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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles

Yue ZhaoOcean College, Zhejiang University, Zhoushan, China; View further author information
,
Yanan TanOcean College, Zhejiang University, Zhoushan, China; View further author information
,
Tingting MengCollege of Pharmaceutical Science, Zhejiang University, Hangzhou, China; View further author information
,
Xuan LiuCollege of Pharmaceutical Science, Zhejiang University, Hangzhou, China; View further author information
,
Yun ZhuOcean College, Zhejiang University, Zhoushan, China; View further author information
,
Yun HongThe First Affiliated Hospital, College of Pharmaceutical Medicine, Zhejiang University, Hangzhou, China; View further author information
,
Xiqin YangCollege of Pharmaceutical Science, Zhejiang University, Hangzhou, China; View further author information
,
Hong YuanCollege of Pharmaceutical Science, Zhejiang University, Hangzhou, China; View further author information
,
Xuan HuangDepartment of Pharmacy, School of Medicine Science, Jiaxing University, Zhejiang, ChinaView further author information
&
Fuqiang HuOcean College, Zhejiang University, Zhoushan, China; ;College of Pharmaceutical Science, Zhejiang University, Hangzhou, China; Correspondence[email protected]
View further author information
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Pages 341-352 | Received 07 Nov 2017, Accepted 05 Jan 2018, Published online: 22 Jan 2018

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Jichao Li, Zeng Zhang & Xiaohan Huang. (2021) Tripterine and all-trans retinoic acid (ATRA) – loaded lipid-polymer hybrid nanoparticles for synergistic anti-arthritic therapy against inflammatory arthritis. Artificial Cells, Nanomedicine, and Biotechnology 49:1, pages 575-585.
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Hailing Yang, Zhenjie Liu, Yonglong Song & Changjiang Hu. (2019) Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis. Drug Delivery 26:1, pages 820-830.
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Articles from other publishers (28)

Cheng Wang, Shu Dai, Xingtao Zhao, Yafang Zhang, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng & Yunxia Li. (2023) Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies. Biomedicine & Pharmacotherapy 163, pages 114882.
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Xiaoxia Song, Rongrong Zhu, Dandan Guo, Wei Dai & Jianying Liang. (2023) Celastrol Loaded PEGylated Nanographene Oxide for Highly Efficient Synergistic Chemo/Photothermal Therapy. Anti-Cancer Agents in Medicinal Chemistry 23:3, pages 306-316.
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Na Hui Kim, Minji Kwon, Jiwoo Jung, Hyo Byeong Chae, Jiwoo Lee, Yeo-Jun Yoon, In Seok Moon, Ho K. Lee, Wan Namkung, Konstantina M. Stankovic, Se A. Lee, Jong Dae Lee & Sin-Aye Park. (2022) Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin. Acta Pharmacologica Sinica 43:11, pages 2993-3001.
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Shaomin Liu, Qiufang Chen, Liang Yan, Yuehong Ren, Jun Fan, Xingwang Zhang & Shiping Zhu. (2022) Phytosomal tripterine with selenium modification attenuates the cytotoxicity and restrains the inflammatory evolution via inhibiting NLRP3 inflammasome activation and pyroptosis. International Immunopharmacology 108, pages 108871.
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Qingsi Wu, Jiading Wang, Yuanfang Wang, Ling Xiang, Yulu Tan, Jiaxing Feng, Zhirong Zhang & Ling Zhang. (2021) Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment. Nano Research 15:4, pages 3556-3568.
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Zhi Cai, Bin Qian, Jing Pang, Zhou-bin Tan, Kai Zhao & Ting Lei. (2022) Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells. Current Medical Science 42:2, pages 387-396.
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Yu Geng, Jiajia Xiang, Shiqun Shao, Jianbin Tang & Youqing Shen. (2022) Mitochondria-targeted polymer-celastrol conjugate with enhanced anticancer efficacy. Journal of Controlled Release 342, pages 122-133.
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Xiaqing Wu, Xiaoqing Han, Jiao Yan, Runxiao Zheng, Yanjing Wang, Panpan Song & Haiyuan Zhang. (2021) Iron Oxyhydroxide Nanorods Coated with Poly(acrylic acid) to Reprogram Tumor-Associated Macrophages for Antitumor Immunotherapy. ACS Applied Nano Materials 4:12, pages 12966-12976.
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Jinfeng Shi, Yali Ren, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao & Jinming Zhang. (2021) Novel CD44-targeting and pH/redox-dual-stimuli-responsive core–shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis. Journal of Nanobiotechnology 19:1.
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Ling Guo, Yongping Zhang & Khuloud T. Al-Jamal. (2021) Recent progress in nanotechnology-based drug carriers for celastrol delivery. Biomaterials Science 9:19, pages 6355-6380.
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Xueqing Zhou, Xuan Liu, Xiqin Yang, Li Wang, Yiling Hong, Keke Lian, Guoxi Qiu, Xuwei Shang, Zhongjun Ma, Hong Yuan & Fuqiang Hu. (2021) Tumor progress intercept by intervening in Caveolin-1 related intercellular communication via ROS-sensitive c-Myc targeting therapy. Biomaterials 275, pages 120958.
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Yun Qian, Jun Zhang, Rui Xu, Qiang Li, Qi Shen & Guofu Zhu. (2021) Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment. International Journal of Biological Macromolecules 183, pages 2215-2226.
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Pushkaraj Rajendra Wagh, Preshita Desai, Sunil Prabhu & Jeffrey Wang. (2021) Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications. Frontiers in Pharmacology 12.
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Kai Yang, Shushu Yan, Jian Xie, Fang Xie, Zhenzhen Zhao & Keming Zhu. (2021) Sodium houttuyfonate relieves acute lung injury by nano micellar carrier and inhibits mitogen-activated protein kinase and nuclear factor kappa-B activation in mice. Materials Express 11:5, pages 781-788.
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Yun Lu, Yuan Liu, Jiawei Zhou, Dan Li & Wei Gao. (2020) Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol. Medicinal Research Reviews 41:2, pages 1022-1060.
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Jinfeng Shi, Jiaxin Li, Ziyi Xu, Liang Chen, Ruifeng Luo, Chen Zhang, Fei Gao, Jinming Zhang & Chaomei Fu. (2020) Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application. Frontiers in Pharmacology 11.
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Rujing Chen, Leaf Huang & Kaili Hu. (2020) Natural products remodel cancer-associated fibroblasts in desmoplastic tumors. Acta Pharmaceutica Sinica B 10:11, pages 2140-2155.
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Shuyu Zhan, Amy Paik, Felicia Onyeabor, Baoyue Ding, Sunil Prabhu & Jeffrey Wang. (2020) Oral Bioavailability Evaluation of Celastrol-Encapsulated Silk Fibroin Nanoparticles Using an Optimized LC-MS/MS Method. Molecules 25:15, pages 3422.
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Aleck Hercbergs, Paul J. Davis, Hung-Yun Lin, Kelly A. Keating & Shaker A. Mousa. 2020. Hormone Therapy and Replacement in Cancer and Aging-related Diseases. Hormone Therapy and Replacement in Cancer and Aging-related Diseases.
Tiantian Huang, Yian Wang, Yiping Shen, Hui Ao, Yifei Guo, Meihua Han & Xiangtao Wang. (2020) Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo. Scientific Reports 10:1.
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Lijuan Wen, Kai Wang, Fengtian Zhang, Yanan Tan, Xuwei Shang, Yun Zhu, Xueqing Zhou, Hong Yuan & Fuqiang Hu. (2020) AKT activation by SC79 to transiently re-open pathological blood brain barrier for improved functionalized nanoparticles therapy of glioblastoma. Biomaterials 237, pages 119793.
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Shiping Zhu, Chunhua Luo, Weifeng Feng, Yan Li, Mujuan Zhu, Shengyun Sun & Xingwang Zhang. (2020) Selenium-deposited tripterine phytosomes ameliorate the antiarthritic efficacy of the phytomedicine via a synergistic sensitization. International Journal of Pharmaceutics 578, pages 119104.
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Sameh Saber, Amal M. H. Ghanim, Eman El-Ahwany & Eman M. Abd El-Kader. (2020) Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis. Cancer Chemotherapy and Pharmacology 85:2, pages 331-343.
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Biqiang Zhu & Yunwei Wei. (2019) Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway. Cancer Medicine 9:2, pages 783-796.
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Ming-Yue Yang, Rui-Rui Zhao, Yi-Fan Fang, Jia-Li Jiang, Xiao-Tian Yuan & Jing-Wei Shao. (2019) Carrier-free nanodrug: A novel strategy of cancer diagnosis and synergistic therapy. International Journal of Pharmaceutics 570, pages 118663.
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Xi Cao, Ying Hu, Shi Luo, Yuejing Wang, Tao Gong, Xun Sun, Yao Fu & Zhirong Zhang. (2019) Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma. Acta Pharmaceutica Sinica B 9:3, pages 575-589.
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Xuerong Liu, Cheng Wang, Huisong Ma, Fangying Yu, Fuqiang Hu & Hong Yuan. (2019) Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration. Advanced Healthcare Materials 8:8, pages 1801486.
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Jack Prescott & Simon Cook. (2018) Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors. Cells 7:9, pages 115.
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