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Original Articles

Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve

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Pages 97-108 | Received 25 Nov 2019, Accepted 20 Jan 2020, Published online: 05 Feb 2020

Keep up to date with the latest research on this topic with citation updates for this article.

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Bingqian Li, Huili Shao, Lei Gao, Huan Li, Huagang Sheng & Liqiao Zhu. (2022) Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review. Drug Delivery 29:1, pages 2130-2161.
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Kenan Yıldızhan & Mustafa Nazıroğlu. (2022) Protective role of selenium on MPP+ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells. Journal of Receptors and Signal Transduction 42:4, pages 399-408.
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Qing Wang, Ning Liu, Yuan-Shu Ni, Jia-Mei Yang, Lin Ma, Xiao-Bing Lan, Jing Wu, Jian-Guo Niu & Jian-Qiang Yu. (2021) TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention. Channels 15:1, pages 136-154.
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Articles from other publishers (19)

Bünyamin Aydın & Mustafa Nazıroğlu. (2022) Involvement of TRPM7 Channel on the Induction of Diabetic Neuropathic Pain in Mice: Protective Role of Selenium and Curcumin. Biological Trace Element Research 201:5, pages 2377-2395.
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Alper Ertuğrul, Dilek Özkaya & Mustafa Nazıroğlu. (2023) Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line. Graefe's Archive for Clinical and Experimental Ophthalmology.
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Mojtaba Heydari, Mohammad Reza Khalili, Mohammad Hossein Nowroozzadeh, Shahram Bamdad, Amirhossein Sahebkar, Mohammad Ali Shariati & Muthu Thiruvengadam. (2023) Therapeutic Implications of Curcumin in the Treatment of Inflammatory Eye Diseases: A Review. Current Pharmaceutical Biotechnology 24:4, pages 553-561.
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Adem Ahlatcı, Kenan Yıldızhan, Yasin Tülüce & Muhammet Bektaş. (2022) Valproic Acid Attenuated PTZ-induced Oxidative Stress, Inflammation, and Apoptosis in the SH-SY5Y Cells via Modulating the TRPM2 Channel. Neurotoxicity Research 40:6, pages 1979-1988.
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Ramazan ÇINAR. (2022) Depletion of glutathione induced apoptosis and oxidative stress via the activation of TRPM2 channels in the microglia cells with Alzheimer’ disease model. Journal of Cellular Neuroscience and Oxidative Stress 14:1, pages 1063-1073.
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Hatice Daldal & Mustafa Nazıroğlu. (2022) Selenium and Resveratrol Attenuated Diabetes Mellitus-Mediated Oxidative Retinopathy and Apoptosis via the Modulation of TRPM2 Activity in Mice. Biological Trace Element Research 200:5, pages 2283-2297.
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Delphine Ji, Zheng-wei Luo, Andrea Ovcjak, Rahmah Alanazi, Mei-Hua Bao, Zhong-Ping Feng & Hong-Shuo Sun. (2021) Role of TRPM2 in brain tumours and potential as a drug target. Acta Pharmacologica Sinica 43:4, pages 759-770.
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Asal Jalal Abadi, Sepideh Mirzaei, Mahmood Khaksary Mahabady, Farid Hashemi, Amirhossein Zabolian, Fardin Hashemi, Pourya Raee, Shahin Aghamiri, Milad Ashrafizadeh, Amir Reza Aref, Michael R. Hamblin, Kiavash Hushmandi, Ali Zarrabi & Gautam Sethi. (2021) Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects. Phytotherapy Research 36:1, pages 189-213.
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Mustafa Güzel, Mustafa Nazıroğlu, Orhan Akpınar & Ramazan Çınar. (2021) Interferon Gamma-Mediated Oxidative Stress Induces Apoptosis, Neuroinflammation, Zinc Ion Influx, and TRPM2 Channel Activation in Neuronal Cell Line: Modulator Role of Curcumin. Inflammation 44:5, pages 1878-1894.
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Wioletta Zielińska, Jan Zabrzyński, Maciej Gagat & Alina Grzanka. (2021) The Role of TRPM2 in Endothelial Function and Dysfunction. International Journal of Molecular Sciences 22:14, pages 7635.
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Hamit Hakan Armağan & Mustafa Nazıroğlu. (2020) Curcumin Attenuates Hypoxia-Induced Oxidative Neurotoxicity, Apoptosis, Calcium, and Zinc Ion Influxes in a Neuronal Cell Line: Involvement of TRPM2 Channel. Neurotoxicity Research 39:3, pages 618-633.
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İzem Olcay Şahin. (2021) How curcumin affects hyperglycemia-induced optic nerve damage: A short review. Journal of Chemical Neuroanatomy 113, pages 101932.
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Huiru Fu, Zexin Jiao, Yongjing Li, Jing Tian, Liting Ren, Fuqiang Zhang, Qi Li & Shikai Liu. (2021) Transient Receptor Potential (TRP) Channels in the Pacific Oyster (Crassostrea gigas): Genome-Wide Identification and Expression Profiling after Heat Stress between C. gigas and C. angulata. International Journal of Molecular Sciences 22:6, pages 3222.
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Jian Huang, Ruilin Zhang, Shangwen Wang, Dongxian Zhang, Chi-Kwan Leung, Genmeng Yang, Yuanyuan Li, Liu Liu, Yue Xu, Shucheng Lin, Chan Wang, Xiaofeng Zeng & Juan Li. (2021) Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel. Frontiers in Pharmacology 12.
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Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Farid Hashemi, Ebrahim Rahmani Moghadam, Marzieh Owrang, Fardin Hashemi, Pooyan Makvandi, Mohammad Ali Sheikh Beig Goharrizi, Masoud Najafi & Haroon Khan. (2021) Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators. Cellular Signalling 78, pages 109871.
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Yener Akyuva, Mustafa Nazıroğlu & Kenan Yıldızhan. (2020) Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia. Metabolic Brain Disease 36:2, pages 285-298.
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Martial Caillaud, Yu Aung Myo, Bryan McKiver, Urszula Osinska Warncke, Danielle Thompson, Jared Mann, Egidio Del Fabbro, Alexis Desmoulière, Fabrice Billet & M. Damaj. (2020) Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies. Antioxidants 9:10, pages 950.
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Kenan Yıldızhan & Mustafa Nazıroğlu. (2020) Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia. Molecular Neurobiology 57:8, pages 3508-3525.
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Elif İlknur Ekici, Mehmet Güney & Mustafa Nazıroğlu. (2020) Protective effect of cabergoline on mitochondrial oxidative stress-induced apoptosis is mediated by modulations of TRPM2 in neutrophils of patients with endometriosis. Journal of Bioenergetics and Biomembranes 52:3, pages 131-142.
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