6,162
Views
75
CrossRef citations to date
0
Altmetric
Review Article

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

ORCID Icon
Pages 860-869 | Received 02 Jul 2019, Accepted 23 Aug 2019, Published online: 14 Sep 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Yanan Feng, Wenxiu Sun, Fengcui Sun, Guoliang Yin, Pengpeng Liang, Suwen Chen, Xiangyi Liu, Tongfei Jiang & Fengxia Zhang. (2022) Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver. Drug Design, Development and Therapy 16, pages 3829-3845.
Read now
Soo Hyun Youn, Chang-Kyun Han, Jae Hyun Suh, Sun Hee Hyun, Jong-Soo Kyung, Seung-Ho So, Jong-Han Kim & Hwi Won Seo. (2022) Subacute oral toxicity and bacterial mutagenicity of a mixture of Puerariae radix and Hizikia fusiforme extracts. Drug and Chemical Toxicology 45:5, pages 2193-2201.
Read now
Qingzhuo Ye, Jinghong Li, Ting Li, Jingxin Ruan, Hongyue Wang, Fang Wang & Xiangrong Zhang. (2021) Development and evaluation of puerarin-loaded controlled release nanostructured lipid carries by central composite design. Drug Development and Industrial Pharmacy 47:1, pages 113-125.
Read now
Tingting Wang, Jun Hou, Wenjing Xiao, Yaolei Zhang, Longfu Zhou, Li Yuan, Xiaoqiang Yin, Xin Chen & Yonghe Hu. (2020) Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension. Pharmaceutical Biology 58:1, pages 815-827.
Read now

Articles from other publishers (70)

Xinyi Jiao, Xingru Peng, Xin Jin, Ning Liu, Yang Yu, Rui Liu & Zheng Li. (2023) Nano-composite system of traditional Chinese medicine for ocular applications: molecular docking and three-dimensional modeling insight for intelligent drug evaluation. Drug Delivery and Translational Research 13:12, pages 3132-3144.
Crossref
Bo Yang & Nengwei Yu. (2023) Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review. Brain Research Bulletin 204, pages 110800.
Crossref
Depeng Fang, Zainen Qin, Li Zheng, Pek Yin Michelle Yew, Xianfang Jiang, Dan Kai, Fangming Song & Jinmin Zhao. (2023) Ros-responsive nanocomposite scaffolds for sustained releasing puerarin to achieve chondroprotection in OA rats. Materials & Design 233, pages 112214.
Crossref
Rongyuan Yang, Yingming Gu, Jinying Qin, Qingqing Liu & Qing Liu. (2023) Potential role of Chinese medicine nanoparticles to treat coronary artery disease. Heliyon 9:9, pages e19766.
Crossref
Yaoyao Ren & Shengtao Qu. (2023) Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing Research Reviews 90, pages 102040.
Crossref
Wanhai Zhou, Heng He, Qin Wei, Litao Che, Xin Zhao, Wenwen Liu, Yue Yan, Lianqing Hu, Yonghua Du, Zhongqiong Yin, Yongkang Shuai, Li Yang & Ruizhang Feng. (2023) Puerarin protects against acetaminophen‐induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway. Food Science & Nutrition.
Crossref
Tian Liu, Kai Su, Weiye Cai, Hui Ao & Mingxiu Li. (2023) Therapeutic potential of puerarin against cerebral diseases: From bench to bedside. European Journal of Pharmacology 953, pages 175695.
Crossref
Jun-bin Yan, Yun-meng Nie, SumeFIi Xu, Shuo Zhang & Zhi-yun Chen. (2023) Pure total flavonoids from citrus alleviate oxidative stress and inflammation in nonalcoholic fatty liver disease by regulating the miR-137-3p/NOXA2/NOX2 pathway. Phytomedicine, pages 154944.
Crossref
Tina Oberacker, Leonie Kraft, Moritz Schanz, Jörg Latus & Severin Schricker. (2023) The Importance of Thioredoxin-1 in Health and Disease. Antioxidants 12:5, pages 1078.
Crossref
Li Wang, Tao Wang, Shuangquan Wen, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu & Yan Yuan. (2023) Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons. International Journal of Molecular Sciences 24:9, pages 8328.
Crossref
Rafał P Kampa, Aleksandra Sęk, Piotr Bednarczyk, Adam Szewczyk, Vincenzo Calderone & Lara Testai. (2023) Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection. Journal of Pharmacy and Pharmacology 75:4, pages 466-481.
Crossref
Shuang Zhou, Yuhua Li, Yi Hong, Zhitao Zhong & Min Zhao. (2023) Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage. European Journal of Pharmacology 945, pages 175616.
Crossref
Abid Naeem, Chengqun Yu, Weifeng Zhu, Zhenzhong Zang & Yongmei Guan. (2023) Study of Hydroxypropyl β-Cyclodextrin and Puerarin Inclusion Complexes Encapsulated in Sodium Alginate-Grafted 2-Acrylamido-2-Methyl-1-Propane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery. Gels 9:3, pages 246.
Crossref
Wei-Hang Chen, Yan Tan, Ya-Lei Wang, Xu Wang & Zhao-Heng Liu. (2023) Rheumatic valvular heart disease treated with traditional Chinese medicine: A case report. World Journal of Clinical Cases 11:7, pages 1600-1606.
Crossref
Yung-Hsin Cheng, Hsin-Ho Chen, Yu-Cheng Liu & Kai-Chiang Yang. (2023) ROS-triggered drug release of puerarin from boronic ester modified nanoparticles to reduce oxidative damage in HUVECs. Journal of Drug Delivery Science and Technology 81, pages 104210.
Crossref
Muling Zeng, Dongdong Guo, Guillermo Fernández-Varo, Xu Zhang, Siqi Fu, Shijie Ju, Huiling Yang, Xingfei Liu, Ya-Chao Wang, Yu Zeng, Gregori Casals & Eudald Casals. (2022) The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities. Molecular Pharmaceutics 20:2, pages 886-904.
Crossref
Jinsong Zeng, Tingting Bao, Kailin Yang, Xiaofei Zhu, Shanshan Wang, Wang Xiang, Anqi Ge, Liuting Zeng & Jinwen Ge. (2023) The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review. Frontiers in Immunology 13.
Crossref
Kangyu Wang, Zhao Tang, Shuai Liu, Yan Liu, Huiqing Zhang & Haocheng Zhan. (2023) Puerarin protects renal ischemia-reperfusion injury in rats through NLRP3/Caspase-1/GSDMD pathway. Acta Cirúrgica Brasileira 38.
Crossref
Siyu Qiang, Lixiang Gu, Yu Kuang, Minyao Zhao, Yu You & Qin Han. (2023) Changes in the content of Puerarin-PLGA nanoparticles in mice under the influence of alcohol and analysis of their antialcoholism. Journal of Applied Biomaterials & Functional Materials 21, pages 228080002211481.
Crossref
Xue Bai, Zhigang Bian & Meng Zhang. (2023) Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases. Phytomedicine 109, pages 154582.
Crossref
Song Wang, Wei Yao, Xudong Zhu, Jingjing Wang, Longhui Lu, Na Zhu, Tong Lan, Yunxia Kuang, Weifeng Zhu, Ronghua Liu & Liping Huang. (2023) Exploring the mechanism of the antithrombotic effects of Pueraria lobata and Pueraria lobata var. thomsonii based on network pharmacology. Journal of Ethnopharmacology 300, pages 115701.
Crossref
Deependra Singh, Krishna Yadav, Manju Rawat Singh, Narayan D. Chaurasiya & Babu L. Tekwani. 2023. Phytopharmaceuticals and Herbal Drugs. Phytopharmaceuticals and Herbal Drugs 375 401 .
Magdalena Maciejewska-Turska & Elwira Sieniawska. 2023. Handbook of Dietary Flavonoids. Handbook of Dietary Flavonoids 1 30 .
Xiaoxuan Jing, Jingxuan Zhou, Nanhai Zhang, Liang Zhao, Shiran Wang, Liebing Zhang & Feng Zhou. (2022) A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities. Foods 11:23, pages 3941.
Crossref
Fan Meng, Bin Guo, Yi-qing Ma, Kun-wei Li & Feng-ju Niu. (2022) Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology. Phytomedicine 107, pages 154465.
Crossref
Xiujie Shi, Meiying Chang, Mingming Zhao, Yue Shi & Yu Zhang. (2022) Traditional Chinese medicine compounds ameliorating glomerular diseases via autophagy: A mechanism review. Biomedicine & Pharmacotherapy 156, pages 113916.
Crossref
Xia-xia Zhang, Yan-fei Lang, Xin Li, Zheng Li, You-qing Xu & Hong-qian Chu. (2022) The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Biomedical Microdevices 24:4.
Crossref
Zafarullah Muhammad, Rabia Ramzan, Ruifen Zhang, Dong Zhao, Nazia Khalid, Mei Deng, Lihong Dong, Mahwash Aziz, Rizwana Batool & Mingwei Zhang. (2022) Enhanced Bioaccessibility of Microencapsulated Puerarin Delivered by Pickering Emulsions Stabilized with OSA-Modified Hydrolyzed Pueraria montana Starch: In Vitro Release, Storage Stability, and Physicochemical Properties. Foods 11:22, pages 3591.
Crossref
Qiang Lu, Daopeng Tan, Jingbin Luo, Yonghao Ye, Manhua Zuo, Siyu Wang & Cailan Li. (2022) Potential of natural products in the treatment of irritable bowel syndrome. Phytomedicine 106, pages 154419.
Crossref
Xiaoxue Fang, Yegang Zhang, Yiming Cao, Mengyao Shan, Dimeng Song, Chao Ye & Difu Zhu. (2022) Studies on Chemical Composition of Pueraria lobata and Its Anti-Tumor Mechanism. Molecules 27:21, pages 7253.
Crossref
Qian Wang, Zi-Nuo Shen, Shu-Jing Zhang, Yan Sun, Feng-Jie Zheng & Yu-Hang Li. (2022) Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases. Frontiers in Pharmacology 13.
Crossref
Cailan Li, Jianhui Xie, Jiahao Wang, Ying Cao, Min Pu, Qihai Gong & Qiang Lu. (2022) Therapeutic effects and mechanisms of plant-derived natural compounds against intestinal mucositis. Frontiers in Pharmacology 13.
Crossref
Yingyi Zheng, Ruoqi Li & Xiang Fan. (2022) Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach. Antioxidants 11:9, pages 1811.
Crossref
Yang Li, Cheng Liu, Lian Yang, Lu Li & Li Hong. (2022) Puerarin protects fibroblasts against mechanical stretching injury through Nrf2/TGF-β1 signaling pathway. International Urogynecology Journal 33:9, pages 2565-2576.
Crossref
Xinwei Zhang, Si Chen, Xue Li, Liying Zhang & Linzhu Ren. (2022) Flavonoids as Potential Antiviral Agents for Porcine Viruses. Pharmaceutics 14:9, pages 1793.
Crossref
Minglang Gao, Ziyao Zhang, Kai Lai, Yu Deng, Chuanbing Zhao, Zilong Lu & Qing Geng. (2022) Puerarin: A protective drug against ischemia-reperfusion injury. Frontiers in Pharmacology 13.
Crossref
Dasheng Cai, Yue Zhao & Fang Yu. (2022) Puerarin ameliorates acute lung injury by modulating NLRP3 inflammasome-induced pyroptosis. Cell Death Discovery 8:1.
Crossref
Zunjiang Li, Ye Fan, Chunxia Huang, Quanle Liu, Manhua Huang, Baijian Chen, Zhe Peng, Wei Zhu & Banghan Ding. (2022) Efficacy and safety of Puerarin injection on acute heart failure: A systematic review and meta-analysis. Frontiers in Cardiovascular Medicine 9.
Crossref
Hsiou-Yu Ding, Tzi-Yuan Wang, Jiumn-Yih Wu, Yu-Li Tsai & Te-Sheng Chang. (2022) Enzymatic Synthesis of Novel and Highly Soluble Puerarin Glucoside by Deinococcus geothermalis Amylosucrase. Molecules 27:13, pages 4074.
Crossref
Baohui Chen, Haifeng Zhang, Jiajun Qiu, Shaoyun Wang, Liping Ouyang, Yuqin Qiao & Xuanyong Liu. (2022) Mechanical Force Induced Self‐Assembly of Chinese Herbal Hydrogel with Synergistic Effects of Antibacterial Activity and Immune Regulation for Wound Healing. Small 18:21.
Crossref
Xue Zhou, Qimanguli Saiding, Xianjing Wang, Juan Wang, Wenguo Cui & Xinliang Chen. (2022) Regulated Exogenous/Endogenous Inflammation via “Inner‐Outer” Medicated Electrospun Fibers for Promoting Tissue Reconstruction. Advanced Healthcare Materials 11:10, pages 2102534.
Crossref
Shan Ye, Weiyan Chen, Caiwen Ou & Min-Sheng Chen. (2022) RNA sequencing reveals novel LncRNA/mRNAs co-expression network associated with puerarin-mediated inhibition of cardiac hypertrophy in mice. PeerJ 10, pages e13144.
Crossref
Jiayu Lv, Shuqing Shi, Bingxuan Zhang, Xia Xu, Haoran Zheng, Yumeng Li, Xiangning Cui, Huaqin Wu & Qingqiao Song. (2022) Role of puerarin in pathological cardiac remodeling: A review. Pharmacological Research 178, pages 106152.
Crossref
Yi Li, Chunli Zhang, Xiaohan Ma, Liuqing Yang & Huijun Ren. (2022) Identification of the potential mechanism of Radix pueraria in colon cancer based on network pharmacology. Scientific Reports 12:1.
Crossref
Ruren Li, Gaibo Yuan, Denghui Li, Chen Xu, Mingying Du, Shuyu Tan, Zhifu Liu, Qing He, Liangyan Rong & Jianrong Li. (2022) Enhancing the bioaccessibility of puerarin through the collaboration of high internal phase Pickering emulsions with β-carotene. Food & Function 13:5, pages 2534-2544.
Crossref
Lan Mo, Guang-lei Zhao, Xiao-feng Li, Ning He, Xing-long Xiao, Hai-xia Xu & Yi-gang Yu. (2021) Biocatalytical Acyl-Modification of Puerarin: Shape Gut Microbiota Profile and Improve Short Chain Fatty Acids Production in Rats. Plant Foods for Human Nutrition 77:1, pages 44-50.
Crossref
Revathi Ponnusamy, Kalaiarasi Giriraj, Magesh Selvakumar AM, Parimelazhagan Thangaraj, Saikumar Sathyanarayanan, Adriano Antunes de Souza Araújo, Saravanan Shanmugam & Lucindo José Quintans Junior. (2022) Glycogen synthase kinase 3β inhibition and insulin-receptor binding enhancement of compounds isolated from wild leafy vegetable Acalypha alnifolia. Phytomedicine Plus 2:1, pages 100216.
Crossref
Chao-Chao Yu, Yan-Jun Du, Jin Li, Yi Li, Li Wang, Li-Hong Kong & Ying-Wen Zhang. (2022) Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update. Aging and disease 13:4, pages 1092.
Crossref
Lan Mo, Guang-lei Zhao, Xiao-feng Li, Xing-long Xiao, Ning He, Hai-xia Xu & Yi-gang Yu. (2022) Green synthesis of puerarin acid esters and their oral absorption evaluation in vivo. Journal of Drug Delivery Science and Technology 67, pages 102882.
Crossref
Anna S. Morozova, Elena N. Vilchevskaya, Wolfgang Müller & Nikolay M. Bessonov. (2021) A holistic continuum model-based approach to drug release. Continuum Mechanics and Thermodynamics 34:1, pages 81-91.
Crossref
Heng He, Shuwei Peng, Xu Song, Renyong Jia, Yuanfeng Zou, Lixia Li & Zhongqiong Yin. (2021) Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review. Food Science & Nutrition 10:1, pages 272-285.
Crossref
Yan-Xi Zhou, Hong Zhang & Cheng Peng. (2021) Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases. Frontiers in Pharmacology 12.
Crossref
Yaobin Pang, Shi Wu, Yingjie He, Qing Nian, Jing Lei, Yejing Yao, Jing Guo & Jinhao Zeng. (2021) Plant-Derived Compounds as Promising Therapeutics for Vitiligo. Frontiers in Pharmacology 12.
Crossref
Lu Wang, Qi Lu, Wenwen Gao & Shuwen Yu. (2021) Recent advancement on development of drug-induced macrophage polarization in control of human diseases. Life Sciences 284, pages 119914.
Crossref
Meng Zhang, Guanhua Hu, Nan Shao, Yunpeng Qin, Qian Chen, Yan Wang, Peng Zhou & Biao Cai. (2021) Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols. Inflammopharmacology 29:5, pages 1317-1329.
Crossref
Zhengming Zhu, Qingsheng Liu, Jianshi Sun, Ziyang Bao & Weiwei Wang. (2021) Silencing of PFKFB3 protects podocytes against high glucose‑induced injury by inducing autophagy. Molecular Medicine Reports 24:5.
Crossref
Yanhui Han, Honglei Wang, Yan Wang, Pingshuan Dong, Jingjing Jia & Shaohui Yang. (2021) Puerarin protects cardiomyocytes from ischemia–reperfusion injury by upregulating LncRNA ANRIL and inhibiting autophagy. Cell and Tissue Research 385:3, pages 739-751.
Crossref
Jeevan K. Prasain, Stephen Barnes & J. Michael Wyss. (2021) Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism. Food Frontiers 2:3, pages 383-389.
Crossref
Sze Wan Hung, Ruizhe Zhang, Zhouyurong Tan, Jacqueline Pui Wah Chung, Tao Zhang & Chi Chiu Wang. (2021) Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review. Medicinal Research Reviews 41:4, pages 2489-2564.
Crossref
Tao Wang, Li Wang, Yi Zhang, Jian Sun, Yilin Xie, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu & Hui Zou. (2021) Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes. Frontiers in Pharmacology 12.
Crossref
Sureerat Namken, Phanit Songvut, Nitra Nuengchamnong, Taratorn Kemthong, Phisit Khemawoot & Suchinda Malaivijitnond. (2020) Comparative Pharmacokinetics of Puerarin Alone and in Pueraria mirifica Extract in Female Cynomolgus Monkeys. Planta Medica 87:05, pages 395-403.
Crossref
Qian-yu Zhao, Rong-hua Tang, Guo-xiong Lu, Xu-zheng Cao, Lu-ran Liu, Ji-hua Zhang, Jin-tao Zhang, Bin Xu, Hong-tao Wei, Miao Yang, Ling Wei, Mei Zhang, Wen-zong Zhu, Hong Wang, Hong-lin Li, Li-ping Ma, Chi Zhong, Yan-jie Gao, Na Zhang, Shan Ren, Lu Chen, Yun-hai Liu & Zhi-gang Chen. (2020) Efficacy of Getong Tongluo Capsule (葛酮通络胶囊) for Convalescent-Phase of Ischemic Stroke and Primary Hypertension: A Multicenter, Randomized, Double-Blind, Controlled Trial. Chinese Journal of Integrative Medicine 27:4, pages 252-258.
Crossref
Sha Xiong, Jingshan Luo, Qun Wang, Zhongjun Li, Juntong Li, Qiao Liu, Liqian Gao, Shuhuan Fang, Yunyong Li, Huafeng Pan, Hong Wang, Yongbin Zhang, Qi Wang, Xiaojia Chen & Tongkai Chen. (2021) Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease. Biomaterials Science 9:5, pages 1705-1715.
Crossref
Xing Chang, Tian Zhang, Dong Liu, Qingyan Meng, Peizheng Yan, Duosheng Luo, Xue Wang & XiuTeng Zhou. (2021) Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control. Oxidative Medicine and Cellular Longevity 2021, pages 1-14.
Crossref
Gabriela F Meresman, Martin Götte & Matthias W Laschke. (2021) Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies. Human Reproduction Update 27:2, pages 367-392.
Crossref
Limei Chen, E. Jiang, Yongmei Guan, Pan Xu, Qian Shen, Zhiyong Liu, Weifeng Zhu, Lihua Chen, Hongning Liu & Huanhuan Dong. (2020) Safety of high‐dose Puerariae Lobatae Radix in adolescent rats based on metabolomics . Food Science & Nutrition 9:2, pages 794-810.
Crossref
Jung Suk Kim, Fakhar ud Din, Sang Min Lee, Dong Shik Kim, Yoo Jin Choi, Mi Ran Woo, Jong Oh Kim, Yu Seok Youn, Sung Giu Jin & Han-Gon Choi. (2021) Comparative study between high-pressure homogenisation and Shirasu porous glass membrane technique in sildenafil base-loaded solid SNEDDS: Effects on physicochemical properties and in vivo characteristics. International Journal of Pharmaceutics 592, pages 120039.
Crossref
Shijia Fu, Yi Lu, Rongrong Lai, Ziyi Liu & Yuehong Xu. 2021. Novel Drug Delivery Systems for Chinese Medicines. Novel Drug Delivery Systems for Chinese Medicines 315 336 .
Jinqiu Ma, Chenyun Wang, Yunbo Sun, Lulu Pang, Siqing Zhu, Yijing Liu, Lin Zhu, Shouguo Zhang, Lin Wang & Lina Du. (2020) Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia. International Journal of Pharmaceutics 591, pages 120002.
Crossref
Jie Yan, Zhi-Yu Guan, Wei-Feng Zhu, Ling-Yun Zhong, Zhuo-Qi Qiu, Peng-Fei Yue, Wen-Ting Wu, Jing Liu & Xiao Huang. (2020) Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics. Pharmaceutics 12:3, pages 216.
Crossref