604 – 610 .
   PubMed Web of Science ®Google Scholar
• Lawson , K A , Wright , M E , Subar , A , Mouw , T , Hollenbeck , A , Schatzkin , A and Leitzmann , MF. 2007 . Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study . J Natl Cancer Inst. , 99 : 754 – 764 .
   PubMed Web of Science ®Google Scholar
• Zhang , Y , Coogan , P , Palmer , J R , Strom , B L and Rosenberg , L. 2009 . Vitamin and mineral use and risk of prostate cancer: the case-control surveillance study . Cancer Causes Control. , 20 : 691 – 698 .
   PubMed Web of Science ®Google Scholar
• Rothman , K J , Greenland , S and Lash , TL. 2008 . Modern Epidemiology , Edited by: Edition , T . Philadelphia : Lippincott Williams & Wilkins .
   Google Scholar
• Vinceti , M , Rovesti , S , Gabrielli , C , Marchesi , C , Bergomi , M , Martini , M and Vivoli , G. 1995 . Cancer mortality in a residential cohort exposed to environmental selenium through drinking water . J Clin Epidemiol. , 48 : 1091 – 1097 .
   PubMed Web of Science ®Google Scholar
• Ammar , E M and Couri , D. 1981 . Acute toxicity of sodium selenite and selenomethionine in mice after ICV or IV administration . Neurotoxicology. , 2 : 383 – 386 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Crespi , C M , Bonvicini , F , Malagoli , C , Ferrante , M , Marmiroli , S and Stranges , S. 2013 . The need for a reassessment of the safe upper limit of selenium in drinking water . Sci Total Environ. , 443 : 633 – 642 .
   PubMed Web of Science ®Google Scholar
• 2000 . Institute of Medicine. Dietary references intakes for vitamin C, vitamin E, selenium, and carotenoids , Washington , DC : National Academy Press .
   Google Scholar
• 2004 . Nordic Nutrition Recommendations 2004. 4th Edition ed , Copenhagen : Nordic Council of Ministers .
   Google Scholar
• Levander , OA. 1997 . Selenium requirements as discussed in the 1996 joint FAO/IAEA/WHO expert consultation on trace elements in human nutrition . Biomed Environ Sci. , 10 : 214 – 219 .
   PubMedGoogle Scholar
• Reszka , E , Jablonska , E , Gromadzinska , J and Wasowicz , W. 2012 . Relevance of selenoprotein transcripts for selenium status in humans . Genes Nutr. , 7 : 127 – 137 .
   PubMed Web of Science ®Google Scholar
• Macallan , D C and Sedgwick , P. 2000 . Selenium supplementation and selenoenzyme activity . Clin Sci. , 99 : 579 – 281 .
   PubMed Web of Science ®Google Scholar
• Brätter , P and Negretti de Brätter , VE. 1996 . Influence of high dietary intake on the thyroid hormone level in human serum . J Trace Elem Med Biol. , 10 : 163 – 166 .
   PubMed Web of Science ®Google Scholar
• Stranges , S , Sieri , S , Vinceti , M , Grioni , S , Guallar , E , Laclaustra , M , Muti , P , Berrino , F and Krogh , V. 2010 . A prospective study of dietary selenium intake and risk of type 2 diabetes . BMC Public Health. , 10 : 564
   PubMed Web of Science ®Google Scholar
• Hafeman , D G , Sunde , R A and Hoekstra , WG. 1974 . Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat . J Nutr. , 104 : 580 – 587 .
   PubMed Web of Science ®Google Scholar
• Kramer , G F and Ames , BN. 1988 . Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium . Mutat Res. , 201 : 169 – 180 .
   PubMed Web of Science ®Google Scholar
• Sinha , R , Sinha , I , Facompre , N , Russell , S , Somiari , R I , Richie , J P Jr and El-Bayoumy , K. 2010 . Selenium-responsive proteins in the sera of selenium-enriched yeast-supplemented healthy African American and Caucasian men . Cancer Epidemiol Biomarkers Prev. , 19 : 2332 – 2340 .
   PubMed Web of Science ®Google Scholar
• Loison , F , Debure , L , Nizard , P , le Goff , P , Michel , D and le Drean , Y. 2006 . Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes . Biochem J. , 395 : 223 – 231 .
   PubMed Web of Science ®Google Scholar
• Trougakos , IP. 2013 . The molecular chaperone apolipoprotein J/clusterin as a sensor of oxidative stress: implications in therapeutic approaches—a mini-review . Gerontology. , in press
   PubMed Web of Science ®Google Scholar
• Chen , Q , Wang , Z , Xiong , Y , Zou , X and Liu , Z. 2010 . Comparative study of p38 MAPK signal transduction pathway of peripheral blood mononuclear cells from patients with coal-combustion-type fluorosis with and without high hair selenium levels . Int J Hyg Environ Health. , 213 : 381 – 386 .
   PubMed Web of Science ®Google Scholar
• Karunasinghe , N , Han , D Y , Zhu , S , Yu , J , Lange , K Duan , H . 2012 . Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand . Genes Nutr. , 7 : 179 – 190 .
   PubMed Web of Science ®Google Scholar
• Koyama , H , Mutakin , Abdulah , R , Yamazaki , C and Kameo , S. 2013 . Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus . Nihon Eiseigaku Zasshi. , 68 : 1 – 10 .
   PubMedGoogle Scholar
• Lillico , A , Jacobs , E and Reid , ME. 2002 . Selenium supplementations and risk of glaucoma in the NPC trial , Tucson : University of Arizona .
   Google Scholar
• Bruhn , R L , Stamer , W D , Herrygers , L A , Levine , J M and Noecker , RJ. 2009 . Relationship between glaucoma and selenium levels in plasma and aqueous humour . Br J Ophthalmol. , 93 : 1155 – 1158 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Bonvicini , F , Rothman , K J , Vescovi , L and Wang , F. 2010 . The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study . Environ Health. , 9 : 77
   PubMed Web of Science ®Google Scholar
• Conley , S M , Bruhn , R L , Morgan , P V and Stamer , WD. 2004 . Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells . Invest Ophthalmol Vis Sci. , 45 : 473 – 479 .
   PubMed Web of Science ®Google Scholar
• Casteignau , A , Fontan , A , Morillo , A , Oliveros , J A and Segales , J. 2006 . Clinical, pathological and toxicological findings of a iatrogenic selenium toxicosis case in feeder pigs . J Vet Med A Physiol Pathol Clin Med. , 53 : 323 – 326 .
   PubMedGoogle Scholar
• Tsunoda , M , Johnson , V J and Sharma , RP. 2000 . Increase in dopamine metabolites in murine striatum after oral exposure to inorganic but not organic form of selenium . Arch Environ Contam Toxicol. , 39 : 32 – 37 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Guidetti , D , Pinotti , M , Rovesti , S , Merlin , M , Vescovi , L , Bergomi , M and Vivoli , G. 1996 . Amyotrophic lateral sclerosis after long-term exposure to drinking water with high selenium content . Epidemiology. , 7 : 529 – 532 .
   PubMed Web of Science ®Google Scholar
• Vinceti , M , Wei , E T , Malagoli , C , Bergomi , M and Vivoli , G. 2001 . Adverse health effects of selenium in humans . Rev Environ Health. , 16 : 233 – 251 .
   PubMedGoogle Scholar
• Ravn-Haren , G , Krath , B N , Overvad , K , Cold , S , Moesgaard , S , Larsen , E H and Dragsted , LO. 2008 . Effect of long-term selenium yeast intervention on activity and gene expression of antioxidant and xenobiotic metabolising enzymes in healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) pilot study . Br J Nutr. , 99 : 1190 – 1198 .
   PubMed Web of Science ®Google Scholar
• Saint-Amour , D , Roy , M S , Bastien , C , Ayotte , P , Dewailly , E , Despres , C , Gingras , S and Muckle , G. 2006 . Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet . Neurotoxicology. , 27 : 567 – 578 .
   PubMed Web of Science ®Google Scholar
• Berthold , H K , Michalke , B , Krone , W , Guallar , E and Gouni-Berthold , I. 2012 . Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study . J Hypertens. , 30 : 1328 – 1335 .
   PubMed Web of Science ®Google Scholar
• Platz , E A and Lippman , SM. 2009 . Selenium, genetic variation, and prostate cancer risk: epidemiology reflects back on selenium and vitamin E cancer prevention trial . J Clin Oncol. , 27 : 3569 – 3572 .
   PubMed Web of Science ®Google Scholar
• Marcocci , C , Kahaly , G J , Krassas , G E , Bartalena , L , Prummel , M Stahl , M . 2011 . Selenium and the course of mild Graves’ orbitopathy . N Engl J Med. , 364 : 1920 – 1931 .
   PubMed Web of Science ®Google Scholar
• Goossens , M E , Buntinx , F , Joniau , S , Ackaert , K , Ameye , F Billiet , I . 2012 . Designing the selenium and bladder cancer trial (SELEBLAT), a phase lll randomized chemoprevention study with selenium on recurrence of bladder cancer in Belgium . BMC Urol. , 12 : 8
   PubMed Web of Science ®Google Scholar
• Bhattacharya , A , Turowski , S G , San Martin , I D , Rajput , A , Rustum , Y M , Hoffman , R M and Seshadri , M. 2011 . Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer . Anticancer Res. , 31 : 387 – 393 .
   PubMed Web of Science ®Google Scholar
• Desai , D , Sinha , I , Null , K , Wolter , W , Suckow , M A , King , T , Amin , S and Sinha , R. 2010 . Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells . Int J Cancer. , 127 : 230 – 238 .
   PubMed Web of Science ®Google Scholar
• Nguyen , N , Sharma , A , Sharma , A K , Desai , D , Huh , S J , Amin , S , Meyers , C and Robertson , GP. 2011 . Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4 . Cancer Prev Res (Phila). , 4 : 248 – 258 .
   PubMed Web of Science ®Google Scholar
• Cheng , Y , Sk , U H , Zhang , Y , Ren , X , Zhang , L Huber-Keener , K J . 2012 . Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death . PLoS One. , 7 : e35104
   PubMed Web of Science ®Google Scholar
• Qi , Y , Fu , X , Xiong , Z , Zhang , H , Hill , S M , Rowan , B G and Dong , Y. 2012 . Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer . PLoS One. , 7 : e31539
   PubMed Web of Science ®Google Scholar
• Zheng , S , Li , X , Zhang , Y , Xie , Q , Wong , Y S , Zheng , W and Chen , T. 2012 . PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction . Int J Nanomedicine. , 7 : 3939 – 3949 .
   PubMed Web of Science ®Google Scholar
• Gowda , R , Madhunapantula , S V , Desai , D , Amin , S and Robertson , GP. 2013 . Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma . Mol Cancer Ther. , 12 : 3 – 15 .
   PubMed Web of Science ®Google Scholar
• Li , F , Jiang , Q , Shi , K J , Luo , H , Yang , Y and Xu , CM. 2013 . RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells . Cell Death Dis. , 4 : e708
   PubMed Web of Science ®Google Scholar
• Dos Santos , E D , Hamel , E , Bai , R , Burnett , J C , Tozatti , C S Bogo , D . 2013 . Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity . Bioorg Med Chem Lett. , 23 : 4669 – 4673 .
   PubMed Web of Science ®Google Scholar
• Huang , Y , He , L , Liu , W , Fan , C , Zheng , W , Wong , Y S and Chen , T. 2013 . Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles . Biomaterials. , 34 : 7106 – 7116 .
   PubMed Web of Science ®Google Scholar
• Kim , Y W , Bae , S M , Liu , H B , Kim , I W , Chun , H J and Ahn , WS. 2012 . Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in TC-1 tumor development . Oncol Rep. , 28 : 576 – 584 .
   PubMed Web of Science ®Google Scholar
• Chintala , S , Najrana , T , Toth , K , Cao , S , Durrani , F A , Pili , R and Rustum , YM. 2012 . Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition . BMC Cancer. , 12 : 293
   PubMed Web of Science ®Google Scholar
• Sonaa , E , Usha , S and Ja In , J. 2013 . An ex vivo study of selenium, genistein on the morphological and nuclear changes in anticancer drug-induced apoptosis in human peripheral blood lymphocytes . Biofactors. , 39 : 279 – 293 .
   PubMed Web of Science ®Google Scholar
• Zeng , H , Briske-Anderson , M , Wu , M and Moyer , MP. 2012 . Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation . Nutr Cancer. , 64 : 128 – 135 .
   PubMed Web of Science ®Google Scholar
• Weiller , M , Latta , M , Kresse , M , Lucas , R and Wendel , A. 2004 . Toxicity of nutritionally available selenium compounds in primary and transformed hepatocytes . Toxicology. , 201 : 21 – 30 .
   PubMed Web of Science ®Google Scholar
• Asfour , I A , El-Tehewi , M M , Ahmed , M H , Abdel-Sattar , M A , Moustafa , N N , Hegab , H M and Fathey , OM. 2009 . High-dose sodium selenite can induce apoptosis of lymphoma cells in adult patients with non-Hodgkin's lymphoma . Biol Trace Elem Res. , 127 : 200 – 210 .
   PubMed Web of Science ®Google Scholar
• Karp , D D , Lee , S J , Keller , S M , Wright , G S , Aisner , S , Belinsky , S A , Johnson , D H , Johnston , MR , Goodman , G , Clamon , G , Okawara , G , Marks , R , Frechette , E , McCaskill-Stevens , W , Lippman , SM , Ruckdeschel , J and Khuri , FR . Randomized, Double-Blind, Placebo-Controlled, Phase III Chemoprevention Trial of Selenium Supplementation in Patients With Resected Stage I Non-Small-Cell Lung Cancer: ECOG 5597 . J Clin Oncol. , 2013 (in press)
   Google Scholar
• Niraula , S , Pond , G , de Wit , R , Eisenberger , M , Tannock , I F and Joshua , AM. 2013 . Influence of concurrent medications on outcomes of men with prostate cancer included in the TAX 327 study . Can Urol Assoc J. , 7 : E74 – 81 .
   PubMedGoogle Scholar
• Lawenda , B D , Kelly , K M , Ladas , E J , Sagar , S M , Vickers , A and Blumberg , JB. 2008 . Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? . J Natl Cancer Inst. , 100 : 773 – 783 .
   PubMed Web of Science ®Google Scholar
• Buntzel , J , Riesenbeck , D , Glatzel , M , Berndt-Skorka , R , Riedel , T Mucke , R . 2010 . Limited effects of selenium substitution in the prevention of radiation-associated toxicities. results of a randomized study in head and neck cancer patients . Anticancer Res. , 30 : 1829 – 1832 .
   PubMed Web of Science ®Google Scholar
• Chen , Y C , Prabhu , K S , Das , A and Mastro , AM. 2013 . Dietary selenium supplementation modifies breast tumor growth and metastasis . Int J Cancer. , 133 : 2054 – 2064 .
   PubMed Web of Science ®Google Scholar
• Zhuo , H , Smith , A H and Steinmaus , C. 2004 . Selenium and lung cancer: a quantitative analysis of heterogeneity in the current epidemiological literature . Cancer Epidemiol Biomarkers Prev. , 13 : 771 – 778 .
   PubMed Web of Science ®Google Scholar
• Cortes-Jofre , M , Rueda , J R , Corsini-Munoz , G , Fonseca-Cortes , C , Caraballoso , M and Bonfill Cosp , X. 2012 . Drugs for preventing lung cancer in healthy people . Cochrane Database Syst Rev. , 10 : CD002141
   PubMedGoogle Scholar
• Bjelakovic , G , Nikolova , D , Gluud , L L , Simonetti , R G and Gluud , C. 2008 . Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases . Cochrane Database Syst Rev. , : CD007176
   Google Scholar
• Marik , P E and Flemmer , M. 2012 . Do dietary supplements have beneficial health effects in industrialized nations: what is the evidence? . JPEN J Parenter Enteral Nutr. , 36 : 159 – 168 .
   PubMed Web of Science ®Google Scholar
• Mayne , S T , Ferrucci , L M and Cartmel , B. 2012 . Lessons learned from randomized clinical trials of micronutrient supplementation for cancer prevention . Annu Rev Nutr. , 32 : 369 – 390 .
   PubMed Web of Science ®Google Scholar