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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells

Diana RafaelResearch Institute for Medicines and Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa (iMed.ULisboa), Lisbon, Portugal; ;Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; View further author information
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Petra GenerDrug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; ;Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Zaragoza, Spain; View further author information
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Fernanda AndradeNetworking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Zaragoza, Spain; View further author information
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Joaquin Seras-FranzosoDrug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; View further author information
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Sara MonteroDrug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; View further author information
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Yolanda FernándezDrug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; ;Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Zaragoza, Spain; ;Functional Validation and Preclinical Research (FVPR), CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; View further author information
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Manuel HidalgoDivision of Hematology and Oncology, Rosenberg Clinical Cancer Center Beth Israel Deaconess Medical Center, Boston, MA, USA; View further author information
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Diego ArangoBiomedical Research in Digestive Tract Tumors, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; View further author information
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Joan SayósImmune Regulation and Immunotherapy, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, SpainView further author information
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Helena F. FlorindoResearch Institute for Medicines and Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa (iMed.ULisboa), Lisbon, Portugal; View further author information
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Ibane AbasoloDrug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; ;Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Zaragoza, Spain; ;Functional Validation and Preclinical Research (FVPR), CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; View further author information
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Simó Schwartz JrDrug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; ;Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Zaragoza, Spain; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8297-7971View further author information
ORCID Icon &
Mafalda VideiraResearch Institute for Medicines and Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa (iMed.ULisboa), Lisbon, Portugal; Correspondence[email protected]
View further author information
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Pages 961-972 | Received 01 Feb 2018, Accepted 02 Apr 2018, Published online: 18 Apr 2018

Citations (29)

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Li Lv, Yonghui Shi, Junyan Wu & Guocheng Li. (2021) Nanosized Drug Delivery Systems for Breast Cancer Stem Cell Targeting. International Journal of Nanomedicine 16, pages 1487-1508.
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Articles from other publishers (28)

Diana Rafael, Sara Montero, Pilar Carcavilla, Fernanda Andrade, Júlia German-Cortés, Zamira V. Diaz-Riascos, Joaquin Seras-Franzoso, Monserrat Llaguno, Begoña Fernández, Alfredo Pereira, Esteban F. Duran-Lara, Simó SchwartzJr.Jr. & Ibane Abasolo. (2023) Intracellular Delivery of Anti-Kirsten Rat Sarcoma Antibodies Mediated by Polymeric Micelles Exerts Strong In Vitro and In Vivo Anti-Tumorigenic Activity in Kirsten Rat Sarcoma-Mutated Cancers . ACS Applied Materials & Interfaces.
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Refaat A. Eid, Muhammad Alaa Edeen, Eslam M. Shedid, Al Shaimaa S. Kamal, Mona M. Warda, Farag Mamdouh, Sohila A. Khedr, Mohamed A. Soltan, Hee Won Jeon, Mohamed Samir A. Zaki & Bonglee Kim. (2023) Targeting Cancer Stem Cells as the Key Driver of Carcinogenesis and Therapeutic Resistance. International Journal of Molecular Sciences 24:2, pages 1786.
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Sharath Kumar Hari, Ankita Gauba, Neeraj Shrivastava, Ravi Mani Tripathi, Sudhir Kumar Jain & Akhilesh Kumar Pandey. (2022) Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system. Drug Delivery and Translational Research 13:1, pages 135-163.
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Jianqin Yan, Xuehua Long, Yan Liang, Fashun Li, Hongli Yu, Yifei Li, Zhipeng Li, Yu Tian, Bin He & Yong Sun. (2022) Nanodrug delivery systems and cancer stem cells: From delivery carriers to treatment. Colloids and Surfaces B: Biointerfaces 217, pages 112701.
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Silvia Grassilli, Federica Brugnoli, Stefano Cairo, Nicoletta Bianchi, Jean-Gabriel Judde & Valeria Bertagnolo. (2022) Vav1 Selectively Down-Regulates Akt2 through miR-29b in Certain Breast Tumors with Triple Negative Phenotype. Journal of Personalized Medicine 12:6, pages 993.
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Wenzhen Du, Lijing Zhang, Xiaodan Li, Guixia Ling & Peng Zhang. (2022) Nuclear targeting Subcellular-delivery nanosystems for precise cancer treatment. International Journal of Pharmaceutics 619, pages 121735.
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Thibaut Fourniols, Valentina Maggio, Diana Rafael, Ariana Colaco, Elia García Vidal, Alessandra Lopes, Simo Schwartz, Águeda Martínez-Barriocanal, Veronique Preat & Diego Arango. (2022) Colorectal cancer inhibition by BET inhibitor JQ1 is MYC-independent and not improved by nanoencapsulation. European Journal of Pharmaceutics and Biopharmaceutics 171, pages 39-49.
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Sajmina Khatun, Sabeerabi Bonala, Sunil Venkanna Pogu & Aravind Kumar Rengan. 2022. Functional Biomaterials. Functional Biomaterials 1 36 .
Sakib Haque, Kiri Cook, Gaurav Sahay & Conroy Sun. (2021) RNA-Based Therapeutics: Current Developments in Targeted Molecular Therapy of Triple-Negative Breast Cancer. Pharmaceutics 13:10, pages 1694.
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Yingshu Guo, Xiuping Cao & Shusheng Zhang. (2021) Au–Fe 3 O 4 nanoagent coated cell membrane for targeted delivery and enhanced chem/photo therapy . Chemical Communications 57:81, pages 10504-10507.
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Sandeep Kadekar, Ganesh N. Nawale, Vignesh K. Rangasami, Vadim Le Joncour, Pirjo Laakkonen, Jöns Hilborn, Oommen P. Varghese & Oommen P. Oommen. (2021) Redox responsive Pluronic micelle mediated delivery of functional siRNA: a modular nano-assembly for targeted delivery. Biomaterials Science 9:11, pages 3939-3944.
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Xiuping Cao, Xinxin Shang, Yingshu Guo, Xiaofei Zheng, Wenxin Li, Di Wu, Li Sun, Shanliang Mu & Chuanen Guo. (2021) Lysosomal escaped protein nanocarriers for nuclear-targeted siRNA delivery. Analytical and Bioanalytical Chemistry 413:13, pages 3493-3499.
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Hongxia Duan, Yanhong Liu, Zhonggao Gao & Wei Huang. (2021) Recent advances in drug delivery systems for targeting cancer stem cells. Acta Pharmaceutica Sinica B 11:1, pages 55-70.
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Ivana Jarak, Carla L. Varela, Elisiário Tavares da Silva, Fernanda F.M. Roleira, Francisco Veiga & Ana Figueiras. (2020) Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications. European Journal of Medicinal Chemistry 206, pages 112526.
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Diana Hide, Mar Gil, Fernanda Andrade, Diana Rafael, Imma Raurell, Miren Bravo, Aurora Barberá, Jordi Gracia-Sancho, Víctor Vargas, Salvador Augustin, Joan Genescà, Simo SchwartzJr.Jr. & Maria Martell. (2020) Simvastatin-loaded polymeric micelles are more effective and less toxic than conventional statins in a pre-clinical model of advanced chronic liver disease. Nanomedicine: Nanotechnology, Biology and Medicine 29, pages 102267.
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Payal Deepak, Rajinikanth Siddalingam, Praveen Kumar, Sneha Anand, Sunita Thakur, Balasubramaniam Jagdish & Shweta Jaiswal. (2020) Gene based nanocarrier delivery for the treatment of hepatocellular carcinoma. Journal of Drug Delivery Science and Technology 59, pages 101837.
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Muye He, Yan Wang, Xianjun Chen, Yuzheng Zhao, Kaiyan Lou, Yujie Wang, Lei Huang, Xinyu Hou, Jiajun Xu, Xiaoran Cai, Yi Cheng, Minbo Lan, Yi Yang & Feng Gao. (2020) Spatiotemporally controllable diphtheria toxin expression using a light-switchable transgene system combining multifunctional nanoparticle delivery system for targeted melanoma therapy. Journal of Controlled Release 319, pages 1-14.
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Sara Montero, Joaquin Seras-Franzoso, Fernanda Andrade, Francesc Martinez-Trucharte, Mireia Vilar-Hernández, Manuel Quesada, Helena Xandri, Diego Arango, Ibane Abasolo, Diana Rafael & Simo SchwartzJr.Jr.. (2020) Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells. Pharmaceutics 12:2, pages 185.
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Y. Garcia-Mayea, C. Mir, F. Masson, R. Paciucci & M.E. LLeonart. (2020) Insights into new mechanisms and models of cancer stem cell multidrug resistance. Seminars in Cancer Biology 60, pages 166-180.
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Yi Zhao, Daria Y. Alakhova, Xiangshan Zhao, Vimla Band, Elena V. Batrakova & Alexander V. Kabanov. (2020) Eradication of cancer stem cells in triple negative breast cancer using doxorubicin/pluronic polymeric micelles. Nanomedicine: Nanotechnology, Biology and Medicine 24, pages 102124.
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Petra Gener, Sara Montero, Helena Xandri-Monje, Zamira V. Díaz-Riascos, Diana Rafael, Fernanda Andrade, Francesc Martínez-Trucharte, Patricia González, Joaquin Seras-Franzoso, Albert Manzano, Diego Arango, Joan Sayós, Ibane Abasolo & Simo SchwartzJrJr. (2020) Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells. Nanomedicine: Nanotechnology, Biology and Medicine 24, pages 102106.
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Mohammad A. I. Al-Hatamleh, Engku Nur Syafirah E.A.R., Jennifer C. Boer, Khalid Ferji, Jean-Luc Six, Xin Chen, Eyad Elkord, Magdalena Plebanski & Rohimah Mohamud. (2019) Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment. Cells 9:1, pages 33.
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Ângela Sousa, Ana M. Almeida, Rúben Faria, Karidia Konate, Prisca Boisguerin, João A. Queiroz & Diana Costa. (2019) Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments. Colloids and Surfaces B: Biointerfaces 183, pages 110417.
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Gener, Rafael, Seras-Franzoso, Perez, Pindado, Casas, Arango, Fernández, Díaz-Riascos, Abasolo & SchwartzJr.Jr.. (2019) Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells. Cancers 11:8, pages 1058.
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Masoud Najafi, Bagher Farhood & Keywan Mortezaee. (2018) Cancer stem cells (CSCs) in cancer progression and therapy. Journal of Cellular Physiology 234:6, pages 8381-8395.
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Junfen Xu, Shanshan Xu, Yifeng Fang, Tingting Chen, Xing Xie & Weiguo Lu. (2018) Cyclin‐dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway. IUBMB Life.
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Petra Gener, Joaquin Seras-Franzoso, Patricia González Callejo, Fernanda Andrade, Diana Rafael, Francesc Martínez, Sara Montero, Diego Arango, Joan Sayós, Ibane Abasolo & Simó Schwartz. (2018) Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells. Stem Cells International 2018, pages 1-12.
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Diana Rafael, Fernanda Andrade, Sara Montero, Petra Gener, Joaquin Seras-Franzoso, Francesc Martínez, Patricia González, Helena Florindo, Diego Arango, Joan Sayós, Ibane Abasolo, Mafalda Videira & Simó Schwartz Jr.. (2018) Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets. Precision Nanomedicine 1:2, pages 86-105.
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