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Free Radical Research Volume 30, 1999 - Issue 3
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Original Article

Apoptotic macrophage-derived foam cells of human atheromas are rich in iron and ferritin, suggesting iron-catalysed reactions to be involved in apoptosis

Xi Ming Yuan Department of Pathology II and the Clinical Research Center, Faculty of Health Sciences, Linköping University, S-581 85, Linköping, Sweden
Pages 221-231 | Received 14 Sep 1998, Published online: 07 Jul 2009

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Oluwatosin O. Ojo & David S. Leake. (2021) Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH. Free Radical Research 55:5, pages 525-534.
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T. Mukaide, Y. Hattori, N. Misawa, S. Funahashi, L. Jiang, T. Hirayama, H. Nagasawa & S. Toyokuni. (2014) Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model. Free Radical Research 48:9, pages 990-995.
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Annalisa Castagna, Rita Polati, Alessandra Maria Bossi & Domenico Girelli. (2012) Monocyte/macrophage proteomics: recent findings and biomedical applications. Expert Review of Proteomics 9:2, pages 201-215.
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Wei-Yi Ong, Andrew M. Jenner, Ning Pan, Choon-Nam Ong & Barry Halliwell. (2009) Elevated oxidative stress, iron accumulation around microvessels and increased 4-hydroxynonenal immunostaining in zone 1 of the liver acinus in hypercholesterolemic rabbits. Free Radical Research 43:3, pages 241-249.
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Alon Peretz, Erin C. Peck, Theo K. Bammler, Richard P. Beyer, Jeffrey H. Sullivan, Carol A. Trenga, Sengkeo Srinouanprachnah, Federico M. Farin & Joel D. Kaufman. (2007) Diesel Exhaust Inhalation and Assessment of Peripheral Blood Mononuclear Cell Gene Transcription Effects: An Exploratory Study of Healthy Human Volunteers. Inhalation Toxicology 19:14, pages 1107-1119.
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Xi-Ming Yuan, Wei Li, Sarah K. Baird, Maria Carlsson & Öjar Melefors. (2004) Secretion of Ferritin by Iron-laden Macrophages and Influence of Lipoproteins. Free Radical Research 38:10, pages 1133-1142.
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M. Madsen, J.H. Graversen & S.K. Moestrup. (2001) Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes. Redox Report 6:6, pages 386-388.
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Pauline Puylaert, Michelle Zurek, Katey J. Rayner, Guido R.Y. De Meyer & Wim Martinet. (2022) Regulated Necrosis in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 42:11, pages 1283-1306.
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Christian Anthony Aloe, Tracy Li‐Tsein Leong, Hari Wimaleswaran, Paris Clarice Papagianis, Jonathan Luke McQualter, Christine Faye McDonald, Yet Hong Khor, Ryan Francis Hoy, Aviraj Ingle, Vipul Bansal, Nicole Soo Leng Goh & Steven Bozinovski. (2022) Excess iron promotes emergence of foamy macrophages that overexpress ferritin in the lungs of silicosis patients. Respirology 27:6, pages 427-436.
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Tianying Wu, Samantha Sonoda & Hongxia Liu. (2020) Unprocessed red meat intakes are associated with increased inflammation, triglycerides and HDL cholesterol in past smokers. Nutrition & Dietetics 77:2, pages 182-188.
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Oluwatosin O. Ojo & David S. Leake. (2018) Low density lipoprotein oxidation by ferritin at lysosomal pH. Chemistry and Physics of Lipids 217, pages 51-57.
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Manfred Nairz, Igor Theurl, Filip K. Swirski & Guenter Weiss. (2017) “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflügers Archiv - European Journal of Physiology 469:3-4, pages 397-418.
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V. Nandwana, S.-R. Ryoo, S. KanthalaA. Kumar, A. Sharma, F. C. Castro, Y. Li, B. Hoffman, S. Lim & V. P. Dravid. (2017) Engineered ferritin nanocages as natural contrast agents in magnetic resonance imaging. RSC Advances 7:55, pages 34892-34900.
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Liliana Marques, Anne Negre-Salvayre, Luciana Costa & François Canonne-Hergaux. (2016) Iron gene expression profile in atherogenic Mox macrophages. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1862:6, pages 1137-1146.
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David Kopriva, Anastasye Kisheev, Deiter Meena, Shaneen Pelle, Max Karnitsky, Andrea Lavoie & Josef Buttigieg. (2015) The Nature of Iron Deposits Differs between Symptomatic and Asymptomatic Carotid Atherosclerotic Plaques. PLOS ONE 10:11, pages e0143138.
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Eun Ji Chung & Matthew Tirrell. (2015) Recent Advances in Targeted, Self-Assembling Nanoparticles to Address Vascular Damage Due to Atherosclerosis. Advanced Healthcare Materials 4:16, pages 2408-2422.
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Eliisa Ollikainen, Riikka Tulamo, Juhana Frösen, Satu Lehti, Petri Honkanen, Juha Hernesniemi, Mika Niemelä & Petri T. Kovanen. (2014) Mast Cells, Neovascularization, and Microhemorrhages are Associated With Saccular Intracranial Artery Aneurysm Wall Remodeling. Journal of Neuropathology & Experimental Neurology 73:9, pages 855-864.
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Nosratola D. Vaziri. (2013) Understanding Iron: Promoting Its Safe Use in Patients With Chronic Kidney Failure Treated by Hemodialysis. American Journal of Kidney Diseases 61:6, pages 992-1000.
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Shuping Zhong, Jun Xu, Peggy Li & Hidekazu Tsukamoto. (2012) Caveosomal Oxidative Stress Causes Src-p21 Activation and Lysine 63 TRAF6 Protein Polyubiquitination in Iron-induced M1 Hepatic Macrophage Activation. Journal of Biological Chemistry 287:38, pages 32078-32084.
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Leanne SatchellDavid S. Leake. (2012) Oxidation of Low-Density Lipoprotein by Iron at Lysosomal pH: Implications for Atherosclerosis. Biochemistry 51:18, pages 3767-3775.
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Fernando de la Cuesta, Gloria Alvarez-Llamas, Aroa S. Maroto, Alicia Donado, Irene Zubiri, Maria Posada, Luis R. Padial, Angel G. Pinto, Maria G. Barderas & Fernando Vivanco. (2011) A Proteomic Focus on the Alterations Occurring at the Human Atherosclerotic Coronary Intima. Molecular & Cellular Proteomics 10:4, pages M110.003517.
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Moumita Ghosh, Fredrik Carlsson, Amit Laskar, Xi-Ming Yuan & Wei Li. (2011) Lysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophages. FEBS Letters 585:4, pages 623-629.
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Masahiro Terashima, Masaki Uchida, Hisanori Kosuge, Philip S. Tsao, Mark J. Young, Steven M. Conolly, Trevor Douglas & Michael V. McConnell. (2011) Human ferritin cages for imaging vascular macrophages. Biomaterials 32:5, pages 1430-1437.
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Marianne Wessling-Resnick. (2010) Iron Homeostasis and the Inflammatory Response. Annual Review of Nutrition 30:1, pages 105-122.
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Jerome L. Sullivan. (2009) Iron in arterial plaque: A modifiable risk factor for atherosclerosis. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:7, pages 718-723.
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Mahbub M. Rahman, Farzana Rahman, Lloyd Sansom, Ravi Naidu & Otto Schmidt. (2008) Arsenic interactions with lipid particles containing iron. Environmental Geochemistry and Health 31:S1, pages 201-206.
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Wei Li, Louise Kornmark, Lena Jonasson, Claes Forssell & Xi-Ming Yuan. (2009) Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis. Atherosclerosis 202:1, pages 92-102.
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Wei Li, Li-Hua Xu, Claes Forssell, Jerome L. Sullivan & Xi-Ming Yuan. (2008) Overexpression of Transferrin Receptor and Ferritin Related to Clinical Symptoms and Destabilization of Human Carotid Plaques. Experimental Biology and Medicine 233:7, pages 818-826.
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Subha V. Raman, Marshall W. WinnerIIIIII, Tam Tran, Murugesan Velayutham, Orlando P. Simonetti, Peter B. Baker, John Olesik, Beth McCarthy, Amy K. Ferketich & Jay L. Zweier. (2008) In Vivo Atherosclerotic Plaque Characterization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques. JACC: Cardiovascular Imaging 1:1, pages 49-57.
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S. G. Berrak, M. Angaji, E. Turkkan, C. Canpolat, C. Timur & E. Eksioglu-Demiralp. (2007) The effects of iron deficiency on neutrophil/monocyte apoptosis in children. Cell Proliferation 40:5, pages 741-754.
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Jerome l. Sullivan. (2016) Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability. Experimental Biology and Medicine 232:8, pages 1014-1020.
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Li Chen, Shigang Xiong, Hongyun She, Sharon W. Lin, Jiaohong Wang & Hidekazu Tsukamoto. (2007) Iron Causes Interactions of TAK1, p21ras, and Phosphatidylinositol 3-Kinase in Caveolae to Activate IκB Kinase in Hepatic Macrophages. Journal of Biological Chemistry 282:8, pages 5582-5588.
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Gorm Danscher & Meredin Stoltenberg. (2006) Silver enhancement of quantum dots resulting from (1) metabolism of toxic metals in animals and humans, (2) in vivo, in vitro and immersion created zinc–sulphur/zinc–selenium nanocrystals, (3) metal ions liberated from metal implants and particles. Progress in Histochemistry and Cytochemistry 41:2, pages 57-139.
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Wei Li, Anna Hellsten, Li-Hua Xu, Da-Ming Zhuang, Katarina Jansson, Ulf T. Brunk & Xi-Ming Yuan. (2005) Foam cell death induced by 7β-hydroxycholesterol is mediated by labile iron-driven oxidative injury: Mechanisms underlying induction of ferritin in human atheroma. Free Radical Biology and Medicine 39:7, pages 864-875.
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J. H. W. Distler, L. C. Huber, A. J. Hueber, C. F. ReichIIIIII, S. Gay, O. Distler & D. S. Pisetsky. (2005) The release of microparticles by apoptotic cells and their effects on macrophages. Apoptosis 10:4, pages 731-741.
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WEI LI, ANNA HELLSTEN, JEROME DINGA NYHALAH & XI-MING YUAN. (2004) Enhanced Expression of Natural Resistance-Associated Macrophage Protein 1 in Atherosclerotic Lesions May Be Associated with Oxidized Lipid-Induced Apoptosis. Annals of the New York Academy of Sciences 1030:1, pages 202-207.
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WEI LI, LI-HUA XU & XI-MING YUAN. (2004) Macrophage Hemoglobin Scavenger Receptor and Ferritin Accumulation in Human Atherosclerotic Lesions. Annals of the New York Academy of Sciences 1030:1, pages 196-201.
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Scott M WassermanJames N Topper. (2016) Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications. Vascular Medicine 9:1, pages 35-45.
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Wendy Jessup, Paul Wilson, Katharina Gaus & Len Kritharides. (2002) Oxidized lipoproteins and macrophages. Vascular Pharmacology 38:4, pages 239-248.
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Wei LiHelge DalenJohn W. EatonXi-Ming Yuan. (2001) Apoptotic Death of Inflammatory Cells in Human Atheroma. Arteriosclerosis, Thrombosis, and Vascular Biology 21:7, pages 1124-1130.
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Anna Baoutina, Roger T. Dean & Wendy Jessup. (2001) Trans‐plasma membrane electron transport induces macrophage‐mediated low‐density lipoprotein oxidation. The FASEB Journal 15:9, pages 1580-1582.
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Frank Watt, M.Q Ren, J.P Xie, B.K.H Tan & B Halliwell. (2001) Nuclear microscopy of atherosclerotic tissue: A review. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 181:1-4, pages 431-436.
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Kirsteen Maclean, Hui Yang & John L. Cleveland. (2001) Serum suppresses myeloid progenitor apoptosis by regulating iron homeostasis. Journal of Cellular Biochemistry 82:1, pages 171-186.
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Durairaj Ponraj, Jagoda Makjanic, Patricia S.P Thong, Benny K.H Tan & Frank Watt. (1999) The onset of atherosclerotic lesion formation in hypercholesterolemic rabbits is delayed by iron depletion. FEBS Letters 459:2, pages 218-222.
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