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Research Article

TRPM2 Is Elevated in the tMCAO Stroke Model, Transcriptionally Regulated, and Functionally Expressed in C13 Microglia

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Pages 179-198 | Published online: 10 Oct 2008

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Qing Wang, Ning Liu, Yuan-Shu Ni, Jia-Mei Yang, Lin Ma, Xiao-Bing Lan, Jing Wu, Jian-Guo Niu & Jian-Qiang Yu. (2021) TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention. Channels 15:1, pages 136-154.
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Yuyang Sun, Pramod Sukumaran, Anne Schaar & Brij B Singh. (2015) TRPM7 and its role in neurodegenerative diseases. Channels 9:5, pages 253-261.
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Lin-Hua Jiang, Wei Yang, Jie Zou & David J Beech. (2010) TRPM2 channel properties, functions and therapeutic potentials. Expert Opinion on Therapeutic Targets 14:9, pages 973-988.
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Articles from other publishers (65)

Maria Maliougina & Yassine El Hiani. (2023) TRPM2: bridging calcium and ROS signaling pathways—implications for human diseases. Frontiers in Physiology 14.
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Kalina Kazandzhieva, Elmina Mammadova-Bach, Alexander Dietrich, Thomas Gudermann & Attila Braun. (2022) TRP channel function in platelets and megakaryocytes: basic mechanisms and pathophysiological impact. Pharmacology & Therapeutics 237, pages 108164.
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Ranabir Chakraborty & Chandan Goswami. (2022) Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity. Biochemical and Biophysical Research Communications 611, pages 132-139.
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Pengyu Zong, Jianlin Feng, Zhichao Yue, Albert S. Yu, Jean Vacher, Evan R. Jellison, Barbara Miller, Yasuo Mori & Lixia Yue. (2022) TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2–CD36 inflammatory axis in macrophages. Nature Cardiovascular Research 1:4, pages 344-360.
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Ana Flávia Fernandes Ferreira, Monique Patricio Singulani, Henning Ulrich, Zhong-Ping Feng, Hong-Shuo Sun & Luiz Roberto Britto. (2022) Inhibition of TRPM2 by AG490 Is Neuroprotective in a Parkinson’s Disease Animal Model. Molecular Neurobiology 59:3, pages 1543-1559.
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Pengyu Zong, Qiaoshan Lin, Jianlin Feng & Lixia Yue. (2022) A Systemic Review of the Integral Role of TRPM2 in Ischemic Stroke: From Upstream Risk Factors to Ultimate Neuronal Death. Cells 11:3, pages 491.
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Pei-Pei Guan, Long-Long Cao, Yi Yang & Pu Wang. (2021) Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits. Frontiers in Molecular Neuroscience 14.
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Maniselvan Kuppusamy, Matteo Ottolini & Swapnil K. Sonkusare. (2021) Role of TRP ion channels in cerebral circulation and neurovascular communication. Neuroscience Letters 765, pages 136258.
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Pavan Thapak, Mahendra Bishnoi & Shyam S. Sharma. (2020) Pharmacological Inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study. Current Neurovascular Research 17:3, pages 249-258.
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Rui Wang, Sheng Tu, Jianmin Zhang & Anwen Shao. (2020) Roles of TRP Channels in Neurological Diseases. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
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Chendi Mai, Harneet Mankoo, Linyu Wei, Xinfang An, Chaokun Li, Dongliang Li & Lin‐Hua Jiang. (2019) TRPM2 channel: A novel target for alleviating ischaemia‐reperfusion, chronic cerebral hypo‐perfusion and neonatal hypoxic‐ischaemic brain damage. Journal of Cellular and Molecular Medicine 24:1, pages 4-12.
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Pratik Adhya & Shyam Sunder Sharma. (2019) Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation. Pharmacological Research 146, pages 104271.
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Ondřej BaszczyňskiJoanna M. WattMonika D. Rozewitz, Andreas H. Guse, Ralf Fliegert & Barry V. L. Potter. (2019) Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2. The Journal of Organic Chemistry 84:10, pages 6143-6157.
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Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori & Shunichi Shimizu. (2019) Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition. Journal of Pharmacology and Experimental Therapeutics 368:2, pages 246-254.
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Melanie Ratnam, Jonathan Chan, Naghmeh Lesani, Elena Sidorova‐Darmos, James H. Eubanks & Michelle M. Aarts. (2018) mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. International Journal of Developmental Neuroscience 69:1, pages 23-31.
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Giulia Sita, Patrizia Hrelia, Agnese Graziosi, Gloria Ravegnini & Fabiana Morroni. (2018) TRPM2 in the Brain: Role in Health and Disease. Cells 7:7, pages 82.
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Jillian Corinne Belrose & Michael Frederick Jackson. (2018) TRPM2: a candidate therapeutic target for treating neurological diseases. Acta Pharmacologica Sinica 39:5, pages 722-732.
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Ekaterina Turlova, Zhong-ping Feng & Hong-shuo Sun. (2018) The role of TRPM2 channels in neurons, glial cells and the blood-brain barrier in cerebral ischemia and hypoxia. Acta Pharmacologica Sinica 39:5, pages 713-721.
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Chun-Hsiang Tan & Peter A. McNaughton. (2018) TRPM2 and warmth sensation. Pflügers Archiv - European Journal of Physiology 470:5, pages 787-798.
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Yuyang Sun, Pramod Sukumaran, Senthil Selvaraj, Nicholas I. Cilz, Anne Schaar, Saobo Lei & Brij B. Singh. (2016) TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death. Molecular Neurobiology 55:1, pages 409-420.
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Xin Li, Wei Yang & Lin-Hua Jiang. (2017) Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death. Frontiers in Molecular Neuroscience 10.
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John G. Starkus, Peter Poerzgen, Kristine Layugan, Kelly Galbraith Kawabata, Jun-Ichi Goto, Sayuri Suzuki, George Myers, Michelle Kelly, Reinhold Penner, Andrea Fleig & F. David Horgen. (2017) Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels. Journal of Natural Products 80:10, pages 2741-2750.
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Sammen Huang, Ekaterina Turlova, Feiya Li, Mei-hua Bao, Vivian Szeto, Raymond Wong, Ahmed Abussaud, Haitao Wang, Shuzhen Zhu, Xinzheng Gao, Yasuo Mori, Zhong-Ping Feng & Hong-Shuo Sun. (2017) Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice. Experimental Neurology 296, pages 32-40.
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Ralf Fliegert, Andreas Bauche, Adriana-Michelle Wolf Pérez, Joanna M Watt, Monika D Rozewitz, Riekje Winzer, Mareike Janus, Feng Gu, Annette Rosche, Angelika Harneit, Marianne Flato, Christelle Moreau, Tanja Kirchberger, Valerie Wolters, Barry V L Potter & Andreas H Guse. (2017) 2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist. Nature Chemical Biology 13:9, pages 1036-1044.
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Murat Cakir, Halil Duzova, Suat Tekin, Elif Taslıdere, Gul Busra Kaya, Yılmaz Cigremis, Tuba Ozgocer & Saim Yologlu. (2017) ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats. Life Sciences 176, pages 10-20.
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Paulo Wagner Pires & Scott Earley. (2017) Redox regulation of transient receptor potential channels in the endothelium. Microcirculation 24:3.
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Sharifah Syed Mortadza, Joan A. Sim, Martin Stacey & Lin-Hua Jiang. (2017) Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells. Scientific Reports 7:1.
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Ling-Yan Zhao, Wan-Lin Xu, Zeng-Qi Xu, Cui Qi, Yang Li, Jie Cheng, Lai-Kui Liu, Yu-Nong Wu, Jun Gao & Jin-Hai Ye. (2016) The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma. Scientific Reports 6:1.
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Kai-yu Zhan, Pei-lin Yu, Chun-hui Liu, Jian-hong Luo & Wei Yang. (2016) Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury. Acta Pharmacologica Sinica 37:1, pages 4-12.
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