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Free Radical Research Volume 54, 2020 - Issue 5
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Original Articles

Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model

Brian FinkDepartment of Veterans Affairs, Iowa City Health Care System, Iowa City, IA, USA; View further author information
,
Lawrence CoppeyDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA; View further author information
,
Eric DavidsonDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA; View further author information
,
Hanna ShevalyeDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA; View further author information
,
Alexander ObrosovDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA; View further author information
,
Pratik Rajesh ChhedaCollege of Pharmacy, University of Iowa, Iowa City, IA, USA; View further author information
,
Robert KernsCollege of Pharmacy, University of Iowa, Iowa City, IA, USA; View further author information
,
William SivitzDepartment of Veterans Affairs, Iowa City Health Care System, Iowa City, IA, USA; ;Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; ;Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA; View further author information
&
Mark YorekDepartment of Veterans Affairs, Iowa City Health Care System, Iowa City, IA, USA; ;Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; ;Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA; ;Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USACorrespondence[email protected]
View further author information
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Pages 311-318 | Received 11 Nov 2019, Accepted 05 Apr 2020, Published online: 24 Apr 2020

Citations (18)

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Balaraman Kalyanaraman, Gang Cheng, Micael Hardy & Ming You. (2023) OXPHOS-targeting drugs in oncology: new perspectives. Expert Opinion on Therapeutic Targets 27:10, pages 939-952.
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Prashanth Komirishetty, Aparna Areti, Vijay Kumar Arruri, Ramakrishna Sistla, Ranadeep Gogoi & Ashutosh Kumar. (2021) FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats. Free Radical Research 55:9-10, pages 1005-1017.
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Jing Feng & Yangyang Zhang. (2023) The potential benefits of polyphenols for corneal diseases. Biomedicine & Pharmacotherapy 169, pages 115862.
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Nadezda ApostolovaTeresa VezzaJordi MuntaneMilagros RochaVíctor M. Víctor. (2023) Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets. Antioxidants & Redox Signaling 39:4-6, pages 278-320.
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Gang Cheng, Hakim Karoui, Micael Hardy & Balaraman Kalyanaraman. (2023) Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies. Free Radical Biology and Medicine 205, pages 175-187.
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Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov & Doan T. M. Ngo. (2023) Overexpression of Mitochondrial Catalase within Adipose Tissue Does Not Confer Systemic Metabolic Protection against Diet-Induced Obesity. Antioxidants 12:5, pages 1137.
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Tarun Pant, Nnamdi Uche, Matea Juric & Zeljko J. Bosnjak. (2023) Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes. Antioxidants 12:4, pages 898.
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Guillermo López-Lluch. 2023. Molecular Nutrition and Mitochondria. Molecular Nutrition and Mitochondria 255 302 .
Mark Yorek. 2023. Diabetic Neuropathy. Diabetic Neuropathy 253 277 .
Farhana Naznin, T. M. Zaved Waise & Paul Fernyhough. (2022) Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons. Molecular Neurobiology 59:11, pages 6754-6770.
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Dan Zhou, Qingrui Zhuan, Yuwen Luo, Hongyu Liu, Lin Meng, Xingzhu Du, Guoquan Wu, Yunpeng Hou, Jun Li & Xiangwei Fu. (2022) Mito-Q promotes porcine oocytes maturation by maintaining mitochondrial thermogenesis via UCP2 downregulation. Theriogenology 187, pages 205-214.
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Mohamad-Reza Aghanoori, Prasoon Agarwal, Evan Gauvin, Raghu S. Nagalingam, Raiza Bonomo, Vinith Yathindranath, Darrell R. Smith, Yan Hai, Samantha Lee, Corinne G. Jolivalt, Nigel A. Calcutt, Meaghan J. Jones, Michael P. Czubryt, Donald W. Miller, Vernon W. Dolinsky, Virginie Mansuy-Aubert & Paul Fernyhough. (2022) CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth. Cellular and Molecular Life Sciences 79:4.
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Md Jakir Hossain, Michael D. Kendig, Meg E. Letton, Margaret J. Morris & Ria Arnold. (2022) Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions. Diabetes & Metabolism Journal 46:2, pages 198-221.
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Ting Zhou, Allie Lee, Amy Cheuk Yin Lo & Jeremy Sze Wai John Kwok. (2022) Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies. Frontiers in Pharmacology 13.
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Mingxuan Liu & Ying Wu. (2022) Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation. Frontiers in Cardiovascular Medicine 9.
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Danielle A. Clarkson-Townsend, Amber J. Douglass, Anayesha Singh, Rachael S. Allen, Ivie N. Uwaifo & Machelle T. Pardue. (2021) Impacts of high fat diet on ocular outcomes in rodent models of visual disease. Experimental Eye Research 204, pages 108440.
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Brian D. Fink, Liping Yu, Lawrence Coppey, Alexander Obrosov, Hanna Shevalye, Robert J. Kerns, Mark A. Yorek & William I. Sivitz. (2021) Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacology Research & Perspectives 9:1.
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Laura Bordoni & Rosita Gabbianelli. (2020) Mitochondrial DNA and Neurodegeneration: Any Role for Dietary Antioxidants?. Antioxidants 9:8, pages 764.
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