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Research Article

Chitosan Phthalate Microspheres for Oral Delivery of Insulin: Preparation, Characterization, and In Vitro Evaluation

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Pages 19-23 | Received 27 Sep 2005, Accepted 01 Dec 2005, Published online: 10 Oct 2008

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Jiang Ni, Fengchun Tian, Fatima Zohra Dahmani, Hui Yang, Deren Yue, Shuwang He, Jianping Zhou & Jing Yao. (2016) Curcumin-carboxymethyl chitosan (CNC) conjugate and CNC/LHR mixed polymeric micelles as new approaches to improve the oral absorption of P-gp substrate drugs. Drug Delivery 23:9, pages 3424-3435.
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Khalid Al Rubeaan, Mohamed Rafiullah & Sanjay Jayavanth. (2016) Oral insulin delivery systems using chitosan-based formulation: a review. Expert Opinion on Drug Delivery 13:2, pages 223-237.
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Udhumansha Ubaidulla, R.K. Khar, F.J. Ahmad & Purnima Tripathi. (2009) Optimization of Chitosan Succinate and Chitosan Phthalate Microspheres for Oral Delivery of Insulin using Response Surface Methodology. Pharmaceutical Development and Technology 14:1, pages 99-108.
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Rahul Kumar, Arvind Sirvi, Shamandeep Kaur, Sanjaya K. Samal, Sabyasachi Roy & Abhay T. Sangamwar. (2020) Polymeric micelles based on amphiphilic oleic acid modified carboxymethyl chitosan for oral drug delivery of bcs class iv compound: Intestinal permeability and pharmacokinetic evaluation. European Journal of Pharmaceutical Sciences 153, pages 105466.
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Xinxin Sang, Meng Zhang, Quanwu Wen, Gang Shi, Liping Zhang & Caihua Ni. (2019) Preparation of Drug-Eluting Microspheres Based on Semi-Interpenetrating Polymer Network of Modified Chitosan and Poly(2-acrylamide-2-methylpropanesulfonic acid). Polymer Science, Series A 61:1, pages 61-69.
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Sharad Prakash Pandey, Tripti Shukla, Vinod Kumar Dhote, Dinesh K. Mishra, Rahul Maheshwari & Rakesh K. Tekade. 2019. Basic Fundamentals of Drug Delivery. Basic Fundamentals of Drug Delivery 113 172 .
Xiao Zheng, Fei Wu, Yanlong Hong, Lan Shen, Xiao Lin & Yi Feng. (2018) Developments in Taste-Masking Techniques for Traditional Chinese Medicines. Pharmaceutics 10:3, pages 157.
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Mahmoud A. Mohsin, Yousef Haik & Tahir Abdulrehman. (2018) Glucose-Mediated Insulin Release Carrier. Polymer Science, Series A 60:5, pages 618-627.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2018) Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin. International Journal of Pharmaceutics 537:1-2, pages 223-244.
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Stine Harloff-Helleberg, Line Hagner Nielsen & Hanne Mørck Nielsen. (2017) Animal models for evaluation of oral delivery of biopharmaceuticals. Journal of Controlled Release 268, pages 57-71.
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Marlene Lopes, Susana Simões, Francisco Veiga, Raquel Seiça & António Ribeiro. (2015) Why most oral insulin formulations do not reach clinical trials. Therapeutic Delivery 6:8, pages 973-987.
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Thundiparambil Azeez Sonia & Chandra P. Sharma. 2014. Oral Delivery of Insulin. Oral Delivery of Insulin 257 310 .
S. Jose, J.F. Fangueiro, J. Smitha, T.A. Cinu, A.J. Chacko, K. Premaletha & E.B. Souto. (2013) Predictive modeling of insulin release profile from cross-linked chitosan microspheres. European Journal of Medicinal Chemistry 60, pages 249-253.
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S. Jose, J.F. Fangueiro, J. Smitha, T.A. Cinu, A.J. Chacko, K. Premaletha & E.B. Souto. (2012) Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing. Colloids and Surfaces B: Biointerfaces 92, pages 175-179.
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Kuntal Ganguly, Tejraj M. Aminabhavi & Anandrao R. Kulkarni. (2011) Colon Targeting of 5-Fluorouracil Using Polyethylene Glycol Cross-linked Chitosan Microspheres Enteric Coated with Cellulose Acetate Phthalate. Industrial & Engineering Chemistry Research 50:21, pages 11797-11807.
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S. Jose, M.T. Prema, A.J. Chacko, A. Cinu Thomas & E.B. Souto. (2011) Colon specific chitosan microspheres for chronotherapy of chronic stable angina. Colloids and Surfaces B: Biointerfaces 83:2, pages 277-283.
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T. A. Sonia & Chandra P. Sharma. 2011. Chitosan for Biomaterials I. Chitosan for Biomaterials I 23 53 .
Kazuki Akamatsu, Wei Chen, Yukimitsu Suzuki, Taichi Ito, Aiko Nakao, Takashi Sugawara, Ryuji Kikuchi & Shin-ichi Nakao. (2010) Preparation of Monodisperse Chitosan Microcapsules with Hollow Structures Using the SPG Membrane Emulsification Technique. Langmuir 26:18, pages 14854-14860.
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Kazuki Akamatsu, Daisaku Kaneko, Takashi Sugawara, Ryuji Kikuchi & Shin-ichi Nakao. (2010) Three Preparation Methods for Monodispersed Chitosan Microspheres Using the Shirasu Porous Glass Membrane Emulsification Technique and Mechanisms of Microsphere Formation. Industrial & Engineering Chemistry Research 49:7, pages 3236-3241.
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Punit P Shah, Rajashree C Mashru, Arti R Thakkar & Atul C Badhan. (2008) Effect of chitosan crosslinking on bitterness of artemether using response surface methodology. Journal of Pharmacy and Pharmacology 60:4, pages 421-427.
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Udhumansha Ubaidulla, Roop Kishan Khar, Farhan Jalees Ahmed & Amulya Kumar Panda. (2007) Development and in-vivo evaluation of insulin-loaded chitosan phthalate microspheres for oral delivery. Journal of Pharmacy and Pharmacology 59:10, pages 1345-1351.
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Patrícia B. MalafayaJoão T. OliveiraRui L. Reis. (2010) The Effect of Insulin-Loaded Chitosan Particle–Aggregated Scaffolds in Chondrogenic Differentiation. Tissue Engineering Part A 16:2, pages 735-747.
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Punit P. Shah & Rajashree C. Mashru. (2009) Influence of Chitosan Crosslinking on Bitterness of Mefloquine Hydrochloride Microparticles Using Central Composite Design. Journal of Pharmaceutical Sciences 98:2, pages 690-703.
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