Drug Delivery, Volume 27, Issue 1 (2020)

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Drug Delivery, Volume 27, Issue 1 (2020)

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Research Article

Article
Neutrophils, as “Trojan horses”, participate in the delivery of therapeutical PLGA nanoparticles into a tumor based on the chemotactic effect
Jifu Hao, Junlan Chen, Meixiang Wang, Jing Zhao, Jianze Wang, Xingrong Wang, Yuhong Li & Hua Tang
Pages: 1-14
Published online: 09 Dec 2019
AbstractforNeutrophils, as “Trojan horses”, participate in the delivery of therapeutical PLGA nanoparticles into a tumor based on the chemotactic effect | Full Text | References | PDF (2.6 MB) | EPUB
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Open Access
Article
Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer
Yu Xia, Guoyi Tang, Changbing Wang, Jiayu Zhong, Yi Chen, Liang Hua, Yinghua Li, Hongsheng Liu & Bing Zhu
Pages: 15-25
Published online: 12 Dec 2019
AbstractforFunctionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer | Full Text | References | PDF (1.9 MB) | EPUB
  • 5039 Views
  • 58 CrossRef citations
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Open Access
Article
Preparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection
Mona G. Arafa, Hadeel A. Mousa & Nagia N. Afifi
Pages: 26-39
Published online: 13 Dec 2019
AbstractforPreparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection | Full Text | References | PDF (1.8 MB) | EPUB
  • 5563 Views
  • 85 CrossRef citations
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Open Access
Article
Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review
Leen Van de Sande, Sarah Cosyns, Wouter Willaert & Wim Ceelen
Pages: 40-53
Published online: 20 Dec 2019
AbstractforAlbumin-based cancer therapeutics for intraperitoneal drug delivery: a review | Full Text | References | PDF (2.4 MB) | EPUB
  • 6980 Views
  • 54 CrossRef citations
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Open Access
Article
In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity
Qing Yao, Meng-Ting Lin, Qing-Hua Lan, Zhi-Wei Huang, Ya-Wen Zheng, Xue Jiang, Yin-Di Zhu, Longfa Kou, He-Lin Xu & Ying-Zheng Zhao
Pages: 54-65
Published online: 20 Dec 2019
AbstractforIn vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity | Full Text | References | PDF (3.1 MB) | EPUB
  • 2323 Views
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Open Access
Article
[12]aneN3-based multifunctional compounds as fluorescent probes and nucleic acids delivering agents
Yong-Guang Gao, Shu-Yuan Huangfu, Suryaji Patil, Quan Tang, Wan Sun, Yu Li, Zhong-Lin Lu & Airong Qian
Pages: 66-80
Published online: 20 Dec 2019
Abstractfor[12]aneN3-based multifunctional compounds as fluorescent probes and nucleic acids delivering agents | Full Text | References | PDF (4.6 MB) | EPUB
  • 1565 Views
  • 12 CrossRef citations
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Open Access
Article
Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability
Mingfang Wu, Chen Zhong, Yiping Deng, Qian Zhang, Xiaoxue Zhang & Xiuhua Zhao
Pages: 81-90
Published online: 20 Dec 2019
AbstractforResveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability | Full Text | References | PDF (1.6 MB) | EPUB
  • 2614 Views
  • 15 CrossRef citations
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Open Access
Article
SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
Jingjing Song, Sujie Huang, Zhengzheng Zhang, Bo Jia, Huan Xie, Ming Kai & Wei Zhang
Pages: 91-99
Published online: 24 Dec 2019
AbstractforSPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery | Full Text | References | PDF (1.6 MB) | EPUB
  • 2164 Views
  • 11 CrossRef citations
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Open Access
Article
Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer
Xianglong Yu, Huichao Wu, Haiyan Hu, Ziyi Dong, Yunni Dang, Qi Qi, Yan Wang, Shouying Du & Yang Lu
Pages: 100-109
Published online: 24 Dec 2019
AbstractforZein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer | Full Text | References | PDF (2.8 MB) | EPUB
  • 3940 Views
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Open Access
Article
Mechanisms of increased bioavailability through amorphous solid dispersions: a review
Andreas Schittny, Jörg Huwyler & Maxim Puchkov
Pages: 110-127
Published online: 30 Dec 2019
AbstractforMechanisms of increased bioavailability through amorphous solid dispersions: a review | Full Text | References | PDF (1.8 MB) | EPUB
  • 14237 Views
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Open Access
Article
Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms
Yunai Du, Sheng Wang, Tianhao Zhang, Dongsheng He, Jiasheng Tu & Yan Shen
Pages: 128-136
Published online: 02 Jan 2020
AbstractforEnhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms | Full Text | References | PDF (2.7 MB) | EPUB
  • 2179 Views
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Open Access
Article
Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles
Xue Feng, Yuting Chen, Luya Li, Yuqian Zhang, Lantong Zhang & Zhiqing Zhang
Pages: 137-150
Published online: 08 Jan 2020
AbstractforPreparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles | Full Text | References | PDF (2.6 MB) | EPUB
  • 2512 Views
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Open Access
Article
Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
Yihui Ma, Jinlin Song, Huthayfa N. S. Almassri, Dan Zhang, Ting Zhang, Yuting Cheng & Xiaohong Wu
Pages: 151-160
Published online: 08 Jan 2020
AbstractforMinocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis | Full Text | References | PDF (2.4 MB) | EPUB
  • 2980 Views
  • 37 CrossRef citations
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Open Access
Article
Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles
Yongwei Gu, Xinmei Chen, Haiyan Zhang, Heyi Wang, Hang Chen, Sifan Huang, Youfa Xu, Yuansheng Zhang, Xin Wu & Jianming Chen
Pages: 161-169
Published online: 08 Jan 2020
AbstractforStudy on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles | Full Text | References | PDF (2.4 MB) | EPUB
  • 2052 Views
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Open Access
Article
OCTN2-targeted nanoparticles for oral delivery of paclitaxel: differential impact of the polyethylene glycol linker size on drug delivery in vitro, in situ, and in vivo
Longfa Kou, Rui Sun, Shuyi Xiao, Xiao Cui, Jin Sun, Vadivel Ganapathy, Qing Yao & Ruijie Chen
Pages: 170-179
Published online: 08 Jan 2020
AbstractforOCTN2-targeted nanoparticles for oral delivery of paclitaxel: differential impact of the polyethylene glycol linker size on drug delivery in vitro, in situ, and in vivo | Full Text | References | PDF (2.4 MB) | EPUB
  • 2011 Views
  • 19 CrossRef citations
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Open Access
Article
Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo
Wanfu Men, Peiyao Zhu, Siyuan Dong, Wenke Liu, Kun Zhou, Yu Bai, Xiangli Liu, Shulei Gong & Shuguang Zhang
Pages: 180-190
Published online: 10 Jan 2020
AbstractforLayer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo | Full Text | References | PDF (2 MB) | EPUB
  • 5063 Views
  • 59 CrossRef citations
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Open Access
Article
Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance
Danyang Li, Ruixue Cui, Shuning Xu & Ying Liu
Pages: 191-199
Published online: 10 Jan 2020
AbstractforSynergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance | Full Text | References | PDF (1.7 MB) | EPUB
  • 2234 Views
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Open Access
Review
Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery
Qingming Ma, Yang Gao, Wentao Sun, Jie Cao, Yan Liang, Shangcong Han, Xinyu Wang & Yong Sun
Pages: 200-215
Published online: 27 Jan 2020
AbstractforSelf-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery | Full Text | References | PDF (3.7 MB) | EPUB
  • 4859 Views
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Open Access
Article
Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents
Fengyi Zhao, Xu Sun, Wen Lu, Li Xu, Jiuzhou Shi, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin & Fuliang Cao
Pages: 216-227
Published online: 27 Jan 2020
AbstractforSynthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents | Full Text | References | PDF (2.2 MB) | EPUB
  • 1763 Views
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Open Access
Article
Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer
Yian Wang, Tiantian Huang, Haowen Li, Jingxin Fu, Hui Ao, Likang Lu, Meihua Han, Yifei Guo, Feng Yue & Xiangtao Wang
Pages: 228-237
Published online: 31 Jan 2020
AbstractforHydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer | Full Text | References | PDF (2 MB) | EPUB
  • 1877 Views
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Open Access
Article
Drug-interactive mPEG-b-PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel
Feirong Gong, Rongrong Wang, Zhengquan Zhu, Jiayao Duan, Xin Teng & Zhong-Kai Cui
Pages: 238-247
Published online: 31 Jan 2020
AbstractforDrug-interactive mPEG-b-PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel | Full Text | References | PDF (1.5 MB) | EPUB
  • 4560 Views
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Open Access
Article
Highly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy
Chang Zu, Yinglan Yu, Caiwei Yu, Yi Li, Runing Sun, Birendra Chaurasiya, Baoqiang Tang, Daquan Chen, Jiasheng Tu & Yan Shen
Pages: 248-257
Published online: 31 Jan 2020
AbstractforHighly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy | Full Text | References | PDF (1.9 MB) | EPUB
  • 1880 Views
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Open Access
Article
Folate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-7721
Yue Cao, Chao Wu, Ying Liu, Lili Hu, Wenjing Shang, Zhanshan Gao & Nan Xia
Pages: 258-268
Published online: 03 Feb 2020
AbstractforFolate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-7721 | Full Text | References | PDF (2.5 MB) | EPUB
  • 2386 Views
  • 28 CrossRef citations
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Open Access
Article
Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
Azizeh Rahmani Del Bakhshayesh, Abolfazl Akbarzadeh, Alireza Alihemmati, Hamid Tayefi Nasrabadi, Azadeh Montaseri, Soodabeh Davaran & Ali Abedelahi
Pages: 269-282
Published online: 03 Feb 2020
AbstractforPreparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery | Full Text | References | PDF (3.4 MB) | EPUB
  • 2917 Views
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Open Access
Article
Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment
Zhongyao Cheng, Siyu Liu, Xinyi Wu, Faisal Raza, Yichen Li, Weien Yuan, Mingfeng Qiu & Jing Su
Pages: 283-291
Published online: 03 Feb 2020
AbstractforAutologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment | Full Text | References | PDF (2 MB) | EPUB
  • 1750 Views
  • 23 CrossRef citations
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Open Access

Article

Article
Nanoparticles for treatment of bovine Staphylococcus aureus mastitis
Samah Attia Algharib, Ali Dawood & Shuyu Xie
Pages: 292-308
Published online: 08 Feb 2020
AbstractforNanoparticles for treatment of bovine Staphylococcus aureus mastitis | Full Text | References | PDF (2.4 MB) | EPUB
  • 10749 Views
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Open Access

Research Article

Article
Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion
Bing Chen, Xuewen Wang, Yanyan Zhang, Kangping Huang, Hao Liu, Dafen Xu, Shaoguang Li, Qicai Liu, Jianyong Huang, Hong Yao & Xinhua Lin
Pages: 309-322
Published online: 10 Feb 2020
AbstractforImproved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion | Full Text | References | PDF (2.7 MB) | EPUB
  • 3473 Views
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Open Access
Article
Nanocomplexes loaded with miR-128-3p for enhancing chemotherapy effect of colorectal cancer through dual-targeting silence the activity of PI3K/AKT and MEK/ERK pathway
Xin Liu, Chao Dong, Siping Ma, Yongpeng Wang, Tao Lin, Yanxi Li, Shihua Yang, Wanchuan Zhang, Rui Zhang & Guohua Zhao
Pages: 323-333
Published online: 24 Feb 2020
AbstractforNanocomplexes loaded with miR-128-3p for enhancing chemotherapy effect of colorectal cancer through dual-targeting silence the activity of PI3K/AKT and MEK/ERK pathway | Full Text | References | PDF (2.6 MB) | EPUB
  • 1875 Views
  • 15 CrossRef citations
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Open Access
Article
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
Yili Ding, Yuchang Pang, Chamakura V. N. S. Vara Prasad & Bingyun Wang
Pages: 334-343
Published online: 24 Feb 2020
AbstractforFormation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin | Full Text | References | PDF (1.9 MB) | EPUB
  • 3059 Views
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Open Access

Retracted Article

Article
RETRACTED ARTICLE: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin
Chunyun Wang, Peilan Qi, Yan Lu, Lei Liu, Yanan Zhang, Qianli Sheng, Tianshun Wang, Mengying Zhang, Rui Wang & Shiyong Song
Pages: 344-357
Published online: 24 Feb 2020
AbstractforRETRACTED ARTICLE: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin | PDF (5.1 MB)
  • 2893 Views
  • 38 CrossRef citations
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Open Access

Research Article

Article
Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
Zhanrong Li, Zhihua Guo, Dandan Chu, Huayang Feng, Junjie Zhang, Lei Zhu & Jingguo Li
Pages: 358-366
Published online: 24 Feb 2020
AbstractforEffectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles | Full Text | References | PDF (2.4 MB) | EPUB
  • 2538 Views
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Open Access
Article
Fabrication of doxorubicin-gated mesoporous polydopamine nanoplatforms for multimode imaging-guided synergistic chemophotothermal therapy of tumors
Min Yang, Ningnan Zhang, Tao Zhang, Xian Yin & Jie Shen
Pages: 367-377
Published online: 24 Feb 2020
AbstractforFabrication of doxorubicin-gated mesoporous polydopamine nanoplatforms for multimode imaging-guided synergistic chemophotothermal therapy of tumors | Full Text | References | PDF (2.8 MB) | EPUB
  • 2466 Views
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Open Access
Article
Supramolecular self-assembly of a hybrid ‘hyalurosome’ for targeted photothermal therapy in non-small cell lung cancer
Haipeng Xu, Lin Dong, Zhang Bin, Huo Yansong, Lin Shaofeng, Liu Chang, Chen Chen & Wang Changli
Pages: 378-386
Published online: 25 Feb 2020
AbstractforSupramolecular self-assembly of a hybrid ‘hyalurosome’ for targeted photothermal therapy in non-small cell lung cancer | Full Text | References | PDF (1.5 MB) | EPUB
  • 1982 Views
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Open Access

Article

Article
Erythrocyte-mimicking paclitaxel nanoparticles for improving biodistributions of hydrophobic drugs to enhance antitumor efficacy
Zheng Zhai, Pengcheng Xu, Jun Yao, Ridong Li, Lidong Gong, Yuxin Yin & Zhiqiang Lin
Pages: 387-399
Published online: 25 Feb 2020
AbstractforErythrocyte-mimicking paclitaxel nanoparticles for improving biodistributions of hydrophobic drugs to enhance antitumor efficacy | Full Text | References | PDF (3 MB) | EPUB
  • 2053 Views
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Research Article

Article
Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion
Lei Wu, Lin Zhao, Xitong Su, Peng Zhang & Guixia Ling
Pages: 400-409
Published online: 15 Nov 2019
AbstractforRepaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion | Full Text | References | PDF (2.1 MB) | EPUB
  • 2951 Views
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Open Access
Article
Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy
Tingting Li, Ye Wang, Jiahao Chen, Xiaoshu Gao, Siqi Pan, Yu Su & Xinrong Zhou
Pages: 410-421
Published online: 05 Mar 2020
AbstractforCo-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 2584 Views
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Article
Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress
Mayson H. Alkhatib, Shaza A. Alyamani & Faiza Abdu
Pages: 422-430
Published online: 05 Mar 2020
AbstractforIncorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress | Full Text | References | PDF (2 MB) | EPUB
  • 2222 Views
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Article
Fibroin nanoparticles: a promising drug delivery system
Duy Toan Pham & Waree Tiyaboonchai
Pages: 431-448
Published online: 11 Mar 2020
AbstractforFibroin nanoparticles: a promising drug delivery system | Full Text | References | PDF (1.6 MB) | EPUB
  • 7445 Views
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Article
Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs
Xuejuan Zhang, Yujun Xiao, Zhengwei Huang, Jintian Chen, Yingtong Cui, Boyi Niu, Ying Huang, Xin Pan & Chuanbin Wu
Pages: 449-459
Published online: 11 Mar 2020
AbstractforSmart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs | Full Text | References | PDF (2.6 MB) | EPUB
  • 2196 Views
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Review Article

Review
Research progress in the application of in situ hydrogel system in tumor treatment
Weipeng Wei, Hongfang Li, Chengchen Yin & Fushan Tang
Pages: 460-468
Published online: 13 Mar 2020
AbstractforResearch progress in the application of in situ hydrogel system in tumor treatment | Full Text | References | PDF (1,011.4 KB) | EPUB
  • 6337 Views
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Research Article

Article
Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo
Xiaoying Zhou, Lu Guo, Dandan Shi, Dong Meng, Xiao Sun, Mengmeng Shang, Xinxin Liu, Yading Zhao & Jie Li
Pages: 469-481
Published online: 13 Mar 2020
AbstractforUltrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo | Full Text | References | PDF (4.5 MB) | EPUB
  • 1702 Views
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Article
Sodium N-lauryl amino acids derived from silk protein can form catanionic aggregates with cytarabine as novel anti-tumor drug delivery systems
Meng Zhang, Shu-Xiang Zhao, Biao Ding & Yu-Qing Zhang
Pages: 482-490
Published online: 26 Mar 2020
AbstractforSodium N-lauryl amino acids derived from silk protein can form catanionic aggregates with cytarabine as novel anti-tumor drug delivery systems | Full Text | References | PDF (2.1 MB) | EPUB
  • 1369 Views
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Article
Developing protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems
Pengcheng Zhang, He Tao, Liyang Yu, Lixiao Zhou & Chenggang Zhu
Pages: 491-501
Published online: 26 Mar 2020
AbstractforDeveloping protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems | Full Text | References | PDF (3.2 MB) | EPUB
  • 1908 Views
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Article
Neuronal mitochondria-targeted therapy for Alzheimer’s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems
Yang Han, Xiaoyang Chu, Lin Cui, Shiyao Fu, Chunsheng Gao, Yi Li & Baoshan Sun
Pages: 502-518
Published online: 31 Mar 2020
AbstractforNeuronal mitochondria-targeted therapy for Alzheimer’s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems | Full Text | References | PDF (5.3 MB) | EPUB
  • 6043 Views
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Article
Lysine-mediated hydroxyethyl starch-10-hydroxy camptothecin micelles for the treatment of liver cancer
Guofei Li, Mingming Zhao & Limei Zhao
Pages: 519-529
Published online: 31 Mar 2020
AbstractforLysine-mediated hydroxyethyl starch-10-hydroxy camptothecin micelles for the treatment of liver cancer | Full Text | References | PDF (2.2 MB) | EPUB
  • 1763 Views
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Article
Sterically stabilized recombined HDL composed of modified apolipoprotein A-I for efficient targeting toward glioma cells
Jin Li, Mengmeng Han, Jianfei Li, Zhiming Ge, Qianqian Wang, Kai Zhou & Xiaoxing Yin
Pages: 530-541
Published online: 03 Apr 2020
AbstractforSterically stabilized recombined HDL composed of modified apolipoprotein A-I for efficient targeting toward glioma cells | Full Text | References | PDF (2.4 MB) | EPUB
  • 1499 Views
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Article
Heparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors
Ping-Hsueh Kuo, Yi-Hsien Teng, Ann-Lun Cin, Wen Han, Pei-Wan Huang, Lily Hui-Ching Wang, Yu-Ting Chou, Jia-Ling Yang, Yun-Long Tseng, Minhsiung Kao & Margaret Dah-Tsyr Chang
Pages: 542-555
Published online: 03 Apr 2020
AbstractforHeparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors | Full Text | References | PDF (3.1 MB) | EPUB
  • 2569 Views
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Article
Localized co-delivery of CNTF and FK506 using a thermosensitive hydrogel for retina ganglion cells protection after traumatic optic nerve injury
Dongmei Wang, Mengmeng Luo, Baoshan Huang, Wa Gao, Yan Jiang, Qing Li, Kaihui Nan & Sen Lin
Pages: 556-564
Published online: 30 Apr 2020
AbstractforLocalized co-delivery of CNTF and FK506 using a thermosensitive hydrogel for retina ganglion cells protection after traumatic optic nerve injury | Full Text | References | PDF (2.6 MB) | EPUB
  • 2380 Views
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Article
Preparation and antitumor evaluation of hinokiflavone hybrid micelles with mitochondria targeted for lung adenocarcinoma treatment
Yuting Chen, Xue Feng, Luya Li, Kewei Song & Lantong Zhang
Pages: 565-574
Published online: 06 Apr 2020
AbstractforPreparation and antitumor evaluation of hinokiflavone hybrid micelles with mitochondria targeted for lung adenocarcinoma treatment | Full Text | References | PDF (2.8 MB) | EPUB
  • 1784 Views
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Article
l-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel
Tan Yang, Jianfang Feng, Qian Zhang, Wei Wu, Hailan Mo, Lanzhen Huang & Wei Zhang
Pages: 575-584
Published online: 20 Apr 2020
Abstractforl-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel | Full Text | References | PDF (1.6 MB) | EPUB
  • 2534 Views
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Article
Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source
Wanrong Meng, Chuanshi He, Yaying Hao, Linlin Wang, Ling Li & Guiquan Zhu
Pages: 585-598
Published online: 08 Apr 2020
AbstractforProspects and challenges of extracellular vesicle-based drug delivery system: considering cell source | Full Text | References | PDF (1.5 MB) | EPUB
  • 17992 Views
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Article
In vitro and in vivo evaluation of liposomes modified with polypeptides and red cell membrane as a novel drug delivery system for myocardium targeting
Xueyan Liu, Liangke Zhang, Wengao Jiang, Zhangyou Yang, Zongjie Gan, Chao Yu, Ran Tao & Huali Chen
Pages: 599-606
Published online: 20 Apr 2020
AbstractforIn vitro and in vivo evaluation of liposomes modified with polypeptides and red cell membrane as a novel drug delivery system for myocardium targeting | Full Text | References | PDF (1.4 MB) | EPUB
  • 3167 Views
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Article
Novel nano-pomegranates based on astragalus polysaccharides for targeting ERα-positive breast cancer and multidrug resistance
Bingjie Wang, Chunjing Guo, Yanhui Liu, Guangting Han, Yi Li, Yanchun Zhang, Haiyu Xu & Daquan Chen
Pages: 607-621
Published online: 20 Apr 2020
AbstractforNovel nano-pomegranates based on astragalus polysaccharides for targeting ERα-positive breast cancer and multidrug resistance | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Gefitinib loaded nanostructured lipid carriers: characterization, evaluation and anti-human colon cancer activity in vitro
Hafiz A. Makeen, Syam Mohan, Mohamed Ahmed Al-Kasim, Ibraheem M. Attafi, Rayan A. Ahmed, Nabeel Kashan Syed, Muhammad Hadi Sultan, Mohammed Al-Bratty, Hassan A. Alhazmi, Mohammed M. Safhi, Raisuddin Ali & M. Intakhab Alam
Pages: 622-631
Published online: 24 Apr 2020
AbstractforGefitinib loaded nanostructured lipid carriers: characterization, evaluation and anti-human colon cancer activity in vitro | Full Text | References | PDF (2.9 MB) | EPUB
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Article
PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections
Minghao Sun, Chune Zhu, Jieyu Long, Chao Lu, Xin Pan & Chuanbin Wu
Pages: 632-641
Published online: 24 Apr 2020
AbstractforPLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism
Zixuan Shu, Yingji Cao, Yaotian Tao, Xiao Liang, Fangyuan Wang, Zhi Li, Zhenbao Li & Shuangying Gui
Pages: 642-651
Published online: 24 Apr 2020
AbstractforPolyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism | Full Text | References | PDF (2 MB) | EPUB
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Original Paper

Article
Incorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment
Shuo Liu, Xinyue Han, Hanyu Liu, Yawen Zhao, Huamei Li, Ilva D. Rupenthal, Zhufen Lv, Yanzhong Chen, Fan Yang, Qineng Ping, Yufang Pan & Dongzhi Hou
Pages: 652-661
Published online: 29 Apr 2020
AbstractforIncorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment | Full Text | References | PDF (1.5 MB) | EPUB
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Research Article

Article
Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis
Salma A. Fereig, Ghada M. El-Zaafarany, Mona G. Arafa & Mona M. A. Abdel-Mottaleb
Pages: 662-680
Published online: 12 May 2020
AbstractforTackling the various classes of nano-therapeutics employed in topical therapy of psoriasis | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell
Qi Y. Wang, Yi S. Xu, Nan X. Zhang, Zhi P. Dong, Bo N. Zhao, Lin C. Liu, Tao Lu & Yue Wang
Pages: 681-690
Published online: 12 May 2020
AbstractforPhenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Enhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis
Zhandong Zhang, Wei Yang, Fei Ma, Qi Ma, Bin Zhang, Yonglei Zhang, Yingqiang Liu, Hongxing Liu & Yawei Hua
Pages: 691-702
Published online: 13 May 2020
AbstractforEnhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis | Full Text | References | PDF (3.2 MB) | EPUB
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Article

Article
Intravitreal safety profiles of sol-gel mesoporous silica microparticles and the degradation product (Si(OH)4)
Yaoyao Sun, Kristyn Huffman, William R. Freeman, Michael J. Sailor & Lingyun Cheng
Pages: 703-711
Published online: 12 May 2020
AbstractforIntravitreal safety profiles of sol-gel mesoporous silica microparticles and the degradation product (Si(OH)4) | Full Text | References | PDF (2.2 MB) | EPUB
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Research Article

Article
A composite nanocarrier to inhibit precipitation of the weakly basic drug in the gastrointestinal tract
Chunli Zheng, Yun Li, Zhen Peng, Xinyi He, Juan Tao, Liang Ge, Yixin Sun & Yunkai Wu
Pages: 712-722
Published online: 13 May 2020
AbstractforA composite nanocarrier to inhibit precipitation of the weakly basic drug in the gastrointestinal tract | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Chiral 4-O-acylterpineol as transdermal permeation enhancers: insights of the enhancement mechanisms of a transdermal enantioselective delivery system for flurbiprofen
Tianzhe Chu, Chunyan Wang, Jing Wang, Heping Wang, Dandan Geng, Chensi Wu, Linlin Zhao & Ligang Zhao
Pages: 723-735
Published online: 13 May 2020
AbstractforChiral 4-O-acylterpineol as transdermal permeation enhancers: insights of the enhancement mechanisms of a transdermal enantioselective delivery system for flurbiprofen | Full Text | References | PDF (2.6 MB) | EPUB
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Article

Article
DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment
Zerong Li, Wenmei Qiao, Chenghao Wang, Heqiao Wang, Mengchao Ma, Xinyu Han & Jingling Tang
Pages: 736-744
Published online: 13 May 2020
AbstractforDPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment | Full Text | References | PDF (1.6 MB) | EPUB
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Research Article

Article
Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles
Yao Qi, Lin Guo, Yibing Jiang, Yijie Shi, Haijuan Sui & Liang Zhao
Pages: 745-755
Published online: 13 May 2020
AbstractforBrain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles | Full Text | References | PDF (3.3 MB) | EPUB
  • 6009 Views
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Article
Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential
Ravinder Verma & Deepak Kaushik
Pages: 756-771
Published online: 13 May 2020
AbstractforDesign and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential | Full Text | References | PDF (2.2 MB) | EPUB
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Article
RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
Rubin Hao, Bixi Sun, Lihua Yang, Chun Ma & Shuling Li
Pages: 772-781
Published online: 13 May 2020
AbstractforRVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium
Rachasit Jeencham, Manote Sutheerawattananonda, Saowaluk Rungchang & Waree Tiyaboonchai
Pages: 782-790
Published online: 13 May 2020
AbstractforNovel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium | Full Text | References | PDF (1.5 MB) | EPUB
  • 2383 Views
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Article
Combined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system
Xin Li, Kandasamy Vinothini, Thiyagarajan Ramesh, Mariappan Rajan & Andy Ramu
Pages: 791-804
Published online: 18 May 2020
AbstractforCombined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system | Full Text | References | PDF (5 MB) | EPUB
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Original Article

Article
Calcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cells
V. S. S. Abhinav Ayyadevara & Kyung-Ho Roh
Pages: 805-815
Published online: 03 Jun 2020
AbstractforCalcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cells | Full Text | References | PDF (1.8 MB) | EPUB
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Research Article

Article
Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer
Hui Ao, Yijing Li, Haowen Li, Yian Wang, Meihua Han, Yifei Guo, Rongxing Shi, Feng Yue & Xiangtao Wang
Pages: 816-824
Published online: 03 Jun 2020
AbstractforPreparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance
Xiaoqing Zhang, Xiaomei Ren, Jiayin Tang, Jiangtao Wang, Xiang Zhang, Peng He, Chang Yao, Weihe Bian & Lizhu Sun
Pages: 825-835
Published online: 03 Jun 2020
AbstractforHyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance | Full Text | References | PDF (2.8 MB) | EPUB
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Article
F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia
Chunyang Du, Shuangshuang Li, Yuan Li, Hervé Galons, Na Guo, Yuou Teng, Yongmin Zhang, Mingyuan Li & Peng Yu
Pages: 836-847
Published online: 08 Jun 2020
AbstractforF7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia | Full Text | References | PDF (2.7 MB) | EPUB
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Article

Article
In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration
Huahui Zeng, Xin Zhu, Qikang Tian, Yinyin Yan, Lan Zhang, Min Yan, Ruiqin Li, Xiaofang Li, Guoqiang Wang, Jinlian Ma, Yufang Su, Xiangbo Zhang, Linyu Ma, Zhenqiang Zhang & Xiangxiang Wu
Pages: 848-854
Published online: 08 Jun 2020
AbstractforIn vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration | Full Text | References | PDF (2 MB) | EPUB
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Original Article

Article
NIR triggered PLGA coated Au-TiO2 core loaded CPT-11 nanoparticles for human papillary thyroid carcinoma therapy
Tianyu Yu, Lingling Tong, Yu Ao, Genmao Zhang, Yunpeng Liu & Hejia Zhang
Pages: 855-863
Published online: 09 Jun 2020
AbstractforNIR triggered PLGA coated Au-TiO2 core loaded CPT-11 nanoparticles for human papillary thyroid carcinoma therapy | Full Text | References | PDF (2.3 MB) | EPUB
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Research Article

Article
Multifunctional magnetite nanoparticles to enable delivery of siRNA for the potential treatment of Alzheimer’s
Natalia Lopez-Barbosa, Juan G. Garcia, Javier Cifuentes, Lina M. Castro, Felipe Vargas, Carlos Ostos, Gloria P. Cardona-Gomez, Alher Mauricio Hernandez & Juan C. Cruz
Pages: 864-875
Published online: 09 Jun 2020
AbstractforMultifunctional magnetite nanoparticles to enable delivery of siRNA for the potential treatment of Alzheimer’s | Full Text | References | PDF (2.7 MB) | EPUB
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Original Article

Article
Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy
Yun Lu, Qian Wen, Jia Luo, Kang Xiong, ZhouXue Wu, BiQiong Wang, Yue Chen, Bo Yang & ShaoZhi Fu
Pages: 876-887
Published online: 09 Jun 2020
AbstractforSelf-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy | Full Text | References | PDF (4.3 MB) | EPUB
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Research Article

Article
Formulation and investigation of pilocarpine hydrochloride niosomal gels for the treatment of glaucoma: intraocular pressure measurement in white albino rabbits
Neelam Jain, Anurag Verma & Neeraj Jain
Pages: 888-899
Published online: 18 Jun 2020
AbstractforFormulation and investigation of pilocarpine hydrochloride niosomal gels for the treatment of glaucoma: intraocular pressure measurement in white albino rabbits | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Factors affecting the buccal delivery of deformable nanovesicles based on insulin–phospholipid complex: an in vivo investigation
Yuqi Yang, Yiyue Guo, You Xu, Yingying Meng, Xing Zhang, Xuejun Xia & YuLing Liu
Pages: 900-908
Published online: 29 Jun 2020
AbstractforFactors affecting the buccal delivery of deformable nanovesicles based on insulin–phospholipid complex: an in vivo investigation | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Functionalized MoS2-nanoparticles for transdermal drug delivery of atenolol
Kai Zhang, Yanling Zhuang, Weidan Zhang, Yali Guo & Xiaochang Liu
Pages: 909-916
Published online: 29 Jun 2020
AbstractforFunctionalized MoS2-nanoparticles for transdermal drug delivery of atenolol | Full Text | References | PDF (1.6 MB) | EPUB
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Critical Review

Review
Engineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids
Amal A. Aziz, Rafat A. Siddiqui & Zareen Amtul
Pages: 917-926
Published online: 29 Jun 2020
AbstractforEngineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids | Full Text | References | PDF (1.3 MB) | EPUB
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Research Article

Article
Enhanced anti-hepatoma effect of a novel curcumin analog C086 via solid dispersion technology
Yanping Deng, Chun Chen, Zhifeng Xiao, Xiuwang Huang & Jianhua Xu
Pages: 927-937
Published online: 29 Jun 2020
AbstractforEnhanced anti-hepatoma effect of a novel curcumin analog C086 via solid dispersion technology | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Combined treatment with ultrasound-targeted microbubble destruction technique and NM-aFGF-loaded PEG-nanoliposomes protects against diabetic cardiomyopathy-induced oxidative stress by activating the AKT/GSK-3β1/Nrf-2 pathway
Ming Zhang, Ning-Wei Zhu, Wei-Cheng Ma, Meng-Jia Chen & Lei Zheng
Pages: 938-952
Published online: 02 Jul 2020
AbstractforCombined treatment with ultrasound-targeted microbubble destruction technique and NM-aFGF-loaded PEG-nanoliposomes protects against diabetic cardiomyopathy-induced oxidative stress by activating the AKT/GSK-3β1/Nrf-2 pathway | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Biological investigations on therapeutic effect of chitosan encapsulated nano resveratrol against gestational diabetes mellitus rats induced by streptozotocin
Shengye Du, Yan Lv, Na Li, Xianxia Huang, Xuemei Liu, Hui Li, Chao Wang & Yi-Fang Jia
Pages: 953-963
Published online: 02 Jul 2020
AbstractforBiological investigations on therapeutic effect of chitosan encapsulated nano resveratrol against gestational diabetes mellitus rats induced by streptozotocin | Full Text | References | PDF (4 MB) | EPUB
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Article
Acylation of the antimicrobial peptide CAMEL for cancer gene therapy
Jingjing Song, Panpan Ma, Sujie Huang, Juanli Wang, Huan Xie, Bo Jia & Wei Zhang
Pages: 964-973
Published online: 02 Jul 2020
AbstractforAcylation of the antimicrobial peptide CAMEL for cancer gene therapy | Full Text | References | PDF (1.9 MB) | EPUB
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RESEARCH Article

Article
Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants
Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao & Zhengbao Zha
Pages: 974-982
Published online: 02 Jul 2020
AbstractforBiodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants | Full Text | References | PDF (1.7 MB) | EPUB
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Research Article

Article
Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
Man Xu, Guangmeng Li, Haoxiang Zhang, Xiaoming Chen, Yi Li, Qianming Yao & Maobin Xie
Pages: 983-995
Published online: 02 Jul 2020
AbstractforSequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency
Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey & Ibrahim Elsayed
Pages: 996-1009
Published online: 02 Jul 2020
AbstractforMolecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188
Guoyuan Li, Yuting Lu, Yongchun Fan, Qing Ning & Weiguang Li
Pages: 1010-1017
Published online: 07 Jul 2020
AbstractforEnhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188 | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Synergistic ultrasonic biophysical effect-responsive nanoparticles for enhanced gene delivery to ovarian cancer stem cells
Chun Liufu, Yue Li, Yan Lin, Jinsui Yu, Meng Du, Yuhao Chen, Yaozhang Yang, Xiaojing Gong & Zhiyi Chen
Pages: 1018-1033
Published online: 05 Jul 2020
AbstractforSynergistic ultrasonic biophysical effect-responsive nanoparticles for enhanced gene delivery to ovarian cancer stem cells | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis
Peinan Li, Haokun Li, Xiaohong Shu, Moli Wu, Jia Liu, Tangna Hao, Hongxia Cui & Lianjie Zheng
Pages: 1034-1043
Published online: 05 Jul 2020
AbstractforIntra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Co-delivery of doxorubicin and paclitaxel by reduction/pH dual responsive nanocarriers for osteosarcoma therapy
Yongshuang Li, Hao Hou, Peng Zhang & Zhiyu Zhang
Pages: 1044-1053
Published online: 07 Jul 2020
AbstractforCo-delivery of doxorubicin and paclitaxel by reduction/pH dual responsive nanocarriers for osteosarcoma therapy | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Strategies to enhance oral delivery of amphotericin B: a comparison of uncoated and enteric-coated nanostructured lipid carriers
Pataranapa Nimtrakul, Pakawadee Sermsappasuk & Waree Tiyaboonchai
Pages: 1054-1062
Published online: 07 Jul 2020
AbstractforStrategies to enhance oral delivery of amphotericin B: a comparison of uncoated and enteric-coated nanostructured lipid carriers | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Precise engineering of Gemcitabine prodrug cocktails into single polymeric nanoparticles delivery for metastatic thyroid cancer cells
Chenggong Liu, Qiongmei Han, Hua Liu, Cuirong Zhu, Wei Gui, Xiaodong Yang & Wansen Li
Pages: 1063-1072
Published online: 16 Jul 2020
AbstractforPrecise engineering of Gemcitabine prodrug cocktails into single polymeric nanoparticles delivery for metastatic thyroid cancer cells | Full Text | References | PDF (2.2 MB) | EPUB
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Article
A pH/ROS cascade-responsive and self-accelerating drug release nanosystem for the targeted treatment of multi-drug-resistant colon cancer
Na Chang, Yufei Zhao, Ning Ge & Liting Qian
Pages: 1073-1086
Published online: 24 Jul 2020
AbstractforA pH/ROS cascade-responsive and self-accelerating drug release nanosystem for the targeted treatment of multi-drug-resistant colon cancer | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Combined effect of sonophoresis and a microemulsion on the dermal delivery of celecoxib
Thirapit Subongkot
Pages: 1087-1093
Published online: 24 Jul 2020
AbstractforCombined effect of sonophoresis and a microemulsion on the dermal delivery of celecoxib | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Adjudin-loaded redox-sensitive paclitaxel-prodrug micelles for overcoming multidrug resistance with efficient targeted Colon cancer therapy
Deli Chen, Sitang Ge, Lugen Zuo, Shuanhu Wang, Mulin Liu & Shiqing Li
Pages: 1094-1105
Published online: 24 Jul 2020
AbstractforAdjudin-loaded redox-sensitive paclitaxel-prodrug micelles for overcoming multidrug resistance with efficient targeted Colon cancer therapy | Full Text | References | PDF (2.8 MB) | EPUB
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Article
IGF-1-releasing PLGA nanoparticles modified 3D printed PCL scaffolds for cartilage tissue engineering
Peiran Wei, Yan Xu, Yue Gu, Qingqiang Yao, Jiayin Li & Liming Wang
Pages: 1106-1114
Published online: 25 Jul 2020
AbstractforIGF-1-releasing PLGA nanoparticles modified 3D printed PCL scaffolds for cartilage tissue engineering | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Polymeric micelles for the ocular delivery of triamcinolone acetonide: preparation and in vivo evaluation in a rabbit ocular inflammatory model
Mohamed A. Safwat, Heba F. Mansour, Amal K. Hussein, Soha Abdelwahab & Ghareb M. Soliman
Pages: 1115-1124
Published online: 28 Jul 2020
AbstractforPolymeric micelles for the ocular delivery of triamcinolone acetonide: preparation and in vivo evaluation in a rabbit ocular inflammatory model | Full Text | References | PDF (1.6 MB) | EPUB
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Article
A theoretical mathematical model for assessing diclofenac release from chitosan-based formulations
Manuela Maria Iftime, Daniel Lucian Dobreci, Stefan Andrei Irimiciuc, Maricel Agop, Tudor Petrescu & Bogdan Doroftei
Pages: 1125-1133
Published online: 28 Jul 2020
AbstractforA theoretical mathematical model for assessing diclofenac release from chitosan-based formulations | Full Text | References | PDF (1.6 MB) | EPUB
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Original Article

Article
Development, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles
Heba S. Elsewedy, Bandar E. Al Dhubiab, Mahmoud A. Mahdy & Hanan M. Elnahas
Pages: 1134-1146
Published online: 30 Jul 2020
AbstractforDevelopment, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles | Full Text | References | PDF (2.5 MB) | EPUB
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Research Article

Article
Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease
Qinying Yan, Weiwei Wang, Jiaqi Weng, Zhenghan Zhang, Lina Yin, Qingliang Yang, Fangyuan Guo, Xingang Wang, Fan Chen & Gensheng Yang
Pages: 1147-1155
Published online: 30 Jul 2020
AbstractforDissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release
Zhihang Yang, Na Zhang, Teng Ma, Libo Liu, Lini Zhao & Hui Xie
Pages: 1156-1164
Published online: 05 Aug 2020
AbstractforEngineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release | Full Text | References | PDF (1.5 MB) | EPUB
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Research Article

Article
Sustained delivery of 17β-estradiol by human amniotic extracellular matrix (HAECM) scaffold integrated with PLGA microspheres for endometrium regeneration
Yue Chen, Weidong Fei, Yunchun Zhao, Fengmei Wang, Xiaoling Zheng, Xiaofei Luan & Caihong Zheng
Pages: 1165-1175
Published online: 05 Aug 2020
AbstractforSustained delivery of 17β-estradiol by human amniotic extracellular matrix (HAECM) scaffold integrated with PLGA microspheres for endometrium regeneration | Full Text | References | PDF (2.1 MB) | EPUB
  • 2297 Views
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Article
A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
Haowen Li, Yijing Li, Hui Ao, Jingxin Fu, Yifei Guo, Meihua Han, Xueying Yan, Xi Chen & Xiangtao Wang
Pages: 1176-1187
Published online: 07 Aug 2020
AbstractforA comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Thiopental sodium loaded solid lipid nano-particles attenuates obesity-induced cardiac dysfunction and cardiac hypertrophy via inactivation of inflammatory pathway
Canzhan Zhu, Wanjing Li, Xinhong Wang, Jiahong Xue, Ling Zhao, Yafan Song, Tian Zhou & Mingjuan Zhang
Pages: 1188-1200
Published online: 07 Aug 2020
AbstractforThiopental sodium loaded solid lipid nano-particles attenuates obesity-induced cardiac dysfunction and cardiac hypertrophy via inactivation of inflammatory pathway | Full Text | References | PDF (3 MB) | EPUB
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Article
Synthesis and toxicity assessment of Fe3O4 NPs grafted by ∼ NH2-Schiff base as anticancer drug: modeling and proposed molecular mechanism through docking and molecular dynamic simulation
Rahime Eshaghi Malekshah, Bahareh Fahimirad, Mohammadreza Aallaei & Ali Khaleghian
Pages: 1201-1217
Published online: 10 Aug 2020
AbstractforSynthesis and toxicity assessment of Fe3O4 NPs grafted by ∼ NH2-Schiff base as anticancer drug: modeling and proposed molecular mechanism through docking and molecular dynamic simulation | Full Text | References | PDF (5.2 MB) | EPUB
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Article
Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats
Saud Bawazeer, Dalia Farag A. El-Telbany, Majid Mohammad Al-Sawahli, Gamal Zayed, Ahmed Abdallah A. Keed, Abdelaziz E. Abdelaziz & Doaa H. Abdel-Naby
Pages: 1218-1230
Published online: 10 Aug 2020
AbstractforEffect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats | Full Text | References | PDF (2.8 MB) | EPUB
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Functional differences between protamine preparations for the transfection of mRNA
Natalia Teresa Jarzebska, Severin Lauchli, Christoph Iselin, Lars E French, Pal Johansen, Emmanuella Guenova, Thomas M Kündig & Steve Pascolo
Pages: 1231-1235
Published online: 17 Aug 2020
AbstractforFunctional differences between protamine preparations for the transfection of mRNA | Full Text | References | PDF (879 KB) | EPUB
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Article
Enhanced antitumor activity of bovine lactoferrin through immobilization onto functionalized nano graphene oxide: an in vitro/in vivo study
Azam Najmafshar, Mahboubeh Rostami, Jaleh Varshosaz, Dariush Norouzian & Seyed Ziyae Aldin Samsam Shariat
Pages: 1236-1247
Published online: 19 Aug 2020
AbstractforEnhanced antitumor activity of bovine lactoferrin through immobilization onto functionalized nano graphene oxide: an in vitro/in vivo study | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective
Huanrong Lan, Wei Zhang, Ketao Jin, Yuyao Liu & Zhen Wang
Pages: 1248-1262
Published online: 31 Aug 2020
AbstractforModulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective | Full Text | References | PDF (2.4 MB) | EPUB
  • 3362 Views
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Article
Novel greener approached synthesis of polyacrylic nanoparticles for therapy and care of gestational diabetes
Xianghong Cheng, Yahui Xu, Qian Jia, Ning Guo, Zhenzhen Wang & Yu Wang
Pages: 1263-1270
Published online: 03 Sep 2020
AbstractforNovel greener approached synthesis of polyacrylic nanoparticles for therapy and care of gestational diabetes | Full Text | References | PDF (1.7 MB) | EPUB
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Article
A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic Serratia marcescens
Ping Shi, Rajendran Amarnath Praphakar, Sadhasivan Deepa, Kannan Suganya, Prashant Gupta, Riaz Ullah, Ahmed Bari, Marudhamuthu Murugan & Mariappan Rajan
Pages: 1271-1282
Published online: 04 Sep 2020
AbstractforA promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic Serratia marcescens | Full Text | References | PDF (4.3 MB) | EPUB
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Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases
Junqiu Zhai, Yu-e Wang, Xiangping Zhou, Yan Ma & Shixia Guan
Pages: 1283-1291
Published online: 04 Sep 2020
AbstractforLong-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases | Full Text | References | PDF (1.8 MB) | EPUB
  • 1812 Views
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Article
Supersaturable organic-inorganic hybrid matrix based on well-ordered mesoporous silica to improve the bioavailability of water insoluble drugs
Qiaoli Wu, Disang Feng, Zhengwei Huang, Minglong Chen, Dan Yang, Xin Pan, Chao Lu, Guilan Quan & Chuanbin Wu
Pages: 1292-1300
Published online: 04 Sep 2020
AbstractforSupersaturable organic-inorganic hybrid matrix based on well-ordered mesoporous silica to improve the bioavailability of water insoluble drugs | Full Text | References | PDF (1.9 MB) | EPUB
  • 1222 Views
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Article
Apatinib-loaded CalliSpheres Beads for embolization in a rabbit VX2 liver tumor: characterization in vitro, pharmacokinetics and tumor response in vivo
Qin Shi, Yongning Lu, Songjiang Huang, Chen Zhou, Chongtu Yang, Jiacheng Liu, Jinqiang Ma & Bin Xiong
Pages: 1301-1307
Published online: 14 Sep 2020
AbstractforApatinib-loaded CalliSpheres Beads for embolization in a rabbit VX2 liver tumor: characterization in vitro, pharmacokinetics and tumor response in vivo | Full Text | References | PDF (1.4 MB) | EPUB
  • 1848 Views
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Article
Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles
Orlando J. Ramírez, Simón Alvarez, Pamina Contreras-Kallens, Nelson P. Barrera, Sebastian Aguayo & Christina M. A. P. Schuh
Pages: 1308-1318
Published online: 14 Sep 2020
AbstractforType I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles | Full Text | References | PDF (2.9 MB) | EPUB
  • 3161 Views
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Article
Co-drug delivery of regorafenib and cisplatin with amphiphilic copolymer nanoparticles: enhanced in vivo antitumor cancer therapy in nursing care
Zhe Zhou
Pages: 1319-1328
Published online: 16 Sep 2020
AbstractforCo-drug delivery of regorafenib and cisplatin with amphiphilic copolymer nanoparticles: enhanced in vivo antitumor cancer therapy in nursing care | Full Text | References | PDF (3 MB) | EPUB
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Article
β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway
Feng Zhang, Zhiyu Liu, Xijing He, Zhanqi Li, Bin Shi & Fengmei Cai
Pages: 1329-1341
Published online: 18 Sep 2020
Abstractforβ-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway | Full Text | References | PDF (2 MB) | EPUB
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Article
A polyoxyethylene sorbitan oleate modified hollow gold nanoparticle system to escape macrophage phagocytosis designed for triple combination lung cancer therapy via LDL-R mediated endocytosis
Yan Shen, Yun Xia, Ershuang Yang, Zixuan Ye, Yuan Ding, Jiasheng Tu, Yong Zhang & Pengcheng Xu
Pages: 1342-1359
Published online: 23 Sep 2020
AbstractforA polyoxyethylene sorbitan oleate modified hollow gold nanoparticle system to escape macrophage phagocytosis designed for triple combination lung cancer therapy via LDL-R mediated endocytosis | Full Text | References | PDF (4 MB) | EPUB
  • 1460 Views
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Article
Protamine and BSA–dextran complex emulsion improves oral bioavailability and anti-tumor efficacy of paclitaxel
Guangrui Xu, Xiaoyan Bao & Ping Yao
Pages: 1360-1368
Published online: 28 Sep 2020
AbstractforProtamine and BSA–dextran complex emulsion improves oral bioavailability and anti-tumor efficacy of paclitaxel | Full Text | References | PDF (1.7 MB) | EPUB
  • 2249 Views
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Article
Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation
Xiaojing Xia, Jin Tao, Zhuwa Ji, Chencheng Long, Ying Hu & Zhiying Zhao
Pages: 1369-1377
Published online: 30 Sep 2020
AbstractforIncreased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Optimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth
Yanhai Xi, Wenming Pan, Dan Xi, Xue Liu, Jiangmin Yu, Mintao Xue, Ning Xu, Jiankun Wen, Weiheng Wang, Hailong He, Yanyan Liu, Yue He, Chunjing Guo, Daquan Chen & Xiaojian Ye
Pages: 1378-1385
Published online: 30 Sep 2020
AbstractforOptimization, characterization and evaluation of ZnO/polyvinylidene fluoride nanocomposites for orthopedic applications: improved antibacterial ability and promoted osteoblast growth | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Intravitreous delivery of melatonin affects the retinal neuron survival and visual signal transmission: in vivo and ex vivo study
Ye Tao, Bang Hu, Zhao Ma, Haijun Li, Enming Du, Gang Wang, Biao Xing, Jie Ma & Zongming Song
Pages: 1386-1396
Published online: 05 Oct 2020
AbstractforIntravitreous delivery of melatonin affects the retinal neuron survival and visual signal transmission: in vivo and ex vivo study | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy
Chuanmin Zhang, Yinan Zhao, Enxia Zhang, Meilin Jiang, Defu Zhi, Huiying Chen, Shaohui Cui, Yuhong Zhen, Jingnan Cui & Shubiao Zhang
Pages: 1397-1411
Published online: 23 Oct 2020
AbstractforCo-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy | Full Text | References | PDF (4.9 MB) | EPUB
  • 2541 Views
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Article
Hypoxic targeting and activating TH-302 loaded transcatheter arterial embolization microsphere
Pengkai Ma, Jianhua Chen, Haixian Qu, Ye Li, Xiaohui Li, Xuemei Tang, Zhigang Song, Hainan Xin, Jinbang Zhang, Jingxue Nai, Zhiping Li & Zhijun Wang
Pages: 1412-1424
Published online: 23 Oct 2020
AbstractforHypoxic targeting and activating TH-302 loaded transcatheter arterial embolization microsphere | Full Text | References | PDF (4.4 MB) | EPUB
  • 2075 Views
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Article
Cell-mediated targeting drugs delivery systems
Hongli Yu, Zhihong Yang, Fei Li, Lisa Xu & Yong Sun
Pages: 1425-1437
Published online: 23 Oct 2020
AbstractforCell-mediated targeting drugs delivery systems | Full Text | References | PDF (2.2 MB) | EPUB
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Review Article

Review
Engineered biomaterial strategies for controlling growth factors in tissue engineering
Na Guan, Zhihai Liu, Yonghui Zhao, Qiu Li & Yitao Wang
Pages: 1438-1451
Published online: 26 Oct 2020
AbstractforEngineered biomaterial strategies for controlling growth factors in tissue engineering | Full Text | References | PDF (2.7 MB) | EPUB
  • 2869 Views
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Research Article

Article
Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles, which performed better for local anesthetic therapy?
Min Li, Shuo Feng, Huaixin Xing & Yingui Sun
Pages: 1452-1460
Published online: 26 Oct 2020
AbstractforDexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles, which performed better for local anesthetic therapy? | Full Text | References | PDF (1.6 MB) | EPUB
  • 1235 Views
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Article
A sustained dual drug delivery system for proliferative vitreoretinopathy
Ying Xiao, Kyung Seek Choi, David Warther, Kristyn Huffman, Stephanie Landeros, William R. Freeman, Michael J. Sailor & Lingyun Cheng
Pages: 1461-1473
Published online: 26 Oct 2020
AbstractforA sustained dual drug delivery system for proliferative vitreoretinopathy | Full Text | References | PDF (2.6 MB) | EPUB
  • 1299 Views
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Article
Recent advances in drug delivery systems for enhancing drug penetration into tumors
Bin He, Xin Sui, Bing Yu, Song Wang, Youqing Shen & Hailin Cong
Pages: 1474-1490
Published online: 26 Oct 2020
AbstractforRecent advances in drug delivery systems for enhancing drug penetration into tumors | Full Text | References | PDF (4.5 MB) | EPUB
  • 6587 Views
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Article
Combinational dual drug delivery system to enhance the care and treatment of gastric cancer patients
Ying Xiao, Yuewen Gao, Fajuan Li & Zhihe Deng
Pages: 1491-1500
Published online: 26 Oct 2020
AbstractforCombinational dual drug delivery system to enhance the care and treatment of gastric cancer patients | Full Text | References | PDF (3.1 MB) | EPUB
  • 2101 Views
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Article
Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative–lipid complex
Saurav Kumar Jha, Hee-Soo Han, Laxman Subedi, Rudra Pangeni, Jee Young Chung, Seho Kweon, Jeong Uk Choi, Youngro Byun, Yong-Hee Kim & Jin Woo Park
Pages: 1501-1513
Published online: 27 Oct 2020
AbstractforEnhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative–lipid complex | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies
Rofida Albash, Yasmina Elmahboub, Kholoud Baraka, Menna M. Abdellatif & Ahmed Adel Alaa-Eldin
Pages: 1514-1523
Published online: 28 Oct 2020
AbstractforUltra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies | Full Text | References | PDF (2.4 MB) | EPUB
  • 2595 Views
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Article
Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer
Qin Gao, Shan Tang, Han Chen, Hui Chen, XiaoJie Li, YiQing Jiang, ShaoZhi Fu & Sheng Lin
Pages: 1524-1534
Published online: 29 Oct 2020
AbstractforIntratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer | Full Text | References | PDF (4 MB) | EPUB
  • 1857 Views
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Article
Chemo-immune synergetic therapy of esophageal carcinoma: trastuzumab modified, cisplatin and fluorouracil co-delivered lipid–polymer hybrid nanoparticles
Qingxia Fu, Jiancheng Wang & Hong Liu
Pages: 1535-1543
Published online: 29 Oct 2020
AbstractforChemo-immune synergetic therapy of esophageal carcinoma: trastuzumab modified, cisplatin and fluorouracil co-delivered lipid–polymer hybrid nanoparticles | Full Text | References | PDF (1.5 MB) | EPUB
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Radioactive polymeric nanoparticles for biomedical application
Shentian Wu, Edward Helal-Neto, Ana Paula dos Santos Matos, Amir Jafari, Ján Kozempel, Yuri José de Albuquerque Silva, Carolina Serrano-Larrea, Severino Alves Junior, Eduardo Ricci-Junior, Frank Alexis & Ralph Santos-Oliveira
Pages: 1544-1561
Published online: 29 Oct 2020
AbstractforRadioactive polymeric nanoparticles for biomedical application | Full Text | References | PDF (2.1 MB) | EPUB
  • 4654 Views
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Drug discovery and formulation development for acute pancreatitis
Xue Jiang, Ya-Wen Zheng, Shihui Bao, Hailin Zhang, Ruijie Chen, Qing Yao & Longfa Kou
Pages: 1562-1580
Published online: 29 Oct 2020
AbstractforDrug discovery and formulation development for acute pancreatitis | Full Text | References | PDF (3.6 MB) | EPUB
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DEC-205 receptor-mediated long-circling nanoliposome as an antigen and Eucommia ulmoides polysaccharide delivery system enhances the immune response via facilitating dendritic cells maturation
Haibo Feng, Xiaonong Yang, Jing Fan, Linzi Zhang, Qianqian Liu & Dongkun Chai
Pages: 1581-1596
Published online: 10 Nov 2020
AbstractforDEC-205 receptor-mediated long-circling nanoliposome as an antigen and Eucommia ulmoides polysaccharide delivery system enhances the immune response via facilitating dendritic cells maturation | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats
Deborah Dhuyvetter, Fetene Tekle, Maxim Nazarov, Rob J. Vreeken, Herman Borghys, Frederik Rombouts, Ilse Lenaerts & Astrid Bottelbergs
Pages: 1597-1607
Published online: 10 Nov 2020
AbstractforDirect nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats | Full Text | References | PDF (1.4 MB) | EPUB
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Furin-responsive triterpenine-based liposomal complex enhances anticervical cancer therapy through size modulation
Yunyan Chen, Mengfei Guo, Ding Qu, Yuping Liu, Jian Guo & Yan Chen
Pages: 1608-1624
Published online: 12 Nov 2020
AbstractforFurin-responsive triterpenine-based liposomal complex enhances anticervical cancer therapy through size modulation | Full Text | References | PDF (6.6 MB) | EPUB
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Article
RETRACTED ARTICLE: Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents
Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Mohammad A. Altamimi, Nabil K. Alruwaili, Fahad Alotaibi, Abdullah Alanazi & Faiyaz Shakeel
Pages: 1625-1643
Published online: 18 Nov 2020
AbstractforRETRACTED ARTICLE: Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents | PDF (2 MB)
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RESEARCH ARTICLE

Article
Probing the drug delivery strategies in ischemic stroke therapy
Qiong Wu, Rong Yan & Jingjing Sun
Pages: 1644-1655
Published online: 26 Nov 2020
AbstractforProbing the drug delivery strategies in ischemic stroke therapy | Full Text | References | PDF (2 MB) | EPUB
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Research Article

Article
Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy
Qisan Ma, Yanna Zhao, Qingran Guan, Yuping Zhao, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Yushu Wu, Min Liu & Jun Han
Pages: 1656-1666
Published online: 25 Nov 2020
AbstractforAmphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Exenatide-loaded inside-porous poly(lactic-co-glycolic acid) microspheres as a long-acting drug delivery system with improved release characteristics
Junqiu Zhai, Zhanlun Ou, Liuting Zhong, Yu-e Wang, Li-Ping Cao & Shixia Guan
Pages: 1667-1675
Published online: 26 Nov 2020
AbstractforExenatide-loaded inside-porous poly(lactic-co-glycolic acid) microspheres as a long-acting drug delivery system with improved release characteristics | Full Text | References | PDF (1.8 MB) | EPUB
  • 1996 Views
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Research Article

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Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing
QingQing Leng, Yue Li, XianLun Pang, BiQiong Wang, ZhouXue Wu, Yun Lu, Kang Xiong, Ling Zhao, Ping Zhou & ShaoZhi Fu
Pages: 1676-1685
Published online: 30 Nov 2020
AbstractforCurcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing | Full Text | References | PDF (3.4 MB) | EPUB
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3D optical/CT as a preclinical companion imaging platform for glioblastoma drug development
Andrei Molotkov, Mikhail Doubrovin, Nikunj Bhatt, Fang-Chi Hsu, Amanda Beserra, Rajiv Chopra & Akiva Mintz
Pages: 1686-1694
Published online: 02 Dec 2020
Abstractfor3D optical/CT as a preclinical companion imaging platform for glioblastoma drug development | Full Text | References | PDF (1.7 MB) | EPUB
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The effect of radiolabeled nanostructured lipid carrier systems containing imatinib mesylate on NIH-3T3 and CRL-1739 cells
Evren Atlihan Gundogdu, Emine Selin Demir, Meliha Ekinci, Emre Ozgenc, Derya Ilem Ozdemir, Zeynep Senyigit & Makbule Asikoglu
Pages: 1695-1703
Published online: 02 Dec 2020
AbstractforThe effect of radiolabeled nanostructured lipid carrier systems containing imatinib mesylate on NIH-3T3 and CRL-1739 cells | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Application of tumor-targeting peptide-decorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma
Renna Qiu, Denghua Sun, Yuzhuo Bai, Jiannan Li & Lizhe Wang
Pages: 1704-1717
Published online: 11 Dec 2020
AbstractforApplication of tumor-targeting peptide-decorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Preparation, optimization, and in vivo evaluation of an inhaled solution of total saponins of Panax notoginseng and its protective effect against idiopathic pulmonary fibrosis
Mengjiao Liu, Tianyi Zhang, Chen Zang, Xiaolan Cui, Jianliang Li & Guohua Wang
Pages: 1718-1728
Published online: 13 Dec 2020
AbstractforPreparation, optimization, and in vivo evaluation of an inhaled solution of total saponins of Panax notoginseng and its protective effect against idiopathic pulmonary fibrosis | Full Text | References | PDF (2.7 MB) | EPUB
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Research Article

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Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal
Degang Kong, Tao Jiang, Jian Liu, Xinyi Jiang, Bei Liu, Cheng Lou, Baobing Zhao, Steven L. Carroll & Gong Feng
Pages: 1729-1740
Published online: 13 Dec 2020
AbstractforChemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal | Full Text | References | PDF (2.6 MB) | EPUB
  • 1622 Views
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Article
Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
Rongqiang Liao, Ying Liu, Pin Lv, Di Wu, Meiling Xu & Xiaoyuan Zheng
Pages: 1741-1749
Published online: 13 Dec 2020
AbstractforCyclodextrin pendant polymer as an efficient drug carrier for scutellarin | Full Text | References | PDF (1.9 MB) | EPUB
  • 1368 Views
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Correction

Correction
Correction
Pages: 1750-1751
Published online: 12 Feb 2020
CitationforCorrection | Full Text | PDF (1,021.9 KB) | EPUB
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Correction
Correction
Pages: 1752-1753
Published online: 13 Apr 2020
CitationforCorrection | Full Text | PDF (822.4 KB) | EPUB
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Correction
Correction
Pages: 1754-1755
Published online: 16 Jul 2020
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