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Free Radical Research Volume 34, 2001 - Issue 3
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Original Article

Protective effects of vitamins C and E on the number of micronuclei in lymphocytes in smokers and their role in ascorbate free radical formation in plasma

Matthias Schneider Institut fuer Biologische Chemie und Ernaehrungswissenschaften, Universitaet Hohenheim, 70593, Stuttgart, Germany
,
Kerstin Diemer Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, 94141-9100
,
Karin Engelhart Fachbereich Biologie / Abteilung Humanbiologie der Universitaet Kaiserslautern, Germany
,
Heinrich Zankl Fachbereich Chemie / Abteilung Biochemie der Universitaet Kaiserslautern, 67653, Kaiserslautern, Germany
,
Wolfgang E. Trommer Institut fuer Biologische Chemie und Ernaehrungswissenschaften, Universitaet Hohenheim, 70593, Stuttgart, Germany
&
Hans K. Biesalski Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, 94141-9100
Pages 209-219 | Received 02 Jun 1999, Published online: 07 Jul 2009

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Clara A. Veloso, Bárbara F. Oliveira, Fernanda Elisa P. Mariani, Fernanda S. Fagundes-Neto, Caroline Maria O. Volpe, José Augusto Nogueira-Machado & Míriam M. Chaves. (2013) Vitamin complex (ascorbic acid, alpha-tocopherol and beta-carotene) induces micronucleus formation in PBMNC unrelated to ROS production. Redox Report 18:6, pages 219-223.
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Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Akari Yoshimura, Hanako Yoshii, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe & Keizo Tano. (2013) Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Free Radical Research 47:1, pages 1-7.
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Eun-Sun Hwang & PhyllisE. Bowen. (2007) DNA Damage, a Biomarker of Carcinogenesis: Its Measurement and Modulation by Diet and Environment. Critical Reviews in Food Science and Nutrition 47:1, pages 27-50.
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Yvonne M. Jeanes, Wendy L. Hall, Anna R. Proteggente & John K. Lodge. (2004) Cigarette Smokers have Decreased Lymphocyte and Platelet α-tocopherol Levels and Increased Excretion of the γ-tocopherol Metabolite γ-carboxyethyl-hydroxychroman (γ-CEHC). Free Radical Research 38:8, pages 861-868.
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Articles from other publishers (41)

C. Meenakshi, K. Sivasubramanian & B. Venkatraman. (2017) Nucleoplasmic bridges as a biomarker of DNA damage exposed to radon. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 814, pages 22-28.
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Carina Ladeira, Mário Pádua, Luísa Veiga, Susana Viegas, Elisabete Carolino, Manuel C. Gomes & Miguel Brito. (2015) Influence of Serum Levels of Vitamins A, D, and E as well as Vitamin D Receptor Polymorphisms on Micronucleus Frequencies and Other Biomarkers of Genotoxicity in Workers Exposed to Formaldehyde. Lifestyle Genomics 8:4-6, pages 205-214.
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Olivia Torres-Bugarín, María Guadalupe Zavala-Cerna, Arnulfo Nava, Aurelio Flores-García & María Luisa Ramos-Ibarra. (2014) Potential Uses, Limitations, and Basic Procedures of Micronuclei and Nuclear Abnormalities in Buccal Cells. Disease Markers 2014, pages 1-13.
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Hyo Won Suh, So-Hyun Kim, Shin Jung Park, Sun-Hee Hyun, Seok-Young Lee, Joong-Hyuck Auh, Hong Jin Lee, Soo-Muk Cho, Jung-Hyun Kim & Hyung-Kyoon Choi. (2013) Effect of Korean black raspberry (Rubus coreanus Miquel) fruit administration on DNA damage levels in smokers and screening biomarker investigation using 1H-NMR-based metabolic profiling. Food Research International 54:1, pages 1255-1262.
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Elisabeth Müllner, Helmut Brath, Daniela Toferer, Sonja Adrigan, Marie-Therese Bulla, Roswitha Stieglmayer, Marlies Wallner, Reinhard Marek & Karl-Heinz Wagner. (2013) Genome damage in peripheral blood lymphocytes of diabetic and non-diabetic individuals after intervention with vegetables and plant oil. Mutagenesis 28:2, pages 205-211.
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O. Yu. Abasova, N. V. Reutova, L. P. Sycheva & E. A. Chernysheva. (2013) Studies of Antimutagenic Effects of Vitamins A and C in Humans. Bulletin of Experimental Biology and Medicine 154:5, pages 649-653.
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Jasminka Mrđanović, Saša Jungić, Slavica Šolajić, Višnja Bogdanović & Vladimir Jurišić. (2012) Effects of orally administered antioxidants on micronuclei and sister chromatid exchange frequency in workers professionally exposed to antineoplastic agents. Food and Chemical Toxicology 50:8, pages 2937-2944.
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Radim J. Sram, Blanka Binkova & Pavel RossnerJr.Jr.. (2012) Vitamin C for DNA damage prevention. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 733:1-2, pages 39-49.
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K. H. Jones, T. P. York, J. Juusola, A. Ferreira-Gonzalez, H. H. Maes & C. Jackson-Cook. (2011) Genetic and environmental influences on spontaneous micronuclei frequencies in children and adults: a twin study. Mutagenesis 26:6, pages 745-752.
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Hans Konrad Biesalski, Peter J. Aggett, Robert Anton, Paul S. Bernstein, Jeffrey Blumberg, Robert P. Heaney, Jeya Henry, John M. Nolan, David P. Richardson, Ben van Ommen, Renger F. Witkamp, Ger T. Rijkers & Iris Zöllner. (2011) 26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: Evidence-based nutrition. Nutrition 27:10, pages S1-S20.
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Iman A. Khaled, Mervat S. El-Ansary, Abeya F. Saleh, Ola M. Mahmoud, Emad A. Baioumi & Heba A. Bakr. (2010) Cytogenetic study of the effect of Schistosoma mansoni infection on human peripheral blood lymphocytes and the role of β-carotene and vitamin E in modulating this effect. Molecular Biology Reports 38:6, pages 4101-4109.
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Ghazaleh Moshkdanian, Seyed Noureddin Nematollahi-mahani, Fatemeh Pouya & Amirmahdi Nematollahi-mahani. (2011) Antioxidants rescue stressed embryos at a rate comparable with co-culturing of embryos with human umbilical cord mesenchymal cells. Journal of Assisted Reproduction and Genetics 28:4, pages 343-349.
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Hye-Jin LeeYoo Kyoung ParkMyung-Hee Kang. (2011) The effect of carrot juice, β-carotene supplementation on lymphocyte DNA damage, erythrocyte antioxidant enzymes and plasma lipid profiles in Korean smoker. Nutrition Research and Practice 5:6, pages 540.
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P. Thomas, J. Wu, V. Dhillon & M. Fenech. (2010) Effect of dietary intervention on human micronucleus frequency in lymphocytes and buccal cells. Mutagenesis 26:1, pages 69-76.
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M. Fenech & S. Bonassi. (2010) The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes. Mutagenesis 26:1, pages 43-49.
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Nevenka Kopjar, Vilena Kašuba, Mirta Milić, Ružica Rozgaj, Davor Želježić, Goran Gajski, Marin Mladinić & Vera Garaj-Vrhovac. (2010) Normal and Cut-Off Values of the Cytokinesis-Block Micronucleus Assay on Peripheral Blood Lymphocytes in the Croatian General Population. Archives of Industrial Hygiene and Toxicology 61:2, pages 219-234.
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Michael F Fenech. (2010) Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future. The American Journal of Clinical Nutrition 91:5, pages 1438S-1454S.
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Renato Minozzo, Luiz Irineu Deimling & Renato Santos-Mello. (2010) Cytokinesis-blocked micronucleus cytome and comet assays in peripheral blood lymphocytes of workers exposed to lead considering folate and vitamin B12 status. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 697:1-2, pages 24-32.
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Ayman A. Farghaly & Mona A. M. Abo-Zeid. (2010) Protective Effect of Vitamin C on Trimethyltin Induced DNA Damage Using Comet Assay and Chromosomal Aberrations. CYTOLOGIA 75:3, pages 229-236.
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J. M. Battershill, K. Burnett & S. Bull. (2008) Factors affecting the incidence of genotoxicity biomarkers in peripheral blood lymphocytes: impact on design of biomonitoring studies. Mutagenesis 23:6, pages 423-437.
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Maha A. Fahmy, Nagwa H.A. Hassan, Ayman A. Farghaly & Entesar E.S. Hassan. (2008) Studies on the genotoxic effect of beryllium chloride and the possible protective role of selenium/vitamins A, C and E. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 652:2, pages 103-111.
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Ilse Decordier, Kelly De Bont, Kirsten De Bock, Raluca Mateuca, Mathieu Roelants, Roberta Ciardelli, Dominique Haumont, Lisbeth E. Knudsen & Micheline Kirsch-Volders. (2007) Genetic susceptibility of newborn daughters to oxidative stress. Toxicology Letters 172:1-2, pages 68-84.
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Julie A. PascoMargaret J. HenryLaura K. WilkinsonGeoffrey C. NicholsonHans G. SchneiderMark A. Kotowicz. (2006) Antioxidant Vitamin Supplements and Markers of Bone Turnover in a Community Sample of Nonsmoking Women. Journal of Women's Health 15:3, pages 295-300.
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Subramanian Senthilkumar, Surinder Kumar Yogeeta, Rajakannu Subashini & Thiruvengadam Devaki. (2006) Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. Chemico-Biological Interactions 160:3, pages 252-260.
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Tal Offer, Emily Ho, Maret G. Traber, Richard S. Bruno, Frans A. Kuypers & Bruce N. Ames. (2004) A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes. The FASEB Journal 19:3, pages 1-18.
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Der-Cherng Tarng, Tsung-Yun Liu & Tung-Po Huang. (2004) Protective effect of vitamin C on 8-hydroxy-2′-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients. Kidney International 66:2, pages 820-831.
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A Mühlhöfer, S Mrosek, B Schlegel, W Trommer, F Rozario, H Böhles, D Schremmer, W G Zoller & HK Biesalski. (2004) High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers. European Journal of Clinical Nutrition 58:8, pages 1151-1158.
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Kumpati Premkumar & Christopher L. Bowlus. (2003) Ascorbic acid reduces the frequency of iron induced micronuclei in bone marrow cells of mice. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 542:1-2, pages 99-103.
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Genro Kashino, Seiji Kodama, Yukiko Nakayama, Keiji Suzuki, Kazuaki Fukase, Makoto Goto & Masami Watanabe. (2003) Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells. Free Radical Biology and Medicine 35:4, pages 438-443.
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Stefano Bonassi, Monica Neri, Cecilia Lando, Marcello Ceppi, Yi-ping Lin, Wushou P Chang, Nina Holland, Micheline Kirsch-Volders, Errol Zeiger & Michael Fenech. (2003) Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutation Research/Reviews in Mutation Research 543:2, pages 155-166.
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Eugene A. Lutsenko, Juan M. Cárcamo & David W. Golde. (2002) Vitamin C Prevents DNA Mutation Induced by Oxidative Stress. Journal of Biological Chemistry 277:19, pages 16895-16899.
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