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Original Article

Pyruvate prevents hydrogen peroxide-induced apoptosis

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Pages 283-295 | Received 04 Feb 1998, Published online: 07 Jul 2009

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Diana Barrera-Oviedo, Miriam Gabriela Carranza-Pérez, Mario T. Candelario-Mota, Nicandro Mendoza-Patiño, Perla D. Maldonado & José Pedraza-Chaverrí. (2013) Protective Effect of SnCl2 on K2Cr2O7-Induced Toxicity in LLC-PK1 Cells. Renal Failure 35:1, pages 132-137.
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Hideaki Miwa, Junichi Fujii, Hiroyuki Kanno, Naoyuki Taniguchi & Katsuyuki Aozasa. (2000) Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated cell death. Free Radical Research 33:1, pages 45-56.
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Mingyue Li, Weina Guo, Yalan Dong, Wenzhu Wang, Chunxia Tian, Zili Zhang, Ting Yu, Haifeng Zhou, Yang Gui, Kaming Xue, Junyi Li, Feng Jiang, Alexey Sarapultsev, Huafang Wang, Ge Zhang, Shanshan Luo, Heng Fan & Desheng Hu. (2022) Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice. Genomics, Proteomics & Bioinformatics 20:2, pages 288-303.
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Changpeng Han, Haojie Yang, Bin Li & Zhenyi Wang. (2020) Exogenous pyruvate facilitates ultraviolet B-induced DNA damage repair by promoting H3K9 acetylation in keratinocytes and melanocytes. Biomedicine & Pharmacotherapy 126, pages 110082.
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N. Lewis, K. Hinrichs, H. J. Leese, C. McG. Argo, D. R. Brison & R. Sturmey. (2020) Energy metabolism of the equine cumulus oocyte complex during in vitro maturation. Scientific Reports 10:1.
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N. A. Martino, G. Marzano, A. Mastrorocco, G. M. Lacalandra, L. Vincenti, K. Hinrichs & M. E. Dell'Aquila. (2019) Use of time-lapse imaging to evaluate morphokinetics of in vitro equine blastocyst development after oocyte holding for two days at 15°C versus room temperature before intracytoplasmic sperm injection. Reproduction, Fertility and Development 31:12, pages 1862.
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Chanjuan Yue, Jin Chen, Ranran Hou, Weijun Tian, Kuanhui Liu, Deyun Wang, Yu Lu, Jiaguo Liu, Yi Wu & Yuanliang Hu. (2017) The antioxidant action and mechanism of selenizing Schisandra chinensis polysaccharide in chicken embryo hepatocyte. International Journal of Biological Macromolecules 98, pages 506-514.
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Anna VysochanArjun Sengupta, Aalim M. Weljie, James C. AlwineYongjun Yu. (2017) ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. Proceedings of the National Academy of Sciences 114:8.
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Anh Q Nguyen, Brandon H Cherry, Gary F Scott, Myoung-Gwi Ryou & Robert T Mallet. (2014) Erythropoietin: Powerful protection of ischemic and post-ischemic brain. Experimental Biology and Medicine 239:11, pages 1461-1475.
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Celaleddin Demircan, Zülfiye Gül & R. Levent Büyükuysal. (2014) High Glutamate Attenuates S100B and LDH Outputs from Rat Cortical Slices Enhanced by Either Oxygen–Glucose Deprivation or Menadione. Neurochemical Research 39:7, pages 1232-1244.
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T.-Y. Wang, Q. Li, Q. Li, H. Li, J. Zhu, W. Cui, G.-Z. Jiao & J.-H. Tan. (2013) Non-frozen preservation protocols for mature mouse oocytes dramatically extend their developmental competence by reducing oxidative stress. Molecular Human Reproduction 20:4, pages 318-329.
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Bryan Troxell, Jun-Jie Zhang, Travis J. Bourret, Melody Yue Zeng, Janice Blum, Frank Gherardini, Hosni M. Hassan & X. Frank Yang. (2014) Pyruvate Protects Pathogenic Spirochetes from H2O2 Killing. PLoS ONE 9:1, pages e84625.
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Qing Li, Gang Wang, Jie Zhang, Ping Zhou, Tian-Yang Wang, Wei Cui, Ming-Jiu Luo & Jing-He Tan. (2012) Combined Inhibitory Effects of Pyruvate and Low Temperature on Postovulatory Aging of Mouse Oocytes1. Biology of Reproduction 87:5.
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Qing Li, De-Qiang Miao, Ping Zhou, Yan-Guang Wu, Da Gao, De-Li Wei, Wei Cui & Jing-He Tan. (2011) Glucose Metabolism in Mouse Cumulus Cells Prevents Oocyte Aging by Maintaining Both Energy Supply and the Intracellular Redox Potential1. Biology of Reproduction 84:6, pages 1111-1118.
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D. Mathioudakis, J. Engel, I. D. Welters, M. G. Dehne, R. Matejec, H. Harbach, M. Henrich, T. Schwandner, M. Fuchs, K. Weismüller, G. J. Scheffer & Jörg Mühling. (2010) Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production. Amino Acids 40:4, pages 1077-1090.
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Yu Ou, Shan Zheng, Lin Lin & Qian Li. (2011) C-phycocyanin from Spirulina maxima protects hepatocytes against oxidative damage induced by H2O2 in vitro. Biomedicine & Preventive Nutrition 1:1, pages 8-11.
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Miguel López-Lázaro. (2009) A New View of Carcinogenesis and an Alternative Approach to Cancer Therapy. Molecular Medicine 16:3-4, pages 144-153.
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Zhenqing Li, Feng Wang, Sashwati Roy, Chandan K. Sen & Jianjun Guan. (2009) Injectable, Highly Flexible, and Thermosensitive Hydrogels Capable of Delivering Superoxide Dismutase. Biomacromolecules 10:12, pages 3306-3316.
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Na Liu, Yan-Guang Wu, Guo-Cheng Lan, Hong-Shu Sui, Li Ge, Jun-Zuo Wang, Yong Liu, Tian-Wu Qiao & Jing-He Tan. (2009) Pyruvate prevents aging of mouse oocytes. REPRODUCTION 138:2, pages 223-234.
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Rodrigo Franco, Mihalis I. Panayiotidis & Lenin D. Ochoa de la Paz. (2008) Autocrine signaling involved in cell volume regulation: The role of released transmitters and plasma membrane receptors. Journal of Cellular Physiology 216:1, pages 14-28.
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Rodrigo Franco, Mihalis I. Panayiotidis & John A. Cidlowski. (2007) Glutathione Depletion Is Necessary for Apoptosis in Lymphoid Cells Independent of Reactive Oxygen Species Formation. Journal of Biological Chemistry 282:42, pages 30452-30465.
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Hermann Unterluggauer, Eveline Hütter, Regina Voglauer, Johannes Grillari, Monika Vöth, Jürgen Bereiter-Hahn, Pidder Jansen-Dürr & Marina Jendrach. (2007) Identification of cultivation-independent markers of human endothelial cell senescence in vitro. Biogerontology 8:4, pages 383-397.
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Judith A. Gilbert, Linda M. Frederick, Lori J. Pobst & Matthew M. Ames. (2005) Hydrogen peroxide degradation and selective carbidopa-induced cytotoxicity against human tumor lines. Biochemical Pharmacology 69:8, pages 1159-1166.
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Se-Jin Chung, Se-Hee Lee, Yong-Jin Lee, Hyoung-Sook Park, Rolf Bunger & Young-Hee Kang. (2004) Pyruvate Protection against Endothelial Cytotoxicity Induced by Blockade of Glucose Uptake. BMB Reports 37:2, pages 239-245.
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Gentian Kristo, Yukihiro Yoshimura, Jianli Niu, Byron J. Keith, Robert M. MentzerJr.Jr., Rolf Bünger & Robert D. Lasley. (2004) The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium. American Journal of Physiology-Heart and Circulatory Physiology 286:2, pages H517-H524.
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Armando González-Falcón, Eduardo Candelario-Jalil, Michel Garcı&#x;a-Cabrera & Olga Sonia León. (2003) Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. Brain Research 990:1-2, pages 1-7.
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Yong-Jin Lee, Il-Jun Kang, Rolf Bünger & Young-Hee Kang. (2003) Mechanisms of pyruvate inhibition of oxidant-induced apoptosis in human endothelial cells. Microvascular Research 66:2, pages 91-101.
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Noriko Tonomura, Kelly McLaughlin, Lisa Grimm, Richard A. Goldsby & Barbara A. Osborne. (2003) Glucocorticoid-Induced Apoptosis of Thymocytes: Requirement of Proteasome-Dependent Mitochondrial Activity. The Journal of Immunology 170:5, pages 2469-2478.
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Noriko Tonomura, Richard A. Goldsby, Eric V. Granowitz & Barbara Osborne. 2003. Molecular Mechanisms of Programmed Cell Death. Molecular Mechanisms of Programmed Cell Death 79 93 .
Ed W. J. van Niel, Karin Hofvendahl & Bärbel Hahn-Hägerdal. (2002) Formation and Conversion of Oxygen Metabolites by Lactococcus lactis subsp. lactis ATCC 19435 under Different Growth Conditions . Applied and Environmental Microbiology 68:9, pages 4350-4356.
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Zakaria S. Tawadrous, Russell L. Delude & Mitchell P. Fink. (2002) Resuscitation from Hemorrhagic Shock with Ringer's Ethyl Pyruvate Solution Improves Survival And Ameliorates Intestinal Mucosal Hyperpermeability in Rats. Shock 17:6, pages 473-477.
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Eiichi Hinoi, Sayumi Fujimori, Akihiro Takemori & Yukio Yoneda. (2002) Cell death by pyruvate deficiency in proliferative cultured calvarial osteoblasts. Biochemical and Biophysical Research Communications 294:5, pages 1177-1183.
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C. M. O'Flaherty, N. B. Beorlegui & M. T. Beconi. (2002) Lactate dehydrogenase-C4 is involved in heparin- and NADH-dependent bovine sperm capacitation. Andrologia 34:2, pages 91-97.
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Montserrat Marı́, Jingxiang Bai & Arthur I Cederbaum. (2002) Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria. Free Radical Biology and Medicine 32:1, pages 73-83.
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R. Venkataraman & M. P. Fink. 2002. Mechanisms of Organ Dysfunction in Critical Illness. Mechanisms of Organ Dysfunction in Critical Illness 282 300 .
Carrie A. Sims, Somkiat Wattanasirichaigoon, Michael J. Menconi, Alfred M. Ajami & Mitchell P. Fink. (2001) Ringer’s ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Critical Care Medicine 29:8, pages 1513-1518.
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Paul N. Slovin, Chun-Jen Huang, J.Robert Cade, Charles E. Wood, Omer Nasiroglu, Malcolm Privette, Pini Orbach & Jeffrey W. Skimming. (2001) Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock. Resuscitation 50:1, pages 109-115.
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Eberhard Bassenge, Olaf Sommer, Michael Schwemmer & Rolf Bünger. (2000) Antioxidant pyruvate inhibits cardiac formation of reactive oxygen species through changes in redox state. American Journal of Physiology-Heart and Circulatory Physiology 279:5, pages H2431-H2438.
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