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Original Article

Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (α-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II)

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Pages 171-179 | Received 10 Feb 1999, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (19)

Jinghong Huo, Yanzhong Xue, Xiaoying Dong, Jinming Lv, Lingyu Wu, Hua Gao, Xiuqin Yang, Huanhuan Liu & Qinghan Gao. (2023) Efficacy of vitamin and antioxidant supplements for treatment of diabetic peripheral neuropathy: systematic review and meta-analysis of randomized controlled trials. Nutritional Neuroscience 26:8, pages 778-795.
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Fatemeh Seifar, Mohammad Khalili, Habib Khaledyan, Shirin Amiri Moghadam, Azimeh Izadi, Amirreza Azimi & Seied Kazem Shakouri. (2019) α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review. Nutritional Neuroscience 22:5, pages 306-316.
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Gonul Vural, Hesna Bektas, Sadiye Gumusyayla, Orhan Deniz, Murat Alışık & Ozcan Erel. (2018) Impaired thiol-disulphide homeostasis in patients with axonal polyneuropathy. Neurological Research 40:3, pages 166-172.
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Nikolaos Papanas & Dan Ziegler. (2014) Efficacy of α-lipoic acid in diabetic neuropathy. Expert Opinion on Pharmacotherapy 15:18, pages 2721-2731.
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U Rausch, IL Labuschagne & MJ Lombard. (2014) Development of a diabetes mellitus nutritional management manual for South African healthcare professionals. South African Family Practice 56:6, pages 320-323.
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Marcella Nebbioso, Federica Pranno & Nicola Pescosolido. (2013) Lipoic acid in animal models and clinical use in diabetic retinopathy. Expert Opinion on Pharmacotherapy 14:13, pages 1829-1838.
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Utku Karaarslan, Rana İşgüder, Özlem Bağ, Miray Kışla, Hasan Ağın & Nurettin Ünal. (2013) Alpha lipoic acid intoxication, treatment and outcome. Clinical Toxicology 51:6, pages 522-522.
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Courtney E McIlduff & Seward B Rutkove. (2011) Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. Therapeutics and Clinical Risk Management 7, pages 377-385.
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Jayadave Shakher & Martin J Stevens. (2011) Update on the management of diabetic polyneuropathies. Diabetes, Metabolic Syndrome and Obesity 4, pages 289-305.
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Hideki TAKAHASHI, Yuri BUNGO & Katsuhiko MIKUNI. (2011) The Aqueous Solubility and Thermal Stability of α-Lipoic Acid Are Enhanced by Cyclodextrin. Bioscience, Biotechnology, and Biochemistry 75:4, pages 633-637.
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Abd A Tahrani, Trevor Askwith & Martin J Stevens. (2010) Emerging drugs for diabetic neuropathy. Expert Opinion on Emerging Drugs 15:4, pages 661-683.
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Vijayshree Yadav, Lynne Shinto & Dennis Bourdette. (2010) Complementary and alternative medicine for the treatment of multiple sclerosis. Expert Review of Clinical Immunology 6:3, pages 381-395.
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Vladimir Skljarevski, Sarah J Ferdinand & Keri A Kles. (2007) Role of protein kinase C inhibition in the development of diabetic microvascular complications. Expert Review of Endocrinology & Metabolism 2:3, pages 321-329.
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Steven K Baker & Mark A Tarnopolsky. (2003) Targeting cellular energy production in neurological disorders. Expert Opinion on Investigational Drugs 12:10, pages 1655-1679.
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Anders AF Sima. (2001) Diabetic neuropathy: pathogenetic background, current and future therapies. Expert Review of Neurotherapeutics 1:2, pages 225-238.
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Hideki Yamamoto, Tomohiro Watanabe, Hatsue Mizuno, Kazuo Endo, Junichiro Fukushige, Tsunemichi Hosokawa, Akio Kazusaka & Shoichi Fujita. (2001) The antioxidant effect of DL-α-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radical Research 34:1, pages 69-80.
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Marina A. Lynch. (2001) Lipoic Acid Confers Protection Against Oxidative Injury in Non-neuronal and Neuronal Tissue. Nutritional Neuroscience 4:6, pages 419-438.
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