9,969
Views
68
CrossRef citations to date
0
Altmetric
Research Article

Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation

, &
Pages 1501-1509 | Received 27 May 2021, Accepted 28 Jun 2021, Published online: 14 Jul 2021

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Hiroaki Komuro, Shakhlo Aminova, Katherine Lauro & Masako Harada. (2022) Advances of engineered extracellular vesicles-based therapeutics strategy. Science and Technology of Advanced Materials 23:1, pages 655-681.
Read now
Prajakta Teli, Anuradha Vaidya & Vaijayanti Kale. (2015) Signal Transduction Pathways Alter the Molecular Cargo of Extracellular Vesicles: Implications in Regenerative Medicine. Regenerative Medicine 18:12, pages 935-944.
Read now

Articles from other publishers (66)

Manjusha Vaidya, Ayaka Kimura, Arjun Bajaj & Kiminobu Sugaya. (2024) 3′-UTR Sequence of Exosomal NANOGP8 DNA as an Extracellular Vesicle-Localization Signal. International Journal of Molecular Sciences 25:13, pages 7294.
Crossref
Arezoo Hormozi, Sajedeh Hasanzadeh, Faezeh Ebrahimi, Narges Daei, Zahra Hajimortezayi, Amir Mehdizadeh & Majid Zamani. (2024) Treatment with Exosomes Derived from Mesenchymal Stem Cells: A New Window of Healing Science in Regenerative Medicine. Current Stem Cell Research & Therapy 19:6, pages 879-893.
Crossref
Haoran Shen, Rui Zheng, Mulong Du & David C Christiani. (2024) Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders. Thorax 79:7, pages 680-691.
Crossref
Ting-Yi Chen, Tung-Yung Huang, Yao-Yu Chung, Wei-Chun Lin, Hung-Yun Lin, Hsien-Chung Chiu & Sheng-Yang Lee. (2024) Exosomes Derived from Polygonum multiflorum-Treated Human Dental pulp Stem Cells (hDPSCs): new approach in regenerative medicine. Journal of Drug Delivery Science and Technology, pages 105941.
Crossref
YuLing Yang, JiaNi Zhang, SiWen Wu, Yu Deng, ShiHan Wang, Li Xie, XiaoPeng Li & Li Yang. (2024) Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions. Biomaterials 308, pages 122558.
Crossref
Abolfazl Rahmani, Ali Soleymani, Mustafa Almukhtar, Kimia Behzad Moghadam, Zahra Vaziri, Ali Hosein Tabar Kashi, Reza Adabi Firoozjah, Mehrdad Jafari Tadi, Maryam Zolfaghari Dehkharghani, Hadi Valadi, Ali Akbar Moghadamnia, Robin B. Gasser & Ali Rostami. (2024) Exosomes, and the potential for exosome‐based interventions against COVID‐19. Reviews in Medical Virology 34:4.
Crossref
Morgane E. Golan & Steven L. Stice. (2024) Extracellular vesicle lyophilization for enhanced distribution to the point of care. Extracellular Vesicle 3, pages 100041.
Crossref
Xiaolei Zhou, Shiyin Xu, Zixuan Zhang, Mingmeng Tang, Zitong Meng, Zhao Peng, Yuxiao Liao, Xuefeng Yang, Andreas K. Nüssler, Liegang Liu & Wei Yang. (2024) Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway. Journal of Nanobiotechnology 22:1.
Crossref
Rodolphe Poupardin, Martin Wolf, Nicole Maeding, Liliia Paniushkina, Sven Geissler, Paolo Bergese, Kenneth W. Witwer, Katharina Schallmoser, Gregor Fuhrmann & Dirk Strunk. (2024) Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function. Advanced Healthcare Materials.
Crossref
Dan Wu, Xiansheng Zhao, Jiaheng Xie, Ruoyue Yuan, Yue Li, Quyang Yang, Xiujun Cheng, Changyue Wu, Jinyan Wu & Ningwen Zhu. (2024) Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine. Cell Proliferation.
Crossref
Tianjiao Geng, Song Yee Paek, Euphemia Leung, Lawrence W. Chamley & Zimei Wu. (2024) Comparing extracellular vesicles from four different cell origins for intracellular drug delivery to pancreatic cancer cells: Small or large vesicles?. Journal of Drug Delivery Science and Technology 93, pages 105416.
Crossref
Rachayeeta Ray, Sougata Ghosh Chowdhury & Parimal Karmakar. (2024) A vivid outline demonstrating the benefits of exosome-mediated drug delivery in CNS-associated disease environments. Archives of Biochemistry and Biophysics 753, pages 109906.
Crossref
Xinya Zheng, Hongru Ai, Kewen Qian, Guangyao Li, Shuyi Zhang, Yitan Zou, Changhai Lei, Wenyan Fu & Shi Hu. (2024) Small extracellular vesicles purification and scale-up. Frontiers in Immunology 15.
Crossref
Akanksha Onkar, Fatima Khan, Anshika Goenka, Ramya Lakshmi Rajendran, Crismita Dmello, Chae Moon Hong, Nida Mubin, Prakash Gangadaran & Byeong-Cheol Ahn. (2024) Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications. ACS Applied Materials & Interfaces 16:6, pages 6709-6742.
Crossref
Nico Hüttmann, Yingxi Li, Suttinee Poolsup, Emil Zaripov, Rochelle D’Mello, Vanessa Susevski, Zoran Minic & Maxim V. Berezovski. (2024) Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers. Cancers 16:3, pages 520.
Crossref
Hanzhe Liu, Guo-Feng Luo & Zhengjun Shang. (2024) Plant-derived nanovesicles as an emerging platform for cancer therapy. Acta Pharmaceutica Sinica B 14:1, pages 133-154.
Crossref
Morteza Abyadeh, Mehdi Alikhani, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari & Ghasem Hosseini Salekdeh. 2024. Functional Proteomics. Functional Proteomics 101 133 .
Sehrish Khan, Hassan Zafar & Aftab Ahmad. 2024. Global Regulatory Outlook for CRISPRized Plants. Global Regulatory Outlook for CRISPRized Plants 71 90 .
Laurianne Simon, Vincent Lapinte & Marie Morille. (2023) Exploring the role of polymers to overcome ongoing challenges in the field of extracellular vesicles. Journal of Extracellular Vesicles 12:12.
Crossref
Zhe Wang, Xinpei Wang, Wanting Xu, Yongxiao Li, Ruizhi Lai, Xiaohui Qiu, Xu Chen, Zhidong Chen, Bobin Mi, Meiying Wu & Junqing Wang. (2023) Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems. Pharmaceutics 15:11, pages 2623.
Crossref
Chunyu Zhang, Xuchang Zhou, Dongxue Wang, Li Hao, Zhipeng Zeng & Lei Su. (2023) Hydrogel-Loaded Exosomes: A Promising Therapeutic Strategy for Musculoskeletal Disorders. Journal of Clinical Pharmacy and Therapeutics 2023, pages 1-36.
Crossref
Marta Díaz, Paula Casano, Tania Quesada, Abel López-Bermejo, Francis de Zegher, Francesc Villarroya & Lourdes Ibáñez. (2023) Circulating exosomes decrease in size and increase in number between birth and age 7: relations to fetal growth and liver fat. Frontiers in Endocrinology 14.
Crossref
Francesca Susa, Tania Limongi, Francesca Borgione, Silvia Peiretti, Marta Vallino, Valentina Cauda & Roberto Pisano. (2023) Comparative Studies of Different Preservation Methods and Relative Freeze-Drying Formulations for Extracellular Vesicle Pharmaceutical Applications. ACS Biomaterials Science & Engineering 9:10, pages 5871-5885.
Crossref
Yangfan Leng, Liubin Yang, Hangxin Zhu, Dongqin Li, Siyi Pan & Fang Yuan. (2023) Stability of Blueberry Extracellular Vesicles and Their Gene Regulation Effects in Intestinal Caco-2 Cells. Biomolecules 13:9, pages 1412.
Crossref
Manon Jammes, Romain Contentin, Fabrice Audigié, Frédéric Cassé & Philippe Galéra. (2023) Effect of pro-inflammatory cytokine priming and storage temperature of the mesenchymal stromal cell (MSC) secretome on equine articular chondrocytes. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Zachary F. Greenberg, Kiley S. Graim & Mei He. (2023) Towards artificial intelligence-enabled extracellular vesicle precision drug delivery. Advanced Drug Delivery Reviews 199, pages 114974.
Crossref
An Hendrix, Lien Lippens, Cláudio Pinheiro, Clotilde Théry, Lorena Martin-Jaular, Jan Lötvall, Cecilia Lässer, Andrew F. Hill & Kenneth W. Witwer. (2023) Extracellular vesicle analysis. Nature Reviews Methods Primers 3:1.
Crossref
Shang-Wen Lin, Jui-Chen Tsai & Yan-Jye Shyong. (2023) Drug delivery of extracellular vesicles: Preparation, delivery strategies and applications. International Journal of Pharmaceutics 642, pages 123185.
Crossref
Xiaowen Huang, Aifang Li, Peng Xu, Yangfan Yu, Shuxuan Li, Lina Hu & Shuying Feng. (2023) Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles. Journal of Nanobiotechnology 21:1.
Crossref
Faezeh Shekari, Morteza Abyadeh, Anna Meyfour, Mehdi Mirzaei, Nitin Chitranshi, Vivek Gupta, Stuart L. Graham & Ghasem Hosseini Salekdeh. (2023) Extracellular vesicles as reconfigurable therapeutics for eye diseases: Promises and hurdles. Progress in Neurobiology 225, pages 102437.
Crossref
Luciana M. Domínguez, Bárbara Bueloni, Ma. José Cantero, Milagros Albornoz, Natalia Pacienza, Celeste Biani, Carlos Luzzani, Santiago Miriuka, Mariana García, Catalina Atorrasagasti, Gustavo Yannarelli, Juan Bayo, Esteban Fiore & Guillermo Mazzolini. (2023) Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice. International Journal of Molecular Sciences 24:11, pages 9586.
Crossref
Dong-Myong Kim, Won-Jin Kim, Hyung-Kon Lee, Yong-Seong Kwon & Yeon-Mea Choi. (2023) Skin Improvement of the Composition Containing Nano-exosome Derived from Aloe vera Bark Callus as New Type of Transdermal Delivery System. Asian Journal of Beauty and Cosmetology 21:1, pages 117-130.
Crossref
Harley Robinson, Matthew J. Roberts, Robert A. Gardiner & Michelle M. Hill. (2023) Extracellular vesicles for precision medicine in prostate cancer – Is it ready for clinical translation?. Seminars in Cancer Biology 89, pages 18-29.
Crossref
Monika Ruzycka-Ayoush, Anna M. Nowicka, Agata Kowalczyk, Agata Gluchowska, Alicja Targonska, Grazyna Mosieniak, Kamil Sobczak, Mikolaj Donten & Ireneusz P. Grudzinski. (2023) Exosomes derived from lung cancer cells: Isolation, characterization, and stability studies. European Journal of Pharmaceutical Sciences 181, pages 106369.
Crossref
Gang Wang, Wan Jin, Zilin Xu, Lingao Ju, Danni Shan, Shenjuan Li, Mengxue Yu, Xinyue Cao, Nan Liu, Kaiyu Qian, Yi Zhang, Yu Xiao & Xinghuan Wang. (2023) Urine‐based liquid biopsy in bladder cancer: Opportunities and challenges. Clinical and Translational Discovery 3:1.
Crossref
O.G. Davies, S. Williams & K. Goldie. (2023) The therapeutic and commercial landscape of stem cell vesicles in regenerative dermatology. Journal of Controlled Release 353, pages 1096-1106.
Crossref
Chenglong Wang, Maochang Xu, Qingze Fan, Chunhong Li & Xiangyu Zhou. (2023) Therapeutic potential of exosome‐based personalized delivery platform in chronic inflammatory diseases. Asian Journal of Pharmaceutical Sciences 18:1, pages 100772.
Crossref
Komal Umashankar Rao & Gabriela Godaly. 2023. Bacterial Pathogenesis. Bacterial Pathogenesis 55 60 .
Yasunari Matsuzaka & Ryu Yashiro. (2022) Advances in Purification, Modification, and Application of Extracellular Vesicles for Novel Clinical Treatments. Membranes 12:12, pages 1244.
Crossref
Fusheng Zhang, Jinshuai Guo, Zhenghou Zhang, Meiqi Duan, Guang Wang, Yiping Qian, Haiying Zhao, Zhi Yang & Xiaofeng Jiang. (2022) Application of engineered extracellular vesicles for targeted tumor therapy. Journal of Biomedical Science 29:1.
Crossref
Elisabeth Rackles, Patricia Hernández Lopez & Juan M. Falcon-Perez. (2022) Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma. Seminars in Cancer Biology 87, pages 148-159.
Crossref
Xinan Huang, Dimitri Hürlimann, Hendrik T. Spanke, Dalin Wu, Michal Skowicki, Ionel Adrian Dinu, Eric R. Dufresne & Cornelia G. Palivan. (2022) Cell‐Derived Vesicles with Increased Stability and On‐Demand Functionality by Equipping Their Membrane with a Cross‐Linkable Copolymer. Advanced Healthcare Materials 11:23.
Crossref
Ju-Sheng Shieh, Yu-Tang Chin, Hsien-Chung Chiu, Ya-Yu Hsieh, Hui-Rong Cheng, Hai Gu & Fung-Wei Chang. (2022) Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells. International Journal of Molecular Sciences 23:23, pages 15010.
Crossref
Qi Chen, Di Wu, Yi Wang & Zhong Chen. (2022) Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine. Molecules 27:22, pages 7789.
Crossref
Fulong Man, Huaran Xing, Haoran Wang, Junfeng Wang & Rong Lu. (2022) Engineered small extracellular vesicles as a versatile platform to efficiently load ferulic acid via an “esterase-responsive active loading” strategy. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Bibi S. SubhanMichelle KiAlexandra VerzellaShruthi ShankarPiul S. Rabbani. (2022) Behind the Scenes of Extracellular Vesicle Therapy for Skin Injuries and Disorders. Advances in Wound Care 11:11, pages 575-597.
Crossref
Charysse Vandendriessche, Dimitrios Kapogiannis & Roosmarijn E. Vandenbroucke. (2022) Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease. Advanced Drug Delivery Reviews 190, pages 114486.
Crossref
Riccardo Vago, Giorgia Radano, Davide Zocco & Natasa Zarovni. (2022) Urine stabilization and normalization strategies favor unbiased analysis of urinary EV content. Scientific Reports 12:1.
Crossref
Carolina Carvalho Serres Da-Silva, Ana Carolina Anauate, Tatiana Pinotti Guirao, Antônio da Silva Novaes, Edgar Maquigussa & Mirian Aparecida Boim. (2022) Analysis of exosome-derived microRNAs as early biomarkers of lipopolysaccharide-induced acute kidney injury in rats. Frontiers in Physiology 13.
Crossref
Yury Shkryl, Zhargalma Tsydeneshieva, Anton Degtyarenko, Yulia Yugay, Larissa Balabanova, Tatiana Rusapetova & Victor Bulgakov. (2022) Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine. Applied Sciences 12:16, pages 8262.
Crossref
Kaushik Das, Usha R. Pendurthi, Marylyn Manco‐Johnson, Erika J. Martin, Donald F. Brophy & L. Vijaya Mohan Rao. (2022) Factor VIIa treatment increases circulating extracellular vesicles in hemophilia patients: Implications for the therapeutic hemostatic effect of FVIIa. Journal of Thrombosis and Haemostasis 20:8, pages 1928-1933.
Crossref
Prakash Gangadaran, Ramya Lakshmi Rajendran, Mi Hee Kwack, Madhan Jeyaraman, Chae Moon Hong, Young Kwan Sung & Byeong-Cheol Ahn. (2022) Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics. Frontiers in Cell and Developmental Biology 10.
Crossref
Aniko Bertokova, Natalia Svecova, Katarina Kozics, Alena Gabelova, Alica Vikartovska, Eduard Jane, Michal Hires, Tomas Bertok & Jan Tkac. (2022) Exosomes from prostate cancer cell lines: Isolation optimisation and characterisation. Biomedicine & Pharmacotherapy 151, pages 113093.
Crossref
Yasunari Matsuzaka & Ryu Yashiro. (2022) Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine. International Journal of Molecular Sciences 23:12, pages 6480.
Crossref
François BerthiaumeHenry C. Hsia. (2022) Regenerative Approaches for Chronic Wounds. Annual Review of Biomedical Engineering 24:1, pages 61-83.
Crossref
Lukui Chen, Guilong Zhang, Shiqing Feng, Mengzhou Xue, Jinquan Cai, Lin Chen, Yubin Deng & Yunliang Wang. (2022) Preparation and quality control standard of clinical-grade neural progenitor/precursor cells-derived exosomes (2022 China version). Journal of Neurorestoratology 10:2, pages 100001.
Crossref
André Görgens, Giulia Corso, Daniel W. Hagey, Rim Jawad Wiklander, Manuela O. Gustafsson, Ulrika Felldin, Yi Lee, R. Beklem Bostancioglu, Helena Sork, Xiuming Liang, Wenyi Zheng, Dara K. Mohammad, Simonides I. van de Wakker, Pieter Vader, Antje M. Zickler, Doste R. Mamand, Li Ma, Margaret N. Holme, Molly M. Stevens, Oscar P. B. Wiklander & Samir EL Andaloussi. (2022) Identification of storage conditions stabilizing extracellular vesicles preparations. Journal of Extracellular Vesicles 11:6.
Crossref
Gecioni Loch-Neckel, Ana Teresa Matos, Ana Rita Vaz & Dora Brites. (2022) Challenges in the Development of Drug Delivery Systems Based on Small Extracellular Vesicles for Therapy of Brain Diseases. Frontiers in Pharmacology 13.
Crossref
Madlen Reinicke, Saikal Shamkeeva, Max Hell, Berend Isermann, Uta Ceglarek & Mitja L. Heinemann. (2022) Targeted Lipidomics for Characterization of PUFAs and Eicosanoids in Extracellular Vesicles. Nutrients 14:7, pages 1319.
Crossref
Weifei Zhang, Pengzhou Huang, Jianjing Lin & Hui Zeng. (2022) The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review. Membranes 12:3, pages 324.
Crossref
Frederic St-Denis-Bissonnette, Rachil Khoury, Karan Mediratta, Sara El-Sahli, Lisheng Wang & Jessie R. Lavoie. (2022) Applications of Extracellular Vesicles in Triple-Negative Breast Cancer. Cancers 14:2, pages 451.
Crossref
YASHVI SHARMA, SHARDA RAY & SUJATA MOHANTY. (2022) MSCs derived extracellular vesicles as a therapeutic paragon for neurodegenerative disorders: A viewpoint. BIOCELL 46:6, pages 1435-1438.
Crossref
Thanh Huyen Phan, Sally Yunsun Kim, Christopher Rudge & Wojciech Chrzanowski. (2022) Made by cells for cells – extracellular vesicles as next-generation mainstream medicines. Journal of Cell Science 135:1.
Crossref
Darja Božič, Matej Hočevar, Matic Kisovec, Manca Pajnič, Ljubiša Pađen, Marko Jeran, Apolonija Bedina Zavec, Marjetka Podobnik, Ksenija Kogej, Aleš Iglič & Veronika Kralj-Iglič. (2021) Stability of Erythrocyte-Derived Nanovesicles Assessed by Light Scattering and Electron Microscopy. International Journal of Molecular Sciences 22:23, pages 12772.
Crossref
Marie J. Pauwels, Charysse Vandendriessche & Roosmarijn E. Vandenbroucke. (2021) Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain. Biomedicines 9:11, pages 1734.
Crossref
Thomas De Luca, Robert E. StratfordJr.Jr., Madison E. Edwards, Christina R. Ferreira & Eric A. Benson. (2021) Novel Quantification of Extracellular Vesicles with Unaltered Surface Membranes Using an Internalized Oligonucleotide Tracer and Applied Pharmacokinetic Multiple Compartment Modeling. Pharmaceutical Research 38:10, pages 1677-1695.
Crossref