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SAR and QSAR in Environmental Research Volume 10, 1999 - Issue 6
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Original Articles

Chemical Diversity Approach for Evaluating Mechanistic Relatedness Among Toxicological Phenomena

N. Pollack Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA, 15238, USA
,
A. R. Cunningham Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA, 15238, USA
,
G. Klopman Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA
&
H. S. Rosenkranz Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA, 15238, USA
Pages 533-543 | Received 16 Apr 1999, Accepted 11 Jun 1999, Published online: 24 Sep 2006

Citations (21)

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Read on this site (3)

J. Devillers, N. Marchand-Geneste, A. Carpy & J. M. Porcher. (2006) SAR and QSAR modeling of endocrine disruptors. SAR and QSAR in Environmental Research 17:4, pages 393-412.
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A.R. Cunningham, S.L. Cunningham & H.S. Rosenkranz. (2004) Structure–Activity Approach to the Identification of Environmental Estrogens: The MCASE Approach. SAR and QSAR in Environmental Research 15:1, pages 55-67.
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H.S. Rosenkranz & A.R. Cunningham†. (2003) A substructure-based SAR model for odor perception in humans relevant to health risk assessments . SAR and QSAR in Environmental Research 14:3, pages 215-222.
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Articles from other publishers (18)

Albert R. Cunningham, Shanna T. Moss, Seena A. Iype, Gefei Qian, Shahid Qamar & Suzanne L. Cunningham. (2008) Structure−Activity Relationship Analysis of Rat Mammary Carcinogens. Chemical Research in Toxicology 21:10, pages 1970-1982.
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Herbert Rosenkranz & Bhavani Thampatty. 2005. Predictive Toxicology. Predictive Toxicology 309 383 .
Herbert S. RosenkranzAlbert R. Cunningham. (2019) Lack of Predictivity of the Rat Lethality (LD50) Test for Ecological and Human Health Effects. Alternatives to Laboratory Animals 33:1, pages 9-19.
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Herbert S. Rosenkranz & Albert R. Cunningham. (2003) Environmental odors and health hazards. Science of The Total Environment 313:1-3, pages 15-24.
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Herbert S Rosenkranz. (2003) Synergy between systemic toxicity and genotoxicity: relevance to human cancer risk. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 529:1-2, pages 117-127.
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Herbert S Rosenkranz. (2003) A data mining approach for the elucidation of the action of putative etiological agents: application to the non-genotoxic carcinogenicity of genistein. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 526:1-2, pages 85-92.
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Herbert Rosenkranz. 2003. Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens. Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens.
Harold E Selick, Alan P Beresford & Michael H Tarbit. (2002) The emerging importance of predictive ADME simulation in drug discovery. Drug Discovery Today 7:2, pages 109-116.
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Herbert S. Rosenkranz & Albert R. Cunningham. (2001) Prevalence of mutagens in the environment: experimental data versus simulations. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 484:1-2, pages 49-51.
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Herbert S. Rosenkranz. (2001) Allergic contact dermatitis and its relationship to carcinogenicity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 483:1-2, pages 51-55.
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A R Cunningham & H S Rosenkranz. (2001) Estimating the extent of the health hazard posed by high-production volume chemicals.. Environmental Health Perspectives 109:9, pages 953-956.
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José S. Duca & A. J. Hopfinger. (2001) Estimation of Molecular Similarity Based on 4D-QSAR Analysis:  Formalism and Validation. Journal of Chemical Information and Computer Sciences 41:5, pages 1367-1387.
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Dale E Johnson & Grushenka H.I Wolfgang. (2000) Predicting human safety: screening and computational approaches. Drug Discovery Today 5:10, pages 445-454.
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Xinyu Zhu & Herbert S. Rosenkranz. (2019) Structural Basis of the Toxicity of Chemicals in Cultured Human HeLa Cells. Alternatives to Laboratory Animals 28:4, pages 557-574.
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Herbert S. Rosenkranz & Albert R. Cunningham. (2000) A Battery of Cell Toxicity Assays as Predictors of Eye Irritation: A Feasibility Study. Alternatives to Laboratory Animals 28:4, pages 603-607.
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Herbert S. Rosenkranz & Albert R. Cunningham. (2000) The High Production Volume Chemical Challenge Program: The Relevance of the in Vivo Micronucleus Assay. Regulatory Toxicology and Pharmacology 31:2, pages 182-189.
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Herbert S. Rosenkranz & Albert R. Cunningham. (2000) The High Production Volume Chemical Challenge Program: The Rodent LD50 and its Possible Replacement. Alternatives to Laboratory Animals 28:2, pages 271-277.
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Herbert S Rosenkranz, Volker Mersch-Sundermann & Gilles Klopman. (1999) SOS chromotest and mutagenicity in Salmonella: evidence for mechanistic differences. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 431:1, pages 31-38.
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