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Journal of Drug Targeting Volume 28, 2020 - Issue 4
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Original Articles

LPS-induced inflammation delays the transportation of ASP+ due to down-regulation of OCTN1/2 in alveolar epithelial cells

Dalang LiInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaView further author information
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Chuanzong QiInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaView further author information
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Jian ZhouInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaView further author information
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Zeqiang WenInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaView further author information
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Xiangyu ZhuInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaView further author information
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Hongguang XiaInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaView further author information
&
Jue SongInstitute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; ;Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaCorrespondence[email protected]
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Pages 437-447 | Received 03 Jun 2019, Accepted 06 Oct 2019, Published online: 21 Oct 2019

Citations (10)

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Xin Fang, Zihao Wang, Chuanzong Qi, Jian Zhou, Shuyi Zhang & Jue Song. (2021) The changes of MRP2 expression in three kinds of pulmonary inflammation models: the downregulation occurred in cigarette smoke extract (CSE) stimulation group and CSE plus LPS stimulation group, unchanged in LPS stimulation group. Toxicology Mechanisms and Methods 31:6, pages 413-424.
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Articles from other publishers (9)

Dirk Gründemann, Lea Hartmann & Svenja Flögel. (2022) The ergothioneine transporter (ETT): substrates and locations, an inventory. FEBS Letters 596:10, pages 1252-1269.
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Lorena Pochini, Michele Galluccio, Mariafrancesca Scalise, Lara Console, Gilda Pappacoda & Cesare Indiveri. (2022) OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions. International Journal of Molecular Sciences 23:2, pages 914.
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Xin Fang, Shuyi Zhang, Zihao Wang, Jian Zhou, Chuanzong Qi & Jue Song. (2021) Cigarette smoke extract combined with LPS down-regulates the expression of MRP2 in chronic pulmonary inflammation may be related to FXR. Molecular Immunology 137, pages 174-186.
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Jian Zhou, Chuanzong Qi, Xin Fang, Zihao Wang, Shuyi Zhang, Dalang Li & Jue Song. (2021) DJ-1 modulates Nrf2-mediated MRP1 expression by activating Wnt3a/β-catenin signalling in A549 cells exposed to cigarette smoke extract and LPS. Life Sciences 276, pages 119089.
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Mohammed Ali Selo, Johannes A. Sake, Carsten Ehrhardt & Johanna J. Salomon. (2020) Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts. International Journal of Molecular Sciences 21:23, pages 9168.
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Chuanzong Qi, Jian Zhou, Zihao Wang, Xin Fang, Dalang Li, Yong Jin & Jue Song. (2020) Cigarette smoke extract combined with lipopolysaccharide reduces OCTN1/2 expression in human alveolar epithelial cells in vitro and rat lung in vivo under inflammatory conditions. International Immunopharmacology 87, pages 106812.
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Bianca Maria Rotoli, Rossana Visigalli, Amelia Barilli, Francesca Ferrari, Massimiliano G. Bianchi, Maria Di Lascia, Benedetta Riccardi, Paola Puccini & Valeria Dall’Asta. (2020) Functional analysis of OCTN2 and ATB0,+ in normal human airway epithelial cells. PLOS ONE 15:2, pages e0228568.
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Wen-juan Liu, Yue Du, Ru Wen, Ming Yang & Jian Xu. (2020) Drug resistance to targeted therapeutic strategies in non-small cell lung cancer. Pharmacology & Therapeutics 206, pages 107438.
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Ying Lv, Zhaoming Liu, Jiancheng Huang, Jie Yu, Yanbo Dong & Jun Wang. (2019) LncRNA nuclear-enriched abundant transcript 1 regulates hypoxia-evoked apoptosis and autophagy via mediation of microRNA-181b. Molecular and Cellular Biochemistry 464:1-2, pages 193-203.
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