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Research Article

Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency

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Pages 3374-3386 | Received 14 Mar 2016, Accepted 25 Apr 2016, Published online: 17 May 2016

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Shady M Abd El-Halim, Mohamed A Mamdouh, Sherif M Eid, Bassant M M Ibrahim, Dina A Aly Labib & Sara M Soliman. (2021) The Potential Synergistic Activity of Zolmitriptan Combined in New Self-Nanoemulsifying Drug Delivery Systems: ATR-FTIR Real-Time Fast Dissolution Monitoring and Pharmacodynamic Assessment. International Journal of Nanomedicine 16, pages 6395-6412.
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Shaimaa Mosallam, Maha H Ragaie, Noha H Moftah, Ahmed Hassen Elshafeey & Aly Ahmed Abdelbary. (2021) Use of Novasomes as a Vesicular Carrier for Improving the Topical Delivery of Terconazole: In Vitro Characterization, In Vivo Assessment and Exploratory Clinical Experimentation. International Journal of Nanomedicine 16, pages 119-132.
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Sinar Sayed, Fatma M. Elsharkawy, Maha M. Amin, Hesham A. Shamsel-Din & Ahmed B. Ibrahim. (2021) Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m. Drug Delivery 28:1, pages 1524-1538.
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Randa Hanie Awadeen, Mariza Fouad Boughdady & Mahasen Mohamed Meshali. (2020) Quality by Design Approach for Preparation of Zolmitriptan/Chitosan Nanostructured Lipid Carrier Particles – Formulation and Pharmacodynamic Assessment. International Journal of Nanomedicine 15, pages 8553-8568.
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Shravan Kumar Pitta, Narendar Dudhipala, Arjun Narala & Kishan Veerabrahma. (2018) Development of zolmitriptan transfersomes by Box–Behnken design for nasal delivery: in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 44:3, pages 484-492.
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Mohammed A. Khedr, Hassan M. Rashed, Hamed Farag & Tamer M. Sakr. (2019) Rational design of some substituted phenyl azanediyl (bis) methylene phosphonic acid derivatives as potential anticancer agents and imaging probes: Computational inputs, chemical synthesis, radiolabeling, biodistribution and gamma scintigraphy. Bioorganic Chemistry 92, pages 103282.
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Tatiana N. Pashirova, Irina V. Zueva, Konstantin A. Petrov, Svetlana S. Lukashenko, Irek R. Nizameev, Natalya V. Kulik, Aleksandra D. Voloshina, Laszlo Almasy, Marsil K. Kadirov, Patrick Masson, Eliana B. Souto, Lucia Ya. Zakharova & Oleg G. Sinyashin. (2018) Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model. Colloids and Surfaces B: Biointerfaces 171, pages 358-367.
Crossref
Dinesh K. Mishra, Ruchita Shandilya & Pradyumna K. Mishra. (2018) Lipid based nanocarriers: a translational perspective. Nanomedicine: Nanotechnology, Biology and Medicine 14:7, pages 2023-2050.
Crossref
Hassan M. Rashed, Rehab N. Shamma & Hanan A. El-Sabagh. (2018) Preparation of 99mTc-levetiracetam intranasal microemulsion as the first radiotracer for SPECT imaging of the Synaptic Vesicle Protein SV2A. European Journal of Pharmaceutical Sciences 121, pages 29-33.
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Tamer Nasr, Samir Bondock, Hassan M. Rashed, Walid Fayad, Mahmoud Youns & Tamer M. Sakr. (2018) Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies. European Journal of Medicinal Chemistry 151, pages 723-739.
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Crossref
Tamer Sakr, Mohammed Khedr, Hassan Rashed & Maged Mohamed. (2018) In Silico-Based Repositioning of Phosphinothricin as a Novel Technetium-99m Imaging Probe with Potential Anti-Cancer Activity. Molecules 23:2, pages 496.
Crossref
Patrícia C. Pires & Adriana O. Santos. (2018) Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies. Journal of Controlled Release 270, pages 89-100.
Crossref
Tamer M. Sakr, A. B. Ibrahim, T. W. Fasih & H. M. Rashed. (2017) Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel. Journal of Radioanalytical and Nuclear Chemistry 314:3, pages 2091-2098.
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M.A. Motaleb, I.T. Ibrahim, M.E. Sayyed & G.A.S. Awad. (2017) 131 I-trazodone: preparation, quality control and in vivo biodistribution study by intranasal and intravenous routes as a hopeful brain imaging radiopharmaceutical. Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 36:6, pages 371-376.
Crossref
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H. M. Rashed, I. T. Ibrahim & M. A. Motaleb. (2017) 99mTc-hexoprenaline and 131I-dapoxetine: preparation, in silico modeling and biological evaluation as promising lung scintigraphy radiopharmaceuticals. Journal of Radioanalytical and Nuclear Chemistry 314:2, pages 1297-1307.
Crossref
Ebtsam M. Abdou, Soha M. Kandil & Hala M.F. El Miniawy. (2017) Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion. International Journal of Pharmaceutics 529:1-2, pages 667-677.
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