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Drug Delivery Volume 27, 2020 - Issue 1
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Research Article

Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy

Tingting Lia Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China;b Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen, ChinaView further author information
,
Ye Wangc Department of Biological pharmacy, School of Pharmacy, Jilin University, Changchun, ChinaView further author information
,
Jiahao Chenc Department of Biological pharmacy, School of Pharmacy, Jilin University, Changchun, ChinaView further author information
,
Xiaoshu Gaoc Department of Biological pharmacy, School of Pharmacy, Jilin University, Changchun, ChinaView further author information
,
Siqi Panc Department of Biological pharmacy, School of Pharmacy, Jilin University, Changchun, ChinaView further author information
,
Yu Suc Department of Biological pharmacy, School of Pharmacy, Jilin University, Changchun, ChinaView further author information
&
Xinrong Zhoua Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, ChinaCorrespondence[email protected]
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Pages 410-421 | Received 09 Sep 2019, Accepted 15 Feb 2020, Published online: 05 Mar 2020

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Yilin Chen, Zi Ye, Haixu Chen & Zhaohui Li. (2024) Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment. International Journal of Nanomedicine 19, pages 4021-4040.
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Yujin Zhao, Chang Huang, Zhutian Zhang, Jiaxu Hong, Jianjiang Xu, Xinghuai Sun & Jianguo Sun. (2022) Sustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma. Drug Delivery 29:1, pages 613-623.
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Jun Guo, Haojie Liu & Lin Fu. (2022) MicroRNA-124 ameliorates autophagic dysregulation in glaucoma via regulation of P2X7-mediated Akt/mTOR signaling. Cutaneous and Ocular Toxicology 41:1, pages 43-48.
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Jingjing Zhang, Xuejiao Yang, Yao Zong, Tao Yu & Xian Yang. (2024) miR-196b-5p regulates inflammatory process and migration via targeting Nras in trabecular meshwork cells. International Immunopharmacology 129, pages 111646.
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Yong Ma, Zhe Zhang, Yanze Yu, Xuejun Wang, Shengtao Liu, Bingqing Sun, Zhengwei Cai, Wenguo Cui, Xingtao Zhou & Jing Zhao. (2024) Nanomaterials in the diagnosis and treatment of ophthalmic diseases. Nano Today 54, pages 102117.
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Lemeng Feng, Chao Wang, Cheng Zhang, Wulong Zhang & Weitao Song. (2023) Role of epigenetic regulation in glaucoma. Biomedicine & Pharmacotherapy 168, pages 115633.
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Margarita Dobrzycka, Anetta Sulewska, Przemyslaw Biecek, Radoslaw Charkiewicz, Piotr Karabowicz, Angelika Charkiewicz, Kinga Golaszewska, Patrycja Milewska, Anna Michalska-Falkowska, Karolina Nowak, Jacek Niklinski & Joanna Konopińska. (2023) miRNA Studies in Glaucoma: A Comprehensive Review of Current Knowledge and Future Perspectives. International Journal of Molecular Sciences 24:19, pages 14699.
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Mohammad Chehelgerdi & Matin Chehelgerdi. (2023) The use of RNA-based treatments in the field of cancer immunotherapy. Molecular Cancer 22:1.
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Yuening Shen, Jianguo Sun & Xinghuai Sun. (2023) Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress. Journal of Nanobiotechnology 21:1.
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Kevin Y. Wu, Said Ashkar, Shrieda Jain, Michael Marchand & Simon D. Tran. (2023) Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma. Polymers 15:6, pages 1373.
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Yash Sharma, Kanak Chahar, Lopamudra Mishra, Lakshmi Kumari, Aarchi Singla, Preeti Patel, Dilpreet Singh & Balak Das Kurmi. (2023) Recent overviews on the drug delivery aspects and applications of brinzolamide for the management of glaucoma. Health Sciences Review 6, pages 100083.
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N.I. Kurysheva, V.Yu. Kim, V.E. Kim & H.M. Pliyeva. (2023) The value of lamina cribrosa in the diagnosis and treatment of glaucoma. Remodeling of lamina cribrosa collagen and approaches to its therapeutic treatment. Vestnik oftal'mologii 139:4, pages 121.
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Ryan G. Strickland, Mary Anne Garner, Alecia K. Gross & Christopher A. Girkin. (2022) Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma. International Journal of Molecular Sciences 23:15, pages 8068.
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K.D. Patel, L. Barrios Silva, Y. Park, T. Shakouri, Z. Keskin-Erdogan, P. Sawadkar, K.J. Cho, J.C. Knowles, D.Y.S. Chau & H.-W. Kim. (2022) Recent advances in drug delivery systems for glaucoma treatment. Materials Today Nano 18, pages 100178.
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Zhimin Tang, Xianqun Fan, Yu Chen & Ping Gu. (2022) Ocular Nanomedicine. Advanced Science 9:15.
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Karah M. Greene, W. Daniel Stamer & Yutao Liu. (2022) The role of microRNAs in glaucoma. Experimental Eye Research 215, pages 108909.
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Ben Mead & Stanislav Tomarev. (2022) The role of miRNA in retinal ganglion cell health and disease. Neural Regeneration Research 17:3, pages 516.
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Najam A. Sharif. 2022. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics 309 316 .
Maira Anwar, Faqir Muhammad & Bushra Akhtar. (2021) Biodegradable nanoparticles as drug delivery devices. Journal of Drug Delivery Science and Technology 64, pages 102638.
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Yue Ding, Seong H. Chow, Jinying Chen, Anton P. Le Brun, Chun-Ming Wu, Anthony P. Duff, Yajun Wang, Jiangning Song, Jiang-Hui Wang, Vickie H.Y. Wong, Da Zhao, Tomoharu Nishimura, Tzong-Hsien Lee, Charlotte E. Conn, Hsien-Yi Hsu, Bang V. Bui, Guei-Sheung Liu & Hsin-Hui Shen. (2021) Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model. Acta Biomaterialia 126, pages 433-444.
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Zimeng Zhai, Yiyun Cheng & Jiaxu Hong. (2021) Nanomedicines for the treatment of glaucoma: Current status and future perspectives. Acta Biomaterialia 125, pages 41-56.
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Saray Tabak, Sofia Schreiber-Avissar & Elie Beit-Yannai. (2021) Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma. International Journal of Molecular Sciences 22:5, pages 2421.
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Jing Song & Ziping Zhang. (2020) Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma. Journal of Applied Biomaterials & Functional Materials 18, pages 228080002094271.
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