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Drug Delivery Volume 28, 2021 - Issue 1
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Research Article

Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies

Rofida Albasha Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt
,
Abdurrahman M. Fahmyb Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected]
,
Mohammed I.A. Hamedc Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt
,
Khaled M. Darwishd Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
&
Rania Moataz El-Dahmye Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Cairo, Egypt
Pages 2289-2300 | Received 23 Aug 2021, Accepted 27 Sep 2021, Published online: 02 Nov 2021

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Rofida Albash, Rania Moataz El-Dahmy, Mohammed I. A. Hamed, Khaled M. Darwish, Abdulrahman M. Alahdal, Amira B. Kassem & Abdurrahman M. Fahmy. (2022) Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies. Drug Delivery 29:1, pages 2784-2795.
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Moaz A Eltabeeb, Menna M Abdellatif, Mohamed A El-Nabarawi, Mahmoud H Teaima, Mohammed I A Hamed, Khaled M Darwish, Mariam Hassan, Ahmed ME Hamdan & Raghda Rabe Hamed. Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans-vaginal infection. Nanomedicine 0:0, pages 1-19.
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Devika Nayak, Mahalaxmi Rathnanand & Vamshi Krishna Tippavajhala. (2024) Navigating Skin Delivery Horizon: An Innovative Approach in Pioneering Surface Modification of Ultradeformable Vesicles. AAPS PharmSciTech 25:5.
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Bjad K. Almutairy, El-Sayed Khafagy, Mohammed F. Aldawsari, Abdullah Alshetaili, Hadil Faris Alotaibi & Amr Selim Abu Lila. (2024) Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia. International Journal of Pharmaceutics: X 7, pages 100240.
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Moaz A. Eltabeeb, Raghda Rabe Hamed, Mohamed A. El-Nabarawi, Mahmoud H. Teaima, Mohammed I. A. Hamed, Khaled M. Darwish, Mariam Hassan & Menna M. Abdellatif. (2024) Nanocomposite alginate hydrogel loaded with propranolol hydrochloride kolliphor® based cerosomes as a repurposed platform for Methicillin-Resistant Staphylococcus aureus-(MRSA)-induced skin infection; in-vitro, ex-vivo, in-silico, and in-vivo evaluation. Drug Delivery and Translational Research.
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Yasmina Elmahboub, Rofida Albash, Mira Magdy William, Amal H. Rayan, Najat O. Hamed, Mona S. Ousman, Nahed A Raslan & Shaimaa Mosallam. (2024) Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study. Molecules 29:7, pages 1614.
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Rania El Hosary, Mahmoud H. Teaima, Mohamed El-Nabarawi, Yousra Yousry, Mahmoud Eltahan, Ahmed Bakr, Hussein Aboelela, Rehab Abdelmonem & Rafik M. Nassif. (2024) Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation. Saudi Pharmaceutical Journal 32:1, pages 101912.
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Neelam Sharma, Sonam Grewal, Sukhbir Singh, Sumeet Gupta, Tapan Behl & Ishrat Zahoor. 2024. Targeting Angiogenesis, Inflammation, and Oxidative Stress in Chronic Diseases. Targeting Angiogenesis, Inflammation, and Oxidative Stress in Chronic Diseases 431 458 .
Rania Moataz El-Dahmy, Ibrahim Elsayed, Jihan Hussein, Mohammad Althubiti, Riyad A. Almaimani, Mahmoud Zaki El-Readi, Marawan A. Elbaset & Bassant M. M. Ibrahim. (2023) Development of Transdermal Oleogel Containing Olmesartan Medoxomil: Statistical Optimization and Pharmacological Evaluation. Pharmaceutics 15:4, pages 1083.
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Moaz M. El-Naggar, Mohamed A. El-Nabarawi, Mahmoud H. Teaima, Mariam Hassan, Mohammed I.A. Hamed, Ahmed A. Elrashedy & Rofida Albash. (2023) Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin infection; D-optimal optimization, ex-vivo, in-silico, and in-vivo studies. International Journal of Pharmaceutics 633, pages 122621.
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Rofida Albash, Noha M. Badawi, Mohammed I. A. Hamed, Maha H. Ragaie, Sahar S. Mohammed, Rovan M. Elbesh, Khaled M. Darwish, Manar O. Lashkar, Sameh S. Elhady & Shaimaa Mosallam. (2023) Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation. Pharmaceuticals 16:1, pages 128.
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Martin Juhaščik, Andrej Kováčik & Gloria Huerta-Ángeles. (2022) Recent Advances of Hyaluronan for Skin Delivery: From Structure to Fabrication Strategies and Applications. Polymers 14:22, pages 4833.
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