Chemical Diversity Approach for Evaluating Mechanistic Relatedness Among Toxicological Phenomena

References

• Macina , O. T. , Zhang , Y. P. and Rosenkranz , H. S. 1998 . “ Improved predictivity of carcinogens: The use of a battery of SAR models, testing, predicting and integrating carcinogenicity. ” . In Testing, Predicting and Integrating Carcinogenicity , Edited by: Kitchin , K. 227 – 250 . New York : Marcel Dekker .
   Google Scholar
• Zhang , Y. P. , Sussman , N. , Klopman , G. and Rosenkranz , H. S. 1997 . Development of methods to ascertain the predictivity and consistency of SAR models: Application to the U.S. National Toxicology Program rodent carcinogenicity bioassays. . Quant. Struct.-Act. Relat. , 16 : 290 – 295 .
   Google Scholar
• Rosenkranz , H. S. , Matthews , E. J. and Klopman , G. 1993 . Commonalties in the structural determinants of toxicity in fish and mammals. . Ecotoxicol. Environ. Saf. , 25 : 296 – 299 .
   Google Scholar
• Cunningham , A. R. , Rosenkranz , H. S. and Klopman , G. 1998 . Identification of “genotoxic” and “non-genotoxic” alerts for cancer in rats: The carcinogenic potency database. . Mutat. Res. , 405 : 9 – 28 .
   PubMed Web of Science ®Google Scholar
• Rosenkranz , H. S. and Klopman , G. 1990 . The structural basis of the mutagenicity of chemicals in Salmonella typhymurium: The National Toxicology Program data base. . Mutat. Res. , 228 : 1 – 50 .
   Google Scholar
• Rosenkranz , H. S. , Pangrekar , J. and Klopman , G. 1993 . Similarities in the mechanism of antibacterial activity (Microtox TM Assay) and toxicity to vertebrates. . ATLA , 21 : 489 – 500 .
   Google Scholar
• Miller , J. A. and Miller , E. C. 1977 . “ Ultimate chemical carcinogens as reactive mutagenic electrophiles. ” . In Origins of Human Cancer , Edited by: Hiatt , H. H. , Watson , J. D. and Winsten , J. A. 605 – 627 . New York : Cold Spring Harbor Laboratory Press, Cold Spring Harbor .
   Google Scholar
• Ashby , J. and Tennant , R. W. 1991 . Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. . Mutat. Res. , 257 : 229 – 306 .
   PubMed Web of Science ®Google Scholar
• Ashby , J. and Paton , D. 1993 . The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures. . Mutat. Res. , 286 : 3 – 74 .
   PubMed Web of Science ®Google Scholar
• Rosenkranz , H. S. and Klopman , G. 1990 . The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: The National Toxicology Program Data Base. . Mutat. Res. , : 228
   Google Scholar
• Klopman , G. 1992 . MULTICASE 1. A hierarchical computer automated structure evaluation program. . Quant. Struct.-Act. Relat. , 11 : 176 – 184 .
   Web of Science ®Google Scholar
• Klopman , G. and Rosenkranz , H. S. 1994 . Prediction of carcinogenicity/mutagenicity using MULTICASE. . Mutat. Res. , 305 : 33 – 46 .
   PubMed Web of Science ®Google Scholar
• Rosenkranz , H. S. and Klopman , G. 1993 . Structural relationship between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents. . Environmental and Molecular Mutagenesis , 21 : 193 – 206 .
   PubMed Web of Science ®Google Scholar
• Rosenkranz , H. S. , Zhang , Y. P. and Klopman , G. 1994 . Evidence that cell toxicity may contribute to the genotoxic response. . Regul. Toxicol. Pharmacol. , 19 : 176 – 182 .
   PubMed Web of Science ®Google Scholar
• Klopman , G. 1984 . Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules. . J. Am. Chem. Soc. , 106 : 7315 – 7321 .
   Web of Science ®Google Scholar
• Klopman , G. and Rosenkranz , H. S. 1984 . Structural requirements for the mutagenicity of environmental nitroarenes. . Mutat. Res. , 126 : 227 – 238 .
   PubMed Web of Science ®Google Scholar
• Rosenkranz , H. S. and Cunningham , A. G. K. 1996 . Identification of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens and antiestrogens. . Mutagenesis , 11 : 95 – 100 .
   PubMedGoogle Scholar
• Zhang , Y. P. , Sussman , N. , Macina , O. T. , Rosenkranz , H. S. and Klopman , G. 1996 . Prediction of the carcinogenicity of a second group of chemicals undergoing carcinogenicity testing. . Environ. Health Perspect. , 104 : 1045 – 1050 . (Suppl. 5)
   PubMed Web of Science ®Google Scholar
• Chankong , V. , Haimes , Y. Y. , Rosenkranz , H. S. and Pet-Edwards , J. 1985 . The carcinogenicity prediction and battery selection (CPBS) method: A Bayesian approach. . Mutat. Res. , 153 : 135 – 166 .
   PubMedGoogle Scholar
• Rosenkranz , H. S. , Zhang , Y. P. and Klopman , G. 1998 . The development and characterization of an SAR model of the Draize eye irritation test. . ATLA , 20 : 779 – 809 .
   Google Scholar
• Cunningham , A. R. , Rosenkranz , H. S. , Zhang , Y. P. and Klopman , G. 1998 . Identification of “genotoxic” and “non-genotoxic” alerts for cancer in mice: The carcinogenic potency database. . Mutat. Res. , 398 : 1 – 17 .
   PubMed Web of Science ®Google Scholar
• Gealy , R. , Graham , C. , Sussman , N. B. , Macina , O. T. , Rosenkranz , H. S. and Karol , M. H. 1996 . Evaluating clinical case report data for SAR modeling of allergic contact dermatitis. . Hum. Exp. Toxicol. , 15 : 489 – 493 .
   PubMedGoogle Scholar
• Graham , C. , Rosenkranz , H. S. and Karol , M. H. 1997 . Structure-activity model of chemicals that cause human respiratory sensitization. . Regulatory Toxicology and Pharmacology , 26 : 296 – 306 .
   PubMed Web of Science ®Google Scholar
• Macina , O. T. , Klopman , G. and Rosenkranz , H. S. 1997 . Structural basis of sensory irriiation. . Inhal. Toxicol. , 9 : 465 – 476 .
   Web of Science ®Google Scholar
• Rosenkranz , M. and Rosenkranz , H. S. G. K. 1997 . Intercellular communication, tumor promotion and non-genotoxic carcinogenesis: relationships based upon structural considerations. . Mutat. Res. , 381 : 171 – 188 .
   PubMed Web of Science ®Google Scholar
• Rannug , A. , Rannug , U. , Rosenkranz , H. S. , Winqvist , L. , Westerholm , R. , Argurell , E. and Grafstrom , A. K. 1987 . Certain photoxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances. . J. Biol. Chem. , 262 : 15422 – 15427 .
   PubMed Web of Science ®Google Scholar