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Drug Delivery Volume 26, 2019 - Issue 1
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Research Article

Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery

Mengshuang Lia Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; ;b Qingdao Women and Children’s Hospital, Pharmacy Intravenous Admixture Services, Qingdao, China; View further author information
,
Jie Lanc Qingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China; View further author information
,
Xuefei Lia Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; View further author information
,
Meng Xina Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; ;d Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaView further author information
,
Hui Wanga Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; View further author information
,
Fan Zhanga Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; View further author information
,
Xiaohong Lua Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; View further author information
,
Zengfang Zhuanga Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; View further author information
&
Xianggen Wua Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; Correspondence[email protected]
View further author information
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Pages 481-489 | Received 27 Jan 2019, Accepted 23 Mar 2019, Published online: 08 Apr 2019

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Zhizheng Li, Li Li, Xiaohui Lv, Yingqian Hu & Kun Cui. (2023) Ginseng Saponin Rb1 Attenuates Cigarette Smoke Exposure-Induced Inflammation, Apoptosis and Oxidative Stress via Activating Nrf2 and Inhibiting NF-κB Signaling Pathways. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1883-1897.
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Minfang Feng, Xingxing Dai, Cuiting Yang, Yingying Zhang, Yuting Tian, Qingsong Qu, Mengke Sheng, Zhixun Li, Xinhui Peng, Shuai Cen & Xinyuan Shi. (2023) Unification of medicines and excipients: The roles of natural excipients for promoting drug delivery. Expert Opinion on Drug Delivery 20:5, pages 597-620.
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Zhan Tang, Lina Yin, Yawen Zhang, Wenying Yu, Qiao Wang & Zhajun Zhan. (2019) Preparation and study of two kinds of ophthalmic nano-preparations of everolimus. Drug Delivery 26:1, pages 1235-1242.
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Sri Renukadevi Balusamy, Haribalan Perumalsamy, Md. Amdadul Huq, Tae Hyun Yoon, Ivan Mijakovic, Lakshmi Thangavelu, Deok Chun Yang & Shadi Rahimi. (2023) A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications. Medicinal Research Reviews 43:5, pages 1374-1410.
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Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi & Xiangtao Wang. (2023) Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. Biomedicine & Pharmacotherapy 163, pages 114870.
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Yujuan Xie & Changhong Wang. (2023) Herb–drug interactions between Panax notoginseng or its biologically active compounds and therapeutic drugs: A comprehensive pharmacodynamic and pharmacokinetic review. Journal of Ethnopharmacology 307, pages 116156.
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Rong-yun Wei, Ye-ying Jiang, Kai Tang, Zhen Wang & Ning-hua Tan. (2023) Simultaneous determination of Panax notoginseng total saponins in rabbit tears by UPLC-QqQ-MS/MS and its application to pharmacokinetic study. Journal of Chromatography B 1218, pages 123490.
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Chul Joong Kim, Ji Hyeong Jeon, Eun Soo Seong, Seon Kang Choi, Jung Dae Lim, Chang Yeon Yu & Jae Geun Lee. (2021) Acetylcholinesterase Inhibition and Neuroprotective Effect of Ginseng Root Steam Treatment Containing Low Molecular Weight Ginsenosides. Korean Journal of Medicinal Crop Science 29:6, pages 388-397.
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Taiyoung Kang, Seokjin Suh, Hye‐Eun Jo & Kyeong‐Ok Choi. (2021) Physical, chemical, and biological characterization of ginsenoside F1 incorporated in nanostructured lipid carrier. Journal of Food Biochemistry 45:8.
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Yuyao Liao, Zhixun Li, Qing Zhou, Mengke Sheng, Qingsong Qu, Yanshuang Shi, Jiaqi Yang, Lijing Lv, Xingxing Dai & Xinyuan Shi. (2021) Saponin surfactants used in drug delivery systems: A new application for natural medicine components. International Journal of Pharmaceutics 603, pages 120709.
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Darcy Wear, Caleb Vegh, Jagdeep K. Sandhu, Marianna Sikorska, Jerome Cohen & Siyaram Pandey. (2021) Ubisol-Q10, a Nanomicellar and Water-Dispersible Formulation of Coenzyme-Q10 as a Potential Treatment for Alzheimer’s and Parkinson’s Disease. Antioxidants 10:5, pages 764.
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Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, Yannan Liu & Daidi Fan. (2021) Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers. Chinese Journal of Chemical Engineering 30, pages 291-300.
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Maria D. Auxtero, Susana Chalante, Mário R. Abade, Rui Jorge & Ana I. Fernandes. (2021) Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 13:1, pages 124.
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Milad Ashrafizadeh, Zahra Ahmadi, Habib Yaribeygi, Thozhukat Sathyapalan, Tannaz Jamialahmadi & Amirhossein Sahebkar. 2021. Natural Products and Human Diseases. Natural Products and Human Diseases 307 322 .
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Alejandra Meza-Rios, Jose Navarro-Partida, Juan Armendariz-Borunda & Arturo Santos. (2020) Therapies Based on Nanoparticles for Eye Drug Delivery. Ophthalmology and Therapy 9:3, pages 1-14.
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Meltem Ezgi DurgunSevgi GüngörYıldız Özsoy. (2020) Micelles: Promising Ocular Drug Carriers for Anterior and Posterior Segment Diseases. Journal of Ocular Pharmacology and Therapeutics 36:6, pages 323-341.
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Zufika Qamar, Farheen Fatima Qizilbash, Mohammad Kashif Iqubal, Asgar Ali, Jasjeet Kaur Narang, Javed Ali & Sanjula Baboota. (2020) Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective. Recent Patents on Drug Delivery & Formulation 13:4, pages 246-254.
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Jing-Wei Shao, Jia-Li Jiang, Jun-Jie Zou, Ming-Yue Yang, Fang-Min Chen, Yong-Jie Zhang & Lee Jia. (2020) Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials. Journal of Functional Foods 64, pages 103630.
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Yousef Pakzad, Marziyeh Fathi, Yadollah Omidi, Ali Zamanian & Masoud Mozafari. 2020. Nanoengineered Biomaterials for Advanced Drug Delivery. Nanoengineered Biomaterials for Advanced Drug Delivery 499 523 .

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