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Original Articles

A conceptual framework for predicting the toxicity of reactive chemicals: modeling soft electrophilicity

, , , , , , , , & show all
Pages 413-428 | Received 19 Jan 2006, Accepted 15 May 2006, Published online: 20 Nov 2006

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S. J. Enoch, C. M. Ellison, T. W. Schultz & M. T. D. Cronin. (2011) A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity. Critical Reviews in Toxicology 41:9, pages 783-802.
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F. Bajot, M.T.D. Cronin, D.W. Roberts & T.W. Schultz. (2011) Reactivity and aquatic toxicity of aromatic compounds transformable to quinone-type Michael acceptors. SAR and QSAR in Environmental Research 22:1-2, pages 51-65.
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D. Mackay, J.A. Arnot, E.P. Petkova, K.B. Wallace, D.J. Call, L.T. Brooke & G.D. Veith. (2009) The physicochemical basis of QSARs for baseline toxicity. SAR and QSAR in Environmental Research 20:3-4, pages 393-414.
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B. Wan, J.W. Yarbrough & T.W. Schultz. (2008) Structure-related clustering of gene expression fingerprints of thp-1 cells exposed to smaller polycyclic aromatic hydrocarbons. SAR and QSAR in Environmental Research 19:3-4, pages 351-373.
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DouglasA. Dawson, JoshuaL. Allen, TerryW. Schultz & Gerald Pöch. (2007) Time-dependence in mixture toxicity with soft-electrophiles: 2. Effects of relative reactivity level on time-dependent toxicity and combined effects for selected Michael acceptors. Journal of Environmental Science and Health, Part A 43:1, pages 43-52.
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G. Patlewicz, A. O. Aptula, E. Uriarte, D. W. Roberts, P. S. Kern, G. F. Gerberick, I. Kimber, R. J. Dearman, C. A. Ryan & D. A. Basketter. (2007) An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential. SAR and QSAR in Environmental Research 18:5-6, pages 515-541.
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T. W. Schultz, K. E. Ralston, D. W. Roberts, G. D. Veith & A. O. Aptula. (2007) Structure–activity relationships for abiotic thiol reactivity and aquatic toxicity of halo-substituted carbonyl compounds . SAR and QSAR in Environmental Research 18:1-2, pages 21-29.
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