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Original

HELLP Syndrome Is Associated with an Increased Inflammatory Response, Which May Be Inhibited by Administration of Prednisolone

, PhD , MD, , PhD, , PhD, , PhD, , MD, , PhD , MD & , PhD , MD show all
Pages 253-265 | Published online: 07 Jul 2009

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Kedra Wallace, Rachael Morris, Patrick B. Kyle, Denise Cornelius, Marie Darby, Jeremy Scott, Janae Moseley, Krystal Chatman & Babbette LaMarca. (2014) Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome. Hypertension in Pregnancy 33:1, pages 41-54.
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Suleyman Guven, Mehmet Sonmez & S. Caner Karahan. (2011) The Role of Fibrinolytic and Antifibrinolytic Activities in the Pathophysiology of HELLP Syndrome. Hypertension in Pregnancy 30:3, pages 275-286.
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Articles from other publishers (36)

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Marta Wiszpolska, Ewa Lepiarczyk, Mateusz A. Maździarz, Łukasz Paukszto, Karol G. Makowczenko, Aleksandra Lipka, Elżbieta Łopieńska-Biernat, Krystyna Makowska, Sławomir Gonkowski, Paulo Correia-de-Sá & Marta Majewska. (2023) The Carcinogenic Potential of Bisphenol A in the Liver Based on Transcriptomic Studies. Cancers 15:20, pages 5014.
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Ayane Nishio, Ryo Kamidani, Hideshi Okada, Keiko Suzuki, Kodai Suzuki, Takahito Miyake, Haruka Okamoto, Tomoaki Doi, Akio Suzuki, Shozo Yoshida & Shinji Ogura. (2023) Serum syndecan-1 concentration in hemolysis, elevated liver enzymes, and low platelets syndrome: A case report. Frontiers in Medicine 10.
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Berna Şermin Kılıç & Nil Atakul. (2022) Evaluation of Platelet Large Cell Ratio (PLCR) Results in Patients with Preeclampsia and HELLP. Cyprus Journal of Medical Sciences 7:3, pages 303-307.
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Viren K. Govindaraju, Olivia C. Schimmel, Matthew G. J. Trese, Bruce R. Garretson & Lisa J. Faia. (2022) Bilateral Exudative Retinal Detachments, Chemosis, and Impaired Ocular Motility in the Setting of Preeclampsia and HELLP Syndrome. Journal of VitreoRetinal Diseases 6:3, pages 255-258.
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Jun-Kun Chen, Ning Tang, Xiong Wang, Ming Huang & Chi Zhang. (2021) A Case of Parturient with Hereditary Thrombotic Thrombocytopenic Purpura: Case Report of a Novel Variant. Seminars in Thrombosis and Hemostasis 48:02, pages 256-261.
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Cha Han, Pengzhu Huang, Meilu Lyu & Jingfei Dong. (2020) Oxidative Stress and Preeclampsia-Associated Prothrombotic State. Antioxidants 9:11, pages 1139.
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Monica A. Bray, Sarah E. Sartain, Jahnavi Gollamudi & Rolando E. Rumbaut. (2020) Microvascular thrombosis: experimental and clinical implications. Translational Research 225, pages 105-130.
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Ozlem Equils, Caitlyn Kellogg, James McGregor, Michael Gravett, Genevieve Neal-Perry & Cem Gabay. (2020) The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications†. Biology of Reproduction 103:4, pages 684-694.
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Violeta Stojanovska & Ana Claudia Zenclussen. (2020) Innate and Adaptive Immune Responses in HELLP Syndrome. Frontiers in Immunology 11.
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Victoria von Salmuth, Yosta van der Heiden, Ilse Bekkers, Pieter van Runnard Heimel, Marc A. Spaanderman, Louis L. Peeters & Ger H. Koek. (2020) The role of hepatic sinusoidal obstruction in the pathogenesis of the hepatic involvement in HELLP syndrome: Exploring the literature. Pregnancy Hypertension 19, pages 37-43.
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Javier E. Fonseca, Juan C Otero & Clara Messa. (2019) Dexamethasone for the treatment of class I HELLP syndrome: A double-blind, placebo-controlled, multicenter, randomized clinical trial. Pregnancy Hypertension 17, pages 158-164.
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Vanja Mandic-Maravic, Vesna Coric, Marija Mitkovic-Voncina, Miroslav Djordjevic, Ana Savic-Radojevic, Marko Ercegovac, Marija Matic, Tatjana Simic, Dusica Lecic-Tosevski, Oliver Toskovic, Tatjana Pekmezovic, Marija Pljesa-Ercegovac & Milica Pejovic-Milovancevic. (2019) Interaction of glutathione S-transferase polymorphisms and tobacco smoking during pregnancy in susceptibility to autism spectrum disorders. Scientific Reports 9:1.
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Tobias Jonathan Pfeffer & Denise Hilfiker-Kleiner. (2018) Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems in Cardiology 43:9, pages 364-388.
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J.M. Wat, M.C. Audette & J.C. Kingdom. (2018) Molecular actions of heparin and their implications in preventing pre‐eclampsia. Journal of Thrombosis and Haemostasis 16:8, pages 1510-1522.
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Xiao-Bo Fang, Dun-Jin Chen, Fang He, Jia Chen, Zhou Zhou, Yan-Ling Liang & Wei-Xi Zhang. (2018) Predictors of oedema type in reversible posterior leukoencephalopathy syndrome with preeclampsia or eclampsia. Pregnancy Hypertension 11, pages 71-76.
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Lars Bremer, Christoph Schramm & Gisa Tiegs. (2016) Immunology of hepatic diseases during pregnancy. Seminars in Immunopathology 38:6, pages 669-685.
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Cynthia Bean, Shauna-Kay Spencer, Teylor Bowles, Patrick B. Kyle, Jan M. Williams, Jacob Gibbens & Kedra Wallace. (2016) Inhibition of T-cell activation attenuates hypertension, TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance. American Journal of Reproductive Immunology 76:4, pages 272-279.
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Andrea Iorio, Marina Spinelli, Renato Polimanti, Federica Lorenzi, Herbert Valensise, Dario Manfellotto & Maria Fuciarelli. (2015) GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions. European Journal of Obstetrics & Gynecology and Reproductive Biology 194, pages 34-37.
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Unzila A. NayeriIrina A. BuhimschiChristine A. LakySarah N. CrossChristina M. DuzyjWenda RammaBaha M. SibaiEdmund F. FunaiAsif AhmedCatalin S. Buhimschi. (2014) Antenatal Corticosteroids Impact the Inflammatory Rather Than the Antiangiogenic Profile of Women With Preeclampsia. Hypertension 63:6, pages 1285-1292.
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Klaus F. Hofmann-Kiefer, D. Chappell, J. Knabl, H. G. Frank, N. Martinoff, P. Conzen, B. F. Becker & M. Rehm. (2013) Placental Syncytiotrophoblast Maintains a Specific Type of Glycocalyx at the Fetomaternal Border: The Glycocalyx at the Fetomaternal Interface in Healthy Women and Patients With HELLP Syndrome. Reproductive Sciences 20:10, pages 1237-1245.
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James Nello MartinJr.Jr.. (2013) Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia). International Journal of Gynecology & Obstetrics 121:3, pages 202-207.
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Kedra Wallace, James N. MartinJrJr, Kiran Tam Tam, Gerd Wallukat, Ralf Dechend, Babbette Lamarca & Michelle Y. Owens. (2013) Seeking the mechanism(s) of action for corticosteroids in HELLP syndrome: SMASH study. American Journal of Obstetrics and Gynecology 208:5, pages 380.e1-380.e8.
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Klaus F. Hofmann-Kiefer, J. Knabl, N. Martinoff, B. Schiessl, P. Conzen, M. Rehm, B. F. Becker & D. Chappell. (2013) Increased Serum Concentrations of Circulating Glycocalyx Components in HELLP Syndrome Compared to Healthy Pregnancy: An Observational Study. Reproductive Sciences 20:3, pages 318-325.
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Ulrich Abildgaard & Ketil Heimdal. (2013) Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. European Journal of Obstetrics & Gynecology and Reproductive Biology 166:2, pages 117-123.
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Jean-Vivien Schaal, Catherine Fischer, Kristel Boyer & Frédéric J. Mercier. (2012) Thrombopénie et grossesse. Le Praticien en Anesthésie Réanimation 16:6, pages 323-334.
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Kristin Palmsten, Sonia Hernández‐Díaz, Bindee Kuriya, Daniel H. Solomon & Soko Setoguchi. (2012) Use of disease‐modifying antirheumatic drugs during pregnancy and risk of preeclampsia. Arthritis Care & Research 64:11, pages 1730-1738.
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Renato Polimanti, Sara Piacentini, Natalia Lazzarin, Elena Vaquero, Maria Antonietta Re, Dario Manfellotto & Maria Fuciarelli. (2012) Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertility and Sterility 98:2, pages 396-400.
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O. Pourrat & F. Pierre. (2012) Utilit? de la corticoth?rapie dans le syndrome HELLP?: mythe ou r?alit???. La Revue de M?decine Interne 33:6, pages 297-299.
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Elizabeth Helen Horn & Lucy H. Kean. 2011. High Risk Pregnancy. High Risk Pregnancy 717 738.e5 .
Chiara Benedetto, Luca Marozio, Annalisa Tancredi, Elisa Picardo, Paola Nardolillo, Anna Maria Tavella & Loredana Salton. 2011. 85 104 .
Yao-Li Chen, Hsin-Shun Tseng, Wu-Hsien Kuo, Shun-Fa Yang, Dar-Ren Chen & Hsiu-Ting Tsai. (2010) Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Medical Genetics 11:1.
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Norbert Gleicher. (2009) Does the Immune System Induce Labor? Lessons from Preterm Deliveries in Women with Autoimmune Diseases. Clinical Reviews in Allergy & Immunology 39:3, pages 194-206.
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Elizabeth J. Carey & J. Eileen Hay. 2010. Practical Gastroenterology and Hepatology: Liver and Biliary Disease. Practical Gastroenterology and Hepatology: Liver and Biliary Disease 152 163 .
Simone Sep, Jef Verbeek, Gerardus Koek, Luc Smits, Marc Spaanderman & Louis Peeters. (2010) Clinical differences between early-onset HELLP syndrome and early-onset preeclampsia during pregnancy and at least 6 months postpartum. American Journal of Obstetrics and Gynecology 202:3, pages 271.e1-271.e5.
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Ann M. Kulungowski, Jeffry L. Kashuk, Ernest E. Moore, Haley G. Hutting, Miral R. Sadaria, C. Clay Cothren, Jeffrey L. Johnson & Angela Sauaia. (2009) Hemolysis, elevated liver enzymes, and low platelets syndrome: when is surgical help needed?. The American Journal of Surgery 198:6, pages 916-920.
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