1,806
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Silica-Based Mesoporous Materials as Drug Delivery System for Methotrexate Release

, , , , , & show all
Pages 491-495 | Received 07 Dec 2006, Accepted 12 Feb 2007, Published online: 20 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Hao Chen, Yao Jun Zhang, Pan Yang He & Ye Zhang. (2019) Effective and eco-friendly seed-assisted synthesis of nanostructurally monolithic mordenite. Ferroelectrics 547:1, pages 44-50.
Read now
Xi Chen, Wang Zhouhua, Zhou Jie, Fu Xinlu, Liang Jinqiang, Qiu Yuwen & Huang Zhiying. (2015) Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway. International Journal of Nanomedicine 10, pages 1-22.
Read now
Roya Salehi, Hamed Hamishehkar, Morteza Eskandani, Mehrdad Mahkam & Soodabeh Davaran. (2014) Development of dual responsive nanocomposite for simultaneous delivery of anticancer drugs. Journal of Drug Targeting 22:4, pages 327-342.
Read now

Articles from other publishers (54)

Fatemeh Farjadian, Zahra Faghih, Maryam Fakhimi, Pooya Iranpour, Soliman Mohammadi-Samani & Mohammad Doroudian. (2023) Glucosamine-Modified Mesoporous Silica-Coated Magnetic Nanoparticles: A “Raisin-Cake”-like Structure as an Efficient Theranostic Platform for Targeted Methotrexate Delivery. Pharmaceutics 15:10, pages 2491.
Crossref
Mohammad Ghafoori, Mehrdad Cheraghi, Maryam Kiani Sadr, Bahareh Lorestani & Soheil Sobhanardakani. (2022) Magnetite graphene oxide modified with β-cyclodextrin as an effective adsorbent for the removal of methotrexate and doxorubicin hydrochloride from water. Environmental Science and Pollution Research 29:23, pages 35012-35024.
Crossref
Georgios K. Eleftheriadis, Eleni Kontogiannidou, Christina Karavasili & Dimitrios G. Fatouros. 2022. Oral Drug Delivery for Modified Release Formulations. Oral Drug Delivery for Modified Release Formulations 161 179 .
N. Zakeri, H.R. Rezaie, J. Javadpour & M. Kharaziha. (2021) Effect of pH on cisplatin encapsulated zeolite nanoparticles: Release mechanism and cytotoxicity. Materials Chemistry and Physics 273, pages 124964.
Crossref
Alessandro Parodi, Polina Buzaeva, Daria Nigovora, Alexey Baldin, Dmitry Kostyushev, Vladimir Chulanov, Lyudmila V. Savvateeva & Andrey A. ZamyatninJrJr. (2021) Nanomedicine for increasing the oral bioavailability of cancer treatments. Journal of Nanobiotechnology 19:1.
Crossref
Katarzyna Trzeciak, Agata Chotera-Ouda, Irena I. Bak-Sypien & Marek J. Potrzebowski. (2021) Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes. Pharmaceutics 13:7, pages 950.
Crossref
Marzieh Samiei Foroushani, Ali Zahmatkeshan, Hassan Arkaban, Reza Karimi Shervedani & Amirhosein Kefayat. (2021) A drug delivery system based on nanocomposites constructed from metal-organic frameworks and Mn3O4 nanoparticles: Preparation and physicochemical characterization for BT-474 and MCF-7 cancer cells. Colloids and Surfaces B: Biointerfaces 202, pages 111712.
Crossref
S. Prabha, D. Durgalakshmi, Saravanan Rajendran & Eric Lichtfouse. (2020) Plant-derived silica nanoparticles and composites for biosensors, bioimaging, drug delivery and supercapacitors: a review. Environmental Chemistry Letters 19:2, pages 1667-1691.
Crossref
Farhad Ahmadijokani, Shima Tajahmadi, Mashallah Rezakazemi, Ali Akbari Sehat, Hossein Molavi, Tejraj M. Aminabhavi & Mohammad Arjmand. (2021) Aluminum-based metal-organic frameworks for adsorptive removal of anti-cancer (methotrexate) drug from aqueous solutions. Journal of Environmental Management 277, pages 111448.
Crossref
Ana J. Coutinho, Sofia A. Costa Lima, Carlos M.M. Afonso & Salette Reis. (2020) Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate. International Journal of Biological Macromolecules 158, pages 180-188.
Crossref
Hossein Molavi, Hamid Moghimi & Ramezan Ali Taheri. (2020) Zr‐Based MOFs with High Drug Loading for Adsorption Removal of Anti‐Cancer Drugs: A Potential Drug Storage. Applied Organometallic Chemistry 34:4.
Crossref
Shuai Wang, Fang Xiang Song, Li Zhang, Xue Zhang & Yan Li. (2019) Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery. Nano 14:08, pages 1950094.
Crossref
Fatih Mehmet EMEN, Ruken Esra DEMİRDÖĞEN, Göktürk AVŞAR & Derya KILIÇ. (2019) 2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery. Journal of the Turkish Chemical Society Section A: Chemistry 6:1, pages 29-34.
Crossref
Chun Xu, Chang Lei & Chengzhong Yu. (2019) Mesoporous Silica Nanoparticles for Protein Protection and Delivery. Frontiers in Chemistry 7.
Crossref
Paola Mura, Maurizio Valleri, Elisa Fabianelli, Francesca Maestrelli & Marzia Cirri. (2019) Characterization and evaluation of different mesoporous silica kinds as carriers for the development of effective oral dosage forms of glibenclamide. International Journal of Pharmaceutics 563, pages 43-52.
Crossref
Jianhui Chen, Xiaofeng Chen, Zhengyu Yang, Xiaojun Tan, Jiachen Wang & Yao Chen. (2019) Preparation and characterization of folic acid functionalized bioactive glass for targeted delivery and sustained release of methotrexate. Journal of Biomedical Materials Research Part A 107:2, pages 319-329.
Crossref
Alessandra Nigro, Michele Pellegrino, Marianna Greco, Alessandra Comandè, Diego Sisci, Luigi Pasqua, Antonella Leggio & Catia Morelli. (2018) Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles. Pharmaceutics 10:4, pages 250.
Crossref
Majid Hamzehloo, Jahangir Karimi, Kioumars Aghapoor, Hani Sayahi & Hossein Reza Darabi. (2017) The synergistic cooperation between MCM-41 and azithromycin: a pH responsive system for drug adsorption and release. Journal of Porous Materials 25:5, pages 1275-1285.
Crossref
Mohammad A. Chowdhury. (2018) Silica Materials for Biomedical Applications in Drug Delivery, Bone Treatment or Regeneration, and MRI Contrast Agent. Review Journal of Chemistry 8:2, pages 223-241.
Crossref
Goeun Choi, Tae-Hyun Kim, Jae-Min Oh & Jin-Ho Choy. (2018) Emerging nanomaterials with advanced drug delivery functions; focused on methotrexate delivery. Coordination Chemistry Reviews 359, pages 32-51.
Crossref
Roudayna Diab, Nadia Canilho, Ileana A. Pavel, Fernanda B. Haffner, Maxime Girardon & Andreea Pasc. (2017) Silica-based systems for oral delivery of drugs, macromolecules and cells. Advances in Colloid and Interface Science 249, pages 346-362.
Crossref
Xiuyan Wang & Husheng Yan. (2017) Methotrexate-loaded porous polymeric adsorbents as oral sustained release formulations. Materials Science and Engineering: C 78, pages 598-602.
Crossref
Shani Egodawatte, Steven DominguezJr.Jr. & Sarah C. Larsen. (2017) Solvent effects in the development of a drug delivery system for 5-fluorouracil using magnetic mesoporous silica nanoparticles. Microporous and Mesoporous Materials 237, pages 108-116.
Crossref
Shou-Cang Shen, Yuan-Cai Dong, Kumaran Letchmanan & Wai Kiong Ng. 2017. Nanostructures for Oral Medicine. Nanostructures for Oral Medicine 699 749 .
M. Colilla & M. Vallet-Regí. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 644 685 .
Hye Jung Park, Jung-Ho Sohn, Yoon-Ju Kim, Yoon Hee Park, Heejae Han, Kyung Hee Park, Kangtaek Lee, Hoon Choi, Kiju Um, In-Hong Choi, Jung-Won Park & Jae-Hyun Lee. (2015) Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics. Experimental & Molecular Medicine 47:7, pages e173-e173.
Crossref
Zohreh Bahrami, Alireza Badiei & Ghodsi Mohammadi Ziarani. (2015) Carboxylic acid-functionalized SBA-15 nanorods for gemcitabine delivery. Journal of Nanoparticle Research 17:3.
Crossref
Magdalena Prokopowicz. (2015) Formulation, characterisation and in vitro studies of doxorubicin-loaded silica?polydimethylsiloxane granules. European Journal of Pharmaceutical Sciences 66, pages 10-19.
Crossref
Yi-Zhuo Liu, Yang Li, Xi-Bin Yu, Li-Na Liu, Zhen-An Zhu & Ya-Ping Guo. (2014) Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass. Materials Science and Engineering: C 41, pages 196-205.
Crossref
Liling Dong, Hailong Peng, Shenqi Wang, Zhong Zhang, Jinhua Li, Fanrong Ai, Qiang Zhao, Mei Luo, Hua Xiong & Lingxin Chen. (2014) Thermally and magnetically dual-responsive mesoporous silica nanospheres: preparation, characterization, and properties for the controlled release of sophoridine. Journal of Applied Polymer Science 131:13, pages n/a-n/a.
Crossref
Zohreh Bahrami, Alireza Badiei & Fatemeh Atyabi. (2014) Surface functionalization of SBA-15 nanorods for anticancer drug delivery. Chemical Engineering Research and Design 92:7, pages 1296-1303.
Crossref
Carolina Acosta, Edgar Pérez-Esteve, Carlos A. Fuenmayor, Simona Benedetti, Maria Stella Cosio, Juan Soto, Félix Sancenón, Saverio Mannino, José Barat, María D. Marcos & Rámon Martínez-Máñez. (2014) Polymer Composites Containing Gated Mesoporous Materials for On-Command Controlled Release. ACS Applied Materials & Interfaces 6:9, pages 6453-6460.
Crossref
Salam J.J. Titinchi, Mayank P. Singh, Hanna S. Abbo & Ivan R. Green. 2014. Advanced Healthcare Materials. Advanced Healthcare Materials 49 85 .
Ganesh Mani, Hemalatha Pushparaj, Mei Mei Peng, Palanichamy Muthiahpillai, Ubaidulla Udhumansha & Hyun Tae Jang. (2014) Synthesis and characterization of pharmaceutical surfactant templated mesoporous silica: Its application to controlled delivery of duloxetine. Materials Research Bulletin 51, pages 228-235.
Crossref
Siva Kumar Natarajan & Stalin Selvaraj. (2014) Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery. RSC Advances 4:28, pages 14328.
Crossref
Yubao Ren, Xin Shi, Qi Sun & Liwei Sun. (2013) Dual-controlled oral colon-targeted delivery of bovine insulin based on mesoporous phosphonate. Materials Research Bulletin 48:11, pages 4850-4855.
Crossref
Ya-Jun Guo, Teng Long, Wei Chen, Cong-Qin Ning, Zhen-An Zhu & Ya-Ping Guo. (2013) Bactericidal property and biocompatibility of gentamicin-loaded mesoporous carbonated hydroxyapatite microspheres. Materials Science and Engineering: C 33:7, pages 3583-3591.
Crossref
Luigi Pasqua, Lucia Veltri, Bartolo Gabriele, Flaviano Testa & Giuseppe Salerno. (2013) Progesterone inclusion into cyclodextrin-functionalized mesoporous silica. Journal of Porous Materials 20:4, pages 917-925.
Crossref
Yang Li, Yi-Zhuo Liu, Teng Long, Xi-Bin Yu, Ting–Ting Tang, Ke-Rong Dai, Bo Tian, Ya-Ping Guo & Zhen-An Zhu. (2013) Mesoporous bioactive glass as a drug delivery system: fabrication, bactericidal properties and biocompatibility. Journal of Materials Science: Materials in Medicine 24:8, pages 1951-1961.
Crossref
Md. Mujibur Rahman, Jong Kwon Lee, Jayoung Jeong & Young Rok Seo. (2013) Usage of nanoparticles with their potential toxicity assessment and regulatory guidelines. Toxicology and Environmental Health Sciences 5:2, pages 49-54.
Crossref
Yan Tang, Yubao Ren & Xin Shi. (2013) Bifunctional Mesoporous Zirconium Phosphonates for Delivery of Nucleic Acids. Inorganic Chemistry 52:3, pages 1388-1397.
Crossref
Dua’a M. Marzouqa, Mohammad B. Zughul, Mutasem O. Taha & Hamdallah A. Hodali. (2011) Effect of particle morphology and pore size on the release kinetics of ephedrine from mesoporous MCM-41 materials. Journal of Porous Materials 19:5, pages 825-833.
Crossref
Manuel Arruebo. (2011) Drug delivery from structured porous inorganic materials. WIREs Nanomedicine and Nanobiotechnology 4:1, pages 16-30.
Crossref
Soyoung Lee, Hui-Suk Yun & Sang-Hyun Kim. (2011) The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis. Biomaterials 32:35, pages 9434-9443.
Crossref
Shou-Cang Shen, Wai Kiong Ng, Leonard Chia, Jun Hu & Reginald B.H. Tan. (2011) Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: Effect of pore and particle size. International Journal of Pharmaceutics 410:1-2, pages 188-195.
Crossref
M. Colilla & M. Vallet-Regí. 2011. Comprehensive Biomaterials. Comprehensive Biomaterials 497 514 .
Jessica M. Rosenholm, Emilia Peuhu, Laurel Tabe Bate-Eya, John E. Eriksson, Cecilia Sahlgren & Mika Lindén. (2010) Cancer-Cell-Specific Induction of Apoptosis Using Mesoporous Silica Nanoparticles as Drug-Delivery Vectors. Small 6:11, pages 1234-1241.
Crossref
Blanca González, Carlos López de Laorden, Montserrat Colilla & Maria Vallet-Regí. (2010) Dendritic Macromolecules: New Possibilities for Advanced Bioceramics. Key Engineering Materials 441, pages 235-267.
Crossref
Chao Zhang, Shanyi Guang & Hongyao Xu. (2010) Controllable preparation and fluorescence properties of Y3+ and Eu3+ co-doped mesoporous silica. Journal of Solid State Chemistry 183:6, pages 1409-1415.
Crossref
Shou‐Cang Shen, Wai Kiong Ng, Leonard Chia, Yuan‐Cai Dong & Reginald B.H. Tan. (2010) Stabilized Amorphous State of Ibuprofen by Co‐Spray Drying With Mesoporous SBA‐15 to Enhance Dissolution Properties. Journal of Pharmaceutical Sciences 99:4, pages 1997-2007.
Crossref
Xin Shi, JianPing Li, Yan Tang & Qihua Yang. (2010) pH-Sensitive mesoporous zirconium diphosphonates for controllable colon-targeted delivery. Journal of Materials Chemistry 20:31, pages 6495.
Crossref
Steven JP McInnesNicolas H Voelcker. (2009) Silicon–polymer hybrid materials for drug delivery. Future Medicinal Chemistry 1:6, pages 1051-1074.
Crossref
Sarah P. Hudson, Robert F. Padera, Robert Langer & Daniel S. Kohane. (2008) The biocompatibility of mesoporous silicates. Biomaterials 29:30, pages 4045-4055.
Crossref
Randy Mellaerts, Jasper A. G. Jammaer, Michiel Van Speybroeck, Hong Chen, Jan Van Humbeeck, Patrick Augustijns, Guy Van den Mooter & Johan A. Martens. (2008) Physical State of Poorly Water Soluble Therapeutic Molecules Loaded into SBA-15 Ordered Mesoporous Silica Carriers: A Case Study with Itraconazole and Ibuprofen. Langmuir 24:16, pages 8651-8659.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.