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Original Article

Commentary
DNA Base Excision Repair Defects in Human Pathologies

Pages 1037-1054 | Received 26 May 2004, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Zexi Liao, Minhan Yi, Jiaxin Li & Yuan Zhang. (2022) DNA repair in lung cancer: a large-scale quantitative analysis for polymorphisms in DNA repairing pathway genes and lung cancer susceptibility. Expert Review of Respiratory Medicine 16:9, pages 997-1010.
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Rachel Abbotts, Nicola Thompson & Srinivasan Madhusudan. (2014) DNA repair in cancer: emerging targets for personalized therapy. Cancer Management and Research 6, pages 77-92.
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Claudia Tarlarini, Silvana Penco, Massimo Conio & Enzo Grossi. (2012) Role of XPC, XPD, XRCC1, GSTP genetic polymorphisms and Barrett’s esophagus in a cohort of Italian subjects. A neural network analysis. Clinical and Experimental Gastroenterology 5, pages 159-166.
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Natalya P. Degtyareva, Lingling Chen, Piotr Mieczkowski, Thomas D. Petes & Paul W. Doetsch. (2008) Chronic Oxidative DNA Damage Due to DNA Repair Defects Causes Chromosomal Instability in Saccharomyces cerevisiae. Molecular and Cellular Biology 28:17, pages 5432-5445.
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Articles from other publishers (23)

Liang Chi, Bei Gao, Pengcheng Tu, Chih-Wei Liu, Jingchuan Xue, Yunjia Lai, Hongyu Ru & Kun Lu. (2018) Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome. Mammalian Genome 29:1-2, pages 63-79.
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Lyda Espitia-Pérez, Milton Quintana Sosa, Shirley Salcedo-Arteaga, Grethel León-Mejía, Luz Stella Hoyos-Giraldo, Hugo Brango, Katia Kvitko, Juliana da Silva & João A.P. Henriques. (2016) Polymorphisms in metabolism and repair genes affects DNA damage caused by open-cast coal mining exposure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 808, pages 38-51.
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Junko Fujihara, Toshihiro Yasuda, Hisato Iwata, Shinsuke Tanabe & Haruo Takeshita. (2015) Association of XRCC1 polymorphisms with arsenic methylation. Archives of Toxicology 90:4, pages 1009-1012.
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Haruo Takeshita, Junko Fujihara, Toshihiro Yasuda & Kaori Kimura-Kataoka. (2015) Worldwide Distribution of Four SNPs in X-Ray and Repair and Cross-Complementing Group 1 (XRCC1). Clinical and Translational Science 8:4, pages 347-350.
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Zoraida Verde, Luis Reinoso, Luis Miguel Chicharro, Pilar Resano, Ignacio Sánchez-Hernández, Jose Miguel Rodríguez González-Moro, Fernando Bandrés, Félix Gómez-Gallego & Catalina Santiago. (2015) Are SNP-Smoking Association Studies Needed in Controls? DNA Repair Gene Polymorphisms and Smoking Intensity. PLOS ONE 10:5, pages e0129374.
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Chien-I Chiang, Ya-Li Huang, Chao-Yuan Huang, Horng-Sheng Shiue, Wei-Jen Chen, Yeong-Shiau Pu, Ying-Chin Lin & Yu-Mei Hsueh. (2015) XRCC1 Polymorphisms and Urinary 8-Hydroxydeoxyguanine Levels Are Associated with Urothelial Carcinoma. PLOS ONE 10:5, pages e0124066.
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Yu Peng, Zheng Li, Shiheng Zhang, Yanli Xiong, Yanping Cun, Chengyuan Qian, Mengxia Li, Tao Ren, Lei Xia, Yi Cheng & Dong Wang. (2014) Association of DNA base excision repair genes ( OGG1 , APE1 and XRCC1 ) polymorphisms with outcome to platinum-based chemotherapy in advanced nonsmall-cell lung cancer patients . International Journal of Cancer 135:11, pages 2687-2696.
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Chien-I Chiang, Ya-Li Huang, Wei-Jen Chen, Horng-Sheng Shiue, Chao-Yuan Huang, Yeong-Shiau Pu, Ying-Chin Lin & Yu-Mei Hsueh. (2014) XRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma. Toxicology and Applied Pharmacology 279:3, pages 373-379.
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Aishwarya Prakash, Brittany L. Carroll, Joann B. Sweasy, Susan S. Wallace & Sylvie Doublié. (2014) Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing. DNA Repair 14, pages 17-26.
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Susan S. Wallace, Drew L. Murphy & Joann B. Sweasy. (2012) Base excision repair and cancer. Cancer Letters 327:1-2, pages 73-89.
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Lydia P. Morris, Natalya Degtyareva, Clayton Sheppard, Lanier Heyburn, Andrei A. Ivanov, Yoke Wah Kow & Paul W. Doetsch. (2012) Saccharomyces cerevisiae Apn1 mutation affecting stable protein expression mimics catalytic activity impairment: Implications for assessing DNA repair capacity in humans. DNA Repair 11:9, pages 753-765.
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Junko Fujihara, Mikiko Soejima, Toshihiro Yasuda, Yoshiro Koda, Takashi Kunito, Hisato Iwata, Shinsuke Tanabe & Haruo Takeshita. (2011) Polymorphic trial in oxidative damage of arsenic exposed Vietnamese. Toxicology and Applied Pharmacology 256:2, pages 174-178.
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Concetta Santonocito, Andrea Paradisi, Rodolfo Capizzi, Eleonora Torti, Sara Lanza-Silveri, Romina Penitente, Cecilia Zuppi & Ettore Capoluongo. (2018) Common Genetic Variants of MUTYH are not Associated with Cutaneous Malignant Melanoma: Application of Molecular Screening by Means of High-Resolution Melting Technique in a Pilot Case-Control Study. The International Journal of Biological Markers 26:1, pages 37-42.
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Paula Rohr, Juliana da Silva, Bernardo Erdtmann, Jenifer Saffi, Temenouga Nikolova Guecheva, João Antônio Pêgas Henriques & Kátia Kvitko. (2011) BER gene polymorphisms (OGG1 Ser326Cys and XRCC1 Arg194Trp) and modulation of DNA damage due to pesticides exposure. Environmental and Molecular Mutagenesis 52:1, pages 20-27.
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Caixia Sun, Xiufang Liu, Huan Zhang, Wenwen Guo, Zhenming Cai, Huimei Chen, Kui Zhang, Dalong Zhu & Yaping Wang. (2010) Functional polymorphism of hOGG1 gene is associated with type 2 diabetes mellitus in Chinese population. Molecular and Cellular Endocrinology 325:1-2, pages 128-134.
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M Felicitas López-Cima, Patricia González-Arriaga, Laura García-Castro, Teresa Pascual, Manuel G Marrón, Xose S Puente & Adonina Tardón. (2007) Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain. BMC Cancer 7:1.
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Carrie V. Breton, Wei Zhou, Molly L. Kile, E.A. Houseman, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin & David C. Christiani. (2007) Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes. Carcinogenesis 28:7, pages 1520-1525.
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Andrew R. Collins & Isabel Gaivão. (2007) DNA base excision repair as a biomarker in molecular epidemiology studies. Molecular Aspects of Medicine 28:3-4, pages 307-322.
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Guido Frosina. (2007) Gene prophylaxis by a DNA repair function. Molecular Aspects of Medicine 28:3-4, pages 323-344.
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Jonine D. Figueroa, Núria Malats, Francisco X. Real, Debra Silverman, Manolis Kogevinas, Stephen Chanock, Robert Welch, Mustafa Dosemeci, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Gemma Castaño-Vinyals, Nathaniel Rothman & Montserrat García-Closas. (2007) Genetic variation in the base excision repair pathway and bladder cancer risk. Human Genetics 121:2, pages 233-242.
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Guido Frosina. (2006) Prophylaxis of oxidative DNA damage by formamidopyrimidine-DNA glycosylase. International Journal of Cancer 119:1, pages 1-7.
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Marcus S. Cooke, Rafal Rozalski, Rosamund Dove, Daniel Gackowski, Agnieszka Siomek, Mark D. Evans & Ryszard Olinski. (2006) Evidence for attenuated cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine removal in cancer patients. Biological Chemistry 387:4.
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D.M. WilsonIIIIII, H.-K. Wong, D.R. McNeill & J. Fan. 2006. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 30 37 .

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