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Drug Delivery Volume 29, 2022 - Issue 1
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Research Articles

The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics

Qiuxia Yua The Second Clinical College of Guangzhou, University of Chinese Medicine, Guangzhou, ChinaView further author information
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Minhua Lib School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Hanbin Chenc The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Lieqiang Xub School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Juanjuan Chengb School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Guoshu Linb School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Yuhong Liub School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Ziren Sub School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaView further author information
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Xiaobo Yangd The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;e State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;f Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, ChinaView further author information
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Yucui Lib School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaCorrespondence[email protected]
View further author information
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Jiannan Chenb School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, ChinaCorrespondence[email protected]
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Jianhui Xied The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;e State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;f Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, ChinaCorrespondence[email protected]
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Pages 856-870 | Received 09 Sep 2021, Accepted 25 Jan 2022, Published online: 11 Mar 2022

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Zehui Qin, Minhua Li, Juanjuan Cheng, Ziwei Huang, Gaoxiang Ai, Chang Qu, Youliang Xie, Yucui Li, Huijun Liao, Jianhui Xie & Ziren Su. (2023) Self-Assembled nanoparticles Combining Berberine and Sodium Taurocholate for Enhanced Anti-Hyperuricemia Effect. International Journal of Nanomedicine 18, pages 4101-4120.
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Yong He, Shiyun Chen, Mengmeng Li, Yonghao Gao, Huiyi Feng, Qasim Umar, Dengke Yin & Yisi Feng. (2023) Novel co-crystal of 3-methylcinnamic acid with berberine (1:1): synthesis, characterization, and intestinal absorption property. Drug Development and Industrial Pharmacy 49:10, pages 617-627.
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Minhua Li, Zehui Qin, Qiuxia Yu, Ziwei Huang, Juanjuan Cheng, Linjiang Zhong, Yuhong Liu, Jianhui Xie, Yucui Li, Jiannan Chen, Ruoting Zhan & Ziren Su. (2022) Anti-Inflammatory Activation of Phellodendri Chinensis Cortex is Mediated by Berberine Erythrocytes Self-Assembly Targeted Delivery System. Drug Design, Development and Therapy 16, pages 4365-4383.
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Bengü Sema Mutafoğlu, Furkan Meletli & Özkan Danış. Investigation of the Interaction of Monoamine Oxidase (MAO) Inhibitor Biscoumarins with Hemoglobin and Albumin Using Multi-Spectroscopic Techniques and Molecular Docking. Analytical Letters 0:0, pages 1-24.
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Articles from other publishers (7)

Ze-Dong Xiang, Hui-Da Guan, Xiang Zhao, Qi Xie, Fu-Jie Cai, Zhe-Jun Xie, Rui Dang, Man-Lin Li & Chang-Hong Wang. (2024) Protoberberine alkaloids: A review of the gastroprotective effects, pharmacokinetics, and toxicity. Phytomedicine 126, pages 155444.
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Sara Biagiotti, Elena Pirla & Mauro Magnani. (2023) Drug transport by red blood cells. Frontiers in Physiology 14.
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Yajie Cai, Qiaoning Yang, Yanqiao Yu, Furong Yang, Ruina Bai & Xiaodi Fan. (2023) Efficacy and underlying mechanisms of berberine against lipid metabolic diseases: a review. Frontiers in Pharmacology 14.
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Ziwei Huang, Minhua Li, Zehui Qin, Xingdong Ma, Ronglei Huang, Yuhong Liu, Jianhui Xie, Huifang Zeng, Ruoting Zhan & Ziren Su. (2023) Intestines-erythrocytes-mediated bio-disposition deciphers the hypolipidemic effect of berberine from Rhizoma Coptidis: A neglected insight. Journal of Ethnopharmacology 314, pages 116600.
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Lu Liu, Rui Xing, Junshu Xue, Jiahao Fan, Junjie Zou, Xu Song, Renyong Jia, Yuanfeng Zou, Lixia Li, Xun Zhou, Cheng Lv, Hongping Wan, Xinghong Zhao & Zhongqiong Yin. (2023) Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine. International Journal of Pharmaceutics 642, pages 123102.
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Arian Khoshandam, Mohsen Imenshahidi & Hossein Hosseinzadeh. (2022) Pharmacokinetic of berberine, the main constituent of Berberis vulgaris L.: A comprehensive review . Phytotherapy Research 36:11, pages 4063-4079.
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Zhongqi Shen, Meng Yu & Shaozhi Zhang. (2022) Network Pharmacology and Molecular Docking Analyses Unveil the Mechanisms of Yiguanjian Decoction against Parkinson’s Disease from Inner/Outer Brain Perspective. BioMed Research International 2022, pages 1-25.
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