Drug Delivery, Volume 29, Issue 1 (2022)

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Drug Delivery, Volume 29, Issue 1 (2022)

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Research Articles

Article
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy
Yun-Chang Zhang, Pei-Yu Zeng, Zhi-Qiang Ma, Zi-Yue Xu, Ze-Kun Wang, Beibei Guo, Feng Yang & Zhan-Ting Li
Pages: 1-9
Published online: 24 Dec 2021
AbstractforA pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 5024 Views
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Open Access
Article
Aerosol release, distribution, and prevention during aerosol therapy: a simulated model for infection control
Marc Mac Giolla Eain, Ronan Cahill, Ronan MacLoughlin & Kevin Nolan
Pages: 10-17
Published online: 28 Dec 2021
AbstractforAerosol release, distribution, and prevention during aerosol therapy: a simulated model for infection control | Full Text | References | PDF (1.4 MB) | EPUB
  • 3704 Views
  • 5 CrossRef citations
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Open Access
Article
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system
Cixin Huang, Xia Qi, Huilin Chen, Chao Wei, Xiaolin Qi, Hongwei Wang & Hua Gao
Pages: 18-30
Published online: 28 Dec 2021
AbstractforMonolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 3571 Views
  • 5 CrossRef citations
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Open Access
Article
Folate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma
Wenwen Shen, Shuke Ge, Xiaoyao Liu, Qi Yu, Xue Jiang, Qian Wu, YuChen Tian, Yu Gao, Ying Liu & Chao Wu
Pages: 31-42
Published online: 28 Dec 2021
AbstractforFolate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 3599 Views
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Open Access
Article
Novel cannula design improves large volume auto-injection rates for high viscosity solutions
Bruce C. Roberts, Christopher Rini, Rick Klug, Douglas B. Sherman, Didier Morel & Ronald J. Pettis
Pages: 43-51
Published online: 28 Dec 2021
AbstractforNovel cannula design improves large volume auto-injection rates for high viscosity solutions | Full Text | References | PDF (1.5 MB) | EPUB
  • 2610 Views
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Open Access
Article
Carbopol emulgel loaded with ebastine for urticaria: development, characterization, in vitro and in vivo evaluation
Barkat Ali Khan, Arshad Ali, Khaled M. Hosny, Abdulrahman A. Halwani, Alshaimaa M. Almehmady, Muhammad Iqbal, Waleed S. Alharbi, Walaa A. Abualsunun, Rana B. Bakhaidar, Samar S. A. Murshid & Muhammad Khalid Khan
Pages: 52-61
Published online: 28 Dec 2021
AbstractforCarbopol emulgel loaded with ebastine for urticaria: development, characterization, in vitro and in vivo evaluation | Full Text | References | PDF (1.9 MB) | EPUB
  • 4903 Views
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Open Access
Article
The efficacy of Origanum majorana nanocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats
Dina B. E. Farag, Carol Yousry, Abdulaziz Mohsen Al-Mahallawi, Hesham I. El-Askary, Meselhy R. Meselhy & Nermeen AbuBakr
Pages: 62-74
Published online: 29 Dec 2021
AbstractforThe efficacy of Origanum majorana nanocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats | Full Text | References | PDF (2.6 MB) | EPUB
  • 2953 Views
  • 11 CrossRef citations
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Open Access
Article
Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy
Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin, Jihui Tang & Xi Cao
Pages: 75-88
Published online: 29 Dec 2021
AbstractforCo-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 5111 Views
  • 25 CrossRef citations
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Open Access
Article
Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer
Xiaohu Zeng, Xin Zhu, Qikang Tian, Xiaoke Tan, Ning Sun, Min Yan, Junwei Zhao, Xiangxiang Wu, Ruiqin Li, Zhenqiang Zhang & Huahui Zeng
Pages: 89-98
Published online: 29 Dec 2021
AbstractforCelastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer | Full Text | References | PDF (2.7 MB) | EPUB
  • 3884 Views
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Open Access
Article
Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC
Chunhong Su, XiaoJun Ren, Fang Yang, Bin Li, Hao Wu, Hui Li & Fang Nie
Pages: 99-110
Published online: 29 Dec 2021
AbstractforUltrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC | Full Text | References | PDF (2.9 MB) | EPUB
  • 3633 Views
  • 15 CrossRef citations
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Open Access
Article
Development of a naringenin microemulsion as a prospective ophthalmic delivery system for the treatment of corneal neovascularization: in vitro and in vivo evaluation
Yu Ma, Jingjing Yang, Yali Zhang, Chunyan Zheng, Zhen Liang, Ping Lu, Fei Song, Yuwei Wang & Junjie Zhang
Pages: 111-127
Published online: 29 Dec 2021
AbstractforDevelopment of a naringenin microemulsion as a prospective ophthalmic delivery system for the treatment of corneal neovascularization: in vitro and in vivo evaluation | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3816 Views
  • 13 CrossRef citations
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Open Access
Article
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy
Yun-Chang Zhang, Pei-Yu Zeng, Zhi-Qiang Ma, Zi-Yue Xu, Ze-Kun Wang, Beibei Guo, Feng Yang & Zhan-Ting Li
Pages: 128-137
Published online: 30 Dec 2021
AbstractforA pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3521 Views
  • 9 CrossRef citations
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Open Access
Article
Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy
Xue Liu, Zhenfeng Wu, Chunjing Guo, Huimin Guo, Yanguo Su, Qiang Chen, Changgang Sun, Qingming Liu, Daquan Chen & Hongjie Mu
Pages: 138-148
Published online: 30 Dec 2021
AbstractforHypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy | Full Text | References | PDF (2.3 MB) | EPUB
  • 9360 Views
  • 48 CrossRef citations
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Open Access
Article
Efficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss
So-Young Jung, Subin Kim, Zion Kang, Soonmin Kwon, Juhye Lee, Joo Won Park, Kab Sig Kim & Dong-Kee Kim
Pages: 149-160
Published online: 30 Dec 2021
AbstractforEfficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss | Full Text | References | PDF (2.6 MB) | EPUB
  • 2955 Views
  • 1 CrossRef citations
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Open Access
Article
Biodegradable hollow mesoporous organosilica nanotheranostics (HMONs) as a versatile platform for multimodal imaging and phototherapeutic-triggered endolysosomal disruption in ovarian cancer
Pengfei Li, Bingquan Lin, Zhian Chen, Pan Liu, Jiaqi Liu, Weili Li, Ping Liu, Zhaoze Guo & Chunlin Chen
Pages: 161-173
Published online: 30 Dec 2021
AbstractforBiodegradable hollow mesoporous organosilica nanotheranostics (HMONs) as a versatile platform for multimodal imaging and phototherapeutic-triggered endolysosomal disruption in ovarian cancer | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 3153 Views
  • 6 CrossRef citations
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Article
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice
Hao Zhang, Mengyao Zhang, Xumei Wang, Mi Zhang, Xuelian Wang, Yiyang Li, Zhuoer Cui, Xiuping Chen, Yantao Han & Wenwen Zhao
Pages: 174-185
Published online: 03 Jan 2022
AbstractforElectrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 5199 Views
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Article
[223Ra] RaCl2 nanomicelles showed potent effect against osteosarcoma: targeted alpha therapy in the nanotechnology era
Yang Yang, Luciana Magalhães Rebelo Alencar, Martha Sahylí Ortega Pijeira, Beatriz da Silva Batista, Alefe Roger Silva França, Erick Rafael Dias Rates, Ruana Cardoso Lima, Sara Gemini-Piperni & Ralph Santos-Oliveira
Pages: 186-191
Published online: 04 Jan 2022
Abstractfor[223Ra] RaCl2 nanomicelles showed potent effect against osteosarcoma: targeted alpha therapy in the nanotechnology era | Full Text | References | PDF (1.4 MB) | EPUB
  • 2787 Views
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Open Access
Article
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles
Huizhen Li, Wan Xu, Fang Li, Ru Zeng, Xiuming Zhang, Xianwu Wang, Shaojun Zhao, Jian Weng, Zhu Li & Liping Sun
Pages: 192-202
Published online: 05 Jan 2022
AbstractforAmplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 4510 Views
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Open Access
Article
GRP78-targeted and doxorubicin-loaded nanodroplets combined with ultrasound: a potential novel theranostics for castration-resistant prostate cancer
Yading Zhao, Dandan Shi, Mengmeng Shang, Xiao Sun, Lu Guo, Dong Meng, Xinxin Liu, Xiaoying Zhou & Jie Li
Pages: 203-213
Published online: 05 Jan 2022
AbstractforGRP78-targeted and doxorubicin-loaded nanodroplets combined with ultrasound: a potential novel theranostics for castration-resistant prostate cancer | Full Text | References | PDF (2.8 MB) | EPUB
  • 3115 Views
  • 11 CrossRef citations
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Article
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
Chengqi Yan, Jing Chen, Cheng Wang, Meng Yuan, Yu Kang, Zihan Wu, Wenqing Li, Guolei Zhang, Hans-Günther Machens, Yuval Rinkevich, Zhenbing Chen, Xiaofan Yang & Xiang Xu
Pages: 214-228
Published online: 05 Jan 2022
AbstractforMilk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 11800 Views
  • 97 CrossRef citations
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Open Access
Article
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance
Yang Liping, He Jian, Tao Zhenchao, Zhou Yan, Yang Jing, Zhang Yangyang, Gao Jing & Qian Liting
Pages: 229-237
Published online: 08 Jan 2022
AbstractforGSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 3497 Views
  • 15 CrossRef citations
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Open Access
Article
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy
Yunxia Dong, Ling Zhou, Zijun Shen, Qingming Ma, Yifan Zhao, Yong Sun & Jie Cao
Pages: 238-253
Published online: 08 Jan 2022
AbstractforIodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 4175 Views
  • 18 CrossRef citations
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Open Access
Article
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis
Khaled M. Hosny, Amal M. Sindi, Sarah Ali, Waleed S. Alharbi, Maher S. Hajjaj, Haitham A. Bukhary, Moutaz Y. Badr, Rayan Y. Mushtaq, Samar S. A. Murshid, Alshaimaa M. Almehmady, Rana B. Bakhaidar, Eman Alfayez & Mallesh Kurakula
Pages: 254-262
Published online: 11 Jan 2022
AbstractforDevelopment, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis | Full Text | References | PDF (1.5 MB) | EPUB
  • 2992 Views
  • 15 CrossRef citations
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Article
Combination anesthetic therapy: co-delivery of ropivacaine and meloxicam using transcriptional transactivator peptide modified nanostructured lipid carriers in vitro and in vivo
Shu Yuan, Jun Chen, Shuo Feng, Min Li, Yingui Sun & Yuzhen Liu
Pages: 263-269
Published online: 11 Jan 2022
AbstractforCombination anesthetic therapy: co-delivery of ropivacaine and meloxicam using transcriptional transactivator peptide modified nanostructured lipid carriers in vitro and in vivo | Full Text | References | PDF (1.3 MB) | EPUB
  • 2474 Views
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Article
Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
Akula S. N. Murthy, Sanket Das, Tejinder Singh, Tae-Wan Kim, Nasim Sepay, Seob Jeon & Jungkyun Im
Pages: 270-283
Published online: 11 Jan 2022
AbstractforMitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 2677 Views
  • 5 CrossRef citations
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Open Access
Article
Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia
Khaled M. Hosny, Waleed Y. Rizg, Eman Alfayez, Samar S. Elgebaly, Abdulmohsin J. Alamoudi, Raed I. Felimban, Hossam H. Tayeb, Rayan Y. Mushtaq, Awaji Y. Safhi, Majed Alharbi & Alshaimaa M. Almehmady
Pages: 284-293
Published online: 12 Jan 2022
AbstractforPreparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia | Full Text | References | PDF (1.8 MB) | EPUB
  • 3605 Views
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Article
Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and ex vivo evaluation
Rania S. Abdel-Rashid, Doaa A. Helal, Ahmed Adel Alaa-Eldin & Raghda Abdel-Monem
Pages: 294-304
Published online: 17 Jan 2022
AbstractforPolymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and ex vivo evaluation | Full Text | References | PDF (1.8 MB) | EPUB
  • 3906 Views
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Article
Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption
Yanzi Liang, Ruihuan Ding, Huihui Wang, Lanze Liu, Jibiao He, Yuping Tao, Zhenyu Zhao, Jie Zhang, Aiping Wang, Kaoxiang Sun, Youxin Li & Yanan Shi
Pages: 305-315
Published online: 17 Jan 2022
AbstractforOrally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption | Full Text | References | PDF (1.9 MB) | EPUB
  • 3934 Views
  • 10 CrossRef citations
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Article
Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA
Lu Guo, Dandan Shi, Mengmeng Shang, Xiao Sun, Dong Meng, Xinxin Liu, Xiaoying Zhou & Jie Li
Pages: 316-327
Published online: 17 Jan 2022
AbstractforUtilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA | Full Text | References | PDF (2.8 MB) | EPUB
  • 4027 Views
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Article
Preparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia
Laxman Subedi, Prashant Pandey, Jung-Hyun Shim, Ki-Taek Kim, Seung-Sik Cho, Kyo-Tan Koo, Beum Joon Kim & Jin Woo Park
Pages: 328-341
Published online: 18 Jan 2022
AbstractforPreparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia | Full Text | References | PDF (2.1 MB) | EPUB
  • 8072 Views
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Article
Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers
Youqiang Liu, Hongxin Zhang, Haijing Cui, Futong Zhang, Liyan Zhao, Yibing Liu & Qingju Meng
Pages: 342-350
Published online: 20 Jan 2022
AbstractforCombined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers | Full Text | References | PDF (1.4 MB) | EPUB
  • 4623 Views
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Article
Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs
Wenhao Xu, Jinli Yang, Xiangyang Gu, Wenjing Su, Faxiang Pu, Zhangfu Xie, Kongliang Jin, Weike Su & Lichan Mao
Pages: 351-363
Published online: 20 Jan 2022
AbstractforMechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs | Full Text | References | PDF (2.2 MB) | EPUB
  • 2866 Views
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Article
Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability
Dalia A. Gaber, Abdulrahman S. Alhuwaymili, Hessah S. Alhawas, Alhnouf A. Almutiri, Amal M. Alsubaiyel, Siham A. Abdoun & Reem A. Almutairi
Pages: 364-373
Published online: 24 Jan 2022
AbstractforSynthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability | Full Text | References | PDF (1.3 MB) | EPUB
  • 2332 Views
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Article
Hybrid thermosensitive-mucoadhesive in situ forming gels for enhanced corneal wound healing effect of L-carnosine
Zeinab Fathalla, Wesam W. Mustafa, Hamdy Abdelkader, Hossam Moharram, Ahmed Mohamed Sabry & Raid G. Alany
Pages: 374-385
Published online: 24 Jan 2022
AbstractforHybrid thermosensitive-mucoadhesive in situ forming gels for enhanced corneal wound healing effect of L-carnosine | Full Text | References | PDF (2.1 MB) | EPUB
  • 3774 Views
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Article
Improved transfer efficiency of supercharged 36 + GFP protein mediate nucleic acid delivery
Lidan Wang, Jingping Geng, Linlin Chen, Xiangli Guo, Tao Wang, Yanfen Fang, Bonn Belingon, Jiao Wu, Manman Li, Ying Zhan, Wendou Shang, Yingying Wan, Xuemei Feng, Xianghui Li & Hu Wang
Pages: 386-398
Published online: 25 Jan 2022
AbstractforImproved transfer efficiency of supercharged 36 + GFP protein mediate nucleic acid delivery | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 2775 Views
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Article
Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management
Wentao Deng, Yu Yan, Peipei Zhuang, Xiaoxu Liu, Ke Tian, Wenfang Huang & Cai Li
Pages: 399-412
Published online: 31 Jan 2022
AbstractforSynthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management | Full Text | References | PDF (3.5 MB) | EPUB
  • 3933 Views
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Article
Chitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors
Toaa A. Abdelrahman, Amira Motawea, Marwa S. El-Dahhan & Galal M. Abdelghani
Pages: 413-426
Published online: 31 Jan 2022
AbstractforChitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors | Full Text | References | PDF (2.1 MB) | EPUB
  • 2652 Views
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Article
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats
Sara M. Soliman, Shaimaa Mosallam, Mohamed A. Mamdouh, Mohammed Abdalla Hussein & Shady M. Abd El-Halim
Pages: 427-439
Published online: 31 Jan 2022
AbstractforDesign and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 3038 Views
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Article
Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis
Li Ma, Junfeng Wei, Yanli Zeng, Junping Liu, Erhui Xiao, Yuehua Kang & Yi Kang
Pages: 440-453
Published online: 31 Jan 2022
AbstractforMesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 7392 Views
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Article
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis
Caiwei Yu, Hui Liu, Chunjing Guo, Qiang Chen, Yanguo Su, Huimin Guo, Xiaoya Hou, Feng Zhao, Huaying Fan, Hui Xu, Yan Zhao, Xiaofeng Mu, Guohua Wang, Haiyu Xu & Daquan Chen
Pages: 454-465
Published online: 04 Feb 2022
AbstractforDextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis | Full Text | References | PDF (3.3 MB) | EPUB
  • 4229 Views
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Article
The combination of MnO2@Lipo-coated gefitinib and bevacizumab inhibits the development of non-small cell lung cancer
Jisong Zhang, Li Xu, Huihui Hu & Enguo Chen
Pages: 466-477
Published online: 11 Feb 2022
AbstractforThe combination of MnO2@Lipo-coated gefitinib and bevacizumab inhibits the development of non-small cell lung cancer | Full Text | References | PDF (3.7 MB) | EPUB
  • 3088 Views
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Article
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy
Peng He, Shenglin Xu, Zehao Guo, Peng Yuan, Yulei Liu, Yu Chen, Tiantian Zhang, Yukang Que & Yong Hu
Pages: 478-488
Published online: 11 Feb 2022
AbstractforPharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3671 Views
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Article
Microchannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery
Han Bi Ji, Jae Young Hong, Cho Rim Kim, Chang Hee Min, Jae Hoon Han, Min Ji Kim, Se-Na Kim, Cheol Lee & Young Bin Choy
Pages: 489-498
Published online: 11 Feb 2022
AbstractforMicrochannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2145 Views
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Article
Ion-pair compounds of diacerein for enhancing skin permeability in vitro: the compatibility–permeability relationship of counter ion and diacerein
Yan Liang, Manzhen Duan, Wei Yi, Teng Zhang, Yonggang Wang, Zhiming Wu & Huaibo Tang
Pages: 499-505
Published online: 11 Feb 2022
AbstractforIon-pair compounds of diacerein for enhancing skin permeability in vitro: the compatibility–permeability relationship of counter ion and diacerein | Full Text | References | PDF (1.3 MB) | EPUB
  • 1455 Views
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Article
Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy
Ning Zhang, Yibin Wu, Weiqi Xu, Zhenjian Li & Lu Wang
Pages: 506-518
Published online: 11 Feb 2022
AbstractforSynergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 3693 Views
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Article
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy
Meng Li, Xintong Bian, Xu Chen, Ningke Fan, Hongmi Zou, Yixi Bao & Yu Zhou
Pages: 519-533
Published online: 14 Feb 2022
AbstractforMultifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy | Full Text | References | PDF (4.2 MB) | EPUB
  • 4129 Views
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Article
Magnesium ascorbyl phosphate vesicular carriers for topical delivery; preparation, in-vitro and ex-vivo evaluation, factorial optimization and clinical assessment in melasma patients
Soha M. Kandil, Iman I. Soliman, Heba M. Diab, Nermeen I. Bedair, Marwa H. Mahrous & Ebtsam M. Abdou
Pages: 534-547
Published online: 14 Feb 2022
AbstractforMagnesium ascorbyl phosphate vesicular carriers for topical delivery; preparation, in-vitro and ex-vivo evaluation, factorial optimization and clinical assessment in melasma patients | Full Text | References | PDF (2.9 MB) | EPUB
  • 4955 Views
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Original Article

Article
Construction and performance of exendin-4-loaded chitosan–PLGA microspheres for enhancing implant osseointegration in type 2 diabetic rats
Shaojie Shi, Shuang Song, Xiangdong Liu, Guoqiang Zhao, Feng Ding, Wenshuang Zhao, Sijia Zhang, Yingliang Song & Wei Ma
Pages: 548-560
Published online: 14 Feb 2022
AbstractforConstruction and performance of exendin-4-loaded chitosan–PLGA microspheres for enhancing implant osseointegration in type 2 diabetic rats | Full Text | References | PDF (3.2 MB) | EPUB
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Research Articles

Article
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms
Xinyu Peng, Qi Han, Xuedong Zhou, Yanyan Chen, Xiaoyu Huang, Xiao Guo, Ruiting Peng, Haohao Wang, Xian Peng & Lei Cheng
Pages: 561-573
Published online: 14 Feb 2022
AbstractforEffect of pH-sensitive nanoparticles on inhibiting oral biofilms | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy
Daoyuan Chen, Peng Zhang, Minghui Li, Congcong Li, Xiaoyan Lu, Yiying Sun & Kaoxiang Sun
Pages: 574-587
Published online: 14 Feb 2022
AbstractforHyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 3847 Views
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Article
Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer
Jing Wang, Yan Zhang, GuangPeng Zhang, Li Xiang, HaoWen Pang, Kang Xiong, Yun Lu, JianMei Li, Jie Dai, Sheng Lin & ShaoZhi Fu
Pages: 588-599
Published online: 14 Feb 2022
AbstractforRadiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation
Uzma Gul, Muhammad Imran Khan, Asadullah Madni, Muhammad Farhan Sohail, Mubashar Rehman, Akhtar Rasul & Leena Peltonen
Pages: 600-612
Published online: 17 Feb 2022
AbstractforOlive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation | Full Text | References | PDF (2.8 MB) | EPUB
  • 5299 Views
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Article
Sustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma
Yujin Zhao, Chang Huang, Zhutian Zhang, Jiaxu Hong, Jianjiang Xu, Xinghuai Sun & Jianguo Sun
Pages: 613-623
Published online: 17 Feb 2022
AbstractforSustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma | Full Text | References | PDF (3.2 MB) | EPUB
  • 2855 Views
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Article
Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
Zhaoqing Shi, Jing Tang, Chuchu Lin, Ting Chen, Fan Zhang, Yuxing Huang, Ping Luan, Zhuo Xin, Qianqian Li & Lin Mei
Pages: 624-636
Published online: 17 Feb 2022
AbstractforConstruction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Review Article

Article
Nanocrystals based pulmonary inhalation delivery system: advance and challenge
Pengfei Yue, Weicheng Zhou, Guiting Huang, Fangfang Lei, Yingchong Chen, Zhilin Ma, Liru Chen & Ming Yang
Pages: 637-651
Published online: 21 Feb 2022
AbstractforNanocrystals based pulmonary inhalation delivery system: advance and challenge | Full Text | References | PDF (2.9 MB) | EPUB
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Research Articles

Article
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment
Heba M. K. Ebada, Maha M. A. Nasra, Rasha A. Nassra & Ossama Y. Abdallah
Pages: 652-663
Published online: 21 Feb 2022
AbstractforChondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2997 Views
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Article
Metal nanoparticles as a promising technology in targeted cancer treatment
Jia-Jie Xu, Wan-Chen Zhang, Ya-Wen Guo, Xiao-Yi Chen & You-Ni Zhang
Pages: 664-678
Published online: 25 Feb 2022
AbstractforMetal nanoparticles as a promising technology in targeted cancer treatment | Full Text | References | PDF (3.1 MB) | EPUB
  • 8645 Views
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Article
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models
Quan Rao, Guang-chao Ma, Hao Wu, Meng Li, Wei Xu, Guo-jun Wang, Dong Wang, Cong-en Zhang, Zhi-jie Ma & Zhong-tao Zhang
Pages: 679-691
Published online: 28 Feb 2022
AbstractforDendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models | Full Text | References | PDF (4.2 MB) | EPUB
  • 2646 Views
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Article
Delivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis
Tingfei Tan, Qi Huang, Weiwei Chu, Bo Li, Jingjing Wu, Quan Xia & Xi Cao
Pages: 692-701
Published online: 28 Feb 2022
AbstractforDelivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis | Full Text | References | PDF (2.1 MB) | EPUB
  • 3215 Views
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Article
Sonodynamical reversion of immunosuppressive microenvironment in prostate cancer via engineered exosomes
Dingyi Wang, Zhuo Wan, Qian Yang, Jianmei Chen, Yunnan Liu, Fan Lu & Jie Tang
Pages: 702-713
Published online: 03 Mar 2022
AbstractforSonodynamical reversion of immunosuppressive microenvironment in prostate cancer via engineered exosomes | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Article
Development and optimization of curcumin analog nano-bilosomes using 21.31 full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma: in-vitro evaluation, in-vivo safety assay
Haidy Abbas, Yasmin A. El-Feky, Majid Mohammad Al-Sawahli, Nehal M. EL-Deeb, Hala Bakr El-Nassan & Mariam Zewail
Pages: 714-727
Published online: 04 Mar 2022
AbstractforDevelopment and optimization of curcumin analog nano-bilosomes using 21.31 full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma: in-vitro evaluation, in-vivo safety assay | Full Text | References | PDF (2.5 MB) | EPUB
  • 3949 Views
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Article
Reassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery
Yuxin Chen, Lulu Han, Xiaoyan Qiu, Meng Wang, Zheng Chen, Ying Cai, Yong Xin, Yanfang Lv, Ankang Hu, Dafei Chai, Liantao Li, Huizhong Li, Junnian Zheng & Gang Wang
Pages: 728-742
Published online: 04 Mar 2022
AbstractforReassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery | Full Text | References | PDF (4.8 MB) | EPUB
  • 2636 Views
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Article
Design of hydroxy-α-sanshool loaded nanostructured lipid carriers as a potential local anesthetic
Fengming Tan, Lulu Xu, Yanling Liu, Huan Li, Dahan Zhang, Cuiying Qin, Yang Han & Jing Han
Pages: 743-753
Published online: 04 Mar 2022
AbstractforDesign of hydroxy-α-sanshool loaded nanostructured lipid carriers as a potential local anesthetic | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 2280 Views
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Article
Development of applicable thiol-linked antibody–drug conjugates with improved stability and therapeutic index
Yanming Wang, Fei Xie, Lianqi Liu, Xin Xu, Shiyong Fan, Wu Zhong & Xinbo Zhou
Pages: 754-766
Published online: 04 Mar 2022
AbstractforDevelopment of applicable thiol-linked antibody–drug conjugates with improved stability and therapeutic index | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage
Huirong Huang, Zijian Lou, Shimin Zheng, Jianing Wu, Qing Yao, Ruijie Chen, Longfa Kou & Daosen Chen
Pages: 767-791
Published online: 09 Mar 2022
AbstractforIntra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage | Full Text | References | PDF (4.1 MB) | EPUB
  • 8062 Views
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Article
Construction of pH-sensitive targeted micelle system co-delivery with curcumin and dasatinib and evaluation of anti-liver cancer
Xiangle Zeng, Yawen Zhang, Xue Xu, Zhuo Chen, Lanlan Ma, Yushuai Wang, Xuliang Guo, Jianchun Li & Xiu Wang
Pages: 792-806
Published online: 09 Mar 2022
AbstractforConstruction of pH-sensitive targeted micelle system co-delivery with curcumin and dasatinib and evaluation of anti-liver cancer | Full Text | References | PDF (4.5 MB) | EPUB
  • 3328 Views
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Article
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles
Mohammed W. Al-Rabia, Nabil A. Alhakamy, Waleed Y. Rizg, Adel F. Alghaith, Osama A. A. Ahmed & Usama A. Fahmy
Pages: 807-820
Published online: 10 Mar 2022
AbstractforBoosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles | Full Text | References | PDF (2.9 MB) | EPUB
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Article
D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes
Basant A. Habib, Nourtan F. Abdeltawab & Ibtehal Salah Ad-Din
Pages: 821-836
Published online: 10 Mar 2022
AbstractforD-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes | Full Text | References | PDF (3.2 MB) | EPUB
  • 2708 Views
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Article
Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study
Qing Luo, Jingjing Yang, Haohang Xu, Jieran Shi, Zhen Liang, Rui Zhang, Ping Lu, Guojuan Pu, Ningmin Zhao & Junjie Zhang
Pages: 837-855
Published online: 11 Mar 2022
AbstractforSorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study | Full Text | References | PDF (3.7 MB) | EPUB
  • 3046 Views
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Article
The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics
Qiuxia Yu, Minhua Li, Hanbin Chen, Lieqiang Xu, Juanjuan Cheng, Guoshu Lin, Yuhong Liu, Ziren Su, Xiaobo Yang, Yucui Li, Jiannan Chen & Jianhui Xie
Pages: 856-870
Published online: 11 Mar 2022
AbstractforThe discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Yijin Wang, Qianqian Ouyang, Xuefei Chang, Min Yang, Junpeng He, Yang Tian & Jun Sheng
Pages: 871-881
Published online: 11 Mar 2022
AbstractforAnti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2980 Views
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Article
Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment
Duy Toan Pham, Nguyen Thi Phuong Thao, Bui Thi Phuong Thuy, Van De Tran, Thanh Q. C. Nguyen & Ngoc Nha Thao Nguyen
Pages: 882-888
Published online: 11 Mar 2022
AbstractforSilk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment | Full Text | References | PDF (1.3 MB) | EPUB
  • 4231 Views
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Article
Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment
Xiangyu Zhang, Qingbin Liu, Tingting Zhang, Pei Gao, Hui Wang, Lu Yao, Jingwen Huang & Shulong Jiang
Pages: 889-905
Published online: 14 Mar 2022
AbstractforBone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 3076 Views
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Article
The protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis
Amira Motawea, Walaa Ebrahim Abd El Hady & Ghada Ahmed El-Emam
Pages: 906-924
Published online: 17 Mar 2022
AbstractforThe protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice
Ruifeng Mao, Menglan Yang, Rui Yang, Yingying Chen, Enjie Diao, Tong Zhang, Dengchao Li, Xin Chang, Zhenjing Chi & Yefu Wang
Pages: 925-936
Published online: 21 Mar 2022
AbstractforOral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice | Full Text | References | PDF (2 MB) | EPUB
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Article
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery
Qi-Rui Li, Hua-Zhen Xu, Rong-Cheng Xiao, Yan Liu, Jun-Ming Tang, Jian Li, Ting-Ting Yu, Bin Liu, Liu-Gen Li, Mei-Fang Wang, Ning Han, Yong-Hong Xu, Chao Wang, Naoki Komatsu, Li Zhao, Xing-Chun Peng, Tong-Fei Li & Xiao Chen
Pages: 937-949
Published online: 23 Mar 2022
AbstractforPlatelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 3928 Views
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Article
Predicting transdermal fentanyl delivery using physics-based simulations for tailored therapy based on the age
Flora Bahrami, René Michel Rossi & Thijs Defraeye
Pages: 950-969
Published online: 23 Mar 2022
AbstractforPredicting transdermal fentanyl delivery using physics-based simulations for tailored therapy based on the age | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 2633 Views
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Article
Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment
Kangkang Li, Xinlong Zang, Xiangjun Meng, Yanfeng Li, Yi Xie & Xuehong Chen
Pages: 970-985
Published online: 28 Mar 2022
AbstractforTargeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment | Full Text | References | PDF (4 MB) | EPUB
  • 3208 Views
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Article
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity
Peng Ji, Xianglong Wang, Jiabing Yin, Yi Mou, Haiqin Huang & Zhenkun Ren
Pages: 986-996
Published online: 01 Apr 2022
AbstractforSelective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2817 Views
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Article
Green synthesis and characterization of gold nanoparticles from Pholiota adiposa and their anticancer effects on hepatic carcinoma
Zhongwei Yang, Zijing Liu, Junmo Zhu, Jie Xu, Youwei Pu & Yixi Bao
Pages: 997-1006
Published online: 01 Apr 2022
AbstractforGreen synthesis and characterization of gold nanoparticles from Pholiota adiposa and their anticancer effects on hepatic carcinoma | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2194 Views
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Review Article

Review
Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications
Victoria Dupuis, Constantin Cerbu, Lucjan Witkowski, Adrian-Valentin Potarniche, Maria Cristina Timar, Monika Żychska & Cristina M. Sabliov
Pages: 1007-1024
Published online: 01 Apr 2022
AbstractforNanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications | Full Text | References | PDF (2.4 MB) | EPUB
  • 4298 Views
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Research Articles

Article
Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy
Xiu Zheng, Xin Yu, Chenglong Wang, Yan Liu, Ming Jia, Fenting Lei, Ji Tian & Chunhong Li
Pages: 1025-1037
Published online: 01 Apr 2022
AbstractforTargeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 4128 Views
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Article
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs
Camila J. Picco, Juan Domínguez-Robles, Emilia Utomo, Alejandro J. Paredes, Fabiana Volpe-Zanutto, Dessislava Malinova, Ryan F. Donnelly & Eneko Larrañeta
Pages: 1038-1048
Published online: 01 Apr 2022
Abstractfor3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs | Full Text | References | PDF (2.7 MB) | EPUB
  • 3717 Views
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Article
Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment
Sahand Mazloum-Ravasan, Maryam Mohammadi, Elaheh Madadi Hiagh, Alireza Ebrahimi, Joo-Hyun Hong, Hamed Hamishehkar & Ki Hyun Kim
Pages: 1049-1059
Published online: 01 Apr 2022
AbstractforNano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment | Full Text | References | PDF (2.7 MB) | EPUB
  • 2824 Views
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Article
Gemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery
Sankha Bhattacharya, Md Meraj Anjum & Krishna Kumar Patel
Pages: 1060-1074
Published online: 01 Apr 2022
AbstractforGemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery | Full Text | References | PDF (2.9 MB) | EPUB
  • 3545 Views
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Article
Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration
Luxi Peng, Jiajun Qiu, Lidan Liu, Xiaoyu Li, Xuanyong Liu & Yongjun Zhang
Pages: 1075-1085
Published online: 04 Apr 2022
AbstractforPreparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration | Full Text | References | PDF (3.8 MB) | EPUB
  • 3378 Views
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Article
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy
Ning Guo, Yu Xia, Weishen Zeng, Jia Chen, Quanxin Wu, Yaxin Shi, Guoying Li, Zhuoyi Huang, Guanhai Wang & Yun Liu
Pages: 1086-1099
Published online: 04 Apr 2022
AbstractforAlginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 3624 Views
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Article
Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal
Rofida Albash, Maha H. Ragaie, Mahmoud A. El Hassab, Radwan El-Haggar, Wagdy M. Eldehna, Sara T. Al-Rashood & Shaimaa Mosallam
Pages: 1100-1111
Published online: 04 Apr 2022
AbstractforFenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2507 Views
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Article
In vitro and in vivo characterization of Entacapone-loaded nanostructured lipid carriers developed by quality-by-design approach
Yogeeta Agrawal, Kiran Patil, Hitendra Mahajan, Mrugendra Potdar, Pratiksha Joshi, Kartik Nakhate, Charu Sharma, Sameer N. Goyal & Shreesh Ojha
Pages: 1112-1121
Published online: 05 Apr 2022
AbstractforIn vitro and in vivo characterization of Entacapone-loaded nanostructured lipid carriers developed by quality-by-design approach | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Pulmonary delivery of resveratrol-β-cyclodextrin inclusion complexes for the prevention of zinc chloride smoke-induced acute lung injury
Wanmei Wang, Yan Liu, Pan Pan, Yueqi Huang, Ting Chen, Tianyu Yuan, Yulong Ma, Guang Han, Jiahuan Li, Yiguang Jin & Fei Xie
Pages: 1122-1131
Published online: 05 Apr 2022
AbstractforPulmonary delivery of resveratrol-β-cyclodextrin inclusion complexes for the prevention of zinc chloride smoke-induced acute lung injury | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Modification of sodium aescinate into a safer, more stable and effective water-soluble drug by liposome-encapsulation: an in vitro and in vivo study
Sifan Huang, Xinyu Wang, Mengmeng Liu, Zhizhe Lin, Wenqian Gu, Haili Zhao, Yanqiu Zhang, Baoyue Ding, Jiyong Liu, Xin Wu, Wei Fan & Jianming Chen
Pages: 1132-1141
Published online: 05 Apr 2022
AbstractforModification of sodium aescinate into a safer, more stable and effective water-soluble drug by liposome-encapsulation: an in vitro and in vivo study | Full Text | References | PDF (2.1 MB) | EPUB
  • 2891 Views
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Article
Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges
Shangyong Li, Hui Zhang, Kaiwei Chen, Mengfei Jin, Son Hai Vu, Samil Jung, Ningning He, Zhou Zheng & Myeong-Sok Lee
Pages: 1142-1149
Published online: 06 Apr 2022
AbstractforApplication of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges | Full Text | References | PDF (959.2 KB) | EPUB
  • 11428 Views
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Article
Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment
Salma El-Sayed Radwan, Riham M. El-Moslemany, Radwa A. Mehanna, Eman H. Thabet, Elsayeda-Zeinab A. Abdelfattah & Amal El-Kamel
Pages: 1150-1163
Published online: 06 Apr 2022
AbstractforChitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment | Full Text | References | PDF (2.6 MB) | EPUB
  • 3454 Views
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Article
Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation
Jing Zheng, Yixuan Sun, Tengfei Long, Dong Yuan, Song Yue, Ni Zhang & Zhu Yang
Pages: 1164-1175
Published online: 08 Apr 2022
AbstractforSonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 4081 Views
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Article
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3
Dennison Trinh, Joanne Nash, David Goertz, Kullervo Hynynen, Sharshi Bulner, Umar Iqbal & James Keenan
Pages: 1176-1183
Published online: 08 Apr 2022
AbstractforMicrobubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3 | Full Text | References | PDF (1.3 MB) | EPUB
  • 4871 Views
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Article
Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives
Xue-Jun Wang, Jian Cheng, Le-Yi Zhang & Jun-Gang Zhang
Pages: 1184-1200
Published online: 09 Apr 2022
AbstractforSelf-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives | Full Text | References | PDF (2.7 MB) | EPUB
  • 3693 Views
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Article
Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer
Zhian Chen, Zhenhao Li, Chuangji Li, Huilin Huang, Yingxin Ren, Zhenyuan Li, Yanfeng Hu & Weihong Guo
Pages: 1201-1211
Published online: 09 Apr 2022
AbstractforManganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment
Shymaa Hatem, Seham A. Elkheshen, Amany O. Kamel, Maha Nasr, Noha H. Moftah, Maha H Ragai, Reham S. Elezaby & Nada M. El Hoffy
Pages: 1212-1231
Published online: 09 Apr 2022
AbstractforFunctionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin
Ming Yuan, Jiangxiu Niu, Qinghan Xiao, Huiyuan Ya, Yansong Zhang, Yanli Fan, Lingmei Li & Xueke Li
Pages: 1232-1242
Published online: 09 Apr 2022
AbstractforHyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin | Full Text | References | PDF (2.5 MB) | EPUB
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Article
A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer
Shiming He, Chunyan Zhao, Hongyu Tao, Weijin Sheng, Ruijuan Gao, Xiujun Liu & Yongsu Zhen
Pages: 1243-1256
Published online: 13 Apr 2022
AbstractforA recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis
Hongya Xie, Jie Yao, Yuxuan Wang & Bin Ni
Pages: 1257-1271
Published online: 25 Apr 2022
AbstractforExosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Article
Inflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment
Yingke Liu, Xingying Qi, Yashi Wang, Man Li, Quan Yuan & Zhihe Zhao
Pages: 1272-1281
Published online: 25 Apr 2022
AbstractforInflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Article
Preparation of baicalin-loaded ligand-modified nanoparticles for nose-to-brain delivery for neuroprotection in cerebral ischemia
Xinxin Li, Shuling Li, Chun Ma, Tieshu Li & Lihua Yang
Pages: 1282-1298
Published online: 25 Apr 2022
AbstractforPreparation of baicalin-loaded ligand-modified nanoparticles for nose-to-brain delivery for neuroprotection in cerebral ischemia | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 3425 Views
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Article
Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats
Nermin M. Sheta, Sylvia A. Boshra, Mohamed A. Mamdouh & Khaled M. Abdel-Haleem
Pages: 1299-1311
Published online: 26 Apr 2022
AbstractforDesign and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats | Full Text | References | PDF (2.1 MB) | EPUB
  • 1464 Views
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Article
Chidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy
Sizhen Wang, Zhiqiang Ma, Zhang Shi, Ying Huang, Tianheng Chen, Lei Hou, Tao Jiang & Feng Yang
Pages: 1312-1325
Published online: 27 Apr 2022
AbstractforChidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 1855 Views
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Article
The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery
Shrirang V. Ranade, Mark R. Wieland, Tammy Tam, Jennifer C. Rea, Judit Horvath, Aaron R. Hieb, Weitao Jia, Lori Grace, Giulio Barteselli & Jay M. Stewart
Pages: 1326-1334
Published online: 02 May 2022
AbstractforThe Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 4388 Views
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Article
Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy
Fan Shi, Yanli Liu, Xuexiao Zhou, Pei Shen, Ran Xue & Min Zhang
Pages: 1335-1344
Published online: 04 May 2022
AbstractforDisitamab vedotin: a novel antibody-drug conjugates for cancer therapy | Full Text | References | PDF (1.2 MB) | EPUB
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Article

Article
Assessment of antifungal efficacy of itraconazole loaded aspasomal cream: comparative clinical study
Caroline Lamie, Enas Elmowafy, Maha H. Ragaie, Dalia A. Attia & Nahed D. Mortada
Pages: 1345-1357
Published online: 04 May 2022
AbstractforAssessment of antifungal efficacy of itraconazole loaded aspasomal cream: comparative clinical study | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Articles

Article
Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy
Xiaoxian Huang, Lingfei Han, Ruyi Wang, Wanfang Zhu, Ning Zhang, Wei Qu, Wenyuan Liu, Fulei Liu, Feng Feng & Jingwei Xue
Pages: 1358-1369
Published online: 04 May 2022
AbstractforDual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1983 Views
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Article
Combinatorial therapeutic strategies for enhanced delivery of therapeutics to brain cancer cells through nanocarriers: current trends and future perspectives
Xiande Wang, Cheng Wu, Shiming Liu & Deqing Peng
Pages: 1370-1383
Published online: 09 May 2022
AbstractforCombinatorial therapeutic strategies for enhanced delivery of therapeutics to brain cancer cells through nanocarriers: current trends and future perspectives | Full Text | References | PDF (2 MB) | EPUB
  • 2374 Views
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Article
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases
Rita Sala, Elisa Rioja-Blanco, Naroa Serna, Laura Sánchez-García, Patricia Álamo, Lorena Alba-Castellón, Isolda Casanova, Antonio López-Pousa, Ugutz Unzueta, María Virtudes Céspedes, Esther Vázquez, Antonio Villaverde & Ramon Mangues
Pages: 1384-1397
Published online: 09 May 2022
AbstractforGSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases | Full Text | References | PDF (3.5 MB) | EPUB
  • 2608 Views
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Article
Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity
Dabu Zhu, Qiuqin Zhang, Yifang Chen, Minghua Xie, Jianbo Li, Shen Yao, Ming Li, Zhao Lou, Yue Cai & Xuanrong Sun
Pages: 1398-1408
Published online: 09 May 2022
AbstractforMechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity | Full Text | References | PDF (2.6 MB) | EPUB
  • 1542 Views
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Article
Unraveling enhanced brain delivery of paliperidone-loaded lipid nanoconstructs: pharmacokinetic, behavioral, biochemical, and histological aspects
Saleha Rehman, Bushra Nabi, Amaan Javed, Tahira Khan, Ashif Iqubal, Mohammad Javed Ansari, Sanjula Baboota & Javed Ali
Pages: 1409-1422
Published online: 09 May 2022
AbstractforUnraveling enhanced brain delivery of paliperidone-loaded lipid nanoconstructs: pharmacokinetic, behavioral, biochemical, and histological aspects | Full Text | References | PDF (3 MB) | EPUB
  • 1908 Views
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Article
Artificial intelligence-assisted development of in situ forming nanoparticles for arthritis therapy via intra-articular delivery
Ahmed S. Yacoub, Hussein O. Ammar, Magdy Ibrahim, Suzan M. Mansour & Nada M. El Hoffy
Pages: 1423-1436
Published online: 09 May 2022
AbstractforArtificial intelligence-assisted development of in situ forming nanoparticles for arthritis therapy via intra-articular delivery | Full Text | References | PDF (2.4 MB) | EPUB
  • 2633 Views
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Article
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo
Yue Su, Jia Liu, Songwen Tan, Wenfang Liu, Rongrong Wang & Chuanpin Chen
Pages: 1437-1446
Published online: 09 May 2022
AbstractforPLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization
Qiu-Chen Bi, Jian-Jun Tang, Jun Zhao, Yang-Feng Lv, Zhi-Qiang Deng, Hong Chen, Yu-Hua Xu, Chuan-Sheng Xie, Qing-Rong Liang, Rong-Guang Luo & Qun Tang
Pages: 1447-1456
Published online: 09 May 2022
AbstractforSevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2166 Views
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Article
Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment
Jianyong Ma, Bingzhu Wang, Haibin Shao, Songou Zhang, Xiaozhen Chen, Feize Li & Wenqing Liang
Pages: 1457-1476
Published online: 09 May 2022
AbstractforHydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment | Full Text | References | PDF (3.3 MB) | EPUB
  • 3989 Views
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Article
Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, in vitro, and in vivo evaluation
Wedad Sakran, Rania S. Abdel-Rashid, Fatma Saleh & Raghda Abdel-Monem
Pages: 1477-1491
Published online: 11 May 2022
AbstractforEthosomal gel for rectal transmucosal delivery of domperidone: design of experiment, in vitro, and in vivo evaluation | Full Text | References | PDF (2.5 MB) | EPUB
  • 2378 Views
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Article
Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations
Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd Wasim, Mohamed A. Alfaleh, Shadab Md, Sanjula Baboota, Javed Ali & Syed Ehtaishamul Haque
Pages: 1492-1511
Published online: 11 May 2022
AbstractforPathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations | Full Text | References | PDF (2.6 MB) | EPUB
  • 3225 Views
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Article
Formulation and characterization of eprosartan mesylate and β-cyclodextrin inclusion complex prepared by microwave technology
Abdul Ahad, Yousef A. Bin Jardan, Mohd. Zaheen Hassan, Mohammad Raish, Ajaz Ahmad, Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi
Pages: 1512-1522
Published online: 13 May 2022
AbstractforFormulation and characterization of eprosartan mesylate and β-cyclodextrin inclusion complex prepared by microwave technology | Full Text | References | PDF (2.3 MB) | EPUB
  • 1460 Views
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Article
Complex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy
Muhammad Sohail, Bin Yu, Zheng Sun, Jiali Liu, Yanli Li, Feng Zhao, Daquan Chen, Xin Yang & Hui Xu
Pages: 1523-1535
Published online: 25 May 2022
AbstractforComplex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy | Full Text | References | PDF (2.6 MB) | EPUB
  • 2045 Views
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Article
Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells
Zuhier A. Awan, Shareefa A. AlGhamdi, Nabil A. Alhakamy, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Mohammed A. S. Abourehab, Hani Z. Asfour, Shadi A. Zakai, Mohammad W. Alrabia, Aya A. Negm, Mohamed A. El-Moselhy, Sara S. Sharkawi & Waleed Y. Rizg
Pages: 1536-1548
Published online: 25 May 2022
AbstractforOptimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells | Full Text | References | PDF (3 MB) | EPUB
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Article
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects
Amr Maged, Reda Abdelbaset, Azza A. Mahmoud & Nermeen A. Elkasabgy
Pages: 1549-1570
Published online: 25 May 2022
AbstractforMerits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects | Full Text | References | PDF (3 MB) | EPUB
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Article
Combination of chemotherapy and immune checkpoint therapy by the immunoconjugates-based nanocomplexes synergistically improves therapeutic efficacy in SCLC
Zhang Tao, Xingwang Kuai, Guangwei Wang, Sanfeng Liu, Kai Liu, Heng Zhang, Shujing Xia & Hua Zhu
Pages: 1571-1581
Published online: 25 May 2022
AbstractforCombination of chemotherapy and immune checkpoint therapy by the immunoconjugates-based nanocomplexes synergistically improves therapeutic efficacy in SCLC | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment
Abeer A. Musallam, M. A. Mahdy, Hanan M. Elnahas & Reem A. Aldeeb
Pages: 1582-1594
Published online: 25 May 2022
AbstractforOptimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment | Full Text | References | PDF (3.1 MB) | EPUB
  • 1957 Views
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Article
Biodegradable gemcitabine-loaded microdevice with sustained local drug delivery and improved tumor recurrence inhibition abilities for postoperative pancreatic tumor treatment
Xiangming Kong, Miao Feng, Lihuang Wu, Yiyan He, Hongli Mao & Zhongwei Gu
Pages: 1595-1607
Published online: 25 May 2022
AbstractforBiodegradable gemcitabine-loaded microdevice with sustained local drug delivery and improved tumor recurrence inhibition abilities for postoperative pancreatic tumor treatment | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 1957 Views
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Article
Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer
Zhiqin Zhang, Kaixin Wang, Manting Liu, Panxiang Hu, Yuchen Xu, Dongge Yin, Yuchang Yang, Xiaoxv Dong, Changhai Qu, Lu Zhang, Jian Ni & Xingbin Yin
Pages: 1608-1619
Published online: 25 May 2022
AbstractforPhototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 1889 Views
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Article
Targeting interleukin-13 receptor α2 (IL-13Rα2) for glioblastoma therapy with surface functionalized nanocarriers
Ruijia Liang, Cheng Wu, Shiming Liu & Wenyan Zhao
Pages: 1620-1630
Published online: 25 May 2022
AbstractforTargeting interleukin-13 receptor α2 (IL-13Rα2) for glioblastoma therapy with surface functionalized nanocarriers | Full Text | References | PDF (1.4 MB) | EPUB
  • 2661 Views
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Article
Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations
Ruyi Shao, Yeben Wang, Laifeng Li, Yongqiang Dong, Jiayi Zhao & Wenqing Liang
Pages: 1631-1647
Published online: 25 May 2022
AbstractforBone tumors effective therapy through functionalized hydrogels: current developments and future expectations | Full Text | References | PDF (3 MB) | EPUB
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Article
Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease
Jiao Wang, Liang Kong, Rui-Bo Guo, Si-Yu He, Xin-Ze Liu, Lu Zhang, Yang Liu, Yang Yu, Xue-Tao Li & Lan Cheng
Pages: 1648-1662
Published online: 26 May 2022
AbstractforMultifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 3198 Views
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Article
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management
Mariam Zewail, Passent M. E. Gaafar, Mai M. Ali & Haidy Abbas
Pages: 1663-1674
Published online: 26 May 2022
AbstractforLipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management | Full Text | References | PDF (2 MB) | EPUB
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Article
Targeted inhibition of methicillin-resistant Staphylococcus aureus biofilm formation by a graphene oxide-loaded aptamer/berberine bifunctional complex
Yi Ning, Xiaoqi Wang, Pingan Chen, Shiwu Liu, Jue Hu, Rong Xiao, Ling Li & Fangguo Lu
Pages: 1675-1683
Published online: 26 May 2022
AbstractforTargeted inhibition of methicillin-resistant Staphylococcus aureus biofilm formation by a graphene oxide-loaded aptamer/berberine bifunctional complex | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Recent advances in anti-multidrug resistance for nano-drug delivery system
Changduo Wang, Fashun Li, Tianao Zhang, Min Yu & Yong Sun
Pages: 1684-1697
Published online: 26 May 2022
AbstractforRecent advances in anti-multidrug resistance for nano-drug delivery system | Full Text | References | PDF (1.9 MB) | EPUB
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Article
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy
Zhao Li, Tianshan She, Hao Yang, Tao Su, Qiuxiao Shi, Ze Tao, Yanru Feng, Fen Yang, Jingqiu Cheng & Xiaofeng Lu
Pages: 1698-1711
Published online: 30 May 2022
AbstractforA novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 2310 Views
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Article
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer
Yao Xiao, Wenxia Yao, Mingzhen Lin, Wei Huang, Ben Li, Bin Peng, Qinhai Ma, Xinke Zhou & Min Liang
Pages: 1712-1725
Published online: 30 May 2022
AbstractforIcaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 4181 Views
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Article
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling
Salma A. Fereig, Ghada M. El-Zaafarany, Mona G. Arafa & Mona M. A. Abdel-Mottaleb
Pages: 1726-1742
Published online: 30 May 2022
AbstractforBoosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Article
Intratumoral Pi deprivation benefits chemoembolization therapy via increased accumulation of intracellular doxorubicin
Yang-Feng Lv, Zhi-Qiang Deng, Qiu-Chen Bi, Jian-Jun Tang, Hong Chen, Chuan-Sheng Xie, Qing-Rong Liang, Yu-Hua Xu, Rong-Guang Luo & Qun Tang
Pages: 1743-1753
Published online: 30 May 2022
AbstractforIntratumoral Pi deprivation benefits chemoembolization therapy via increased accumulation of intracellular doxorubicin | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 1676 Views
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Article
A non-invasive direct nose to brain drug delivery platform vs. invasive brain delivery approach: patient-centered care impact analysis
Ayala Kobo-Greenhut, Hilel Frankenthal, Aziz Darawsha, Avraham Karasik, Adit Zohar Beja, Tamir Ben Hur, Dana Ekstein, Lisa Amir, Daniel Shahaf, Izhar Ben Shlomo, Iris Shichor & William H. Frey
Pages: 1754-1763
Published online: 30 May 2022
AbstractforA non-invasive direct nose to brain drug delivery platform vs. invasive brain delivery approach: patient-centered care impact analysis | Full Text | References | PDF (943.6 KB) | EPUB | Supplemental
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Article
Legumain/pH dual-responsive lytic peptide–paclitaxel conjugate for synergistic cancer therapy
Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li & Xuanrong Sun
Pages: 1764-1775
Published online: 31 May 2022
AbstractforLegumain/pH dual-responsive lytic peptide–paclitaxel conjugate for synergistic cancer therapy | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2700 Views
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Article
Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats
Nabil A. Alhakamy, Gamal A. Mohamed, Usama A. Fahmy, Basma G. Eid, Mohammed W. Al-Rabia, Amgad I. M. Khedr, Mohammed Z. Nasrullah, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Osama A. A. Ahmed & Shadab Md
Pages: 1776-1784
Published online: 01 Jun 2022
AbstractforThioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats | Full Text | References | PDF (2.5 MB) | EPUB
  • 2300 Views
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Article
Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles
Hongmi Zou, Meng Li, Xing Li, Wendi Zheng, Hongyu Kuang, Menglei Wang, Wenli Zhang, Haitao Ran, Huafeng Ma & Xiyuan Zhou
Pages: 1785-1799
Published online: 01 Jun 2022
AbstractforMultimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 2737 Views
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Article
Pentapeptide modified ethosomes for enhanced skin retention and topical efficacy activity of indomethacin
Jiangxiu Niu, Ming Yuan, Hongying Li, Yao Liu, Liye Wang, Yanli Fan, Yansong Zhang, Xianghui Liu, Lingmei Li, Jingxiao Zhang & Chenyu Zhao
Pages: 1800-1810
Published online: 03 Jun 2022
AbstractforPentapeptide modified ethosomes for enhanced skin retention and topical efficacy activity of indomethacin | Full Text | References | PDF (2.3 MB) | EPUB
  • 1627 Views
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Review Article

Review
Self-emulsifying drug delivery systems: a novel approach to deliver drugs
Ahmad Salawi
Pages: 1811-1823
Published online: 06 Jun 2022
AbstractforSelf-emulsifying drug delivery systems: a novel approach to deliver drugs | Full Text | References | PDF (1.1 MB) | EPUB
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Research Articles

Article
Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition
Dan Chen, Yurong Liu, Peiwen Liu, Yang Zhou, Longguang Jiang, Cai Yuan & Mingdong Huang
Pages: 1824-1835
Published online: 08 Jun 2022
AbstractforOrally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2334 Views
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Article
Design and optimization of ganciclovir solid dispersion for improving its bioavailability
Dalia A. Gaber, Manar A. Alnwiser, Nadia L. Alotaibi, Rawan A. Almutairi, Sumaih S. Alsaeed, Siham A. Abdoun & Amal M. Alsubaiyel
Pages: 1836-1847
Published online: 08 Jun 2022
AbstractforDesign and optimization of ganciclovir solid dispersion for improving its bioavailability | Full Text | References | PDF (1.4 MB) | EPUB
  • 2071 Views
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Article
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, and in vivo reno-protective effect in cisplatin induced nephrotoxicity
Badriyah Alotaibi, Thanaa A. El-Masry, Engy Elekhnawy, Aya H. El-Kadem, Asmaa Saleh, Walaa A. Negm & Dalia H. Abdelkader
Pages: 1848-1862
Published online: 16 Jun 2022
AbstractforAqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, and in vivo reno-protective effect in cisplatin induced nephrotoxicity | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 2199 Views
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Article
Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells
Usama A. Fahmy, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Nabil A. Alhakamy, Osama A. A. Ahmed, Mohamed F. Radwan, Basma G. Eid, Shaban R. M. Sayed, Gamal A. El Sherbiny & Walaa Abualsunun
Pages: 1863-1877
Published online: 16 Jun 2022
AbstractforPotentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells | Full Text | References | PDF (2.8 MB) | EPUB
  • 1832 Views
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Article
Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo
Chao Pi, Wenmei Zhao, Mingtang Zeng, Jiyuan Yuan, Hongping Shen, Ke Li, Zhilian Su, Zerong Liu, Jie Wen, Xinjie Song, Robert J. Lee, Yumeng Wei & Ling Zhao
Pages: 1878-1891
Published online: 24 Jun 2022
AbstractforAnti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Enhanced healing efficacy of an optimized gabapentin-melittin nanoconjugate gel-loaded formulation in excised wounds of diabetic rats
Hani Z. Asfour, Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md, Mohamed A. El-Moselhy, Waleed Y. Rizg, Adel F. Alghaith, Basma G. Eid & Ashraf B. Abdel-Naim
Pages: 1892-1902
Published online: 24 Jun 2022
AbstractforEnhanced healing efficacy of an optimized gabapentin-melittin nanoconjugate gel-loaded formulation in excised wounds of diabetic rats | Full Text | References | PDF (3.2 MB) | EPUB
  • 2327 Views
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Article
ROS-sensitive calcipotriol nano-micelles prepared by methoxypolyethylene glycol (mPEG) – modified polymer for the treatment of psoriasis
Yulin Hua, Tiantian Chang, Kun Jiang, Jinhong Wang, Xiaodong Cui, Min Cheng, Fang Yan, Bo Song & Yuzhen Wang
Pages: 1903-1913
Published online: 24 Jun 2022
AbstractforROS-sensitive calcipotriol nano-micelles prepared by methoxypolyethylene glycol (mPEG) – modified polymer for the treatment of psoriasis | Full Text | References | PDF (3.2 MB) | EPUB
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Review Article

Review
Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy
Tingwei Peng, Tianzhao Xu & Xinghui Liu
Pages: 1914-1933
Published online: 24 Jun 2022
AbstractforResearch progress of the engagement of inorganic nanomaterials in cancer immunotherapy | Full Text | References | PDF (2.5 MB) | EPUB
  • 2178 Views
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Review

Review
Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis
Yanyan Zhang, Zhaoju Gao, Shushu Chao, Wenjuan Lu & Pingping Zhang
Pages: 1934-1950
Published online: 27 Jun 2022
AbstractforTransdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis | Full Text | References | PDF (1.8 MB) | EPUB
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Research Articles

Article
Targeted peptide-modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancer in vitro
Shanshan Wang, Wei Wu, Ying Liu, Chunhui Wang, Qing Xu, Qianzhou Lv, Rongqin Huang & Xiaoyu Li
Pages: 1951-1958
Published online: 27 Jun 2022
AbstractforTargeted peptide-modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancer in vitro | Full Text | References | PDF (1.7 MB) | EPUB
  • 1646 Views
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Article
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems
Rajiv Bajracharya, Jae Geun Song, Basavaraj Rudragouda Patil, Sang Hoon Lee, Hye-Mi Noh, Da-Hyun Kim, Gyu-Lin Kim, Soo-Hwa Seo, Ji-Won Park, Seong Hoon Jeong, Chang Hoon Lee & Hyo-Kyung Han
Pages: 1959-1970
Published online: 28 Jun 2022
AbstractforFunctional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid
Aixa Aguilera-Garrido, Elena Arranz, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González & Linda Giblin
Pages: 1971-1982
Published online: 28 Jun 2022
AbstractforSolid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2326 Views
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Article
Green synthesized gold nanoparticles from Pseudobulbus Cremastrae seu Pleiones show efficacy against hepatic carcinoma potentially through immunoregulation
Junmo Zhu, Zijing Liu, Youwei Pu, Jie Xu, Sitong Zhang & Yixi Bao
Pages: 1983-1993
Published online: 28 Jun 2022
AbstractforGreen synthesized gold nanoparticles from Pseudobulbus Cremastrae seu Pleiones show efficacy against hepatic carcinoma potentially through immunoregulation | Full Text | References | PDF (1.9 MB) | EPUB
  • 1735 Views
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Article
Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia
Peng Sun, Haoliang Wu, Hao He, Liwei Zhang, Yuanfeng Liu, Cong Zhang, Chunyang Lou, Jingan Li & Hualong Bai
Pages: 1994-2001
Published online: 28 Jun 2022
AbstractforDelivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Fabrication of bio-engineered chitosan nanoformulations to inhibition of bacterial infection and to improve therapeutic potential of intestinal microflora, intestinal morphology, and immune response in infection induced rat model
Xiao Wan, Liu Liu, Lu Ding & Zhiqiang Zhu
Pages: 2002-2016
Published online: 29 Jun 2022
AbstractforFabrication of bio-engineered chitosan nanoformulations to inhibition of bacterial infection and to improve therapeutic potential of intestinal microflora, intestinal morphology, and immune response in infection induced rat model | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats
Hussam Murad, Osama Ahmed, Thamer Alqurashi & Mostafa Hussien
Pages: 2017-2028
Published online: 29 Jun 2022
AbstractforOlmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats | Full Text | References | PDF (3.4 MB) | EPUB
  • 1540 Views
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Article
Phenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen delivery in cancer immunotherapy
Qiyan Wang, Zhipeng Dong, Fangning Lou, Yunxue Yin, Jiahao Zhang, Hanning Wen, Tao Lu & Yue Wang
Pages: 2029-2043
Published online: 29 Jun 2022
AbstractforPhenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen delivery in cancer immunotherapy | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1862 Views
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Article
Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro
Ke Li, Chao Pi, Jie Wen, Yingmeng He, Jiyuan Yuan, Hongping Shen, Wenmei Zhao, Mingtang Zeng, Xinjie Song, Robert J. Lee, Yumeng Wei & Ling Zhao
Pages: 2044-2057
Published online: 01 Jul 2022
AbstractforFormulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro | Full Text | References | PDF (2 MB) | EPUB
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RESEARCH ARTICLE

Article
Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation
Mohammed H. Elkomy, Shahira F. El Menshawe, Rasha M. Kharshoum, Amany M. Abdeltwab, Raghda R. S. Hussein, Doaa S. Hamad, Izzeddin Alsalahat & Heba M. Aboud
Pages: 2058-2071
Published online: 08 Jul 2022
AbstractforInnovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation | Full Text | References | PDF (2.1 MB) | EPUB
  • 1909 Views
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Research Articles

Article
Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance
Muhammad Umair Amin, Sajid Ali, Muhammad Yasir Ali, Dominik C. Fuhrmann, Imran Tariq, Benjamin S. Seitz, Eduard Preis, Jana Brüßler, Bernhard Brüne & Udo Bakowsky
Pages: 2072-2085
Published online: 17 Jul 2022
AbstractforCo-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1561 Views
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Article
Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels
Ajmal Zarinwall, Viktor Maurer, Jennifer Pierick, Victor Marcus Oldhues, Julian Cedric Porsiel, Jan Henrik Finke & Georg Garnweitner
Pages: 2086-2099
Published online: 15 Jul 2022
AbstractforAmorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Nanoparticles-based anti-aging treatment of Alzheimer’s disease
Jian-Jian Chu, Wen-Bo Ji, Jian-Hua Zhuang, Bao-Feng Gong, Xiao-Han Chen, Wen-Bin Cheng, Wen-Danqi Liang, Gen-Ru Li, Jie Gao & You Yin
Pages: 2100-2116
Published online: 19 Jul 2022
AbstractforNanoparticles-based anti-aging treatment of Alzheimer’s disease | Full Text | References | PDF (8.9 MB) | EPUB
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Article
PLGA-modified Syloid®-based microparticles for the ocular delivery of terconazole: in-vitro and in-vivo investigations
Nada Zaghloul, Azza A. Mahmoud, Nermeen A. Elkasabgy & Nada M. El Hoffy
Pages: 2117-2129
Published online: 15 Jul 2022
AbstractforPLGA-modified Syloid®-based microparticles for the ocular delivery of terconazole: in-vitro and in-vivo investigations | Full Text | References | PDF (2.2 MB) | EPUB
  • 1540 Views
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Review

Review
Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review
Bingqian Li, Huili Shao, Lei Gao, Huan Li, Huagang Sheng & Liqiao Zhu
Pages: 2130-2161
Published online: 10 Jul 2022
AbstractforNano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review | Full Text | References | PDF (2.8 MB) | EPUB
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Research Articles

Article
Implementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo assessment
Diana Aziz, Sally Mohamed, Saadia Tayel & Amal Makhlouf
Pages: 2162-2176
Published online: 10 Jul 2022
AbstractforImplementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo assessment | Full Text | References | PDF (1.6 MB) | EPUB
  • 1339 Views
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Article
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity
Mengmeng Li, Ya Zhu, Chao Yang, Mi Yang, Haitao Ran, Yefeng Zhu & Wei Zhang
Pages: 2177-2189
Published online: 10 Jul 2022
AbstractforAcoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2597 Views
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Article
Oxaliplatin-loaded nanoemulsion containing Teucrium polium L. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway
Waad A. Al-Otaibi & Sahar M. AlMotwaa
Pages: 2190-2205
Published online: 10 Jul 2022
AbstractforOxaliplatin-loaded nanoemulsion containing Teucrium polium L. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2708 Views
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Article
Low-density lipoprotein encapsulated thiosemicarbazone metal complexes is active targeting vehicle for breast, lung, and prostate cancers
Laila Jaragh-Alhadad, Mayada Samir, Terri J. Harford & Sadashiva Karnik
Pages: 2206-2216
Published online: 10 Jul 2022
AbstractforLow-density lipoprotein encapsulated thiosemicarbazone metal complexes is active targeting vehicle for breast, lung, and prostate cancers | Full Text | References | PDF (1.7 MB) | EPUB
  • 1418 Views
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Article
Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization
Rui Zhang, Jingjing Yang, Qing Luo, Jieran Shi, Haohang Xu & Junjie Zhang
Pages: 2217-2233
Published online: 10 Jul 2022
AbstractforPreparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization | Full Text | References | PDF (2.2 MB) | EPUB
  • 2105 Views
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Article
Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis
Phimchanok Sakunpongpitiporn, Witthawat Naeowong & Anuvat Sirivat
Pages: 2234-2244
Published online: 18 Jul 2022
AbstractforEnhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis | Full Text | References | PDF (1.5 MB) | EPUB
  • 1804 Views
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Article
Thermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions
Fanyu Zhao & Jin-Chul Kim
Pages: 2245-2257
Published online: 09 Jul 2022
AbstractforThermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization
Hibah M. Aldawsari, N. Raghavendra Naveen, Nabil A. Alhakamy, Prakash S. Goudanavar, GSN Koteswara Rao, Roja Rani Budha, Anroop B. Nair & Shaimaa M. Badr-Eldin
Pages: 2258-2268
Published online: 15 Jul 2022
AbstractforCompression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization | Full Text | References | PDF (2 MB) | EPUB
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Article
Flexible nano-liposomes-based transdermal hydrogel for targeted delivery of dexamethasone for rheumatoid arthritis therapy
Yi-Pu Zhao, Jiang-Fan Han, Fei-Yue Zhang, Tian-Tian Liao, Ren Na, Xiao-Feng Yuan, Guang-bin He & Weiliang Ye
Pages: 2269-2282
Published online: 10 Jul 2022
AbstractforFlexible nano-liposomes-based transdermal hydrogel for targeted delivery of dexamethasone for rheumatoid arthritis therapy | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency
Lu Li, Zhiguo Li, Yongxin Guo, Kai Zhang, Weidong Mi & Jing Liu
Pages: 2283-2295
Published online: 22 Jul 2022
AbstractforPreparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application
Jingjing Yan, Weidong Fei, Qianqian Song, Yao Zhu, Na Bu, Li Wang, Mengdan Zhao & Xiaoling Zheng
Pages: 2296-2319
Published online: 21 Jul 2022
AbstractforCell membrane-camouflaged PLGA biomimetic system for diverse biomedical application | Full Text | References | PDF (3.7 MB) | EPUB
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Article
PEGylation improves the therapeutic potential of dimerized translationally controlled tumor protein blocking peptide in ovalbumin-induced mouse model of airway inflammation
Hyeran Seo, Hae-Duck Bae, Haejun Pyun, Bo-Gyu Kim, Sang-Il Lee, Jin-Sook Song & Kyunglim Lee
Pages: 2320-2329
Published online: 19 Jul 2022
AbstractforPEGylation improves the therapeutic potential of dimerized translationally controlled tumor protein blocking peptide in ovalbumin-induced mouse model of airway inflammation | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10
Thapa Chhitij, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Santosh Bashyal, Shrawani Lamichhane, Jung Hwan Kim, Jae Heon Lee, Jee Hun Park, Jaewoong Choi, Se Hyun Song & Sangkil Lee
Pages: 2330-2342
Published online: 19 Jul 2022
AbstractforOptimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10 | Full Text | References | PDF (1.4 MB) | EPUB
  • 2164 Views
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Article
Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evaluation in rabbits
Asmaa Ashraf Nemr, Galal Mohamed El-Mahrouk & Hany Abdo Badie
Pages: 2343-2356
Published online: 22 Jul 2022
AbstractforHyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evaluation in rabbits | Full Text | References | PDF (1.8 MB) | EPUB
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Article

Article
Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres
Alba Aragón-Navas, María J. Rodrigo, David Garcia-Herranz, Teresa Martinez, Manuel Subias, Silvia Mendez, Jesús Ruberte, Judit Pampalona, Irene Bravo-Osuna, Julian Garcia-Feijoo, Luis E. Pablo, Elena Garcia-Martin & Rocío Herrero-Vanrell
Pages: 2357-2374
Published online: 29 Jul 2022
AbstractforMimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2324 Views
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Research Articles

Article
Transferrin receptor targeting segment T7 containing peptide gene delivery vectors for efficient transfection of brain tumor cells
Ziyao Kang, Chunlan Zeng, Long Tian, Taoran Wang, Sen Yang, Qin Cheng, Jing Zhang, Qingbin Meng, Changhao Zhang & Zhao Meng
Pages: 2375-2385
Published online: 22 Jul 2022
AbstractforTransferrin receptor targeting segment T7 containing peptide gene delivery vectors for efficient transfection of brain tumor cells | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats
Yanhai Xi, Weiheng Wang, Liang Ma, Ning Xu, Changgui Shi, Guohua Xu, Hailong He & Wenming Pan
Pages: 2386-2402
Published online: 22 Jul 2022
AbstractforAlendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats | Full Text | References | PDF (4 MB) | EPUB
  • 2266 Views
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Article
Therapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma
Priyanca Ahlawat, Kanika Phutela, Amanjit Bal, Navneet Singh & Sadhna Sharma
Pages: 2403-2413
Published online: 26 Jul 2022
AbstractforTherapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma | Full Text | References | PDF (2.9 MB) | EPUB
  • 1649 Views
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Article
A facile method for anti-cancer drug encapsulation into polymersomes with a core-satellite structure
Hongchao Xu, Weiwei Cui, Zhitao Zong, Yinqiu Tan, Congjun Xu, Jiahui Cao, Ting Lai, Qi Tang, Zhongjuan Wang, Xiaofeng Sui & Cuifeng Wang
Pages: 2414-2427
Published online: 29 Jul 2022
AbstractforA facile method for anti-cancer drug encapsulation into polymersomes with a core-satellite structure | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1885 Views
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Article
Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments
Sadek Ahmed, Maha M. Amin, Sarah Mohamed El-Korany & Sinar Sayed
Pages: 2428-2441
Published online: 26 Jul 2022
AbstractforCorneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments | Full Text | References | PDF (1.8 MB) | EPUB
  • 1932 Views
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Article
Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives
Minhua Chen, Zhangxuan Shou, Xue Jin & Yingjun Chen
Pages: 2442-2458
Published online: 27 Jul 2022
AbstractforEmerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives | Full Text | References | PDF (1.7 MB) | EPUB
  • 2654 Views
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Article
Enhanced biological activity of liposomal methylated resveratrol analog 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model
Andrzej Nowicki, Dariusz Wawrzyniak, Mikołaj Czajkowski, Małgorzata Józkowiak, Michał Pawlak, Marcin Wierzchowski, Katarzyna Rolle, Paulina Skupin-Mrugalska & Hanna Piotrowska-Kempisty
Pages: 2459-2468
Published online: 27 Jul 2022
AbstractforEnhanced biological activity of liposomal methylated resveratrol analog 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Eman A. Bseiso, Sarah A. AbdEl-Aal, Maha Nasr, Omaima A. Sammour & Nabaweya A. Abd El Gawad
Pages: 2469-2480
Published online: 27 Jul 2022
AbstractforNose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
ROS-generating, pH-responsive and highly tunable reduced graphene oxide-embedded microbeads showing intrinsic anticancer properties and multi-drug co-delivery capacity for combination cancer therapy
Adilakshmi Boddu, Obireddy Sreekanth Reddy, Dahong Zhang, K. S. V. Krishna Rao & Wing-Fu Lai
Pages: 2481-2490
Published online: 31 Jul 2022
AbstractforROS-generating, pH-responsive and highly tunable reduced graphene oxide-embedded microbeads showing intrinsic anticancer properties and multi-drug co-delivery capacity for combination cancer therapy | Full Text | References | PDF (2 MB) | EPUB
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Article
Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome
Huiyun Zhang, Shunru Wei, Yu Zhang, Anran Pan, Michael Adu-Frimpong, Congyong Sun & Gang Qi
Pages: 2491-2497
Published online: 31 Jul 2022
AbstractforImproving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury
Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian & Chao Wu
Pages: 2498-2512
Published online: 28 Jul 2022
AbstractforChitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2676 Views
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Article
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy
Manling Wu, Min Wang, Haoyuan Jia & Peipei Wu
Pages: 2513-2538
Published online: 01 Aug 2022
AbstractforExtracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy | Full Text | References | PDF (3.5 MB) | EPUB
  • 4678 Views
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Article
A simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid
Jingxin Fu, Yian Wang, Haowen Li, Likang Lu, Meihua Han, Yifei Guo & Xiangtao Wang
Pages: 2539-2548
Published online: 31 Jul 2022
AbstractforA simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation
Mahmoud H. Teaima, Moaz A. Eltabeeb, Mohamed A. El-Nabarawi & Menna M. Abdellatif
Pages: 2549-2560
Published online: 31 Jul 2022
AbstractforUtilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation | Full Text | References | PDF (1.9 MB) | EPUB
  • 1951 Views
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Article
Enzyme-triggered- and tumor-targeted delivery with tunable, methacrylated poly(ethylene glycols) and hyaluronic acid hybrid nanogels
Wioletta Liwinska, Ewelina Waleka-Bagiel, Zbigniew Stojek, Marcin Karbarz & Ewelina Zabost
Pages: 2561-2578
Published online: 07 Aug 2022
AbstractforEnzyme-triggered- and tumor-targeted delivery with tunable, methacrylated poly(ethylene glycols) and hyaluronic acid hybrid nanogels | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Development and optimization of a tamsulosin nanostructured lipid carrier loaded with saw palmetto oil and pumpkin seed oil for treatment of benign prostatic hyperplasia
Rana B. Bakhaidar, Khaled M. Hosny, Imman M. Mahier, Waleed Y. Rizq, Awaji Y. Safhi, Deena M. Bukhary, Muhammad H. Sultan, Haitham A. Bukhary, Osama A. Madkhali & Fahad Y. Sabei
Pages: 2579-2591
Published online: 01 Aug 2022
AbstractforDevelopment and optimization of a tamsulosin nanostructured lipid carrier loaded with saw palmetto oil and pumpkin seed oil for treatment of benign prostatic hyperplasia | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Histopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in bleomycin-induced acute and chronic lung injury in rats
Neama M. Albanawany, Doaa M. Samy, Noha Zahran, Riham M. El-Moslemany, Shefaa Mf. Elsawy & Maha W. Abou Nazel
Pages: 2592-2608
Published online: 09 Aug 2022
AbstractforHistopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in bleomycin-induced acute and chronic lung injury in rats | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Correction Notice

Correction
Correction notice
Page: 2609
Published online: 08 Aug 2022
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Research Articles

Article
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling
Lianbi Zhao, Tian Zhou, Jianmei Chen, Wenbin Cai, Ruijing Shi, Yunyou Duan, Lijun Yuan & Changyang Xing
Pages: 2610-2620
Published online: 07 Aug 2022
AbstractforColon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling | Full Text | References | PDF (1.6 MB) | EPUB
  • 1765 Views
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Article
Tumor-derived extracellular vesicles for the active targeting and effective treatment of colorectal tumors in vivo
Van Du Nguyen, Ho Yong Kim, You Hee Choi, Jong-Oh Park & Eunpyo Choi
Pages: 2621-2631
Published online: 08 Aug 2022
AbstractforTumor-derived extracellular vesicles for the active targeting and effective treatment of colorectal tumors in vivo | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Statement of Retraction

Retraction
Statement of Retraction
Page: 2632
Published online: 25 Aug 2022
CitationforStatement of Retraction | Full Text | PDF (79.2 KB) | EPUB
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Article
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy
Yosif Almoshari, Haroon Iqbal, Anam Razzaq, Khalil Ali Ahmad, Muhammad Khalid Khan, Saad Saeed Alqahtani, Muhammad H. Sultan & Barkat Ali Khan
Pages: 2633-2643
Published online: 08 Aug 2022
AbstractforDevelopment of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Single pot organic solvent-free thermocycling technology for siRNA-ionizable LNPs: a proof-of-concept approach for alternative to microfluidics
Anindita De & Young Tag Ko
Pages: 2644-2657
Published online: 10 Aug 2022
AbstractforSingle pot organic solvent-free thermocycling technology for siRNA-ionizable LNPs: a proof-of-concept approach for alternative to microfluidics | Full Text | References | PDF (1.9 MB) | EPUB
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Article
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma
Shuyue Zhang, Xiuxiu Jiao, Michal Heger, Shen Gao, Mei He, Nan Xu, Jigang Zhang, Mingjian Zhang, Yuan Yu, Baoyue Ding & Xueying Ding
Pages: 2658-2670
Published online: 16 Aug 2022
AbstractforA tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment
Hibah M. Aldawsari, Shaimaa M. Badr-Eldin, Nourah Y. Assiri, Nabil A. Alhakamy, Anna Privitera, Filippo Caraci & Giuseppe Caruso
Pages: 2671-2684
Published online: 16 Aug 2022
AbstractforSurface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Human serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability
Shu-Jyuan Yang, Chih-Hao Chang, Tai-Horng Young, Chung-Hao Wang, Tzu-Hao Tseng & Man-Ling Wang
Pages: 2685-2693
Published online: 16 Aug 2022
AbstractforHuman serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats
Mohammed H. Elkomy, Hussein M. Eid, Mohammed Elmowafy, Khaled Shalaby, Ameeduzzafar Zafar, Mohamed A. Abdelgawad, Mostafa E. Rateb, Mohammed R.A. Ali, Izzeddin Alsalahat & Heba A. Abou-Taleb
Pages: 2694-2704
Published online: 16 Aug 2022
AbstractforBilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Prostate-specific membrane antigen targeted, glutathione-sensitive nanoparticles loaded with docetaxel and enzalutamide for the delivery to prostate cancer
Yang Chen, Zhenyu Xu, Tingxun Lu, Jia Luo & Hua Xue
Pages: 2705-2712
Published online: 18 Aug 2022
AbstractforProstate-specific membrane antigen targeted, glutathione-sensitive nanoparticles loaded with docetaxel and enzalutamide for the delivery to prostate cancer | Full Text | References | PDF (1.2 MB) | EPUB
  • 1905 Views
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Article
Intraperitoneal administration of thermosensitive hydrogel Co-loaded with norcantharidin nanoparticles and oxaliplatin inhibits malignant ascites of hepatocellular carcinoma
Susu Xiao, Yu Wang, Wenqiong Ma, Ping Zhou, Biqiong Wang, Zhouxue Wu, Qian Wen, Kang Xiong, Yanlin Liu & Shaozhi Fu
Pages: 2713-2722
Published online: 16 Aug 2022
AbstractforIntraperitoneal administration of thermosensitive hydrogel Co-loaded with norcantharidin nanoparticles and oxaliplatin inhibits malignant ascites of hepatocellular carcinoma | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
Meng Li, Hao Wu, Shuang Wang, Shengshun Wu, Jing Han & Yang Han
Pages: 2723-2733
Published online: 18 Aug 2022
AbstractforDevelopment of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes
Zhiwei Liang & Dongmei Chen
Pages: 2734-2741
Published online: 18 Aug 2022
AbstractforTargeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes | Full Text | References | PDF (985.3 KB) | EPUB
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Correction Notice

Correction
Correction Notice
Page: 2742
Published online: 22 Aug 2022
CitationforCorrection Notice | Full Text | PDF (75.5 KB) | EPUB
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Article
A novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum–Glycyrrhiza uralensis for targeting lung cancer
Chunjing Guo, Yanguo Su, Hui Wang, Min Cao, Ningning Diao, Zhongxin Liu, Daquan Chen & Ming Kong
Pages: 2743-2750
Published online: 23 Aug 2022
AbstractforA novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum–Glycyrrhiza uralensis for targeting lung cancer | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation
Man Li, Guoqiang Wang, Yinyin Yan, Mengyuan Jiang, Zhirong Wang, Zhenqiang Zhang, Xiangxiang Wu & Huahui Zeng
Pages: 2751-2758
Published online: 23 Aug 2022
AbstractforTriptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Cancer targeted drug delivery using active low-density lipoprotein nanoparticles encapsulated pyrimidines heterocyclic anticancer agents as microtubule inhibitors
Laila Jaragh-Alhadad, Haider Behbehani & Sadashiva Karnik
Pages: 2759-2772
Published online: 26 Aug 2022
AbstractforCancer targeted drug delivery using active low-density lipoprotein nanoparticles encapsulated pyrimidines heterocyclic anticancer agents as microtubule inhibitors | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation
Sarah A. Ali, Nabil A. Alhakamy, Khaled M. Hosny, Eman Alfayez, Deena M. Bukhary, Awaji Y. Safhi, Moutaz Y. Badr, Rayan Y. Mushtaq, Majed Alharbi, Bader Huwaimel, Mohammed Alissa, Sameer Alshehri, Ali H. Alamri & Taha Alqahtani
Pages: 2773-2783
Published online: 28 Aug 2022
AbstractforRapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies
Rofida Albash, Rania Moataz El-Dahmy, Mohammed I. A. Hamed, Khaled M. Darwish, Abdulrahman M. Alahdal, Amira B. Kassem & Abdurrahman M. Fahmy
Pages: 2784-2795
Published online: 01 Sep 2022
AbstractforRepurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Optimal treatment occasion for ultrasound stimulated microbubbles in promoting gemcitabine delivery to VX2 tumors
Tingting Luo, Luhua Bai, Yi Zhang, Leidan Huang, Hui Li, Shunji Gao, Xiaoxiao Dong, Ningshan Li & Zheng Liu
Pages: 2796-2804
Published online: 01 Sep 2022
AbstractforOptimal treatment occasion for ultrasound stimulated microbubbles in promoting gemcitabine delivery to VX2 tumors | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases
Zhengyu Fang, Jie Fang, Chunxiao Gao, Rui Gao, Peihong Lin & Wenying Yu
Pages: 2805-2814
Published online: 01 Sep 2022
AbstractforRecent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment
Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang & Zhaoqiang Dong
Pages: 2815-2823
Published online: 01 Sep 2022
AbstractforAcute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment | Full Text | References | PDF (1 MB) | EPUB
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Article
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin
Yixing Lu, Liuye Yang, Wanying Zhang, Shiting Xie, Feifei Zhao, Xianfeng Peng, Zonghua Qin, Dongping Zeng & Zhenling Zeng
Pages: 2824-2830
Published online: 05 Sep 2022
AbstractforEnhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin | Full Text | References | PDF (987.6 KB) | EPUB
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Article
Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design
Yoon Tae Goo, Sangkil Lee, Ji Yeh Choi, Min Song Kim, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Seh Hyon Song & Young Wook Choi
Pages: 2831-2845
Published online: 01 Sep 2022
AbstractforEnhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysis
Ayca Yildiz Pekoz, Ozlem Akbal Dagistan, Hanan Fael, Meltem Culha, Aybige Erturk, Nur Sena Basarir, Gokben Sahin, Muge Serhatli, Gamze Cakirca, Saban Tekin, Leyla Semiha Sen, Mustafa Sevim, Lutfiye Mulazimoglu Durmusoglu & Berrak C. Yegen
Pages: 2846-2854
Published online: 05 Sep 2022
AbstractforPulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysis | Full Text | References | PDF (989.5 KB) | EPUB
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Article
Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model
Cong Duc Nguyen, Jaehee Yoo, Eun Jin An, Chang Yub Sung, Do Hyeon Jeong, Soo-Yeon Park, Jae-Hong Kim & Gihyun Lee
Pages: 2855-2867
Published online: 05 Sep 2022
AbstractforPharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation
Rehab Abdelmonem, Inas Essam Ibrahim Al-Samadi, Rasha M. El Nashar, Bhaskara R. Jasti & Mohamed A. El-Nabarawi
Pages: 2868-2882
Published online: 05 Sep 2022
AbstractforFabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles
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Pages: 2883-2896
Published online: 05 Sep 2022
AbstractforMulti-fractal modeling of curcumin release mechanism from polymeric nanomicelles | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models
Ho Yong Kim, Hyun-Ki Min, Hyeong-Woo Song, Ami Yoo, Seonmin Lee, Kyu-Pyo Kim, Jong-Oh Park, You Hee Choi & Eunpyo Choi
Pages: 2897-2911
Published online: 06 Sep 2022
AbstractforDelivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models | Full Text | References | PDF (2.5 MB) | EPUB
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Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape
Xing Luo, Xiaoqiang Zeng, Li Gong, Yan Ye, Cun Sun, Ting Chen, Zelong Zhang, Yikun Tao, Hao Zeng, Quanming Zou, Yun Yang, Jieping Li & Hongwu Sun
Pages: 2912-2924
Published online: 08 Sep 2022
AbstractforNanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach
Maged Kharouba, Amal El-Kamel, Radwa Mehanna, Eman Thabet & Lamia Heikal
Pages: 2925-2944
Published online: 08 Sep 2022
AbstractforPitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach | Full Text | References | PDF (3 MB) | EPUB
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Article
Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management
Sadek Ahmed, Maha M. Amin, Sarah Mohamed El-Korany & Sinar Sayed
Pages: 2945-2958
Published online: 07 Sep 2022
AbstractforPronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management | Full Text | References | PDF (1.8 MB) | EPUB
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Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer
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Pages: 2959-2970
Published online: 09 Sep 2022
AbstractforMonoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer | Full Text | References | PDF (1 MB) | EPUB
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Article
The treatment efficacy of three-layered functional polymer materials as drug carrier for orthotopic colon cancer
Zhuo Liu, Dongxin Wang, Qian Cao & Jiannan Li
Pages: 2971-2983
Published online: 13 Sep 2022
AbstractforThe treatment efficacy of three-layered functional polymer materials as drug carrier for orthotopic colon cancer | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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RESEARCH ARTICLE

Article
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model
Yang Liu, Xiaoruo Zhu, Shiliang Ji, Zhen Huang, Yuhui Zang, Ying Ding, Junfeng Zhang & Zhi Ding
Pages: 2984-2994
Published online: 13 Sep 2022
AbstractforTransdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
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Article
Hepatocyte-targeting and tumor microenvironment-responsive liposomes for enhanced anti-hepatocarcinoma efficacy
Dongliang Cheng, Zhiwei Wen, Hui Chen, Shiyuan Lin, Wei Zhang, Xin Tang & Wei Wu
Pages: 2995-3008
Published online: 14 Sep 2022
AbstractforHepatocyte-targeting and tumor microenvironment-responsive liposomes for enhanced anti-hepatocarcinoma efficacy | Full Text | References | PDF (3 MB) | EPUB
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Article
Protein transduction domain of translationally controlled tumor protein: characterization and application in drug delivery
Jeehye Maeng & Kyunglim Lee
Pages: 3009-3021
Published online: 14 Sep 2022
AbstractforProtein transduction domain of translationally controlled tumor protein: characterization and application in drug delivery | Full Text | References | PDF (1 MB) | EPUB
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Article
Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia
Kousalya Prabahar, Ubaidulla Udhumansha, Nehal Elsherbiny & Mona Qushawy
Pages: 3022-3034
Published online: 15 Sep 2022
AbstractforMicroneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Development of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study
Nabil K Alruwaili, Ameeduzzafar Zafar, Omar Awad Alsaidan, Mohd Yasir, Ehab M. Mostafa, Sultan F. Alnomasy, Alenazy Rawaf, Ali Alquraini & Fadhel A. Alomar
Pages: 3035-3050
Published online: 18 Sep 2022
AbstractforDevelopment of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study | Full Text | References | PDF (2.9 MB) | EPUB
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Correction Notice

Correction
Correction notice
Page: 3051
Published online: 22 Sep 2022
CitationforCorrection notice | Full Text | PDF (115.8 KB) | EPUB
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Review

Review
Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges
Ruirui Zhang, Hao Zhang, Houyin Shi, Dan Zhang, Zhuo Zhang & Hao Liu
Pages: 3052-3070
Published online: 22 Sep 2022
AbstractforStrategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges | Full Text | References | PDF (2.6 MB) | EPUB
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RESEARCH ARTICLE

Article
Increased brain uptake of pterostilbene loaded folate modified micellar delivery system
Yinan Wang, Yanan Su, Yunqiao Yang, Huan Jin, Moli Wu, Qian Wang, Pengyuan Sun, Jianbin Zhang, Xiaobo Yang & Xiaohong Shu
Pages: 3071-3086
Published online: 21 Sep 2022
AbstractforIncreased brain uptake of pterostilbene loaded folate modified micellar delivery system | Full Text | References | PDF (2.5 MB) | EPUB
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Research Articles

Article
The most promising microneedle device: present and future of hyaluronic acid microneedle patch
Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han & Jing Han
Pages: 3087-3110
Published online: 23 Sep 2022
AbstractforThe most promising microneedle device: present and future of hyaluronic acid microneedle patch | Full Text | References | PDF (2.2 MB) | EPUB
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Article
‘Mito-Bomb’: a novel mitochondria-targeting nanosystem for ferroptosis-boosted sonodynamic antitumor therapy
Jianxin Wang, Zhiyu Zhao, Yan Liu, Xinyu Cao, Fuxin Li, Haitao Ran, Yang Cao & Changjun Wu
Pages: 3111-3122
Published online: 21 Sep 2022
Abstractfor‘Mito-Bomb’: a novel mitochondria-targeting nanosystem for ferroptosis-boosted sonodynamic antitumor therapy | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
A novel ligand-modified nanocomposite microparticles improved efficiency of quercetin and paclitaxel delivery in the non-small cell lung cancer
Xiaoming Cui, Fang Zhang, Yanyan Zhao, Pan Li, Ting Wang, Zhilu Xu, Jingjing Zhang & Weifen Zhang
Pages: 3123-3133
Published online: 23 Sep 2022
AbstractforA novel ligand-modified nanocomposite microparticles improved efficiency of quercetin and paclitaxel delivery in the non-small cell lung cancer | Full Text | References | PDF (2 MB) | EPUB
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Article
Cuprous oxide-based nanocrystals with combined chemo/chemodynamic therapy to increase tumor drug sensitivity by reducing mitochondria-derived adenosine-triphosphate
Haoran He, Jiaming Wu, Min Liang, Yao Xiao, Xuejian Wei, Yuqin Cao, Zhiheng Chen, Tian Lin & Miaosheng Ye
Pages: 3134-3141
Published online: 25 Sep 2022
AbstractforCuprous oxide-based nanocrystals with combined chemo/chemodynamic therapy to increase tumor drug sensitivity by reducing mitochondria-derived adenosine-triphosphate | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Synthesis of dual-stimuli responsive metal organic framework-coated iridium oxide nanocomposite functionalized with tumor targeting albumin-folate for synergistic photodynamic/photothermal cancer therapy
Xiangtian Deng, Renliang Zhao, Qingcheng Song, Yiran Zhang, Haiyue Zhao, Hongzhi Hu, Zhen Zhang, Weijian Liu, Wei Lin & Guanglin Wang
Pages: 3142-3154
Published online: 26 Sep 2022
AbstractforSynthesis of dual-stimuli responsive metal organic framework-coated iridium oxide nanocomposite functionalized with tumor targeting albumin-folate for synergistic photodynamic/photothermal cancer therapy | Full Text | References | PDF (12 MB) | EPUB | Supplemental
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Article
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments
Mohamed Y. Zakaria, Islam Zaki, Majid Alhomrani, Abdulhakeem S. Alamri, Osama Abdulaziz & Mohammed A.S. Abourehab
Pages: 3155-3167
Published online: 27 Sep 2022
AbstractforBoosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1121 Views
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Article
Novel linezolid loaded bio-composite films as dressings for effective wound healing: experimental design, development, optimization, and antimicrobial activity
Dina Saeed Ghataty, Reham Ibrahim Amer, Reham Wasfi & Rehab Nabil Shamma
Pages: 3168-3185
Published online: 02 Oct 2022
AbstractforNovel linezolid loaded bio-composite films as dressings for effective wound healing: experimental design, development, optimization, and antimicrobial activity | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Article
K. Zheng et al. Gold-nanoparticle-based multistage drug delivery system for antitumor therapy
Kaikai Zheng, Dong Zhou, Lili Wu, Jian Li, Bing Zhao, Shihao Zhang, Ruiying He, Lan Xiao, Iqbal Zoya, Li Yu, Yuhong Zhang, Yulin Li, Jie Gao & Kaichun Li
Pages: 3186-3196
Published online: 13 Oct 2022
AbstractforK. Zheng et al. Gold-nanoparticle-based multistage drug delivery system for antitumor therapy | Full Text | References | PDF (2.6 MB) | EPUB
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Article
A technical note on emerging combination approach involved in the onconanotherapeutics
Mohammad Kashif Iqubal, Harsimran Kaur, Shadab Md, Nabil A. Alhakamy, Ashif Iqubal, Javed Ali & Sanjula Baboota
Pages: 3197-3212
Published online: 13 Oct 2022
AbstractforA technical note on emerging combination approach involved in the onconanotherapeutics | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note
Haocheng Zhou, Dong Huang, Dingquan Zou, Junjiao Hu, Xinning Li & Yaping Wang
Pages: 3213-3217
Published online: 19 Oct 2022
AbstractforPrepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note | Full Text | References | PDF (597.8 KB) | EPUB
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Article
Nanotechnological approaches for diagnosis and treatment of ovarian cancer: a review of recent trends
Haigang Ding, Juan Zhang, Feng Zhang, Yan Xu, Wenqing Liang & Yijun Yu
Pages: 3218-3232
Published online: 19 Oct 2022
AbstractforNanotechnological approaches for diagnosis and treatment of ovarian cancer: a review of recent trends | Full Text | References | PDF (1.7 MB) | EPUB
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RESEARCH ARTICLE

Article
Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization and in vivo burn wound healing activity
Touseef Nawaz, Muhammad Iqbal, Barkat Ali Khan, Naveed Ahmed, Asif Nawaz, Akhtar Rasul, Waleed Y. Rizg, Abdulmajeed M. Jali, Rayan A. Ahmed & Awaji Y. Safhi
Pages: 3233-3244
Published online: 26 Oct 2022
AbstractforPolycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization and in vivo burn wound healing activity | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Design and applications of liposome-in-gel as carriers for cancer therapy
Yixuan Mou, Pu Zhang, Wing-Fu Lai & Dahong Zhang
Pages: 3245-3255
Published online: 30 Oct 2022
AbstractforDesign and applications of liposome-in-gel as carriers for cancer therapy | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Research Articles

Article
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity
Ruijie Lu, Run-Jie Yu, Chunhui Yang, Qian Wang, Yunxia Xuan, Zeqing Wang, Zhimin He, Yan Xu, Longfa Kou, Ying-Zheng Zhao, Qing Yao & Shi-Hao Xu
Pages: 3256-3269
Published online: 02 Nov 2022
AbstractforEvaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis
Asmaa A. Ashour, Amal H. El-Kamel, Radwa A. Mehanna, Ghada Mourad & Lamia A. Heikal
Pages: 3270-3280
Published online: 03 Nov 2022
AbstractforLuteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis | Full Text | References | PDF (2.4 MB) | EPUB
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RESEARCH ARTICLE

Article
Molecularly engineering a dual-drug nanoassembly for self-sensitized photodynamic therapy via thioredoxin impairment and glutathione depletion
Hongyuan Zhang, Zhiqiang Kong, Ziyue Wang, Yao Chen, Shenwu Zhang & Cong Luo
Pages: 3281-3290
Published online: 09 Nov 2022
AbstractforMolecularly engineering a dual-drug nanoassembly for self-sensitized photodynamic therapy via thioredoxin impairment and glutathione depletion | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Articles

Article
Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo
Jinkui Wang, Mujie Li, Liming Jin, Peng Guo, Zhaoxia Zhang, Chenghao Zhanghuang, Xiaojun Tan, Tao Mi, Jiayan Liu, Xin Wu, Guanghui Wei & Dawei He
Pages: 3291-3303
Published online: 09 Nov 2022
AbstractforExosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo | Full Text | References | PDF (2 MB) | EPUB
  • 2252 Views
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Article
Hydroxypropyl chitosan nail lacquer of ciclopirox-PLGA nanocapsules for augmented in vitro nail plate absorption and onychomycosis treatment
Eman Yahya Gaballah, Thanaa Mohammed Borg & Elham Abdelmonem Mohamed
Pages: 3304-3316
Published online: 13 Nov 2022
AbstractforHydroxypropyl chitosan nail lacquer of ciclopirox-PLGA nanocapsules for augmented in vitro nail plate absorption and onychomycosis treatment | Full Text | References | PDF (1.8 MB) | EPUB
  • 1299 Views
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Article
Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo
Zheng Sun, Xuejing Gu, Teng Hao, Jiali Liu, Rongrong Gao, Yanli Li, Bin Yu & Hui Xu
Pages: 3317-3327
Published online: 11 Nov 2022
AbstractforIntra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo | Full Text | References | PDF (2 MB) | EPUB
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Review Article

Review Article
Pullulan based derivatives: synthesis, enhanced physicochemical properties, and applications
Surendra Agrawal, Divya Budhwani, Pravina Gurjar, Darshan Telange & Vijay Lambole
Pages: 3328-3339
Published online: 11 Nov 2022
AbstractforPullulan based derivatives: synthesis, enhanced physicochemical properties, and applications | Full Text | References | PDF (1.2 MB) | EPUB
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Research Articles

Article
Development and optimization of amphiphilic self-assembly into nanostructured liquid crystals for transdermal delivery of an antidiabetic SGLT2 inhibitor
Nancy M. Lotfy, Mohammed Abdallah Ahmed, Nada M. El Hoffy, Ehab R. Bendas & Nadia M. Morsi
Pages: 3340-3357
Published online: 15 Nov 2022
AbstractforDevelopment and optimization of amphiphilic self-assembly into nanostructured liquid crystals for transdermal delivery of an antidiabetic SGLT2 inhibitor | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Docetaxel prodrug and hematoporphyrin co-assembled nanoparticles for anti-tumor combination of chemotherapy and photodynamic therapy
Guolian Ren, Yujie Li, Canqi Ping, Danyu Duan, Ning Li, Jiaqi Tang, Rongrong Wang, Wenju Guo, Xiaomin Niu, Qiuyue Ji, Guoshun Zhang, Ruili Wang & Shuqiu Zhang
Pages: 3358-3369
Published online: 17 Nov 2022
AbstractforDocetaxel prodrug and hematoporphyrin co-assembled nanoparticles for anti-tumor combination of chemotherapy and photodynamic therapy | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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RESEARCH ARTICLE

Article
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing
Mohammed Monirul Islam, Varshini HR, Penmetsa Durga Bhavani, Prakash S. Goudanavar, N. Raghavendra Naveen, B. Ramesh, Santosh Fattepur, Predeepkumar Narayanappa Shiroorkar, Mohammed Habeebuddin, Girish Meravanige, Mallikarjun Telsang & Nagaraja Sreeharsha
Pages: 3370-3383
Published online: 21 Nov 2022
AbstractforOptimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Articles

Article
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats
Ji-Hyun Kang, Min-Seok Yang, Dong-Wook Kim & Chun-Woong Park
Pages: 3384-3396
Published online: 22 Nov 2022
AbstractforIn vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats | Full Text | References | PDF (2.2 MB) | EPUB
  • 1516 Views
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Article
Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids
Laxman Subedi, Prashant Pandey, Bikram Khadka, Jung-Hyun Shim, Seung-Sik Cho, Seho Kweon, Youngro Byun, Ki-Taek Kim & Jin Woo Park
Pages: 3397-3413
Published online: 23 Nov 2022
AbstractforEnhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1455 Views
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RESEARCH ARTICLE

Article
Repurposing of atorvastatin emulsomes as a topical antifungal agent
Alaa S. Eita, Amna M. A. Makky, Asem Anter & Islam A. Khalil
Pages: 3414-3431
Published online: 25 Nov 2022
AbstractforRepurposing of atorvastatin emulsomes as a topical antifungal agent | Full Text | References | PDF (4 MB) | EPUB
  • 1353 Views
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Research Articles

Article
Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy
Wan Liu, Meng Cheng, Zhiyang Lu, Haocheng Li, Yulin Feng, Yi Jin, Shilin Yang, Jianfang Feng & Liangxing Tu
Pages: 3432-3442
Published online: 29 Nov 2022
AbstractforMulti-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 870 Views
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Article
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice
Andang Miatmoko, Nurul Ailda Marufah, Qothrin Nada, Noorma Rosita, Tristiana Erawati, Joni Susanto, Kusuma Eko Purwantari, Arif Nurkanto, Purwati   & Widji Soeratri
Pages: 3443-3453
Published online: 05 Dec 2022
AbstractforThe effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice | Full Text | References | PDF (2.3 MB) | EPUB
  • 1024 Views
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RESEARCH ARTICLE

Article
An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy
Huating Zeng, Xiaoqi Li, Yuping Liu, Xia Li, Ding Qu & Yan Chen
Pages: 3454-3466
Published online: 29 Nov 2022
AbstractforAn icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 911 Views
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